{"title":"Technology Transfer Agency in India","authors":"Y. Chowdhary, Babita Kumar","doi":"10.52711/2231-5713.2023.00011","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00011","url":null,"abstract":"Transfer of technology is defined as “a logical procedure that controls the transfer of any process together with its documentation and professional expertise between development and manufacture or between manufacture sites” • Technology transfer is both integral and critical to the drug discovery and development .Technology of transfer may be defined as a mutually agreed upon, intentional, goal-oriented, and proactive process by which technology flows from an entity that owns the technology (the transferor) to an entity seeking the technology (the transferee). Government of India is in the verge to open Technology Transfer Offices, Universities, institutions which will be funded by central government and will acts as mechanism for transferring or exporting the research conducted and its outcome to the desired place. Examples of technology transfer can be found across virtually every scientific and industrial area, from pharmaceuticals and medical devices to alternative energy solutions, computing, transport, artificial intelligence, robotics, agriculture, aerospace, environmental improvements and many more.. To overcome these limitations, the four levels of knowledge and technology transfer are suggested: Technology transfer can be broadly classified into vertical and horizontal technology transfer. Vertical Technology Transfer– This chain of transfer includes basic research to applied research, applied research to development, and from development to production. It is also known as internal technology transfer. Technology transfer is a process to transfer information and technologies necessary to manufacture quality drug product consistently or technology transfer is the process of taking an invention from its inception in a laboratory to a commercialized product.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80885516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Hemalatha, P. Bhuvaneswari, G. Kalyani, N. K. Veni, K. Naga Durga, P. Yashwanthi, K. Padmalatha
{"title":"Development of Fast Dissolving Tablets of Losartan Potassium using Novel Co-processed Superdisintegrants","authors":"B. Hemalatha, P. Bhuvaneswari, G. Kalyani, N. K. Veni, K. Naga Durga, P. Yashwanthi, K. Padmalatha","doi":"10.52711/2231-5713.2023.00003","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00003","url":null,"abstract":"Losartan is used to treat high blood pressure (hypertension) and also used to lower the risk of stroke in certain people with heart disease. Therefore, the purpose of this study is to formulate mouth dissolving tablet of losartan potassium to improve its bioavailability, to attain fast onset of action and rise patient compliance. Owing to short bioavailability of 33% and to increase onset of action, fast dissolving tablets of Losartan Potassium were formulated using coprocessed superdisintegrants in order to improve the dissolution rate, in that way the bioavailability. The effect of concentration of the Croscarmellose sodium was studied by a set of three formulations (F1, F2, F3) with concentrations of 2%, 4% and 8% w/w respectively. Similarly, the impact of Sodium Starch Glycolate was studied by a set of three formulations (F4, F5 and F6) respectively. The formulation prepared with 8% w/w of superdisintegrant showed relatively rapid release of Losartan potassium when compared with other concentrations of Croscarmellose sodium and Sodium Starch Glycolate. The formulation prepared with Croscarmellose sodium had showed relatively fast release of Losartan Potassium when compared with Sodium Starch Glycolate. Three formulations (F7, F8 and F9) were prepared by including a combination of superdisintegrants (Co-processed Mixtures), Croscarmellose sodium and Sodium Starch Glycolate by direct compression method. Formulation containing Co-processed mixtures had less disintegration time as compared to the individual superdisintegrants. Subsequently, we can conclude that nature, concentration of the superdisintegrant in addition to combination of superdisintegrants (Co-processed) showed influence on the rate of dissolution.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84380165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. S. Vani, C. Kiranmai, B. H. Latha, K. Padmalatha
{"title":"A Review on Osmotic Drug Delivery System","authors":"G. S. Vani, C. Kiranmai, B. H. Latha, K. Padmalatha","doi":"10.52711/2231-5713.2023.00014","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00014","url":null,"abstract":"Conventional drug delivery systems have slight control over their drug release and nearly uncontrollable over the effective concentration at the target site. This type of dosing pattern might effect on constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled design over a prolonged period of time by the controlled or modified release drug delivery systems. For most of the drugs, oral route is the most tolerable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Evolution of an extended-release dosage form also need sensible absorption throughout the gastro-intestinal tract (GIT). Among the existing techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most suitable one. Osmotic drug delivery systems release the drug with the zero-order kinetics at a constant rate. This review brings out advantages, disadvantages, principles, basic components and classification of osmotic drug delivery systems.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85468313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rina G. Maskare, Shital D. Thakre, Om D. Patle, Shirali S. Vishwakarma, Dhyanesh N. Dahake, Rima J. Jagnit, Rohit S. Rahangdale
