Articulation and Evaluation of Extended-Release Beads using a Sulfasalazine Drug

Abstract

The present study was focused on optimization of the formulation for the extended-release capsule of mesalamine. Multi particulate system has long been employed to improve the bioavailability of drugs. Mesalamine pellets were prepared by Coating drug solution on sugar sphere followed by functional coating. The release pattern depends upon the pore formation on the outer surface of the unit particle or beads and then slowly and steadily releasing drugs from the inner core. Ethocel grade 7cps was used as a release controlling polymer with the aid of hydrophilic polymer HPMC E5 with pore former to work as a controlled drug delivery system. The functional coated Pellets were used for various parameters like assay and in-vitro dissolution profile. The study confirmed that mesalamine can deliver its effect into lower part of intestine. The finally prepared pellets were used for the treatment of IBD (Ulcerative colitis) Batch 2 had gave optimised result which follow the US specification. Kinetics was applied to the optimized Batch B-2 which was following Higuchi matrix and the mechanism of release was diffusion as the polymer used was HPMC E5 and Tri ethyl citrate –pore former and Ethocel- impenetrable barrier.