半固体制剂评价的样品制备和提取技术

IF 0.2 Q4 PHARMACOLOGY & PHARMACY
Komal Dhudashia, Nilesh Patel
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引用次数: 0

摘要

有许多半固体形式的药物制剂,如乳霜、软膏、膏状、凝胶和栓剂。半固体配方的定性和定量估计可以使用复杂的仪器/技术进行。样品制备是提取主要成分的重要步骤,需要在适合特定分析技术/仪器的培养基中进行分析。样品制备直接影响分析的最终结果,因此半固体制剂的样品制备具有挑战性。用于半固体配方萃取的萃取技术有液-液萃取、固相萃取、超临界流体萃取、液相微萃取技术、加压流体萃取/加速溶剂萃取、微波辅助萃取、加压热水萃取或过热水萃取、超声辅助萃取、基质固相分散、QuEChERs、固相微萃取、搅拌棒吸附萃取、包装注射器微萃取。简要介绍了各种技术的原理和应用,说明了特定提取技术在特定半固体样品制备中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sample preparation and extraction techniques for evaluation of semisolid formulations
There are many pharmaceutical formulations available in semisolid form such as cream, ointment, paste, gel, and suppository. The qualitative and quantitative estimation of the semisolid formulation can be carried out using sophisticated instruments/techniques. Sample preparation is an important step to extract the main ingredient which needs to be analyzed in a medium suitable for a specific analytical technique/instrument. Sample preparation can directly affect the final result of analysis and thus sample preparation for the semisolid formulation is challenging. Extraction techniques used to carry out the extraction from semisolid formulation are Liquid–Liquid Extraction, Solid-Phase Extraction, Supercritical Fluid Extraction, Liquid-Phase Microextraction Techniques, Pressurized Fluid Extraction/Accelerated Solvent Extraction, Microwave Assisted Extraction, Pressurized Hot Water Extraction or superheated water extraction, Ultrasound-Assisted Extraction, Matrix solid-phase dispersion, QuEChERs, Solid-Phase Microextraction, Stir Bar Sorptive Extraction, Microextraction in Packed Syringe. A brief introduction along with the principle and application of all techniques is explained to demonstrate the application of specific extraction technique for specific semisolid sample preparation.
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