Asian Journal of Pharmaceutical Research and Health Care最新文献_第4页

Burden of malnutrition among under-five children and elderly population in Southern India: A systematic review and meta-analysis 印度南部五岁以下儿童和老年人的营养不良负担:系统回顾和荟萃分析

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_12_23

Lavanya Ayyasamy, PParameshwari Prahalad, S. Chinnaiyan, M. Azarudeen, Janani Kumaresan, Nivedhitha Sekar

{"title":"Burden of malnutrition among under-five children and elderly population in Southern India: A systematic review and meta-analysis","authors":"Lavanya Ayyasamy, PParameshwari Prahalad, S. Chinnaiyan, M. Azarudeen, Janani Kumaresan, Nivedhitha Sekar","doi":"10.4103/ajprhc.ajprhc_12_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_12_23","url":null,"abstract":"Background: Malnutrition remains a leading cause of infant mortality, primarily in low- and middle-income nations such as India. Aim: Based on the existing literature, our systematic review and meta-analysis sought to determine the prevalence of malnutrition among children and the elderly in Southern India. Methods: In accordance with Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, independent researchers searched PubMed, EMBASE, and Web of Science for studies on malnutrition among children and the elderly in Southern India. We estimated the pooled prevalence with confidence intervals (CIs) of 95% using a random-effects model. Results: Twenty studies met the inclusion criteria and were included in the analysis. There were 11,452 children and 1108 elderly population participants included in the review. Thirteen studies reported the prevalence of undernutrition and the pooled number of samples was 8417. The proportion of underweight in under-five children was 41% (95% CI: 36%–46%). Thirteen studies reported wasting, and the pooled sample size was 9789. The pooled proportion of wasting was 25% (95% CI: 20%–31%). Fourteen studies reported stunting, and the pooled sample size was 10,112. The pooled proportion of stunting was 33% among children. Four studies reported malnourishment or undernutrition among the elderly population in southern India. The pooled sample size was 1108 and the pooled proportion of malnourishment among the elderly population was 12% (95% CI: 1%–22%). Conclusion: Combating child malnutrition in India requires public health interventions for cases of mild malnutrition and vulnerable populations, regional strategy implementation and evaluation, investigations on overweight, obesity, and its causes, and socioeconomic development.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91034254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of diaphragmatic breathing exercise in the rehabilitation of chronic low back ache 横膈膜呼吸运动在慢性腰痛康复中的作用

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_41_23

S. Nagaraj, KU Dhanesh Kumar, P. Aaron

引用次数: 0

Efficacy of Dienogest on Pelvic Pain and Dyspareunia: Comprehensive Meta-Analysis and Systematic Review Dienogest治疗盆腔疼痛和性交困难的疗效:综合meta分析和系统评价

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-30 DOI: 10.55561/ajhr.v2i1.73

S. Sutrisno, Wildan Aulia Firdaus

{"title":"Efficacy of Dienogest on Pelvic Pain and Dyspareunia: Comprehensive Meta-Analysis and Systematic Review","authors":"S. Sutrisno, Wildan Aulia Firdaus","doi":"10.55561/ajhr.v2i1.73","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.73","url":null,"abstract":"Introduction: Endometriosis is a severe disorder marked by endometrial tissue outside the uterus and linked to infertility, although typically manifesting as discomfort in the form of dysmenorrhea, dyspareunia, and pelvic pain. Dienogest is indicated as a first-line hormone treatment for endometriosis-related discomfort. The aim of this study is to analyze the efficacy of Dienogest on treating pelvic pain and dyspareunia compared to placebo or combined oral contraceptives (COC) in women with endometriosis.\u0000Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar. The PRISMA 2020 rules were used to screen the articles that were obtained. For the review, studies that examined how using dienogest in improving endometriosis were exposed to were taken into consideration. In a meta-analysis utilizing a random-effects model, odds ratios with their 95% confidence intervals (CI) were provided.\u0000Results: Five studies that met the criteria for inclusion were determined to be pertinent to the association between using dienogest in improving endometriosis (n=711). The Dienogest group had substantially improve pelvic pain with a mean difference of 1.01 (95% CI 1.2, 0.82; p<0.00001) and dyspareunia with a mean difference of 0.58 (95% CI 1.09, 0.08; p=0.02) compared to placebo. Compared to combined oral contraceptives, COC had substantially improves dyspareunia with a mean difference of 0.99 (95% CI 0.62, 1.37; p<0.00001) and pelvic pain with a mean difference of 1.15 (95% CI 0.23, 0.83; p=0.01).\u0000Conclusion: Dienogest should be considered as an alternate treatment for endometriosis-related symptoms. In double-blind research, DNG efficacy was compared to placebo.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84483003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Maternal Comorbidities with Full-Term Pregnancy Who Gave Birth to Low Birth Weight Babies at Dr. Saiful Anwar Malang General Hospital 在Saiful Anwar Malang综合医院生下低出生体重婴儿的足月妊娠孕妇合并症

