Asian Journal of Pharmaceutical Research and Health Care最新文献_第3页

In vitro‒in vivo correlation of oral biodegradable curcumin nanoparticles for sustained treatment regimen of diabetics 口服可生物降解的姜黄素纳米颗粒在糖尿病患者持续治疗方案中的体内外相关性

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_46_23

K. Shailaja, K. Senthilkumaran, Ubaidulla Uthumansha

{"title":"In vitro‒in vivo correlation of oral biodegradable curcumin nanoparticles for sustained treatment regimen of diabetics","authors":"K. Shailaja, K. Senthilkumaran, Ubaidulla Uthumansha","doi":"10.4103/ajprhc.ajprhc_46_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_46_23","url":null,"abstract":"Background: Curcumin (CUR) has the potential to treat diabetes, but its low oral bioavailability makes it challenging to use in the treatment of chronic conditions. Objectives: To investigate in vitro–in vivo correlation (IVIVC) of oral biodegradable CUR nanoparticles (NPs) for sustained treatment regimen of diabetics. Materials and Methods: In this study, CUR biodegradable NPs were prepared using Box–Behnken design to optimize the concentration of polymer and process parameters. Results: The optimized formulation was prepared using the values obtained from the Box-Behenken method, 2.5 %w/v of polymer, 3 % w/v of TPP, and 2534 rpm of stirring speed and the actual response was observed 192.31±6.82 nm particle size, 84.26±2.87 % of entrapment efficiency, and 95.22±1.81 % of drug release (Q24 h) with the desirability function of 0.910 which indicated that the model is valid. In vitro release of curcumin from nanoparticles showed prolonged drug release up to 24 h. CUR-NPs administered orally were found to have longer Tmax, higher Cmax, larger AUC, and larger MRT compared to plain CUR. IVIVC model linear regression plots (R2= 0.9949) were obtained by plotting the graph with percent absorbed versus percent dissolved for CUR-NPs. IVIVCs were established for demonstrating the relationship between in vivo absorption and in vitro release. Conclusions: From the results, it can be concluded that this novel CUR-loaded NPs have potential to improve its therapeutic efficacy.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"40 1","pages":"184 - 190"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82641996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mining of small interacting ligands with cytoplasmic polyadenylation element-binding protein 4 与细胞质聚腺苷化元件结合蛋白相互作用的小配体的挖掘

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_29_23

R. Yadav

{"title":"Mining of small interacting ligands with cytoplasmic polyadenylation element-binding protein 4","authors":"R. Yadav","doi":"10.4103/ajprhc.ajprhc_29_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_29_23","url":null,"abstract":"Cytoplasmic polyadenylation element-binding protein 4 (CPEB 4) is a family member of CPEB proteins that are involved in regulating posttranscriptional expression of mRNAs. These proteins act by binding to cytoplasmic polyadenylation element of genes at their untranslated region with the conservation site of UUUUUAU. CPEB 4 proteins are responsible for modulating gene expression by the process of translational activation or repression by polyadenylation event. Overexpression of CPEB 4 gene has been reported in several classes of cancer such as gastric cancer, neuronal cancer, and pancreatic cancer. CPEB 4 sometimes acts like oncogene and can cause different types of cancer. CPEB 4 protein has been studied in detail in the current research. CPEB 4 protein structure was retrieved from the PDB database with PDB ID: 5DIF and total of 25 ligands were selected through a literature survey, chemical databases, etc., to perform molecular interaction study, docking method was used. Glide docking was done using Schrodinger software, and results were analyzed. Result shows that 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one (PubChem ID: 5281670) ligand has stable interaction with a Glide score of −8.26 and shows bonds with CPEB 4 protein at positions Lys(A: 924), Gly(B: 791), Asn(A: 879), and Thr(A: 878). These findings can help in modeling suitable ligands against the CPEB 4 protein responsible for several types of cancers.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"201 1","pages":"207 - 211"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79941536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic overview of bexagliflozin: A type 2 diabetic drug bexag列净:一种2型糖尿病药物的系统概述

