Asian Pacific Journal of Reproduction最新文献

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Prevalence and risks of reproductive tract infections among women of urban slums in North India: A cross-sectional study 印度北部城市贫民窟妇女生殖道感染的患病率和风险:一项横断面研究
Asian Pacific Journal of Reproduction Pub Date : 2022-11-01 DOI: 10.4103/2305-0500.361221
Mita Singh, Shipra Saini, P. Goyal, E. Gupta, Shweta Goswami
{"title":"Prevalence and risks of reproductive tract infections among women of urban slums in North India: A cross-sectional study","authors":"Mita Singh, Shipra Saini, P. Goyal, E. Gupta, Shweta Goswami","doi":"10.4103/2305-0500.361221","DOIUrl":"https://doi.org/10.4103/2305-0500.361221","url":null,"abstract":"Objective: To identify the prevalence, determinants of reproductive tract infection, and healthcare seeking behavior among ever married women of reproductive age residing in an urban slum of Faridabad, Haryana, North India. Methods: This community based cross-sectional study was conducted among ever married women aged between 15 and 49 years insured under employees state insurance scheme and residing in an urban slum of Faridabad. Simple random sampling technique was used to interview 149 eligible women using a predesigned structured questionnaire. Study variables included sociodemographic profile, family planning methods, menstrual absorbent usage, and symptoms of reproductive tract infection. Binary logistic regression was used to investigate the determinants of reproductive tract infection. Results: Of the women, 46.3% had at least one reproductive tract infection or sexually transmitted infection symptom and 28.9% among them sought treatment for the symptom. Vaginal discharge, itching (14.1%) and lower abdominal pain (30.2%) were the major symptoms reported. Non-usage of condoms as contraceptive was significantly associated with a higher rate of symptoms (50.4% vs. 20.0%). Abortion had a significantly high odds of having reproductive tract infection symptoms (aOR 3.71, 95% CI 1.59-8.62; P<0.01). Less frequent change in absorbent during menstruation was also reported to have a higher rate of symptoms. The majority of those who took treatment sought it from government or employees state insurance dispensary. 2% also went to faith healers. Conclusions: Nearly half of the study population have reproductive tract infection symptom. Abortions and non-usage of condom increase the risk of reproductive tract infection. Menstrual hygiene and condom usage are the significant interventions, which may reduce the prevalence of these symptoms.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"253 - 260"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47377235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ovarian hyperstimulation syndrome following the use of GnRH agonist trigger of final oocyte maturation and freeze-all strategy: A case report and review of the literature 使用GnRH激动剂引发最终卵母细胞成熟和冷冻策略后的卵巢过度刺激综合征:一例报告和文献回顾
Asian Pacific Journal of Reproduction Pub Date : 2022-11-01 DOI: 10.4103/2305-0500.356846
D. Khalife, S. Ghunaim, L. Taha, Omar Odeh, N. Habr, J. Awwad
{"title":"Ovarian hyperstimulation syndrome following the use of GnRH agonist trigger of final oocyte maturation and freeze-all strategy: A case report and review of the literature","authors":"D. Khalife, S. Ghunaim, L. Taha, Omar Odeh, N. Habr, J. Awwad","doi":"10.4103/2305-0500.356846","DOIUrl":"https://doi.org/10.4103/2305-0500.356846","url":null,"abstract":"Rationale: The current literature has a surprising controversy regarding the use of low-dose human chorionic gonadotropin (hCG) for luteal support as an explanation for the development of ovarian hyperstimulation syndrome, and this is because of the gap in the listing of the predisposing factors that put women at an increased risk of ovarian hyperstimulation syndrome. Patient concerns: A case of 25-year-old woman presented with abdominal pain, distention, dyspnea, and nausea with a 6.5 kg increase in weight from baseline. Ultrasonographic examination showed bilaterally enlarged multicystic ovaries after gonadotropin-releasing hormone (GnRH) agonist triggering and cycle segmentation with no hCG rescue administration. Diagnosis: Moderate/severe ovarian hyperstimulation syndrome. Interventions: The woman was admitted to the hospital for medical management of moderate/severe ovarian hyperstimulation syndrome, and pain management was advanced to patient-controlled anesthesia with the start of low molecular weight heparin. On day 2, albumin therapy followed by a furosemide chase was started due to an increase in abdominal girth. On day 1, Cabergoline was maintained, and on day 2 the GnRH antagonist Cetrorelix was started. Outcomes: The woman’s clinical condition improved, and a clinical pregnancy was eventually achieved during the first cryo-warmed blastocyst cycle. Lessons: Ovarian hyperstimulation syndrome can still happen even after the use of GnRH agonist and avoidance of hCG support. Segmentation of in vitro fertilization with complete avoidance of hCG for luteal support remains the best approach.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"292 - 298"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42400931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of readiness for discharge in mothers of preterm infants: The role of stress, self-efficacy and perceived social support 早产儿母亲出院准备的预测因素:压力、自我效能和感知社会支持的作用
