发布求助
文献互助 智能选刊 最新文献

Asian Journal of Pharmacy and Technology最新文献

筛选
英文 中文
Microsphere as Drug Delivery System: An Overview 微球作为药物传递系统:综述
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00020
Nikita D. Gidde, Indrayani D. Raut
{"title":"Microsphere as Drug Delivery System: An Overview","authors":"Nikita D. Gidde, Indrayani D. Raut","doi":"10.52711/2231-5713.2023.00020","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00020","url":null,"abstract":"Microspheres are mainly free flowing powders consisting of proteins or synthetic polymers. Proteins or synthetic polymers are biodegradable in nature. Microspheres having a particle size less than 200 micrometer. Microspheres are novel drug delivery system which has several benefits over conventional multi dose therapy. There are various approaches in delivering a therapeutic agent to the specific targeted site in a sustained controlled release fashion. Microsphere is act as carriers for drugs. Microspheres received much attention for prolonged release as well as for targeting of anticancer drug to the tumour. In this drug delivery, drug dispersed throughout the particle i.e., the internal structure is a drug matrix and polymeric excipients. It is the reliable means delivery of the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. In future microspheres will find an appropriate place in novel delivery by combining various new strategies, particularly in diseased cell sorting, diagnostic, gene and genetic materials, safe, targeted and effective in vivo delivery. The current aim of this review is to study the various aspects of microspheres drug delivery system including advantages, disadvantages, types of microspheres, methods of preparations, Evaluations and Applications of microspheres.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84733239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Potential of Naturally Modified Mucoadhesive Fluconazole Tablets against Vaginal Infection 天然改性黏附氟康唑片治疗阴道感染的潜力
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00019
I. Kumar, Ishwar Singh, Kapil Kumar Verma, Sunny Dhiman, Priyankul Palia
{"title":"Therapeutic Potential of Naturally Modified Mucoadhesive Fluconazole Tablets against Vaginal Infection","authors":"I. Kumar, Ishwar Singh, Kapil Kumar Verma, Sunny Dhiman, Priyankul Palia","doi":"10.52711/2231-5713.2023.00019","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00019","url":null,"abstract":"Vaginitis is a very common gynaecological problem in women of all age groups. Fluconazole chemically known as 2-(2, 4-diflurophenyl)-1, 3-bis (1H-1, 2, 4-triazole-1-yl)-2-propanol. Is a synthetic triazole derivative antifungal agent that is effective against a wide range of systemic and superficial fungal Infections. The mucoadhesive vaginal tablets were prepared by the direct compression method. FTIR had employed to study drug excipient incompatibility. The mucoadhesive vaginal tablet was evaluated for % swelling index, Muco-adhesive strength, drug content, % drug release, and Invitro Dissolution release. It was observed that more than 85% drug was released within 480 min in direct compression method formulations (FLZ1-FLZ9). Formulation FLZ3 that containing 6% of eudragit revealed maximum drug release profile up to 89.20±0.343% within 480 min, whereas formulation FLZ5 showed 87.20±0.765% drug release. The best formulation was compared with the marketed formulations for in-vitro drug release and showed almost similar drug release. Stability study shows no changes. This study may prove potential vaginal formulation of Fluconazole against bacterial vaginosis.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76385197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ipnmicrospheres for Controlled Drug Delivery: An Overeview 纳米微球用于药物控制递送:综述
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00023
Jafar Ikbal Abedin, F. Sheeba
{"title":"Ipnmicrospheres for Controlled Drug Delivery: An Overeview","authors":"Jafar Ikbal Abedin, F. Sheeba","doi":"10.52711/2231-5713.2023.00023","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00023","url":null,"abstract":"Oral modified or controlled dosage forms have always been validated to be a more effective opportunity than conventional or immediate release dosage forms. Controlled or modified drug transport systems provide several benefits of delivering a drug to the body in a specific way to reduce its undesirable side effects and maximize its profit. It also improves the therapeutic efficacy of the drug, decreases toxicity, and with better patient compliance and convenience. In the beyond few decades, microspheres have promised targeted or controlled delivery of drugs in the body which proved to be higher than the conventional drug delivery. It also used to deliver drugs, vaccines, antibiotics, and hormones in a controlled way. Interpenetrating polymer networks have gained a lot of interest in drug delivery systems due to their ease of modification during their synthesis and development state, which evolved novel physicochemical and mechanical properties within the formulation. Interpenetrating polymer network (IPN) systems use novel polymers which are synthesized through the interlacing of two independent polymers in a cross-linked form. The polymers used to formulate an IPN system are independently cross-linked or cross-linked to each other. The present review aims to summarize the IPNmicrospheres systems in terms of their merits, classification, mechanism, method of formulation, evaluation and recent advances in the research field of IPN microspheres.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"32 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82766531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microneedles: A Pharmaceutical Review 微针:药学综述
