Asian Journal of Pharmacy and Technology最新文献

{"title":"A Comprehensive Review of Trigeminal neuralgia","authors":"S. Manjusha, B. S. Priti, S. Monika, N. A. Prajakta","doi":"10.52711/2231-5713.2023.00010","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00010","url":null,"abstract":"General practitioners are often the first doctors to see patients with Trigeminal neuralgia (TN). The aim of this article is to provide an up-to-date review of the literature regarding the presentation, classification, diagnosis and treatment of TN. The most painful neurological disease and is often described as \"lightning\" stuck to the face or a stinging sensation on the face. This condition is almost always unilateral and may involve one or more divisions of the trigeminal nerve. Trigeminal neuralgia, often called tic douloureux. MR imaging, including high-resolution trigeminal sequences, should be performed as part of the diagnostic workup. The most important aspects of TN management are discussed in this review article.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74579007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-diabetic effect of Gymnema sylvestre an Alloxan-Induced Diabetic in Male Albino Wistar Rats","authors":"S. Beula, R. Suthakaran, M. Viswaja, Ch. Shankar, G. Sree Lakshmi","doi":"10.52711/2231-5713.2023.00007","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00007","url":null,"abstract":"Traditional medicine from plant extracts has proved to be more affordable, clinically effective and relatively less adverse effects than modern drugs. The Present study was conducted for the extraction, Identification and Invitro anti diabetic activity of Gymnema sylvestre (Asclepiadaceae), extraction were employed to obtain maximum yield. The method where the leaves were extracted under continuous hot extraction in Soxhlet apparatus with 95% ethanol give the maximum yield. The extract were performed qualitative Studies of different chemical constituent of the plant. Gymnema Sylvestre ethanol extract have shown promising antidiabetic activity against standard control Alloxan.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76807671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Potential of Coumarin derivatives: A Review","authors":"R. K. K PRASAD, Kavita R. Loksh","doi":"10.52711/2231-5713.2022.00060","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00060","url":null,"abstract":"Cancer can conquer or feast on nearly all portions of the body. The cumulative illness and high humanity of cancer generate an innumerable claims for the expansion of innovative anticancer drugs. Coumarin (known as 1,2-benzopyrone or o-hydroxycinnamic acid-8-lactone) encompasses a huge class of phenolic offshoots that originate in plants and they are entailed of bonded benzene and a-pyrone rings. Numerous studies have exposed that several substituents on the coumarin essential structure stimulus different biological activities. Coumarin advert a character of pathways in cancer like kinase inhibition, cell cycle annexation, angiogenesis inhibition, telomerase inhibition, antimitotic activity, carbonic anhydrase inhibition, monocarboxylate transporters inhibition, aromatase inhibition, and sulfatase inhibition. Coumarin moiety is a beneficial template for the progress of novel anticancer agents.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75286689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposome a Nanotechnological benefactor to the field of Medicine and Drug delivery","authors":"Ritesh Kumar Dash, D. Sarangi, Rupak Kumar Swain, Satyajeet Behera","doi":"10.52711/2231-5713.2022.00056","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00056","url":null,"abstract":"Liposomes are spherical vesicles comprises of one or more phospholipid bilayers, which are under substantial research area as drug carriers for enhancing the delivery of drugs, nutritional agents, bioactive agents and many different compounds. The majority of those clinically approved vesicles have diameters of 50–300 nm. Among several new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action and decreases undesirable side effects upgrading its in vitro and in vivo activity, as well as reducing the toxicity of the drug and enhancing the efficacy of the encapsulated drug molecule. The present review will briefly explain the characteristics, advantages, scalable techniques based on the type of produced liposomes and potential applications of liposomes in food, cosmetics and pharmaceuticals.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81690291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence: Comprehensive Overview and its Pharma Application","authors":"Sanjay S. Patel, Sparsh A. Shah","doi":"10.52711/2231-5713.2022.00054","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00054","url":null,"abstract":"Artificial Intelligence (AI) focuses in producing intelligent modeling, which helps in imagining knowledge, cracking problems and decision making. In the year 1943, the first work which is now recognized as AI was done by Warren McCulloch and Walter pits. Previously, Artificial Intelligence was only limited to the field of engineering, but recently, AI plays an important role in various fields of pharmacy like drug discovery, drug delivery formulation development, marketing, management, marketing, quality assurance, hospital pharmacy etc. In drug discovery and drug delivery formulation development, various Artificial Neural Networks (ANNs) like Deep Neural Networks (DNNs) or Recurrent Neural Networks (RNNs) are being employed. Several implementations of drug discovery have currently been analyzed and supported the power of the technology in quantitative structure-property relationship (QSPR) or quantitative structure-activity relationship (QSAR). In addition, de novo design promotes the invention of significantly newer drug molecules with regard to desired/optimal qualities. Now the robots are using in the various medical procedures as they are more trustworthy for doctors, as they are more advanced in their work, as they can do any task within the short time period and effectively than humans. This is concluded that AI is the new evolving field in every sector, even in pharmacy, and it need more development for updating the current scenario as well as for new researches.