Asian Journal of Pharmaceutical Research and Health Care最新文献_第4页

To compare limb strength, core strength, and respiratory endurance between post-COVID-19 and healthy population: A cross-sectional study 比较covid -19后和健康人群的肢体力量、核心力量和呼吸耐力:一项横断面研究

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_16_23

Pardeep Pathak, Sunita Sharma, Nitin Gupta, Diggaj Shrestha, R. Bala, Raval Chinubhai

{"title":"To compare limb strength, core strength, and respiratory endurance between post-COVID-19 and healthy population: A cross-sectional study","authors":"Pardeep Pathak, Sunita Sharma, Nitin Gupta, Diggaj Shrestha, R. Bala, Raval Chinubhai","doi":"10.4103/ajprhc.ajprhc_16_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_16_23","url":null,"abstract":"Background: Coronavirus disease (COVID-19) adversely affects the number of organs and systems of the human body. The most frequently affected organ is the lung, followed by skeletal muscles, which can lead to fatigue, weakness, and poor physical performance. Objective: The objective of this study was to compare the grip strength, core strength, 6-min walk test (6-MWT), and pulmonary function test (PFT) between healthy individuals and post-COVID-19 individuals. Methodology: A cross-sectional study was conducted for the comparison among the post-COVID-19 participants and the healthy ones. Their demographic characteristics were noted. We analyzed heart rate, oxygen saturation, and cardiac rhythm before and 10 min after the 6-MWT and also PFT, core strength, and hand grip strength. The correlations among the tests if any were noted. Results: Forty-six post-COVID-19 individuals and 44 healthy individuals were enrolled in the study. The mean age was 39.18 ± 13.12 years for healthy individuals and 37.28 ± 11.68 for post-COVID individuals with 62% of the female population. The mean distance for a 6-min walk distance was 506.68 ± 64.75 m for healthy individuals and 430.30 ± 52.96 for post-COVID-19 individuals (P < 0.000). The mean value for PFT was 85.59 ± 6.78 for healthy and 72.28 ± 6.20 for post-COVID individuals. We found a positive correlation between PFT with core endurance (P = 0.036) and hand strength (P = 0.037), core endurance with 6-MWT (P = 0.006) and hand strength (P = 0.00), and 6-MWT with hand strength (P ≤ 0.001) in post-COVID participants; whereas no correlation was found in healthy participants group. Conclusion: The PFT correlated significantly with core endurance and hand grip strength on post-COVID-19 individuals.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"286 1","pages":"164 - 170"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82689050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of sacubitril/valsartan versus losartan in heart failure patients with respect to improvements in ejection fraction and New York Heart Association functional class 苏比里尔/缬沙坦与氯沙坦对心力衰竭患者射血分数和纽约心脏协会功能分级改善的疗效

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_113_22

VamsiKrishna Sirimandla, KeerthanaKumar Chithirai, VenkataLakshman Chakali, Sai P. Pydi, A. Shaik, KHarinadha Baba, Jyothi Conjeevaram