Asian Pacific Journal of Reproduction Pub Date : 2022-11-01 DOI: 10.4103/2305-0500.356845
Parvaneh Vasli, Sedighe Valipour, F. Estebsari, M. Nasiri
{"title":"Predictors of readiness for discharge in mothers of preterm infants: The role of stress, self-efficacy and perceived social support","authors":"Parvaneh Vasli, Sedighe Valipour, F. Estebsari, M. Nasiri","doi":"10.4103/2305-0500.356845","DOIUrl":"https://doi.org/10.4103/2305-0500.356845","url":null,"abstract":"Objective: To determine the predictive role of stress, self-efficacy, and perceived social support on readiness for discharge in mothers of preterm infants. Methods: The present cross-sectional, descriptive-analytical study was conducted on 120 mothers of preterm infants admitted to hospitals affiliated to Lorestan University of Medical Sciences, Iran in 2019. Participants were selected by a convenience sampling method and based on inclusion criteria. Data collection tools included the demographic questionnaire of mothers and infants, parent perceptions of their child′s hospital discharge, parental stressor scale: neonatal intensive care unit, perceived maternal parenting, and multidimensional scale of perceived social support. Data were analyzed using Pearson correlation and stepwise regression at the significance level of 0.05. Results: Infant behavior and appearance, situational belief, and family support achieved the highest mean score from parents′ stress, self-efficacy, and perceived social support dimensions, respectively. There was a significant relationship between stress, self-efficacy, and perceived social support with readiness for discharge in mothers of preterm infants (P<0.001). The score of mothers′ readiness for discharge decreased by 0.07 per 1-point increase in stress score, and the score of readiness for discharge in mothers of preterm infants rose by 0.35 and 0.43, respectively, for a unit increase in the scores of self-efficacy and perceived social support. Conclusions: Stress, self-efficacy, and perceived social support can be considered as predictors of readiness for discharge in mothers of preterm infants. It is suggested that nurses in neonatal intensive care units provide a better platform for the readiness for discharge in mothers of preterm infants by reducing stressors and increasing maternal self-efficacy and social support.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"269 - 275"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42267010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Awareness about transmission and preventive measures of COVID-19 from mother to child: A cross-sectional study among pregnant women 对COVID-19母婴传播和预防措施的认识:孕妇的横断面研究
Asian Pacific Journal of Reproduction Pub Date : 2022-11-01 DOI: 10.4103/2305-0500.361222
Neetu Singh, Sugandha Jauhari
{"title":"Awareness about transmission and preventive measures of COVID-19 from mother to child: A cross-sectional study among pregnant women","authors":"Neetu Singh, Sugandha Jauhari","doi":"10.4103/2305-0500.361222","DOIUrl":"https://doi.org/10.4103/2305-0500.361222","url":null,"abstract":"Objective: To study the knowledge, attitude, and practice of pregnant women regarding transmission and preventive measures of COVID-19 from mother to child and to determine the reasons for vaccine hesitancy. Methods: This observational cross-sectional knowledge, attitude, and practice study was conducted among pregnant women of any trimester, attending the antenatal care out-patient department of a tertiary care hospital in Lucknow from October 2020 to March 2021. All the participants were interviewed using a pretested semistructured questionnaire for desired information. Reasons for vaccine hesitancy were also asked to assess their unwillingness to get vaccinated. Results: Totally 652 pregnant women were included and 91.3% were aware that COVID-19 spread through contact with an infected person and 85.3% knew that COVID-19 spread by respiratory droplets. Of pregnant women, 95.7% perceived that social distancing and wearing a proper mask were effective ways to prevent SARS-CoV-2 infection and 96.8% of the pregnant women wore masks regularly when going out. Of pregnant women, 79.0% were hesitant to get vaccinated. The most common reason was that COVID-19 vaccine can harm the developing fetus (77.5%) and was not very safe in pregnancy (75.0%). Conclusions: Of the pregnant women, 22.92% have unsatisfactory knowledge regarding COVID-19, 35.63% have negative attitude and 19.93% have poor practices, indicating that there are still gaps in awareness, and majority of them are unwilling to get vaccinated. Good awareness will help prevent the occurrence of future COVID-19 waves in India.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"261 - 268"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44686660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L–arginine alleviates postmenopausal complications in female rats by stimulating ovarian dopamine beta hydroxylase L-精氨酸通过刺激卵巢多巴胺β-羟化酶减轻雌性大鼠绝经后并发症
