Asian Journal of Pharmaceutical Research and Health Care最新文献

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A Challenging Case: Colorectal Cancer During Pregnancy 一个具有挑战性的案例:妊娠期结直肠癌
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.108
Caesar Ahmad Tidel, Syifa Mustika
{"title":"A Challenging Case: Colorectal Cancer During Pregnancy","authors":"Caesar Ahmad Tidel, Syifa Mustika","doi":"10.55561/ajhr.v2i2.108","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.108","url":null,"abstract":"Introduction: Colorectal cancer (CRC) occurring in younger women can lead to an increased incidence of colorectal cancer during pregnancy. The estimated frequency of malignancy during pregnancy with colorectal cancer specifically estimated at 1 in 13,000 pregnancies. However, the exact causes of colorectal cancer during pregnancy are not yet fully understood. Diagnosing and managing colorectal cancer during pregnancy pose significant challenges because the symptoms can be masked by the normal signs and symptoms of pregnancy.\u0000Case Pesentation: A 42-year-old pregnant patient, Mrs. L, presented with abdominal pain, a history of dark-colored bowel movements, and a lump on the left side of her neck that had been present for a year. She had also experienced a weight loss of 5 kg both before and during pregnancy, and there was no previous history of malignancy. The patient underwent various diagnostic procedures, including pregnancy ultrasound, abdominal ultrasound, and colonoscopy biopsy. Based on the comprehensive evaluation of the patient's medical history, physical examination, and supporting tests, she was diagnosed with stage IV rectal adenocarcinoma with metastases to the liver, kidney, and lymph nodes. The patient was in her second pregnancy (G2P1Ab0) at 27-29 weeks of gestation.\u0000Conclusion: Colorectal cancer during pregnancy poses diagnostic and therapeutic challenges, as the signs and symptoms are often attributed to the normal progression of pregnancy, resulting in delayed diagnosis at an advanced stage. Early detection, evaluation, and monitoring of nonspecific symptoms are crucial, and a multidisciplinary approach is necessary for the management of colorectal cancer during pregnancy.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"106 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73001920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Steroid Induced Glaucoma In A 10-year-old Boy 双侧类固醇性青光眼一例10岁男孩
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.97
Ikatan Dokter, Indonesia Wilayah, Jawa Timur, Rosalia Adriani, Lydia Nuradianti
{"title":"Bilateral Steroid Induced Glaucoma In A 10-year-old Boy","authors":"Ikatan Dokter, Indonesia Wilayah, Jawa Timur, Rosalia Adriani, Lydia Nuradianti","doi":"10.55561/ajhr.v2i2.97","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.97","url":null,"abstract":"Introduction: Topical steroids are used in the treatment of various ocular disorders. However, it can cause numerous side effects. Steroid-induced glaucoma is the most severe complication of the unmonitored use of steroids. It is diagnosed by visual field defects, increased intraocular pressure (IOP), and glaucomatous optic neuropathy (GON) due to prolonged usage of steroids.\u0000Case Presentation: a 10-year-old boy presented to the outpatient clinic in Undaan Eye Hospital complaining of headache, re dness and itchiness in both eyes. He started using dexamethasone 0.1% eye drops without a physician's supervision for the last 2 years. Steroid-induced glaucoma was diagnosed in both eyes. Topical and oral glaucoma medications were given. Both eyes IOP were still elevated in the following months. Trabeculectomy in both eyes was performed due to medically uncontrolled glaucoma. Furthermore, both eyes IOP were getting normal without any topical and oral glaucoma medications.\u0000Conclusion: Unmonitored steroid usage must be avoided. This case suggests general practitioners and health care providers in the front line be aware of the usage of topical steroids. By increasing awareness concerning steroid-induced glaucoma, a patient's visual acuity can be saved, and irreversible blindness can be prevented, especially in children.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"34 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90379137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Secreted Aspartyl Protease-5 (SAP5) on Increasing Vaginal Acidity in Vulvovaginal Candidiasis 外阴阴道念珠菌病患者分泌天冬氨酸蛋白酶-5 (SAP5)与阴道酸度升高的关系