{"title":"Efficacy of sacubitril/valsartan versus losartan in heart failure patients with respect to improvements in ejection fraction and New York Heart Association functional class","authors":"VamsiKrishna Sirimandla, KeerthanaKumar Chithirai, VenkataLakshman Chakali, Sai P. Pydi, A. Shaik, KHarinadha Baba, Jyothi Conjeevaram","doi":"10.4103/ajprhc.ajprhc_113_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_113_22","url":null,"abstract":"Background: Heart failure (HF) is a complicated clinical disease that develops when the Left ventricular becomes symptomatic due to anatomical or functional ventricular malfunction. The symptoms emerge from a cardiac output that is insufficient to meet the body's metabolic needs. Globally, HF has emerged as a major health issue, with an estimated prevalence of >37.7 million. While HF with reduced ejection fraction (HFrEF) is more frequently seen in Indian patients, HF with preserved EF seems to be more prevalent in the western population. Objective: This study was conducted to determine the efficacy of sacubitril/valsartan (S/V) versus losartan in patients with HF with respect to improvements in EF and New York Heart Association (NYHA) functional class symptoms. Materials and Methods: A prospective cohort study was conducted on 62 HF patients who are either on angiotensin receptor-neprilysin inhibitor or angiotensin receptor blocker therapy for a period of 6 months, i.e., November 2021 to April 2022, who attended the Inpatient Cardiology Department of Narayana Medical College and Hospital. By using a semi-structured questionnaire, the data was gathered. The 2013 edition of Microsoft Excel and SPSS version 20.0 software were used for data analysis. Results: Subjects in the S/V group showed a 56% reduction in subjects with HFrEF from the beginning to end of the follow-up, while subjects in the losartan group showed only 16% reduction. With respect to NYHA functional class, subjects in the S/V group showed greater reduction in subjects in NYHA class III and NYHA class IV by the end of follow-up when compared to the losartan group. Conclusion: S/V showed better efficacy in improving EF and NYHA functional class when compared to losartan.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"19 1","pages":"150 - 156"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77874973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of diaphragmatic breathing exercise in the rehabilitation of chronic low back ache 横膈膜呼吸运动在慢性腰痛康复中的作用

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_41_23

S. Nagaraj, KU Dhanesh Kumar, P. Aaron

引用次数: 0

Burden of malnutrition among under-five children and elderly population in Southern India: A systematic review and meta-analysis 印度南部五岁以下儿童和老年人的营养不良负担:系统回顾和荟萃分析

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_12_23

Lavanya Ayyasamy, PParameshwari Prahalad, S. Chinnaiyan, M. Azarudeen, Janani Kumaresan, Nivedhitha Sekar

{"title":"Burden of malnutrition among under-five children and elderly population in Southern India: A systematic review and meta-analysis","authors":"Lavanya Ayyasamy, PParameshwari Prahalad, S. Chinnaiyan, M. Azarudeen, Janani Kumaresan, Nivedhitha Sekar","doi":"10.4103/ajprhc.ajprhc_12_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_12_23","url":null,"abstract":"Background: Malnutrition remains a leading cause of infant mortality, primarily in low- and middle-income nations such as India. Aim: Based on the existing literature, our systematic review and meta-analysis sought to determine the prevalence of malnutrition among children and the elderly in Southern India. Methods: In accordance with Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, independent researchers searched PubMed, EMBASE, and Web of Science for studies on malnutrition among children and the elderly in Southern India. We estimated the pooled prevalence with confidence intervals (CIs) of 95% using a random-effects model. Results: Twenty studies met the inclusion criteria and were included in the analysis. There were 11,452 children and 1108 elderly population participants included in the review. Thirteen studies reported the prevalence of undernutrition and the pooled number of samples was 8417. The proportion of underweight in under-five children was 41% (95% CI: 36%–46%). Thirteen studies reported wasting, and the pooled sample size was 9789. The pooled proportion of wasting was 25% (95% CI: 20%–31%). Fourteen studies reported stunting, and the pooled sample size was 10,112. The pooled proportion of stunting was 33% among children. Four studies reported malnourishment or undernutrition among the elderly population in southern India. The pooled sample size was 1108 and the pooled proportion of malnourishment among the elderly population was 12% (95% CI: 1%–22%). Conclusion: Combating child malnutrition in India requires public health interventions for cases of mild malnutrition and vulnerable populations, regional strategy implementation and evaluation, investigations on overweight, obesity, and its causes, and socioeconomic development.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"65 1","pages":"133 - 145"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91034254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Dienogest on Pelvic Pain and Dyspareunia: Comprehensive Meta-Analysis and Systematic Review Dienogest治疗盆腔疼痛和性交困难的疗效:综合meta分析和系统评价

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-30 DOI: 10.55561/ajhr.v2i1.73