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_25_23

Deepak Dalal, Ravi Kant, Kavita Attri, G. Kapoor, K. Nagarajan, R. Bhutani, K. Sharma, Ujjawal Kaushik, Mandeep Yadav, Neetu S Jamwal

{"title":"A systematic overview of bexagliflozin: A type 2 diabetic drug","authors":"Deepak Dalal, Ravi Kant, Kavita Attri, G. Kapoor, K. Nagarajan, R. Bhutani, K. Sharma, Ujjawal Kaushik, Mandeep Yadav, Neetu S Jamwal","doi":"10.4103/ajprhc.ajprhc_25_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_25_23","url":null,"abstract":"Brenzavvy, the brand name for bexagliflozin, is an antidiabetic medication used in conjunction of exercise and a healthy diet to improve glycemic control in individuals with type 2 diabetes (T2D). Bexacat is another brand name for a cat with diabetes. It is a dietary inhibitor of the sodium–glucose cotransporter-2 (SGLT2). SGLT2 inhibitors are relatively new glucose-lowering medications that also help people lose weight and lower their blood pressure in addition to having other positive benefits. Bexagliflozin is an oral SGLT2 powerful inhibitor. T2D and essential hypertension are the two conditions for which it is being developed by TheracosBio. It received its initial approval in the USA on January 20, 2023, for use as a complement to diet and exercise to enhance glycemic control in people with T2D. Bexagliflozin should not be used by anyone who is having dialysis, has type 1 diabetes, or has a glomerular filtration rate that is predicted to be lower than 30 mL/min/1.73 m2. In the USA, bexagliflozin is being developed for use in treating essential hypertension. The key developments that led to bexagliflozin's first approval for the treatment of T2D are outlined in this article.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"20 1","pages":"109 - 114"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89070090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of lifestyle on psychological and physiological status of individuals during lockdown 封城期间生活方式对个体心理和生理状况的影响

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_19_23

D. Jeyaraj, J. Abishek

{"title":"Impact of lifestyle on psychological and physiological status of individuals during lockdown","authors":"D. Jeyaraj, J. Abishek","doi":"10.4103/ajprhc.ajprhc_19_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_19_23","url":null,"abstract":"Background: Studies prove that individuals' psychological and physiological health is affected during lockdown which is due to their loss of autonomy, fear of disease, and reduced physical activity. Objective: The objective of this study was to find the possible impact that an individual's lifestyle has on his physiological and psychological status during this lockdown. Materials and Methods: A questionnaire was designed with questions interrogating their demographics and assessing their lifestyle, hobbies, their stress level, musculoskeletal pain, fatigue, and how they spent their time during this lockdown. The self-administered questionnaire was circulated online to people of both genders on all platforms. Results: The results showed that those who smoke were more distressed and experienced more pain than those who do not (P < 0.05). People with elevated blood pressure, diabetes, and other musculoskeletal pain were more stressed and experienced more pain and fatigue than those who were healthy (P < 0.005). People who practiced exercising and yoga were less stressed and stayed active with less or no pain and discomfort than the sedentary people (P < 0.05). Those who spend their time gardening and housekeeping felt healthier and more emotionally stable than the others (P < 0.05). The emotional disturbance had a weak positive significant correlation with onscreen time, sleep duration, and activities of daily living (ADL) limitation. Pain severity and fatigue had a weak positive significant correlation with onscreen time, sleep duration, and ADL limitation. Conclusion: People with increased physical activity and habit of regular exercise, yoga, and meditation were psychologically and physiologically healthier and were less affected by lockdown than the people with a sedentary lifestyle.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"2 1","pages":"157 - 163"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89099509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the comparative efficacy of multiple whole-blood count-based testing strategies for thalassaemia diagnosis: A meta-analysis 评估多种基于全血计数的地中海贫血诊断检测策略的比较疗效:一项荟萃分析