{"title":"Novel Formulation for Treatment of Mouth Ulcer","authors":"Rina G. Maskare, Shital D. Thakre, Om D. Patle, Shirali S. Vishwakarma, Dhyanesh N. Dahake, Rima J. Jagnit, Rohit S. Rahangdale","doi":"10.52711/2231-5713.2023.00004","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00004","url":null,"abstract":"Mouth ulcer also known as cankers ulcer are normally small painful abscess that can develop in your mouth or the base of your gum due to these we feel uncomfortable in eating, drinking and talking. Women’s, adolescent and people with a family history of mouth ulcers are higher risk for developing mouth ulcer. There is no major drug therapy required for treatment of mouth ulcer, usually people prefer home remedies. But it is not convenient to take , dose variation may occur because there is no definite quantity given, and also it is unpleasant sometimes irritable thus accordingly we formulate candy like formulation that is lozenges which composed of herbal ingredient like, guava leaves , pigeon pea leave, Tulsi, mint, turmeric, liquorice, clove binded with dextrose , which is convenient for patient The prepared lozengesare evaluated for stability parameter, according to ICH Guideline, the improved formulative lozenges where evaluated for physical characters and results comes under pharmacopeial limit. In-vitro dissolution study show’s 90 % drug release within 30 minutes, the stability studies shows that formulation is stable for last 3 months. Here antimicrobial activity of lozenges is also studied and it shows the positive result for topical application.\u0000From recent work it was assured that the herbal lozenges can be considered as a reliable delivery system for the treatment of mouth ulcer.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75527793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vaccine through Centuries. Major Cornerstone of Global Health","authors":"R. Haider","doi":"10.52711/2231-5713.2023.00013","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00013","url":null,"abstract":"Vaccine have a history that started late in the 18th century. From the late 19th century, Vaccine could be developed in the laboratory, However, In the 20th century it became possible to develop vaccine based on Immunologic makers In the 21st century molecular biology permits vaccine development that was not possible before. In the history of science is the impact of vaccines on human longevity and health over 300 years elapsed since the first vaccine was discovered. In short article it is not possible to do justice to a subject that encompases immunology, molecular biology, and public health, but several more extensive sources are available to the interested reader 1-5 rather than attempting a chronological narrative, In current articles that describe novel technologies, it is often said that they will enable \" rational\" development of vaccines. The opposite of rational is irrational, but presumably the writer mean to contrast rational with \"empiric\" However, in fact vaccine development has been based on rational choices ever since the mid 20th century, when the immunology advanced to the point of distinguishing protection mediated by antibody and that mediated by lymphocytes, and when passage in cell culture permitted the selection of attenuated mutants, After the point successful vaccine have been \" rationally\" developed by protection studies in animal, by inference from immune response shown to protect against repeated natural infection (the so called mechanistic correlates of protection) 6 and from the use of passive administration of antibodies against specific antigens to show that those antigens should be included in vaccines.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77575095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation and Evaluation of Floating Tablet of Nabumetone","authors":"Parmeet K Saluja, N. Jain, N. Jain","doi":"10.52711/2231-5713.2023.00006","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00006","url":null,"abstract":"Nabumetone was used as a model drug in this study to construct and assess floating tablets. By adjusting the drug to polymer ratio to 1:1, 1:1.5, and 1:2, naproxen sodium floating tablets were made utilising the wet granulation method. As generating agents, sodium bicarbonate and citric acid are utilised. With isopropyl alcohol acting as the solvent, lactose is employed as diluents and PVP K30 as a granulating agent. The formulation of the granules was assessed for flow properties, and the tablets were made and assessed for physical characteristics, invitro buoyancy testing, and drug content. All of the formulations displayed values that were within the permitted range, demonstrating the high calibre of the manufactured tablets. A decrease in the density of the tablet below 1 and the emergence of buoyancy were noticed as a result of the gas created being confined and protected within the gel formed by the polymers. As the polymer to drug ratio increases, it was seen that the floating lag time in the formulations F1 to F6 decreased while the total floating duration increased. Drug release from the formulations made in a 1:1 ratio occurred at a higher rate and to a greater extent (i.e. F1, F4, and F7). The produced tablets underwent evaluations for uniformity, hardness, friability, drug content, in vitro buoyancy experiments, and dissolving investigations. In addition, the invitro release data were fitted to various kinetic models.