Asian Pacific Journal of Reproduction Pub Date : 2022-11-01 DOI: 10.4103/2305-0500.361223
Fatemeh Lakzaei, M. Karami, M. Jalali Nadoushan
{"title":"L–arginine alleviates postmenopausal complications in female rats by stimulating ovarian dopamine beta hydroxylase","authors":"Fatemeh Lakzaei, M. Karami, M. Jalali Nadoushan","doi":"10.4103/2305-0500.361223","DOIUrl":"https://doi.org/10.4103/2305-0500.361223","url":null,"abstract":"Objective: To evaluate the levels of estrogen, albumin and gonadotropins (luteinizing hormone, follicle-stimulating hormone) as well as the activity of dopamine beta hydroxylase (DAß H) in aged female rats treated with nitric oxide precursor L-arginine and neuronal nitric oxide synthase antagonist L-NAME. Methods: A total of 224 Wistar rats (36 weeks old, weighing 250 g) based on a random sampling were divided into the control and experimental groups after Pap smear test. The control group received only saline (1 mL/kg) intraperitoneally (i.p.). The experiential groups were treated with L-arginine (5, 25 and 50 mg/kg, i.p.) and L-NAME (5 and 25 mg/kg, i.p.) for 3 to 21 days, once a day. Blood samples were taken from the rats and the levels of estrogen and albumin and gonadotropins in the serum were monitored by enzyme-linked immunosorbent assay kit, and the ovaries were examined immunohistopathologically for DAßH activity. Results: L-arginine (5 mg/kg) significantly increased estrogen level (P<0.05), which was associated with DAßH activation in the ovaries. L-NAME reduced this effect when administered prior to L-arginine dose. L-arginine caused no significant change in the levels of luteinizing hormone and follicle-stimulating hormone. Except for the lowest dose of L-arginine in the shortest period, albumin levels significantly decreased in other treatments compared to the control group (P<0.05). Conclusions: L-arginine is likely to reduce postmenopausal problems due to an increased nitric oxide level.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"276 - 284"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48062255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exogenous gonadotropin releasing hormone (GnRH) modulates scrotal and testicular biometrics, libido, endocrinological and heamatological profiles in Ganjam goat under humid tropical coastal ecosystem of Odisha 外源性促性腺激素释放激素(GnRH)调节奥里萨邦潮湿热带沿海生态系统下甘jam山羊的阴囊和睾丸生物特征、性欲、内分泌和血液学特征
Asian Pacific Journal of Reproduction Pub Date : 2022-11-01 DOI: 10.4103/2305-0500.361224
Jibanjyoti Nayak, A. Nahak, Purna Mishra, D. Karna, C. Mishra, Perumal Ponraj
{"title":"Exogenous gonadotropin releasing hormone (GnRH) modulates scrotal and testicular biometrics, libido, endocrinological and heamatological profiles in Ganjam goat under humid tropical coastal ecosystem of Odisha","authors":"Jibanjyoti Nayak, A. Nahak, Purna Mishra, D. Karna, C. Mishra, Perumal Ponraj","doi":"10.4103/2305-0500.361224","DOIUrl":"https://doi.org/10.4103/2305-0500.361224","url":null,"abstract":"Objective: To assess the effect of exogenous gonadotropin releasing hormone (GnRH) in libido, scrotal and testicular biometrics, endocrinological and heamatological profiles of Ganjam goat buck during winter and pre-monsoon seasons. Methods: Forty eight healty Ganjam goat bucks of 3-4 years old were equally divided into the control and treatment groups. The control group received distilled water as placebo, while the treatment group received GnRH injection (4 μg Buserelin acetate/mL) once a week for four months. Body weight, scrotal circumference and testicular parameters (testicular volume, testicular weight and testis index), endocrinological profiles [follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone], sex behavioural profiles (libido score, mating ability score, and sex behavioural score) and heamatological profiles (red blood cells, white blood cells, haemoglobin, and packed cell volume) were estimated. Results: The libido, scrotal and testicular biometrics, and endocrinological profiles significantly differed between the control and GnRH-treated bucks within and between the seasons within the two groups (P<0.05). Body weight, scrotal circumference, testicular volume, testicular weight, testis index, FSH, LH, testosterone, libido score, mating ability score, sex behavioural score, red blood cells, haemoglobin and packed cell volume were significantly higher in the GnRH-treated bucks compared to the control bucks in pre-monsoon and winter seasons (P<0.05). Body weight, scrotal circumference, testicular