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_37_23

Abhishek Samanta, N. Bhattacharyya

{"title":"Assessing the comparative efficacy of multiple whole-blood count-based testing strategies for thalassaemia diagnosis: A meta-analysis","authors":"Abhishek Samanta, N. Bhattacharyya","doi":"10.4103/ajprhc.ajprhc_37_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_37_23","url":null,"abstract":"Context: Complete blood count (CBC) with confirmatory high-performance liquid chromatography (HPLC) is the gold standard for thalassemia screening. Because of the constraints of a high-pressure liquid chromatography facility, they develop alternative approaches to screening when the population to be screened is large. Aims: The objective of this meta-analysis is to evaluate the diagnostic accuracy of alternative approaches to thalassemia screening. This study is important, as accurate and accessible thalassemia screening can improve the quality of life for patients and reduce the burden on health-care systems. Settings and Design: The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Subjects and Methods: The present systematic review comprises 74,284 thalassemia-positive patients, identified using CBC and conventional HPLC methods was published between 2012 and 2022. After further screening, 23 studies were included in the present study. Statistical Analysis Used: The Moses-Littenberg Summary Receiver Operating Characteristic (SROC) model, the bivariate model, and the SROC reporting model are the examples of models that also consider sensitivity and specificity. Results: The total diagnostic odds ratio was 88.981 (95% confidence interval 37.645–210.321). Subgroup analysis was determined by a mixed-effects model, with I2 (residual heterogeneity/unaccounted variability) at 90% and Partial Area under ROC curve (restricted to observed False Positive Rates and normalized) was 0.951. Conclusions: This systematic review investigated the efficacy of using CBC parameters to distinguish between iron deficiency anemia and the thalassemia trait. This can help reduce health-care costs and improve the accuracy of the results.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"23 3 1","pages":"196 - 203"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83568058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sample preparation and extraction techniques for evaluation of semisolid formulations 半固体制剂评价的样品制备和提取技术

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_116_22

Komal Dhudashia, Nilesh Patel

{"title":"Sample preparation and extraction techniques for evaluation of semisolid formulations","authors":"Komal Dhudashia, Nilesh Patel","doi":"10.4103/ajprhc.ajprhc_116_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_116_22","url":null,"abstract":"There are many pharmaceutical formulations available in semisolid form such as cream, ointment, paste, gel, and suppository. The qualitative and quantitative estimation of the semisolid formulation can be carried out using sophisticated instruments/techniques. Sample preparation is an important step to extract the main ingredient which needs to be analyzed in a medium suitable for a specific analytical technique/instrument. Sample preparation can directly affect the final result of analysis and thus sample preparation for the semisolid formulation is challenging. Extraction techniques used to carry out the extraction from semisolid formulation are Liquid–Liquid Extraction, Solid-Phase Extraction, Supercritical Fluid Extraction, Liquid-Phase Microextraction Techniques, Pressurized Fluid Extraction/Accelerated Solvent Extraction, Microwave Assisted Extraction, Pressurized Hot Water Extraction or superheated water extraction, Ultrasound-Assisted Extraction, Matrix solid-phase dispersion, QuEChERs, Solid-Phase Microextraction, Stir Bar Sorptive Extraction, Microextraction in Packed Syringe. A brief introduction along with the principle and application of all techniques is explained to demonstrate the application of specific extraction technique for specific semisolid sample preparation.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"9 1","pages":"124 - 132"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88216163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of single-shot epidural with bupivacaine and dexamethasone as an adjuvant for postoperative analgesia in patients undergoing major abdominal surgeries 布比卡因加地塞米松单次硬膜外辅助腹部大手术患者术后镇痛的效果