S. Sutrisno, Wildan Aulia Firdaus

{"title":"Efficacy of Dienogest on Pelvic Pain and Dyspareunia: Comprehensive Meta-Analysis and Systematic Review","authors":"S. Sutrisno, Wildan Aulia Firdaus","doi":"10.55561/ajhr.v2i1.73","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.73","url":null,"abstract":"Introduction: Endometriosis is a severe disorder marked by endometrial tissue outside the uterus and linked to infertility, although typically manifesting as discomfort in the form of dysmenorrhea, dyspareunia, and pelvic pain. Dienogest is indicated as a first-line hormone treatment for endometriosis-related discomfort. The aim of this study is to analyze the efficacy of Dienogest on treating pelvic pain and dyspareunia compared to placebo or combined oral contraceptives (COC) in women with endometriosis.\u0000Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar. The PRISMA 2020 rules were used to screen the articles that were obtained. For the review, studies that examined how using dienogest in improving endometriosis were exposed to were taken into consideration. In a meta-analysis utilizing a random-effects model, odds ratios with their 95% confidence intervals (CI) were provided.\u0000Results: Five studies that met the criteria for inclusion were determined to be pertinent to the association between using dienogest in improving endometriosis (n=711). The Dienogest group had substantially improve pelvic pain with a mean difference of 1.01 (95% CI 1.2, 0.82; p<0.00001) and dyspareunia with a mean difference of 0.58 (95% CI 1.09, 0.08; p=0.02) compared to placebo. Compared to combined oral contraceptives, COC had substantially improves dyspareunia with a mean difference of 0.99 (95% CI 0.62, 1.37; p<0.00001) and pelvic pain with a mean difference of 1.15 (95% CI 0.23, 0.83; p=0.01).\u0000Conclusion: Dienogest should be considered as an alternate treatment for endometriosis-related symptoms. In double-blind research, DNG efficacy was compared to placebo.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"65 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84483003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Comorbidities with Full-Term Pregnancy Who Gave Birth to Low Birth Weight Babies at Dr. Saiful Anwar Malang General Hospital 在Saiful Anwar Malang综合医院生下低出生体重婴儿的足月妊娠孕妇合并症

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-17 DOI: 10.55561/ajhr.v2i1.85

I Wayan Agung Indrawan, Obi Candra Kapisa

{"title":"Maternal Comorbidities with Full-Term Pregnancy Who Gave Birth to Low Birth Weight Babies at Dr. Saiful Anwar Malang General Hospital","authors":"I Wayan Agung Indrawan, Obi Candra Kapisa","doi":"10.55561/ajhr.v2i1.85","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.85","url":null,"abstract":"Introduction: Stunting is a challenge for children's growth and development in the future, which has long-term impacts in the form of reduced cognitive abilities, decreased productivity, and increased risk of infection and non-communicable diseases. Low birth weight (LBW) is a major determinant of stunting in Indonesia. Various multidimensional factors contribute to low birth weight, including maternal factors.\u0000Material and Methods: Quantitative descriptive research was conducted at Dr. Saiful Anwar general hospital from July 2021 to September 2022. The variables studied were age, education, occupation, parity status, medical history, number of antenatal care controls, height, mother's body mass index, and baby's birth weight.\u0000Results: Of the 54 full-term pregnant women, the majority who delivered LBW babies were nulliparous (42.6%), aged 20-35 years during pregnancy (79.6%), had a history of hypertension during pregnancy (25.9%), antenatal care visits 1-5 times (48.1%), high school degree (48.1%), housewives (75.9%), height ranging between 151-160 cm (64.8%), and BMI 18.5 to 25 kg/m 2 (51.9%).\u0000Conclusion: Maternal factors that contribute to the birth of LBW babies include low parities, age 20 to 35 years during pregnancy, hypertension in pregnancy, infrequent antenatal care visits, high school degree, work as a housewife, height ranging between 151 -160 cm, and had a normal BMI. The representation of the mother's BMI and educational level in this study differs from that in previous studies.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"108 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81289725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of BAX/BcL2 Expression Ratio in Menstrual Blood between Endometriosis Women and Women without Endometriosis 子宫内膜异位症与非子宫内膜异位症女性经血BAX/BcL2表达比的比较研究

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.83

Arghya Wicaksana, Pande Made Dwijayasa, Rahajeng Rahajeng, Cholid Rohman Riskianto