volume, testicular weight, testis index, FSH, LH, testosterone, libido score, mating ability score, sex behavioural score, red blood cell counts (in treatment), and haemoglobin were significantly higher in pre-monsoon compared to winter season in the experimental groups (P<0.05). The white blood cell counts neither differed between seasons nor between the two groups. Conclusions: Exogenous GnRH supplementation and pre-monsoon season have higher beneficial effects in improvement of endocrinological profiles with cascading beneficial effects on scrotal circumference, testicular volume, testicular weight, and sex behavioural profiles, which in turn will improve the sperm production and its cryo-survivability and fertility rate in Ganjam goat.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"285 - 291"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47243625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical pregnancy rate of women with unexplained infertility with or without cervical mucus aspiration before intrauterine insemination: A randomized controlled trial 不明原因不孕妇女宫内受精前是否吸入宫颈粘液的临床妊娠率:一项随机对照试验
Asian Pacific Journal of Reproduction Pub Date : 2022-11-01 DOI: 10.4103/2305-0500.361220
R. Vatsa, V. Suri, S. Gainder, Aashima Arora, Japleen Kaur, N. Choudhary, Shruti Sharma
{"title":"Clinical pregnancy rate of women with unexplained infertility with or without cervical mucus aspiration before intrauterine insemination: A randomized controlled trial","authors":"R. Vatsa, V. Suri, S. Gainder, Aashima Arora, Japleen Kaur, N. Choudhary, Shruti Sharma","doi":"10.4103/2305-0500.361220","DOIUrl":"https://doi.org/10.4103/2305-0500.361220","url":null,"abstract":"Objective: To detect effect of removing cervical mucus before performing intrauterine insemination (IUI) on pregnancy rate in patients with unexplained infertility. Methods: The randomized controlled trial was conducted in Infertility Division of Department of Obstetrics and Gynaecology of a tertiary care hospital. Totally 80 patients of unexplained infertility were recruited. By computer generated block randomization in block size of 4 and 6, patients were randomly allocated at time of starting ovarian stimulation into the cervical mucus removal group or the non-removal of cervical mucus group before IUI, 40 in each group. Ovarian stimulation with clomiphene 100 mg from day 2-6 of menstrual cycle along with human menopausal gonadotropin 150 IU was given alternate day starting from day 7. Follicular monitoring was done and further doses given as per response; trigger was planned when 1-3 follicle reach a diameter of >18 mm. IUI was planned after trigger. IUI was done as per the group allocated. Mucus cleaning was done in the cervical mucus removal group by aspirating mucus with IUI syringe and sterile cotton swab before IUI. The primary outcome was clinical pregnancy rate. Number of difficult IUIs and cycle cancellation due to ovarian hyperstimulation were also noted. Results: IUI was not done in 4 patients due to hyperstimulation. Pregnancies per IUI cycle occurred in 7.9% (3/38) in the cervical mucus removal group and 21.1% (8/38) in the non-removal of cervical mucus group. There was no statistically significant difference in clinical pregnancy rate between two groups (P=0.19). Conclusions: There is a trend towards a lower clinical pregnancy rate with removal of cervical mucus before IUI in women of unexplained infertility though the difference is not statistically significant. Further studies with large sample size need to be done on this intervention. Trial registration: The trial registration was done with Clinical Trial Registry-India (Registration number: CTRI/2019/03/018326).","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"247 - 252"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42478700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of the microbial culture of follicular fluid, vaginal swab and catheter tip with β–hCG IVF positive and negative 卵泡液、阴道拭子和导管尖端微生物培养与体外受精β-hCG阳性和阴性的关系
Asian Pacific Journal of Reproduction Pub Date : 2022-09-01 DOI: 10.4103/2305-0500.356840
Manoj Chellani, Manju Chellani, S. Rahangdale
{"title":"Association of the microbial culture of follicular fluid, vaginal swab and catheter tip with β–hCG IVF positive and negative","authors":"Manoj Chellani, Manju Chellani, S. Rahangdale","doi":"10.4103/2305-0500.356840","DOIUrl":"https://doi.org/10.4103/2305-0500.356840","url":null,"abstract":"Objective: To find out the association of microbial contamination with β-human chorionic gonadotropin ( β-hCG) in-vitro fertilization (IVF) positive and negative. Methods: A total of 73 fresh IVF cycle women were included in the retrospective study. Vaginal swab culture samples were collected prior to ovum pick-up and embryo transfer. The follicular fluids were collected during ovum pick-up and catheter tip culture samples were collected after successful embryo transfer. After 14 days of the embryo transfer, women