Asia Pacific Allergy最新文献

{"title":"Examining the diagnostic validity of the ISAAC asthma questionnaire among participants from Singapore and Malaysia.","authors":"Qi Yi Ambrose Wong, Dingyu Cen, Jun Jie Lim, Jia Yi Karen Wong, Kashaf Nadeem, Zheng Yang Ervin Yap, Jun Yan Ng, Yi Ying Eliza Lim, Yang Yie Sio, Yee How Say, Kavita Reginald, Fook Tim Chew","doi":"10.5415/apallergy.0000000000000234","DOIUrl":"10.5415/apallergy.0000000000000234","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a chronic respiratory condition affecting 3,340 cases per 100,000 individuals globally. The significant global health burden of asthma necessitates the development and use of valid diagnostic tools for epidemiological purposes.</p><p><strong>Objective: </strong>This study evaluated the diagnostic accuracy of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire among participants from the Singapore/Malaysia Cross-sequential Genetic Epidemiology Study (SMCGES).</p><p><strong>Methods: </strong>Investigators administered the ISAAC survey questionnaire to SMCGES participants. Symptoms related to asthma were compared against diagnosed asthma, which was characterized by a questionnaire-reported history of asthma and exhibiting a positive skin prick reaction to allergen extracts from 2 dust mite species. Diagnostic accuracy was assessed via sensitivity (Se), specificity (Sp), positive and negative predictive values, and Youden's Index (<i>J</i>).</p><p><strong>Results: </strong>This study analyzed data from 4,028 participants from Malaysia and 11,473 participants from Singapore. Asthma symptom prevalence differed between Malaysia and Singapore, with ever wheeze being the most prevalent in both populations. Diagnosed asthma was more prevalent in Singapore (17.3%, 95% confidence interval [CI]: 16.6-18.1%) than in Malaysia (9.7%, 95% CI: 8.8-10.7%). Ever wheeze showed the best diagnostic performance for diagnosed asthma in Malaysia (Se = 0.548, Sp = 0.831, <i>J</i> = 0.379) and Singapore (Se = 0.679, Sp = 0.888, <i>J</i> = 0.566). Combining symptoms or asthma medication usage improved accuracy slightly, with the most valid combinations being ever wheeze or exercise-induced wheeze in Malaysia (Se = 0.557, Sp = 0.824, <i>J</i> = 0.381) and usage of bronchodilators, beta-agonists, inhaled steroids, or leukotriene modifiers in Singapore (Se = 0.771, Sp = 0.871, <i>J</i> = 0.642).</p><p><strong>Conclusion: </strong>The modified ISAAC questionnaire used by the SMCGES showed good Se and Sp for diagnosed asthma, especially when combining various symptom indicators or usages of different asthma medications. These findings substantiate the continued use of the ISAAC questionnaire as a valuable survey tool in epidemiological studies across diverse populations.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"294-299"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet survey on EpiPen adrenaline autoinjector usage in Japanese patients with a history of anaphylaxis.","authors":"Yoichi Nakamura, Yoko Hashiba, Masashi Furuie, Kaori Okayasu, Atsushi Isozaki, Yuko Hasebe, Mariko Kaburaki","doi":"10.5415/apallergy.0000000000000209","DOIUrl":"10.5415/apallergy.0000000000000209","url":null,"abstract":"<p><strong>Background: </strong>Little is known in Japan about anaphylaxis management during an episode and after the episode to prevent recurrence.</p><p><strong>Objective: </strong>This study aimed to clarify the reality of anaphylaxis management by surveying individuals who had experienced an anaphylactic episode and attended a medical institution after the episode.</p><p><strong>Methods: </strong>A general consumer panel was used to identify individuals ≥16 years (or child ≤15 years) with a history of anaphylaxis. Data were collected on the use of an adrenaline autoinjector at the time of the episode, attendance at a medical institution during and after the episode, and prescribing patterns for the adrenaline autoinjector.</p><p><strong>Results: </strong>Data were analyzed from 678 individuals (respondent [n = 552]; respondent on behalf of a child ≤15 years [n = 126]). Adrenaline autoinjector use at the time of the most recent anaphylactic episode was reported by approximately 7% of respondents, including by a subgroup with at least 2 previous anaphylactic episodes (n = 211). Only three-quarters of autoinjector users were prescribed another device at the medical institution they visited when anaphylaxis occurred. Among 349 respondents who visited a medical institution to prepare for recurrence, only 70 were prescribed another adrenaline autoinjector. Common reasons for nonprescription of another device were patients' lack of interest or physicians' lack of initiative.</p><p><strong>Conclusions: </strong>There is a clear need to raise awareness and educate patients, parents, caregivers, and healthcare providers about anaphylaxis management.