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.116
Ikatan Dokter, Indonesia Wilayah, Jawa Timur, Nur Sophia, Matin, Regina Ayu Fristiyanti, Safrina Dewi, N. Nurdiana, S. Santoso, B. Rahardjo
{"title":"Correlation between Secreted Aspartyl Protease-5 (SAP5) on Increasing Vaginal Acidity in Vulvovaginal Candidiasis","authors":"Ikatan Dokter, Indonesia Wilayah, Jawa Timur, Nur Sophia, Matin, Regina Ayu Fristiyanti, Safrina Dewi, N. Nurdiana, S. Santoso, B. Rahardjo","doi":"10.55561/ajhr.v2i2.116","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.116","url":null,"abstract":"Introduction: Vulvovaginal candidiasis (VVC) is an infection of the vaginal mucosa that extends to the vulva due to excessive growth of Candida albicans, causing a progressive decrease of Lactobacillus spp., as the main of normal flora. Decrease in the number of Lactobacillus spp. causes a reduction of lactic acid production that it was causing increasing vaginal pH. The increase in pH is due to the progressive growth of C. albicans colonies in the vaginal mucosa. In addition, the mechanism of candidiasis is also influenced by the secretion of virulence factors by C. albicans. Secreted Aspartyl Protease-5 (SAP5) is the dominant virulence factor that plays a role in changing the morphology of yeast cells into hyphae. This study aims to identify the correlation between SAP5 levels and vaginal pH.\u0000Material and Methods: This research was conducted in vivo using a sample of Rattus norvegicus with a posttest randomized experimental group design approach. This study has two groups, i.e., Negative Control (NC) and Positive Control group (PC). SAP5 and pH samples were taken from vaginal fluids and then measured using ELISA and a digital pH meter. The statistical analysis used was Pearson Correlation to analyze the correlation between SAP5 and pH levels.\u0000Results: There was a strong correlation (R=0.846) that means the increase of SAP5 is related to the increase of vaginal acidity in the PC group.\u0000Conclusion: The increase in SAP5 levels is directly followed by an increase in the pH value of vaginal fluids,","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"79 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82268633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suspicion of Duchenne Muscular Dystrophy in A 7-Year-Old Madurese Boy: A Rare Case Report 一名7岁男童疑似杜氏肌营养不良:罕见病例报告
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.88
Suci Rizalah Islamiyah, Garata Dwi, Yulia Nurul Putri, Suci Rizalah
{"title":"Suspicion of Duchenne Muscular Dystrophy in A 7-Year-Old Madurese Boy: A Rare Case Report","authors":"Suci Rizalah Islamiyah, Garata Dwi, Yulia Nurul Putri, Suci Rizalah","doi":"10.55561/ajhr.v2i2.88","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.88","url":null,"abstract":"Introduction: Duchenne Muscular Dystrophy (DMD) is an X-linked disorder presenting in early childhood and characterized by proximal muscle weakness and calf hypertrophy in affected boys associated with a functional deficiency of dystrophin. The incidence of these cases reached 1 in 3500-6000 male births. Research at RSUPN Dr Cipto Mangunkusumo (RSCM) showed that DMD is the second most frequent neuromuscular disorder in children regardless there is no prevalence data available yet in Indonesia. It is quite complicated to diagnose DMD due to the limited facilities of genetic testing and its high cost.\u0000Case Presentation: A 7-year-old boy came with the main complaint of weakness in both legs progressively two years before admission. He had to hold onto the floor and then both knees when started to stand. There was a history of motor and speech delay but family history was denied. Vital signs and nutritional status were within normal. Laboratory examination revealed significantly elevated levels of CK, ALT, and AST. The EMG result supported the presence of myopathy. Due to a lack of facilities, genetic testing or muscle biopsy could not be done. He received prednisone once a day with a 14 mg dose and was scheduled to attend regular physiotherapy.\u0000Conclusion: In a limited facilities area, the clinician should have a suspicion of DMD not only by anamnesis and clinical features, but also by considering the elevated levels of CK and myopathies on EMG.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"51 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90670122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shortages of Medical Doctors in Indonesia, Is It True? 印尼医生短缺,是真的吗?