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-17 DOI: 10.55561/ajhr.v2i1.85

I Wayan Agung Indrawan, Obi Candra Kapisa

{"title":"Maternal Comorbidities with Full-Term Pregnancy Who Gave Birth to Low Birth Weight Babies at Dr. Saiful Anwar Malang General Hospital","authors":"I Wayan Agung Indrawan, Obi Candra Kapisa","doi":"10.55561/ajhr.v2i1.85","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.85","url":null,"abstract":"Introduction: Stunting is a challenge for children's growth and development in the future, which has long-term impacts in the form of reduced cognitive abilities, decreased productivity, and increased risk of infection and non-communicable diseases. Low birth weight (LBW) is a major determinant of stunting in Indonesia. Various multidimensional factors contribute to low birth weight, including maternal factors.\u0000Material and Methods: Quantitative descriptive research was conducted at Dr. Saiful Anwar general hospital from July 2021 to September 2022. The variables studied were age, education, occupation, parity status, medical history, number of antenatal care controls, height, mother's body mass index, and baby's birth weight.\u0000Results: Of the 54 full-term pregnant women, the majority who delivered LBW babies were nulliparous (42.6%), aged 20-35 years during pregnancy (79.6%), had a history of hypertension during pregnancy (25.9%), antenatal care visits 1-5 times (48.1%), high school degree (48.1%), housewives (75.9%), height ranging between 151-160 cm (64.8%), and BMI 18.5 to 25 kg/m 2 (51.9%).\u0000Conclusion: Maternal factors that contribute to the birth of LBW babies include low parities, age 20 to 35 years during pregnancy, hypertension in pregnancy, infrequent antenatal care visits, high school degree, work as a housewife, height ranging between 151 -160 cm, and had a normal BMI. The representation of the mother's BMI and educational level in this study differs from that in previous studies.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81289725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of BAX/BcL2 Expression Ratio in Menstrual Blood between Endometriosis Women and Women without Endometriosis 子宫内膜异位症与非子宫内膜异位症女性经血BAX/BcL2表达比的比较研究

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.83

Arghya Wicaksana, Pande Made Dwijayasa, Rahajeng Rahajeng, Cholid Rohman Riskianto

{"title":"Comparative Study of BAX/BcL2 Expression Ratio in Menstrual Blood between Endometriosis Women and Women without Endometriosis","authors":"Arghya Wicaksana, Pande Made Dwijayasa, Rahajeng Rahajeng, Cholid Rohman Riskianto","doi":"10.55561/ajhr.v2i1.83","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.83","url":null,"abstract":"Introduction: Endometriosis is characterized by the presence of endometrial tissue outside the uterus and is commonly associated with chronic pelvic pain and infertility. One of the endometrial changes that appear in the eutopic and ectopic endometrium of women with endometriosis is the regulation of apoptosis. The proportion value of the BAX/BcL-2 ratio is a crucial factor in determining the ability of cells to stimulate apoptosis. Higher apoptotic activity is linked to an increased BAX/BcL-2 ratio. The aim of this study was to compare the BAX/BcL-2 ratios in menstrual blood of endometriosis and non-endometriosis patients.\u0000Material and Methods: This research is a quantitative observational study with a cross-sectional method at dr. Saiful Anwar Malang. The case group was postoperative women with ovarian cysts with anatomical pathology examination results indicating endometriosis. While the control group was patients without endometriosis. Data analysis was carried out by using the Independent T Test with SPSS for Windows 19.0 software.\u0000Results: Each group consisted of 17 patients. The normality test for each variable shows p> 0.05. BAX average in patients with endometriosis 4556.29 ± 2338.33 and 6488.06 ± 2649.08 in patients without endometriosis (p = 0.031). The average BcL-2 in endometriosis patients was 6483.82±2489.36 and 4877.18±2023.82 in patients without endometriosis (p=0.047). The average BAX/BcL-2 ratio in patients with endometriosis was 0.698±0.19 and 1.367±0.26 in patients without endometriosis (p=0.000).\u0000Conclusion: The BAX/BcL-2 ratio in women with endometriosis cysts has a lower average rate than women without endometriosis cysts.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85499954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report 腹部癫痫，一个诊断考虑儿童反复呕吐:1例报告

