布比卡因加地塞米松单次硬膜外辅助腹部大手术患者术后镇痛的效果

IF 0.2 Q4 PHARMACOLOGY & PHARMACY
Umesh Dash, M. Mateen, P. Mondal, D. Dwivedi, S. Taneja, Arnab Haldar
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摘要

背景:除了痛苦之外,术后疼痛还会产生一系列有害影响,包括发病率和死亡率。硬膜外镇痛是一种安全有效的控制术后疼痛的方法。目的:本研究比较单次硬膜外布比卡因加地塞米松与单次硬膜外布比卡因加静脉地塞米松在腹部重大择期手术后的镇痛效果。方法:对30例接受择期腹部大手术的成年患者进行横断面队列研究。在神经肌肉阻断逆转前15分钟,研究组“A”接受硬膜外0.125%布比卡因1.0 mL/段,地塞米松8 mg;研究组“B”包括30例成人患者的数据,这些患者来自匹配良好的历史队列,从过去的麻醉记录中提取,患者接受硬膜外0.125%布比卡因1.0 mL/段,但静脉注射地塞米松8 mg。结果:a组患者镇痛时间(905.97±110.89 min)明显长于B组患者(731.0±112.59 min) (P < 0.0001)。次要指标为曲马多镇痛总剂量要求,A组明显低于B组(163.90±15.93 mg∶182.27±30.61 mg), P < 0.005。B组患者术后恶心呕吐发生率较低,这是由于静脉地塞米松的止吐作用所致。结论:与硬膜外布比卡因联合静脉注射地塞米松相比,单次布比卡因联合地塞米松术后镇痛时间更长,抢救性镇痛需求更少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of single-shot epidural with bupivacaine and dexamethasone as an adjuvant for postoperative analgesia in patients undergoing major abdominal surgeries
Background: Apart from being distressful, postoperative pain produces a range of harmful effects, including morbidity and mortality. Epidural analgesia is a safe and effective method for the control of postoperative pain. Aim: This study compared the analgesic efficacy of single-shot epidural bupivacaine plus dexamethasone versus single-shot epidural bupivacaine and intravenous (IV) dexamethasone after major elective abdominal surgery. Methodology: A cross-sectional cohort study was conducted on 30 adult patients undergoing major elective abdominal surgery. Fifteen minutes before the reversal of neuromuscular blockade, study Group “A” received an epidural of 0.125% bupivacaine at the dose of 1.0 mL/segment and dexamethasone 8 mg and Group “B” included data of 30 adult patients which was drawn from the well-matched historic cohort, from past anesthesia records, where patients received an epidural of 0.125% bupivacaine at the dose of 1.0 mL/segment, but an injection of dexamethasone 8 mg was administered intravenously. Results: The primary outcome was a significantly longer duration of analgesia (905.97 ± 110.89 min) in Group “A” patients in comparison to Group “B” patients (731.0 ± 112.59 min) (P < 0.0001). The secondary outcome included the requirement of total rescue analgesic dose of injection tramadol, which was significantly lower in Group “A” compared to Group “B” patients (163.90 ± 15.93 mg vs. 182.27 ± 30.61 mg, respectively), (P < 0.005). Postoperative nausea and vomiting incidence was lower in patients of Group “B” due to the antiemetic effect of IV dexamethasone. Conclusion: Single-shot bupivacaine with dexamethasone gives longer postoperative analgesia and lesser rescue analgesic requirement compared to epidural bupivacaine with IV dexamethasone.
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