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.121
Sutrisno, MD, PhD, OG (REI)
{"title":"Shortages of Medical Doctors in Indonesia, Is It True?","authors":"Sutrisno, MD, PhD, OG (REI)","doi":"10.55561/ajhr.v2i2.121","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.121","url":null,"abstract":"All parts of Indonesia need medical doctors, but it is not a simple thing to be solved. The world of medicine in Indonesia faces many internal problems, specifically regarding medical doctor distribution. Where do the medical doctors in Indonesia reside? Recently many areas in Indonesia experienced a ratio between doctors and population of more than 1 : 1000.   Data   From the Indonesia   Medical   Council   (KKI)   and   Indonesia   Medical doctor association (IDI) in the year 2023 total number of medical doctors are  214,878 doctors, dominated by general physician 165,453 doctors, and followed by doctors specialist  49,425. Total dentists are 41,940, and dentist specialists are 5,201. The fundamental problems, according to population ratios, is related to geographical and demographic handicap because Indonesia is an archipelago country with more than 17,000 islands with more than 280 million populations, with many specific problems in access,  communication, transportation system, socio-economic, cultural, and leadership.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"11 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84361901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of Early Recovery After Caesarean Surgery Protocol in Floating Hospital (Case Series) 漂浮医院剖宫产术后早期康复方案的实施(病例系列)
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.67
Akhyar Nur Uhud, B. Welantika, Senda Sulvain, T. Y. Aden
{"title":"Implementation of Early Recovery After Caesarean Surgery Protocol in Floating Hospital (Case Series)","authors":"Akhyar Nur Uhud, B. Welantika, Senda Sulvain, T. Y. Aden","doi":"10.55561/ajhr.v2i2.67","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.67","url":null,"abstract":"Introduction: Enhanced Recovery After Caesarean Surgery (ERACS) is a new concept that combines various evidence-based perioperative care to reduce post-operative complications and accelerate patient recovery after Caesarean Surgery (C-Section). The advantages of the ERACS Protocol, including accelerating patients' recoveries, shortening hospital stays, and reducing post-operative complications, make it suitable to be applied in floating hospitals. The problem is whether this protocol can be applied if it is carried out in a floating hospital with all its limitations. We would like to present our case series with modified ERACS protocol in Floating Hospital Ksatria Airlangga.\u0000Case Presentation: We present 4 patients scheduled for elective C-Section. Neuraxial opioids with low-dose morphine, the most frequently used technique in ERACS, were not administered due to its unavailability in Ksatria Airlangga Floating Hospital. We provide pre-emptive analgesia and multimodal analgesia to obtain adequate perioperative analgesia. All patients were admitted to the nearest public health centre for post-operative observation and discharged after 1 to 2 days. Satisfaction was achieved in all patients without any significant postoperative complications.\u0000Conclusion: The ERACS protocols’ main goal can be achieved even under limited conditions, but several adjustments are required according to the available resources.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"119 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80532789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Effects of Dienogest and Leuprolide Acetat on Serum Interferon (IFN-Ɣ) Levels in a Mouse Model of Endometriosis (Mus musculus) 双炔诺孕素和醋酸左炔诺列酯对子宫内膜异位症小鼠血清干扰素-Ɣ水平影响的比较
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.111
Ikatan Dokter, Indonesia Wilayah, Jawa Timur, María Antonia, Barbara Batu Mali, Siskanita Nur Fitriana, S. Sutrisno, H. Khotimah, Wayan Arsana Wiyasa, W. Indrawan