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00027
Manasi Mehetar, Suvir Darekar
{"title":"Microneedles: A Pharmaceutical Review","authors":"Manasi Mehetar, Suvir Darekar","doi":"10.52711/2231-5713.2023.00027","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00027","url":null,"abstract":"Microneedles (MNs) are one of the efficient and a unique technique of a drug delivery. MNs are a transdermal drug delivery system which is painless, less invasive with a high drug bioavailability. Over the several years, various research around the world have reported superb featuresof MNs in distinct areas of health care. In relation to the wise use of MNs, in this review we deal in depth with the types of MNs, present fabrication methods, and applications of MNs in drug delivery. Recent advancements in 3D printing and digital technology are contributing to the betterment of MNs fabrication technology. Transdermal drug delivery has the advantage of bypassing the first-pass effect as well as allows the sustained release of the drug. MNs are a transdermal drug delivery system that is painless, less invasive, and easy to self-administer, with a high drug bioavailability. The present review coversseveral fabricating materials and fabrication methods which are used for MN preparation. This review also covers the distinctive applications of MNs, which holds great potential in health care industry.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87854311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-vitro Evaluation of Antioxidant and Photoprotective Activity of Sida cardifolia and Abutilon indicum 芦笋和阿布蒂隆抗氧化和光保护活性的体外评价
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00015
Jyotsna Anandrao Saonere, M. Channawar, Nitin I. Kochar, D. Mohale, Anil V Chandewar
{"title":"In-vitro Evaluation of Antioxidant and Photoprotective Activity of Sida cardifolia and Abutilon indicum","authors":"Jyotsna Anandrao Saonere, M. Channawar, Nitin I. Kochar, D. Mohale, Anil V Chandewar","doi":"10.52711/2231-5713.2023.00015","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00015","url":null,"abstract":"Excess of Free radicals leads to accumulation in body which results in oxidative stress. Accumulation of free radicals results in diseases like cancer, arthritis, skin diseases, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases. Antioxidants play crucial role in the management of such diseases. Polyphenolic constituents of plants are the good source of antioxidant, can be use in the treatment and management of many diseases. The aim of present study invitro evaluation of antioxidant and photoprotective activity of the alcoholic, hydroalcoholic and aquous extracts of S. cardifolia and A. indicum. Aquous, hydroalcholic and alcoholic extract of S. cardifolia and A. indicum were prepared and evaluated for total phenolic content by Folin-ciocaltechu method, antioxidant activity by DPPH method and photoprotective effect by UV spectrophotometer method. Results showed that hydroalcoholic extracts of S. cardifolia and A. indicum showed highest phenolic content, while hydroalcoholic extract of S. cardifolia and water extract of A. indicum showed potent antioxidant activity, while hydroalcoholic extract of S. cardifolia and A. indicum showed maximum photoprotective effect as compared to alcoholic and water extract. Hydroalcoholic extracts of S. cardifolia and A. indicum showed highest phenolic content, potent antioxidant activity and maximum photoprotective effect. The result revealed that S. cardifolia and A. indicum possess potent antioxidant and photoprotectve effect, which can be use in the management of various diseases and as a photo protective in skin diseases.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78972796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and Evaluation of Sumatriptan Succinate Microspheres by Using Different Polymers 不同聚合物对琥珀酸舒马曲坦微球的制备及评价
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00017
Y. Sirisha, Dontharaboina Sneha, R. Sri. S
{"title":"Formulation and Evaluation of Sumatriptan Succinate Microspheres by Using Different Polymers","authors":"Y. Sirisha, Dontharaboina Sneha, R. Sri. S","doi":"10.52711/2231-5713.2023.00017","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00017","url":null,"abstract":"In the present work, Microspheres of Sumatriptan Succinate using PLGA, Ethyl cellulose and HPMC K4M as polymers were formulated to deliver Sumatriptan Succinate via oral route. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Sumatriptan Succinate microspheres. In this work an effort was made to formulate microsphere of Sumatriptan Succinate by using different polymers. Prepared formulations are evaluated for bulk density, tapped density, precent mucoadhesion, Percent compressibility, hausners ration, percentage yield, size and interaction study by Differential scanning calorimeter and in vitro drug release. Formulation which passed all the evaluation parameters was considered as best formulation of Sumatriptan Succinate. The present study conclusively that Sumatriptan Succinate microsphere could be prepared successfully and formulation F5 was shows satisfactory result.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85679529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Review on Buccal Drug Delivery System 口腔给药系统研究综述
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00026
Namita S. Bhosale, Aniket S. Gudur, Rishi Ramesan, Dipasha D. Rane, Pranil D. Arolkar, Afrin S. Darwajkar, Pratiksha P. Mestry, Vijay A. Jagtap