{"title":"Comparative Study of BAX/BcL2 Expression Ratio in Menstrual Blood between Endometriosis Women and Women without Endometriosis","authors":"Arghya Wicaksana, Pande Made Dwijayasa, Rahajeng Rahajeng, Cholid Rohman Riskianto","doi":"10.55561/ajhr.v2i1.83","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.83","url":null,"abstract":"Introduction: Endometriosis is characterized by the presence of endometrial tissue outside the uterus and is commonly associated with chronic pelvic pain and infertility. One of the endometrial changes that appear in the eutopic and ectopic endometrium of women with endometriosis is the regulation of apoptosis. The proportion value of the BAX/BcL-2 ratio is a crucial factor in determining the ability of cells to stimulate apoptosis. Higher apoptotic activity is linked to an increased BAX/BcL-2 ratio. The aim of this study was to compare the BAX/BcL-2 ratios in menstrual blood of endometriosis and non-endometriosis patients.\u0000Material and Methods: This research is a quantitative observational study with a cross-sectional method at dr. Saiful Anwar Malang. The case group was postoperative women with ovarian cysts with anatomical pathology examination results indicating endometriosis. While the control group was patients without endometriosis. Data analysis was carried out by using the Independent T Test with SPSS for Windows 19.0 software.\u0000Results: Each group consisted of 17 patients. The normality test for each variable shows p> 0.05. BAX average in patients with endometriosis 4556.29 ± 2338.33 and 6488.06 ± 2649.08 in patients without endometriosis (p = 0.031). The average BcL-2 in endometriosis patients was 6483.82±2489.36 and 4877.18±2023.82 in patients without endometriosis (p=0.047). The average BAX/BcL-2 ratio in patients with endometriosis was 0.698±0.19 and 1.367±0.26 in patients without endometriosis (p=0.000).\u0000Conclusion: The BAX/BcL-2 ratio in women with endometriosis cysts has a lower average rate than women without endometriosis cysts.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"39 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85499954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report 腹部癫痫，一个诊断考虑儿童反复呕吐:1例报告

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.76

Fatia Murni Chamida, Nirmala Muflihatul Khalida

{"title":"Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report","authors":"Fatia Murni Chamida, Nirmala Muflihatul Khalida","doi":"10.55561/ajhr.v2i1.76","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.76","url":null,"abstract":"gastrointestinal complaints and central nervous system involvement, mainly confusion, fatigue, headache, dizziness, syncope, and lethargy resulting during the abdominal seizure activity. Chronic vomitting or other gastrointestinal symptoms often lead to fluid and nutritional deficiencies which resulted in malnutrition. To date, there was no study has been reported on abdominal epilepsy in Indonesia.\u0000Case Presentation: We presented a case of two-year-old girl with chief complaint of recurrent profuse vomiting every month for the past year. Patient complained of headaches and abdominal pain and tended to sleep all day during relapse. Physical examination showed sunken eyes and decreased skin turgor. EEG showed abnormal results, diffuse irritative, epileptiform with normal basic rhythm. Esophageal polyps were also found on endoscopy. Patient was given anti-epileptic drugs and histamine H2 receptor antagonists and responded well to those therapies.\u0000Conclusion: Abdominal epilepsy is a rare case which may resulted in vomiting and abdominal pain in children. EEG examination is an important test for diagnosing abdominal epilepsy. Treatment with anti-epileptic drugs is known to respond well in this case.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"16 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87288820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Red Bean Extract (Phaseolus vulgaris L. Sp) on Interleukin-1, Inhibin Β and PCNA Expression in Systemic Lupus Erythematosus Mice Model 红豆提取物对系统性红斑狼疮小鼠模型白细胞介素-1、抑制素Β及PCNA表达的影响

