Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis

IF 0.2 Q4 PHARMACOLOGY & PHARMACY
Sutrisno Sutrisno, Lovin Destikatari
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Abstract

Introduction: Endometriosis is the endometrial tissue proliferation outside the uterine space. Anti-angiogenic agents from different groups of substances are currently being discussed as promising therapies for the treatment of endometriosis in the future, one of which is therapy using the phytoestrogen genistein. At the molecular level, genistein's effects on cells include inhibition of proliferation, induction of differentiation, apoptosis, and cell arrest in the cell cycle, which are related to the transforming growth factor. Genistein inhibits cell growth by modulating the signal-transforming growth factor pathway. Methods: We searched PubMed, Scopus, Cochrane Library and Proquest from its inception to December 2022 to collect observational and interventional studies of Genistein consumption in endometriosis mice. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Safety analysis was assessed through TNF-α and IL-6 values of estrogen expression. Results: No significant difference in the values of IL-6 and TNF-α in rats with endometriosis that were given genistein at these three doses. However, if analyzed further, the IL-6 outcome compared to the 0.78mg/day dose most affected the IL-6 value between the two groups, and the TNF-α output compared to the 0.78 mg/day dose most affected the TNF-α value between the two groups. So, a genistein dose of 0.78 mg/day can affect IL-6 and TNF-α in mice with endometriosis. Conclusion: Genistein modulated estrogen expression of TNF-α and IL-6 at all doses, but the best dose for its effect was 0.78 mg/day.
染料木素对子宫内膜异位症小鼠雌激素受体特别是白细胞介素-6和肿瘤坏死因子-α的影响:系统回顾和荟萃分析
简介:子宫内膜异位症是指子宫内膜组织在子宫间隙外增生。来自不同物质的抗血管生成药物目前正在被讨论作为未来治疗子宫内膜异位症的有希望的治疗方法,其中之一是使用植物雌激素染料木素的治疗。在分子水平上,染料木素对细胞的作用包括在细胞周期中抑制增殖、诱导分化、凋亡和细胞阻滞,这些作用都与转化生长因子有关。染料木素通过调节信号转化生长因子途径抑制细胞生长。方法:检索PubMed、Scopus、Cochrane Library和Proquest自成立至2022年12月,收集子宫内膜异位症小鼠染料木素摄入的观察性和干预性研究。两位作者根据纳入和排除标准独立筛选文献,提取数据,评估偏倚风险。通过雌激素表达TNF-α和IL-6值评估安全性。结果:三种剂量染料木素对子宫内膜异位症大鼠IL-6、TNF-α的影响均无显著性差异。然而,如果进一步分析,与0.78mg/天剂量相比,IL-6结局对两组之间IL-6值的影响最大,与0.78mg/天剂量相比,TNF-α输出对两组之间TNF-α值的影响最大。因此,0.78 mg/天的染料木素剂量可以影响子宫内膜异位症小鼠的IL-6和TNF-α。结论:染料木素在各剂量下均可调节TNF-α和IL-6的雌激素表达,但其效果最佳剂量为0.78 mg/d。
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