{"title":"A Comprehensive Review on Buccal Drug Delivery System","authors":"Namita S. Bhosale, Aniket S. Gudur, Rishi Ramesan, Dipasha D. Rane, Pranil D. Arolkar, Afrin S. Darwajkar, Pratiksha P. Mestry, Vijay A. Jagtap","doi":"10.52711/2231-5713.2023.00026","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00026","url":null,"abstract":"This analysis focuses primarily on the several benefits of the buccal drug delivery system (BDDS) over the traditional and systemic formulation. Bypassing first pass metabolism, it aids in improving bioavailability. The formulation of this medication delivery system maintains contact with the mucosal surface, improving absorption and lengthening the resident time. Although not all medications can be administered with this approach, the majority of medications can. Because the degree of mucoadhesion is a crucial phenomenon for the buccal medication delivery system, bio adhesive polymers play a significant role in this drug delivery method. The paper discusses the advantages and disadvantages of the buccal drug delivery system, the anatomy of the oral mucosa, the mechanism of drug penetration, the use of natural polymers and permeation enhancers in the buccal drug delivery system. This evaluation also addresses currently on the market products used as buccal medication delivery systems and their potential future applications.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"21 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90773763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Potential Flavonoids against the Spleen Tyrosine Kinase to Treat Psoriasis: In Silico approach 抗脾酪氨酸激酶类黄酮治疗银屑病的鉴定:硅片法
Asian Journal of Pharmacy and Technology Pub Date : 2023-05-30 DOI: 10.52711/2231-5713.2023.00016
S. Pol, V. Kadam, S. Jagtap, Sampada Bhosale, Nita Pawar, R. Gaikwad
{"title":"Identification of Potential Flavonoids against the Spleen Tyrosine Kinase to Treat Psoriasis: In Silico approach","authors":"S. Pol, V. Kadam, S. Jagtap, Sampada Bhosale, Nita Pawar, R. Gaikwad","doi":"10.52711/2231-5713.2023.00016","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00016","url":null,"abstract":"Now a day, phytochemicals are widely consideration for structure optimization programs which focuses on making more active and less toxic drug products. Psoriasis is an inflammatory, chronic, remitting and relapsing, genetically influenced skin disease. Variety of flavonoid structureswere used to find the potential molecules against the psoriasis. In this current study molecular docking studies were carried out to identify the flavonoids having good binding ability with the target protein of psoriasis. Docked ligands were subjected to identify the drug like properties using drug-likeness prediction. Findings suggested that 23 flavonoid structures may act against the psoriasis.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79938819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on Colon Targeted Drug Delivery System 结肠靶向给药系统研究进展
Asian Journal of Pharmacy and Technology Pub Date : 2023-03-22 DOI: 10.52711/2231-5713.2023.00012
K. Srujana, B. Hemalatha, K. Padmalatha
{"title":"A Review on Colon Targeted Drug Delivery System","authors":"K. Srujana, B. Hemalatha, K. Padmalatha","doi":"10.52711/2231-5713.2023.00012","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00012","url":null,"abstract":"Colon-specific drug delivery systems (CDDS) are advantageous for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. Colon targeted drug delivery system can be utilized to deliver protein and peptide drugs as they that are known to degrade in the extreme gastric pH. These approaches involve the use of formulation components that interact with one or more aspects of gastrointestinal (GI) physiology, such as the variation in the pH along the GI tract, the occurrence of colonic microflora, and enzymes, to attain colon targeting. This article highlights the advantages, limitations and factors influencing colon-specific drug delivery. Further, the review gives information of various conventional, as well as relatively newer formulation approaches presently being utilized for the improvement of CDDS.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91042755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-Vitro Anti-inflammatory Activity of Traditionally reported Poly Herbal Combination 传统报道的多草药组合体外抗炎活性
Asian Journal of Pharmacy and Technology Pub Date : 2023-03-22 DOI: 10.52711/2231-5713.2023.00001
Mital N. Manvar
{"title":"In-Vitro Anti-inflammatory Activity of Traditionally reported Poly Herbal Combination","authors":"Mital N. Manvar","doi":"10.52711/2231-5713.2023.00001","DOIUrl":"https://doi.org/10.52711/2231-5713.2023.00001","url":null,"abstract":"Inflammatory diseases are still one of the most important heath-problems in the world. Most of anti-inflammatory drugs such as non–steroidal anti-inflammatory drugs (NSAIDS) have number of adverse effects hence there are a need to develop safe and new anti-inflammatory formulation with minimum side effects. Present study focused on investigating and comparing anti-inflammatory potential of hydroalcoholic extracts of Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris and their combinations. Inhibition of heat induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The combination ratio of hydroalcoholic extracts of Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris (2:5:3) showed the most significant membrane stabilizing action on HRBC membrane as compare tohydroalcoholic extracts of individual drugs and theirother combinations. The present study revealed that the proper combination of Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris gives more effective anti-inflammatory activity than any of the individual drug.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87466066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信