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.76

Fatia Murni Chamida, Nirmala Muflihatul Khalida

{"title":"Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report","authors":"Fatia Murni Chamida, Nirmala Muflihatul Khalida","doi":"10.55561/ajhr.v2i1.76","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.76","url":null,"abstract":"gastrointestinal complaints and central nervous system involvement, mainly confusion, fatigue, headache, dizziness, syncope, and lethargy resulting during the abdominal seizure activity. Chronic vomitting or other gastrointestinal symptoms often lead to fluid and nutritional deficiencies which resulted in malnutrition. To date, there was no study has been reported on abdominal epilepsy in Indonesia.\u0000Case Presentation: We presented a case of two-year-old girl with chief complaint of recurrent profuse vomiting every month for the past year. Patient complained of headaches and abdominal pain and tended to sleep all day during relapse. Physical examination showed sunken eyes and decreased skin turgor. EEG showed abnormal results, diffuse irritative, epileptiform with normal basic rhythm. Esophageal polyps were also found on endoscopy. Patient was given anti-epileptic drugs and histamine H2 receptor antagonists and responded well to those therapies.\u0000Conclusion: Abdominal epilepsy is a rare case which may resulted in vomiting and abdominal pain in children. EEG examination is an important test for diagnosing abdominal epilepsy. Treatment with anti-epileptic drugs is known to respond well in this case.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87288820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Effect of Red Bean Extract (Phaseolus vulgaris L. Sp) on Interleukin-1, Inhibin Β and PCNA Expression in Systemic Lupus Erythematosus Mice Model 红豆提取物对系统性红斑狼疮小鼠模型白细胞介素-1、抑制素Β及PCNA表达的影响

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.81

Albert Novriadi, Muhammad Nooryanto, I Wayan Agung Indrawan, Puspita Handayani

{"title":"Effect of Red Bean Extract (Phaseolus vulgaris L. Sp) on Interleukin-1, Inhibin Β and PCNA Expression in Systemic Lupus Erythematosus Mice Model","authors":"Albert Novriadi, Muhammad Nooryanto, I Wayan Agung Indrawan, Puspita Handayani","doi":"10.55561/ajhr.v2i1.81","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.81","url":null,"abstract":"Introduction: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by multiple organ involvement. Chronic inflammation due to oxidative stress and autoimmune causes damage to related organs, one of which is the ovary which leads to Premature Ovarian Failure (POF) . Red bean (Phaseolus vulgaris L. Sp.) is an anti-inflammatory and antioxidant agent. This study aims to examine the effect of red beans on IL-1, Inhibin B, and PCNA.\u0000Methods: This is a true experimental study with a post-test-only controlled group design in vivo. The sample in this study were female Balb/c mice treated with red bean extract (Phaseolus vulgaris L. sp.) at doses of 50 mg/KgBW (P1), 75 mg/KgBW (P2), and 100 mg/KgBW (P3). IL-1, Inhibin B, and PCNA levels in each group were statistically analyzed using the SPSS 16 for Windows software program.\u0000Results: Red bean extract (Phaseolus vulgaris L. Sp.) administration at various doses was statistically proven to significantly reduce IL-1 levels (p<0,05) and increase Inhibin levels in all groups (p<0,05). The highest average Inhibin B levels were found in the 100 mg/KgBW dose group (P3), significant increase in PCNA expression in all groups given various doses of red bean extract (p<0,05).\u0000Conclusion: Administration of red bean extract (Phaseoulus vulgaris L. Sp.) can reduce levels of Interleukin-1, increase levels of Inhibin B and PCNA expression in SLE mice.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86813715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Vertical Rectus Abdominis Myocutaneous Flap for Complex Abdominal Wall Reconstruction on a Relapse Case of Monophasic Synovial Sarcoma 垂直腹直肌肌皮瓣复合腹壁重建术治疗单相滑膜肉瘤复发1例

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.70

Alfadz Kholifah Akbar, Muhammad Pratama Mandala Putra, Denny Irwansyah

{"title":"The Vertical Rectus Abdominis Myocutaneous Flap for Complex Abdominal Wall Reconstruction on a Relapse Case of Monophasic Synovial Sarcoma","authors":"Alfadz Kholifah Akbar, Muhammad Pratama Mandala Putra, Denny Irwansyah","doi":"10.55561/ajhr.v2i1.70","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.70","url":null,"abstract":"Introduction: Vertical Rectus Abdominis Myocutaneous (VRAM) flap is a chosen method for a large wound closure instead of Anterolateral Thigh (ALT) flap. Both versatile and highly vascularized flaps share almost similar advantages for large wound closure. In our case, the site and size of the wound are the points of consideration.\u0000Case Presentation: A 16-year-old girl with a chief complaint of a large progressive lower abdominal mass enlarged since January 2021 that has grown back from the same site. Abdominal CT-Scan shows a tumor in the right lower abdomen infiltrated to the pelvic cavity and spanning from the lower abdominal area all the way to the groin area. Histopathology interpretation suggests a Monophasic Synovial Sarcoma. The patient underwent a second tumor resection with VRAM flap as the wound closure. The benefits of this versatile flap are excellent dead space obliteration and low Surgical Site Occurrence (SSO’s).\u0000Conclusion: As postulated in many studies VRAM flap is an excellent flap for a CAWR procedure. The expected SSO’s is non-existence during the postoperative follow-up","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85115522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety Comparison Between Lorazepam and Diazepam in Treating Convulsive Status Epilepticus in Children: An Evidence-Based Case Report 劳拉西泮与地西泮治疗儿童惊厥性癫痫持续状态的疗效和安全性比较:一份循证病例报告