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79928785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Review on Preparation and Characterization of Solid Lipid Nanoparticles","authors":"Wajid Ahmad, Rihan Jawed","doi":"10.52711/2231-5713.2022.00051","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00051","url":null,"abstract":"Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage. Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could use for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies. Appropriate analytical techniques for the characterization of SLN like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of SLN route of administration and the in vivo fate of the carriers are also discussed.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85422944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of pH meter in the study of adsorption of Acetic acid on activated Charcoal","authors":"Ulhas Balkrishna Hadkar, Asavari Sameer Hadkar","doi":"10.52711/2231-5713.2022.00049","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00049","url":null,"abstract":"Absorption of acetic acid on activated charcoal has been studied using pH meter in the concentration range 0.1 to 0.02 normal acetic acid solutions at 28oC. A weighed amount of activated charcoal was added to 50ml of acetic acid solution. Adsorption of acetic acid decreases the concentration of H+ ions in the solution. The pH of the solution consequently increases. The pH of the solution was measured using pH meter before and after adsorption. The normality of acetic acid solution after adsorption was determined from the standard plot of degree of dissociation of acetic acid versus pH of the solution. The amount of acetic acid adsorbed per gram of activated charcoal was calculated and the data was used to plot Freundlich and Langmuir adsorption isotherms. The constants in Freundlich adsorption isotherm were determined and reported here. The specific surface area of activated charcoal was calculated from the Langmuir adsorption isotherm. The aim of this study is to show the utility of pH meter in the adsorption studies of weak acid on activated charcoal.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83066371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Nanocarrier in Drug development with special Emphasis on Liposomes: A Review","authors":"Anshul Sharma, Keshav Dhiman, Kamya Goyal, V. Pandit, M. Ashawat, Shammy Jindal","doi":"10.52711/2231-5713.2022.00052","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00052","url":null,"abstract":"Liposomes are the nano-scale bilayer structure of phospholipid used as a carrier for a Large Variety of drugs. Both lipophilic and hydrophilic drugs can encapsulate into the liposome and delivered to the body. The purpose behind the preparation of liposomes is to reduce the side effects associated with systemic delivery of drugs as well as it also helps in the protection of biodegradable drugs and molecules such as protein and peptides from body enzymes and fluids. Other than these advantages liposome also have high skin permeation due to structural similarities with the stratum corneum and therefore can be used for the topical delivery of drugs. The various types of liposomes and their application in their marketed products are discussed below in the article.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89225089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants","authors":"Arjun Singh","doi":"10.52711/2231-5713.2022.00055","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00055","url":null,"abstract":"Traditional medicine is a body of knowledge, skills, and practices based on traditional cultures' presumptions, beliefs, and experiences in order to maintain their health. Traditional herbal treatments are highly valued among many rural or indigenous people in many underdeveloped nations. According to the World Health Organization, about 80% of the world's population relies on traditional medicine, with 60% of rural Indians using herbal treatments. During the previous five years, utilization of herbal supplements grew from 2.5% to 12 percent. The assessment of novel medications, particularly phytochemically derived materials, has opened up a large arena for study and has aided India's shift from traditional to modern medicine. Tannins, alkaloids, carbohydrates, terpenoids, steroids, flavonoids, and phenols are some of the chemical components found in medicinal plants that have a distinct physiological effect on the human body. Medicinal plants do not only exhibit natural therapeutic properties, but also provide natural prevention against various diseases. As a result, we are attempting to summarize, gather the number of plants, and their ethnopharmacological qualities in this complete review study research.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86914799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Formulation and Evaluation of Fexofenadine HCl Immediate Release Tablets by Solid Dispersion Method using Solvent Evaporation Technique","authors":"Ayanam Vasanthi, Ayanam Vasavi, Miriyala Mrunalini, G. R. Babu, S. M.","doi":"10.52711/2231-5713.2022.00047","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00047","url":null,"abstract":"Currently, this study focuses on developing immediate-release Fexofenadine hydrochloride tablets. The Fexofenadine HCl tablets have super disintegrants that help to accelerate dissolution and bioavailability. Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone, and sodium starch glycolate were used to make the tablets using a direct compression method (2-8 percent). Pre and post compressional parameters were used in the preparation of the tablets. The In-vitro disintegration study shows that as concentration of sodium starch glycolate is increased, there is an increase in the amount of time it takes for the solution to disintegrate, but at the same time, there is a decrease in the amount of time it takes for the solution to disintegrate when the crospovidone level is increased. When combined with the crospovidone tablet formulation, the test found that the resulting tablets broke down in approximately 3 to 6 minutes, with enough force to release the fragments but not to harm the friability of the product. It was found that Fexofenadine hydrochloride tablet, a fast-acting form of treatment for allergic rhinitis, could be formulated in an immediate-release form.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74636747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}