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_42_23

Umesh Dash, M. Mateen, P. Mondal, D. Dwivedi, S. Taneja, Arnab Haldar

{"title":"Efficacy of single-shot epidural with bupivacaine and dexamethasone as an adjuvant for postoperative analgesia in patients undergoing major abdominal surgeries","authors":"Umesh Dash, M. Mateen, P. Mondal, D. Dwivedi, S. Taneja, Arnab Haldar","doi":"10.4103/ajprhc.ajprhc_42_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_42_23","url":null,"abstract":"Background: Apart from being distressful, postoperative pain produces a range of harmful effects, including morbidity and mortality. Epidural analgesia is a safe and effective method for the control of postoperative pain. Aim: This study compared the analgesic efficacy of single-shot epidural bupivacaine plus dexamethasone versus single-shot epidural bupivacaine and intravenous (IV) dexamethasone after major elective abdominal surgery. Methodology: A cross-sectional cohort study was conducted on 30 adult patients undergoing major elective abdominal surgery. Fifteen minutes before the reversal of neuromuscular blockade, study Group “A” received an epidural of 0.125% bupivacaine at the dose of 1.0 mL/segment and dexamethasone 8 mg and Group “B” included data of 30 adult patients which was drawn from the well-matched historic cohort, from past anesthesia records, where patients received an epidural of 0.125% bupivacaine at the dose of 1.0 mL/segment, but an injection of dexamethasone 8 mg was administered intravenously. Results: The primary outcome was a significantly longer duration of analgesia (905.97 ± 110.89 min) in Group “A” patients in comparison to Group “B” patients (731.0 ± 112.59 min) (P < 0.0001). The secondary outcome included the requirement of total rescue analgesic dose of injection tramadol, which was significantly lower in Group “A” compared to Group “B” patients (163.90 ± 15.93 mg vs. 182.27 ± 30.61 mg, respectively), (P < 0.005). Postoperative nausea and vomiting incidence was lower in patients of Group “B” due to the antiemetic effect of IV dexamethasone. Conclusion: Single-shot bupivacaine with dexamethasone gives longer postoperative analgesia and lesser rescue analgesic requirement compared to epidural bupivacaine with IV dexamethasone.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"74 1","pages":"178 - 183"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75144985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of clinical efficacy of systemically administered commercially available antioxidant formulations as an adjunct to scaling and root planing in the treatment of chronic periodontitis 系统使用市售抗氧化制剂作为刮治和牙根刨治辅助治疗慢性牙周炎的临床疗效比较评价

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_24_23

S. Martande, Aditya Banerjee, K. Mangal, P. Swathi, D. Gopalakrishnan, Anita Kulloli, S. Shetty, Shambhavi Thakur, Krishna Suryawanshi

{"title":"Comparative evaluation of clinical efficacy of systemically administered commercially available antioxidant formulations as an adjunct to scaling and root planing in the treatment of chronic periodontitis","authors":"S. Martande, Aditya Banerjee, K. Mangal, P. Swathi, D. Gopalakrishnan, Anita Kulloli, S. Shetty, Shambhavi Thakur, Krishna Suryawanshi","doi":"10.4103/ajprhc.ajprhc_24_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_24_23","url":null,"abstract":"Purpose: Antioxidants are nutraceuticals that reduce the concentration of reactive oxygen species and thereby reduce the inflammatory burden. The current randomized controlled trial was designed to evaluate the clinical efficacy of commercially available antioxidant formulations, oxitard and lycopene tablets as adjuncts to scaling and root planning in the management of chronic periodontitis. Materials and Methods: Forty-five chronic periodontitis patients were randomly divided into three groups, namely Group A – only scaling and root planing (SRP), Group B – SRP with oxitard tablet, and Group C – SRP with lycopene tablet. Clinical parameters – plaque index, gingival index, probing pocket depth, and relative attachment level were evaluated at baseline, 1 month, 3 months, and 6 months. Results: All groups significantly reduced clinical parameters from baseline to 6 months (P < 0.05). Intragroup analysis showed Group B and Group C to be significantly better than Group A (P < 0.05), whereas Group B showed similar results when compared to Group C (P > 0.05). Conclusion: Oxitard and Lycopene showed better improvements in clinical parameters when compared to SRP alone. Thus, both oxitard and lycopene can be potential adjuncts to SRP in the treatment of chronic periodontitis in the near future.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"1 1","pages":"191 - 195"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83580784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of intraoperative use of tranexamic acid in total knee arthroplasty 全膝关节置换术中氨甲环酸的应用效果

