Formulation and Evaluation of Sotalol Gastrorententive Tablets

Abstract

The objective of this study was to formulate floating tablets (GRDDS) of Sotalol using direct compression method to increase its bioavailability and the gastric residence time of the dosage form. The Sotalol tablets were prepared by direct compression method. The tablets were prepared by using different types of polymers i.e.; Sodium CMC, Chitosan and Psyllium Husk which act as a release retardant polymer. Sodium bi carbonate (NaHCO3) was used as a gas degenerating agent and MCC (Micro crystalline cellulose) was used as a diluent. The prepared formulation were subjected to some evaluation parameters like hardness, friability, weight variation, drug content, buoyancy property, drug release study etc. In the FT-IR study it was revealed that there is no interaction between the drug and excipients. The formulation which containing Chitosan polymer and Sodium bicarbonate shows good drug release pattern with less floating lag time and good floating duration. The in vitro drug release pattern of Sotalol floating tablets was fitted to different kinetic models which showed the highest regression for Higuchi order kinetics. Thus, it can be concluded that the floating drug delivery system of Sotalol using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time.