{"title":"Comparison of the Effects of Dienogest and Leuprolide Acetat on Serum Interferon (IFN-Ɣ) Levels in a Mouse Model of Endometriosis (Mus musculus)","authors":"Ikatan Dokter, Indonesia Wilayah, Jawa Timur, María Antonia, Barbara Batu Mali, Siskanita Nur Fitriana, S. Sutrisno, H. Khotimah, Wayan Arsana Wiyasa, W. Indrawan","doi":"10.55561/ajhr.v2i2.111","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.111","url":null,"abstract":"Introduction: Endometriosis is a medical condition in which there is abnormal growth of tissue resembling the endometrium outside the uterus. It can cause symptoms of pain and/or infertility. The current medical therapy focuses on reducing estradiol levels or stimulating progesterone response. One of the most effective options for medical treatment is the use of GnRH analogs. Dienogest have a direct anti-inflammatory effect on endometriotic stromal cells. However, a comparison of the anti-inflammatory effects of these drugs on IFN-Ɣ has not been previously investigated. Therefore, this study aims to compare the effects of reducing IFN-Ɣ by both Dienogest and Leuprolide Acetat in a mouse model.\u0000Material and Methods: This study employed a post-test only control group design and involved 4 groups, namely the negative control group, positive control group, and two treatment groups: one group administered Dienogest at a dosage of 0.0052 milligrams per day for 14 days, and the other administered Leuprolide Acetat at a dosage of 0.00975 milligrams once every 5 days for a period of 14 days. Serum IFN-Ɣ levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). The data were subsequently analyzed using IBM SPSS 25 with One-Way ANOVA test.\u0000Results: This study demonstrated that Leuprolide Acetat significantly decreased serum levels of IFN-Ɣ, whereas Dienogest actually increased the levels .\u0000Conclusion: In a mouse model of endometriosis (Mus musculus), Leuprolide Acetat effectively reduced the levels of IFN-Ɣ (pro-inflammatory). Conversely, Dienogest increased the levels of IFN-Ɣ (anti-inflammatory) in the mouse model of endometriosis.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"18 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90392057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Calcium on Biomarkers of Ovarian Fertility in Premature Ovarian Failure: A Systematic Review 钙对卵巢早衰患者卵巢生育能力生物标志物的影响:系统综述
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI: 10.55561/ajhr.v2i2.29
Sutrisno Sutrisno, None Tri Aji Bangun Nuswantoro
{"title":"The Effect of Calcium on Biomarkers of Ovarian Fertility in Premature Ovarian Failure: A Systematic Review","authors":"Sutrisno Sutrisno, None Tri Aji Bangun Nuswantoro","doi":"10.55561/ajhr.v2i2.29","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.29","url":null,"abstract":"Introduction: Premature ovarian failure (POF) is a condition in which ovarian function decreases or follicles are depleted in women aged less than 40 years. Calcium, along with vitamin D, is a mineral with many benefits for the reproduction system. This review is written to observe the effect of calcium on ovarian fertility biomarkers in premature ovarian failure. Methods: The literatures search was conducted utilizing numerous search engines, namely PubMed, Cochrane, Springer, Science Direct, Nature, and Google Scholar. Article publication year was restricted from 2016 to 2022. Article search keywords included “calcium”, “vitamin D”, “premature ovarian failure”, “premature ovarian insufficiency”, “amenorrhoea”, “ovarian reserve biomarkers”, “estradiol”, “follicle stimulating hormone”, and “luteinizing hormone”. Article selection was performed using the preferred reporting items for systematic review and meta-analysis protocols guidelines (PRISMA-P). The first author’s name, publication year, samples number, age range of subjects, duration of data collection, geographical setting, study design, and conclusions of research results were extracted from the selected paper. Results: 8397 articles were obtained from the six search engines. 13 articles met the inclusion criteria. Research conducted by Iran reported a significant correlation between vitamin D levels and AMH levels (p<0.001). In comparison, the research in Bangladesh showed a significant positive correlation between vitamin D levels and AMH levels (r=0.433; p=0.001) and vitamin D levels and AFC values (r=0.419; r=0.001). However, 11 other researchers reported contradictory results. Conclusion: The calcium and vitamin D effect on reproductive health related to POF occurrence is still inconsistent. Therefore, observational and experimental research is needed to analyze this topic.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135444608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis 染料木素对子宫内膜异位症小鼠雌激素受体特别是白细胞介素-6和肿瘤坏死因子-α的影响:系统回顾和荟萃分析