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_21_23

P. Madhuchandra, P. Hemachandra

{"title":"Effectiveness of intraoperative use of tranexamic acid in total knee arthroplasty","authors":"P. Madhuchandra, P. Hemachandra","doi":"10.4103/ajprhc.ajprhc_21_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_21_23","url":null,"abstract":"Background: Blood loss is among the commonly encountered problems in total knee arthroplasty (TKA) surgeries. Tranexamic acid (TXA) is commonly used intravenously to decrease the blood loss during TKA. However, it has got its own contraindications. In such patients, it can also be used locally to prevent blood loss. We assessed the effectiveness of local TXA by determining the amount of blood loss and transfusion required. Materials and Methods: A total of 60 patients with 72 TKA surgeries were included and analyzed in this observational prospective study. Three Gram of TXA was infiltrated locally into the tissues immediately after skin closure before the release of the tourniquet. The amount of blood loss was calculated by comparing the preoperative and postoperative hemoglobin (Hb) levels. Results: The mean blood loss in patients whom local TXA was used was 433.3 ml. The mean postoperative Hb loss was 1.01. Only one patient with bilateral TKA required postoperative blood transfusion. There were no issues with wound healing in any of our patients. The P value in Hb loss was 0.002 and in total blood was 0.001 and were statistically significant. Conclusion: Local use of TXA is very effective in reducing the amount of postoperative blood loss and the need for the blood transfusion. We recommend for the local use of TXA in primary knee arthroplasty surgeries.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"21 1","pages":"146 - 149"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73632730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study of regulations combating counterfeit medicines across India, USA, and Europe 对印度、美国和欧洲打击假药法规的研究

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_39_23

K. Raju, L. Nori, T. Varma, LakshmiSri Naga Valli Nulu

{"title":"A study of regulations combating counterfeit medicines across India, USA, and Europe","authors":"K. Raju, L. Nori, T. Varma, LakshmiSri Naga Valli Nulu","doi":"10.4103/ajprhc.ajprhc_39_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_39_23","url":null,"abstract":"Counterfeiting is the deliberate and fraudulent production of products including mislabeling in attempts to deliberately morph its identity and source for making its appearance as genuine and as it is concerning the original product. Counterfeit medicines are pharmaceutical medicinal products without anyActive pharmaceutical ingredient (API), substandard quality API, or a fraction of the original amount of API stated as a different API, cross-contaminated API, and expiry products that are repacked including formulations done incorrectly and produced in substandard conditions. Expensive drug's extensive demand like steroids, antibiotics, cancer-treating drugs, vaccines, antivirals, and antihistamines are targets for counterfeiting. Patients deceived into buying counterfeit drugs are people seeking to buy discounted medications and involved in inappropriate usage. With identical labels as well as nearly resemblance to originals, these counterfeits are cheaper to make. Counterfeit medicines kill and threaten the lives of abused patients, fooled by false appearances. Medicines and health-care items are different from other commodities, and their fakes are different from other fakes. They are deceived by misleading characteristics and harm and risk the lives of several mistreated victims daily. This variety of terms and definitions, which might differ from one nation to the next, leads to a lack of awareness of the issue on a worldwide scale. The European Union's mainly prefers the term “counterfeiting,” lately the phrase “falsification” even if the US uses the phrase “false” or “fake” more. We must comprehend the phrase “medicine” and its meanings to define the many terminologies used to describe counterfeiting.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"16 1","pages":"115 - 123"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89431227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0