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.81

Albert Novriadi, Muhammad Nooryanto, I Wayan Agung Indrawan, Puspita Handayani

{"title":"Effect of Red Bean Extract (Phaseolus vulgaris L. Sp) on Interleukin-1, Inhibin Β and PCNA Expression in Systemic Lupus Erythematosus Mice Model","authors":"Albert Novriadi, Muhammad Nooryanto, I Wayan Agung Indrawan, Puspita Handayani","doi":"10.55561/ajhr.v2i1.81","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.81","url":null,"abstract":"Introduction: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by multiple organ involvement. Chronic inflammation due to oxidative stress and autoimmune causes damage to related organs, one of which is the ovary which leads to Premature Ovarian Failure (POF) . Red bean (Phaseolus vulgaris L. Sp.) is an anti-inflammatory and antioxidant agent. This study aims to examine the effect of red beans on IL-1, Inhibin B, and PCNA.\u0000Methods: This is a true experimental study with a post-test-only controlled group design in vivo. The sample in this study were female Balb/c mice treated with red bean extract (Phaseolus vulgaris L. sp.) at doses of 50 mg/KgBW (P1), 75 mg/KgBW (P2), and 100 mg/KgBW (P3). IL-1, Inhibin B, and PCNA levels in each group were statistically analyzed using the SPSS 16 for Windows software program.\u0000Results: Red bean extract (Phaseolus vulgaris L. Sp.) administration at various doses was statistically proven to significantly reduce IL-1 levels (p<0,05) and increase Inhibin levels in all groups (p<0,05). The highest average Inhibin B levels were found in the 100 mg/KgBW dose group (P3), significant increase in PCNA expression in all groups given various doses of red bean extract (p<0,05).\u0000Conclusion: Administration of red bean extract (Phaseoulus vulgaris L. Sp.) can reduce levels of Interleukin-1, increase levels of Inhibin B and PCNA expression in SLE mice.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"44 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86813715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety Comparison Between Lorazepam and Diazepam in Treating Convulsive Status Epilepticus in Children: An Evidence-Based Case Report 劳拉西泮与地西泮治疗儿童惊厥性癫痫持续状态的疗效和安全性比较:一份循证病例报告

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.62

Muhammad Habiburrahman, Widya Khairunnisa Sarkowi

{"title":"Efficacy and Safety Comparison Between Lorazepam and Diazepam in Treating Convulsive Status Epilepticus in Children: An Evidence-Based Case Report","authors":"Muhammad Habiburrahman, Widya Khairunnisa Sarkowi","doi":"10.55561/ajhr.v2i1.62","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.62","url":null,"abstract":"Introduction: Indonesia still recommends diazepam for epilepsy, but the International League Against Epilepsy increasingly favours lorazepam. Some reports indicate diazepam being less effective and causing side effects. This report presents a difficult-to-treat convulsive status epilepticus (CSE) case in a 10-month infant who received diazepam, questioning if intravenous/rectal lorazepam is a better initial therapy than diazepam for hospitalized children with CSE.\u0000Methods: Following the patient-intervention-comparison-outcome (PICO) formula, we searched for evidence in four journal databases (Pubmed, Proquest, EBSCOHost, and Cochrane). Studies meeting inclusion and exclusion criteria were appraised.\u0000Results: Through three systematic reviews and meta-analyses, our clinical query was addressed. One study revealed that rectal lorazepam was more effective in stopping seizures than rectal diazepam (RR 2.86). Meanwhile, two studies found that intravenous lorazepam exhibited similar efficacy in seizure cessation compared to intravenous diazepam (RR 1.04 and OR 1.03, respectively). Both drugs showed no significant difference in the time required to stop seizures or the necessity for additional doses or adjunctive medications to achieve such cessation, nor in the likelihood of refractory seizure within 24 hours. Two studies indicated that intravenous lorazepam had a reduced risk of respiratory depression (RR 0.71 and OR 0.62, respectively). Regardless of the administration route, lorazepam was linked to a lower probability of ICU admission (RR 0.15) than diazepam.\u0000Conclusion: Intravenous lorazepam and diazepam are equally effective for treating CSE, but rectal lorazepam is considered better at stopping seizures and preventing their recurrence compared to diazepam. Furthermore, lorazepam is deemed safer, especially when given intravenously.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"16 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78510689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0