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-29 DOI: 10.55561/ajhr.v2i1.90
Sutrisno Sutrisno, Lovin Destikatari
{"title":"Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis","authors":"Sutrisno Sutrisno, Lovin Destikatari","doi":"10.55561/ajhr.v2i1.90","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.90","url":null,"abstract":"Introduction: Endometriosis is the endometrial tissue proliferation outside the uterine space. Anti-angiogenic agents from different groups of substances are currently being discussed as promising therapies for the treatment of endometriosis in the future, one of which is therapy using the phytoestrogen genistein. At the molecular level, genistein's effects on cells include inhibition of proliferation, induction of differentiation, apoptosis, and cell arrest in the cell cycle, which are related to the transforming growth factor. Genistein inhibits cell growth by modulating the signal-transforming growth factor pathway.\u0000Methods: We searched PubMed, Scopus, Cochrane Library and Proquest from its inception to December 2022 to collect observational and interventional studies of Genistein consumption in endometriosis mice. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Safety analysis was assessed through TNF-α and IL-6 values of estrogen expression.\u0000Results: No significant difference in the values of IL-6 and TNF-α in rats with endometriosis that were given genistein at these three doses. However, if analyzed further, the IL-6 outcome compared to the 0.78mg/day dose most affected the IL-6 value between the two groups, and the TNF-α output compared to the 0.78 mg/day dose most affected the TNF-α value between the two groups. So, a genistein dose of 0.78 mg/day can affect IL-6 and TNF-α in mice with endometriosis.\u0000Conclusion: Genistein modulated estrogen expression of TNF-α and IL-6 at all doses, but the best dose for its effect was 0.78 mg/day.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79425190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Screen Based Activity on Digital Eye Strain in School-Age Children in Peniwen Village, Malang, East Java 东爪哇玛琅Peniwen村学龄儿童数字眼疲劳的屏幕活动分析
IF 0.4
Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-04-29 DOI: 10.55561/ajhr.v2i1.98
Minarni Wartiningsih
{"title":"Analysis of Screen Based Activity on Digital Eye Strain in School-Age Children in Peniwen Village, Malang, East Java","authors":"Minarni Wartiningsih","doi":"10.55561/ajhr.v2i1.98","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.98","url":null,"abstract":"Introduction: The use of digital devices has increased across all age groups and professional fields, making them inseparable from everyday life. This increase in the duration of screen-based activities causes various symptoms of eye health problems. This study aimed to determine the prediction of the relationship and influence between Screen-Based Activity (SBA) and the incidence of Digital Eye Syndrome (DES) in children aged 9-12 years in Peniwen Village, Malang.\u0000Material and Methods: This study used a cross-sectional analytical observational design. There were 62 respondents in the research samples, or the same number as the total population. The analysis technique used in this study is the Partial Leas Square (PLS) modeling technique with testing using software such as SmartPLS (v3.2.9).\u0000Results: Based on the results of the analysis, obtained t-count (23.821) is greater than the t-table (1.96), meaning that there is a relationship and influence between SBA variables on DES. The correlation coefficient of SBA to DES is positive 0.818 which means the higher the Screen Based Activity, the higher the risk of Digital Eye Strain. The use of handphone (X2) is an indicator of SBA with the highest correlation strength of 88.1%.\u0000Conclusion: There is an association between the duration of Screen Based Activity and the incidence of Digital Eye Strain in children. The higher the Screen Based Activity, the higher the risk of Digital Eye Strain. In addition, the use of handphones has the highest correlation in influencing the occurrence of Digital Eye Strain in school-age children in Peniwen Village.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"88 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78298585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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