were classified into β-hCG IVF positive and negative. The comparative statistical analyses of aerobic microbial culture reports were done between β-hCG IVF positive and negative women. Results: Out of 73 women, 42(57.5%) were found to be β-hCG IVF positive and 31(43.5%) were negative. In the aerobic culture of ovum pick-up vaginal swab, follicular fluid, embryo transplantation vaginal swab and catheter tip, Enterococcus faecalis was found to be higher compared to other bacteria (Streptococcus spp., Candida, Escherichia coli and Klebsiella). Regarding the comparison between IVF positive and negative, the overall microbial infection rate of vaginal swab culture during ovum pick-up and embryo transplantation was found to be higher in IVF negative women than in IVF positive women (38.71% vs. 28.57%); however, it was not statistically significant (P>0.05). The follicular fluid and catheter tip culture microbial infection rate was found to slightly higher in IVF positive women than in IVF negative women (54.76% vs. 41.94% and 19.05% vs. 9.68%, respectively), but there were not significant differences (P>0.05). Conclusions: The aerobic microbial culture reports of follicular fluid, vaginal swab culture, and catheter tip culture are not statistically significantly with β-hCG IVF positive.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"217 - 222"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46224723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anti–Müllerian hormone and antral follicle count predict ovarian response in women less than 45 years following GnRH antagonist multiple–dose protocol GnRH拮抗剂多剂量方案后,抗苗勒管激素和窦卵泡计数可预测45岁以下女性的卵巢反应
Asian Pacific Journal of Reproduction Pub Date : 2022-09-01 DOI: 10.4103/2305-0500.356839
M. Laqqan, M. Yassin
{"title":"Anti–Müllerian hormone and antral follicle count predict ovarian response in women less than 45 years following GnRH antagonist multiple–dose protocol","authors":"M. Laqqan, M. Yassin","doi":"10.4103/2305-0500.356839","DOIUrl":"https://doi.org/10.4103/2305-0500.356839","url":null,"abstract":"Objective: To speculate which of the following parameters: antral follicle count (AFC), anti-Müllerian hormone (AMH), follicle- stimulating hormone (FSH) and age can be used as a predictor of ovarian response to gonadotropin-releasing hormone (GnRH) antagonist stimulation multiple-dose protocol in women under 45 years, and to determine the cutoff value of these parameters and their correlations for predicting low and high ovarian response. Methods: This prospective study included 462 women with the mean age of (29.3±6.5) years. All women were subjected to the GnRH antagonist stimulation multiple-dose protocol. On the second day of the menstrual cycle, ultrasonography was conducted to determine AFC in both ovaries. Peripheral blood samples were collected to evaluate the level of estradiol, FSH, luteinizing hormone, prolactin, thyroid-stimulating hormone, and AMH. The women were divided into three groups: low response (AHH<1 ng/mL, n=173), normal response (AMH=1.0-3.5 ng/mL, n=175), and high response (AMH >3.5 ng/mL, n=114). Results: A significant decrease was found in the age and FSH level in the high response group compared to other groups (P<0.001). Conversely, a significant increase was shown in AMH, estradiol on human chorionic gonadotropin (hCG) day, AFC, mature oocytes, fertilized oocytes, and embryos transferred in the high response group compared to the other two groups (P<0.001). The receiver operating characteristic (ROC) curves demonstrated that AFC and AMH had the highest accuracy, followed by basal FSH level and age in the prediction of low ovarian reserves (P<0.001) with cutoff values of ≤4.50 and ≤0.95 for AFC and AMH, respectively. Moreover, the ROC analysis showed that AFC had the highest accuracy, followed by AMH level and age in the prediction of high ovarian reserves with a cutoff value of ≥14.50, ≥3.63, and ≤27.50 years, respectively (P<0.01). A significant decrease was observed in women′s age, estradiol level, and oocyte fertilization rate in pregnant women compared to non-pregnant women (P<0.001). Additionally, significant negative correlations were found between the AFC, the number of mature oocytes, fertilized oocytes, embryos transferred, and the age of pregnant women (P<0.001). Conclusions: AFC and AMH predict low and high ovarian response to GnRH antagonist stimulation multiple-dose protocol in women under 45 years.","PeriodicalId":8564,"journal":{"name":"Asian Pacific Journal of Reproduction","volume":"11 1","pages":"208 - 216"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42110027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Oxytocin improves testicular blood flow without enhancing the steroidogenic activity in Baladi goats 在巴拉迪山羊中,催产素改善睾丸血流量,但不增强类固醇生成活性
Asian Pacific Journal of Reproduction Pub Date : 2022-09-01 DOI: 10.4103/2305-0500.356841
M. Hedia, A. El-Shalofy
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