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.62

Muhammad Habiburrahman, Widya Khairunnisa Sarkowi

{"title":"Efficacy and Safety Comparison Between Lorazepam and Diazepam in Treating Convulsive Status Epilepticus in Children: An Evidence-Based Case Report","authors":"Muhammad Habiburrahman, Widya Khairunnisa Sarkowi","doi":"10.55561/ajhr.v2i1.62","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.62","url":null,"abstract":"Introduction: Indonesia still recommends diazepam for epilepsy, but the International League Against Epilepsy increasingly favours lorazepam. Some reports indicate diazepam being less effective and causing side effects. This report presents a difficult-to-treat convulsive status epilepticus (CSE) case in a 10-month infant who received diazepam, questioning if intravenous/rectal lorazepam is a better initial therapy than diazepam for hospitalized children with CSE.\u0000Methods: Following the patient-intervention-comparison-outcome (PICO) formula, we searched for evidence in four journal databases (Pubmed, Proquest, EBSCOHost, and Cochrane). Studies meeting inclusion and exclusion criteria were appraised.\u0000Results: Through three systematic reviews and meta-analyses, our clinical query was addressed. One study revealed that rectal lorazepam was more effective in stopping seizures than rectal diazepam (RR 2.86). Meanwhile, two studies found that intravenous lorazepam exhibited similar efficacy in seizure cessation compared to intravenous diazepam (RR 1.04 and OR 1.03, respectively). Both drugs showed no significant difference in the time required to stop seizures or the necessity for additional doses or adjunctive medications to achieve such cessation, nor in the likelihood of refractory seizure within 24 hours. Two studies indicated that intravenous lorazepam had a reduced risk of respiratory depression (RR 0.71 and OR 0.62, respectively). Regardless of the administration route, lorazepam was linked to a lower probability of ICU admission (RR 0.15) than diazepam.\u0000Conclusion: Intravenous lorazepam and diazepam are equally effective for treating CSE, but rectal lorazepam is considered better at stopping seizures and preventing their recurrence compared to diazepam. Furthermore, lorazepam is deemed safer, especially when given intravenously.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78510689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Combination Therapy of Electrocautery and Zinc Sulfate in Perianal Giant Condylomata Acuminata with Human Immunodeficiency Virus (HIV) 电灼加硫酸锌联合治疗肛周尖锐湿疣合并HIV病例报告

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Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.57

Lita Setyowatie, Rizky Devitasari

{"title":"Case Report: Combination Therapy of Electrocautery and Zinc Sulfate in Perianal Giant Condylomata Acuminata with Human Immunodeficiency Virus (HIV)","authors":"Lita Setyowatie, Rizky Devitasari","doi":"10.55561/ajhr.v2i1.57","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.57","url":null,"abstract":"Introduction: Giant Condylomata Acuminata (GCA) or Buschke-Lowenstein tumours are rare variations of anogenital warts. Immunocompromising conditions are closely related to the development of GCA. There is no standard therapy in the management of GCA. Its large size allows malignant transformation and high recurrence.\u0000Case Presentation: A male, 26 years old, with a complaint of wart in the anal in the last 11 months. The lump was getting bigger and sometimes bleed. The patient had been diagnosed with HIV 1 year ago and had received routine antiretroviral therapy (ARV). On physical examination of the perianal region showed stalked vegetation which was hypopigmented, partly erythema, verrucous surface, in the form of cauliflower, multiple, measuring 1.5x1.5x4 cm. A positive acetowhite test and histopathological examination showed condylomata acuminata. Patients were given combination electrocautery therapy and zinc sulfate 5-10 mg/kg/day for 2 months. Significant improvement appears and GCA disappears entirely.\u0000Conclusion: Electrocautery and zinc sulfate as an immunomodulator can be considered as a treatment of GCA with HIV because they can work synergistically to achieve resolution of the lesion and prevent recurrence of GCA.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81287962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0