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89340841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IVF Modules of Management for Nurses and Clinical Practitioners which will help to add and keep track of Fertility Treatments","authors":"Wajid Ahmad, Jaza Quazi","doi":"10.52711/2231-5713.2023.00009","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00009","url":null,"abstract":"Infertility is a common problem that requires timely and sensitive intervention. The use of In-Vitro Fertilization (IVF) is now becoming a popular experience in developing countries. Infertility can be managed primarily by improving lifestyle, diet, exercise, and Couples should be advised of the importance of regular sexual intercourse every 2 or 3 days, regardless of the woman’s cycle. A drug like clomifene use in the primary treatment of infertility. Before and during the IVF nursing staff plays an important role in executes treatment plans that fertility doctors formulate with couples starting at the initial visit and also plays important role in supporting patients Psychologically. Some complications like multiple births, sex ratio distortions, and the spread of infectious diseases.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73613861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Andhale, U. T. Jadhao, D. Rathod, S. Thoke, G. N. Dhembre
{"title":"Formulation and Evaluation of Nanosuspension of Ambroxol Hyrochloride","authors":"M. Andhale, U. T. Jadhao, D. Rathod, S. Thoke, G. N. Dhembre","doi":"10.52711/2231-5713.2023.00002","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00002","url":null,"abstract":"The aim of the present investigation was to Formulation and evaluation of Nanosuspension of Ambroxol hydrochloride for pediatric use. Ambroxol hydrochloride is a mucolytic agent used to treat respiratory diseases associated with viscid or excessive mucus accumulated in respiratory tract. The present research involved to find out the effect of different polymer and their ratio on the formulation of ambroxol hydrochloride oral nanosuspension. The prepared nanosuspension is evaluated by solubility, particle size, entrapment efficiency, DSC study, SEM analysis, re-dispersion study, sterility and In-vitro drug release studies shows that the prepared nanosuspension has increased solubility and dissolution rate compared to pure drug. The formulated F5 has shown the better results like as UV rage is 244nm, soluble in methanol, particle size and Stability.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86829568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Swathi, Krishna Jyothi Kumari Bhavan, R. Sri. S
{"title":"Formulation and Evaluation of Sotalol Gastrorententive Tablets","authors":"G. Swathi, Krishna Jyothi Kumari Bhavan, R. Sri. S","doi":"10.52711/2231-5713.2023.00008","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00008","url":null,"abstract":"The objective of this study was to formulate floating tablets (GRDDS) of Sotalol using direct compression method to increase its bioavailability and the gastric residence time of the dosage form. The Sotalol tablets were prepared by direct compression method. The tablets were prepared by using different types of polymers i.e.; Sodium CMC, Chitosan and Psyllium Husk which act as a release retardant polymer. Sodium bi carbonate (NaHCO3) was used as a gas degenerating agent and MCC (Micro crystalline cellulose) was used as a diluent. The prepared formulation were subjected to some evaluation parameters like hardness, friability, weight variation, drug content, buoyancy property, drug release study etc. In the FT-IR study it was revealed that there is no interaction between the drug and excipients. The formulation which containing Chitosan polymer and Sodium bicarbonate shows good drug release pattern with less floating lag time and good floating duration.\u0000The in vitro drug release pattern of Sotalol floating tablets was fitted to different kinetic models which showed the highest regression for Higuchi order kinetics. Thus, it can be concluded that the floating drug delivery system of Sotalol using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86926664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Articulation and Evaluation of Extended-Release Beads using a Sulfasalazine Drug","authors":"K. Krishna, V. Patro","doi":"10.52711/2231-5713.2023.00005","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00005","url":null,"abstract":"The present study was focused on optimization of the formulation for the extended-release capsule of mesalamine. Multi particulate system has long been employed to improve the bioavailability of drugs. Mesalamine pellets were prepared by Coating drug solution on sugar sphere followed by functional coating. The release pattern depends upon the pore formation on the outer surface of the unit particle or beads and then slowly and steadily releasing drugs from the inner core. Ethocel grade 7cps was used as a release controlling polymer with the aid of hydrophilic polymer HPMC E5 with pore former to work as a controlled drug delivery system. The functional coated Pellets were used for various parameters like assay and in-vitro dissolution profile. The study confirmed that mesalamine can deliver its effect into lower part of intestine. The finally prepared pellets were used for the treatment of IBD (Ulcerative colitis) Batch 2 had gave optimised result which follow the US specification. Kinetics was applied to the optimized Batch B-2 which was following Higuchi matrix and the mechanism of release was diffusion as the polymer used was HPMC E5 and Tri ethyl citrate –pore former and Ethocel- impenetrable barrier.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78477850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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