Formulation and Evaluation of Sumatriptan Succinate Microspheres by Using Different Polymers

Abstract

In the present work, Microspheres of Sumatriptan Succinate using PLGA, Ethyl cellulose and HPMC K4M as polymers were formulated to deliver Sumatriptan Succinate via oral route. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Sumatriptan Succinate microspheres. In this work an effort was made to formulate microsphere of Sumatriptan Succinate by using different polymers. Prepared formulations are evaluated for bulk density, tapped density, precent mucoadhesion, Percent compressibility, hausners ration, percentage yield, size and interaction study by Differential scanning calorimeter and in vitro drug release. Formulation which passed all the evaluation parameters was considered as best formulation of Sumatriptan Succinate. The present study conclusively that Sumatriptan Succinate microsphere could be prepared successfully and formulation F5 was shows satisfactory result.