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"268-275"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct regional allergen sensitization patterns in pediatric populations: A comparative latent class analysis of multiple antigen simultaneous test-derived sensitization profiles in Japan and Taiwan.","authors":"Ching-Wei Lin, Su-Boon Yong, Rei Kanai, Lawrence Shih-Hsin Wu, Pei-Chi Chen, Xiao-Ling Liu, Hui-Fang Kao, Mizuho Nagao, Yasunori Sato, Chang-Ching Wei, Jiu-Yao Wang, Takao Fujisawa","doi":"10.5415/apallergy.0000000000000223","DOIUrl":"10.5415/apallergy.0000000000000223","url":null,"abstract":"<p><strong>Background: </strong>Allergen sensitization patterns vary across regions; however, few studies have directly compared pediatric sensitization profiles between Japan and Taiwan.</p><p><strong>Objective: </strong>This study aimed to compare allergen sensitization patterns in children from Japan and Taiwan using the multiple antigen simultaneous test (MAST) and latent class analysis (LCA).</p><p><strong>Methods: </strong>A total of 217 Japanese and 166 Taiwanese children (aged 2-12 years) were enrolled. Based on responses to the International Study on Asthma and Allergy in Childhood questionnaire, participants were classified as either healthy or as having allergic rhinitis (AR), bronchial asthma (BA), or atopic dermatitis. Serum samples were analyzed using a commercial MAST kit available in Japan, and 20 allergens shared with the panel used in Taiwan were selected for analysis. Sensitization was defined as a lumicount value ≥2.78 (equivalent to class 2 or higher). LCA was conducted on the combined dataset, and the optimal number of latent classes was determined using the Akaike Information Criterion.</p><p><strong>Results: </strong>LCA identified 4 latent classes: low-sensitized (LS), house dust mite-dominant (HDM-D), inhalant-sensitized (IH-S), and poly-sensitized (PS). The HDM-D class was more prevalent in Taiwan (50%) than in Japan (6.9%). In contrast, the IH-S and PS classes were more common in Japan (36.4% vs. 3% and 8.8% vs. 2.4%, respectively). AR and BA were primarily associated with HDM-D in Taiwan and with IH-S in Japan, which includes HDM and Japanese cedar pollen. HDM and crab sensitization were strongly correlated in Taiwan.</p><p><strong>Conclusion: </strong>MAST combined with LCA reveals distinct regional sensitization profiles, suggesting divergent pathways in allergic disease development.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"247-254"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145675950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management of allergic rhinitis: An Indian expert consensus by otorhinolaryngologists.","authors":"Mohan Kameswaran, Meenesh Juvekar, Deepak Haldipur, Biplab Nath, A V Ramana Rao, Adip Shetty, Ajitha Kumara, Anil Israni, Anil Jain, Anirudha Mukherjee, Anurag Tandon, Anusha Shashidhara Shetty, Arun Prabhu Ganeshan, Arvind Gupta, Bhanu Pratap Singh, Ch Ramana Chary, Chetan Vijay Ghorpade, D M Narurkar, Debasis Sanyal, Dhiraj Ranjan Sarkar, Dipak Desai, G Gananathan, Jagveer Singh Yadav, K N Mishra, Kabikant Samantray, Khageshwar Rout, Kshitij Bhatnagar, Mainak Moitra, Maneesh Kumar Jain, Mehul S Patel, Milind Nene, Narayan Sahu, G N Narayanamswamy, Neelam Sathe, Neeraj Suri, Nitish Aggarwal, P Venu Gopal Reddy, Prakash V Dhond, Prasanta Gure, Prasheetha Baskar, Praveen Ramchandra Sirdesai, Rajlaxmi Panigrahi, Rakshitha Samanth, Ramakrishnan Vengelote, S G Mahesh, S K E Apparao, S Ramesh Kumar, Sameer Sethi, Sankar Mahadevan, Sarrath Rathnaraajan Subramaniam, Shahid Rasool, Shama Shetty, Smrity Rupa Borah Dutta, Sudhir M Bhalerao, Sulphi Noohu, Sunil Kumar Kp, Swapan Kumar Ghosh, Swapan Kumar Sarkar, V Harishvel, Vikrant Rai, Vishwas K Pai, Ashok Jaiswal, Ravi T Mehta","doi":"10.5415/apallergy.0000000000000237","DOIUrl":"10.5415/apallergy.0000000000000237","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of allergic rhinitis (AR) has increased progressively over the past several years. One of the vital objectives of management of AR is to provide satisfactory symptom control that improves the patient's quality of life. Several classes of drugs, such as antihistamines, intranasal corticosteroids, decongestants, leukotriene receptor antagonists, and immunotherapy, have been developed over the past decades for more effective management of AR. Combinations of pharmacotherapies have also been advocated to treat AR.</p><p><strong>Objective: </strong>To develop clinical practice-relevant consensus statements from experts in the field of otorhinolaryngology after giving due consideration to the real-world clinical dilemmas, current evidence, and preferences of both physicians and patients.</p><p><strong>Methods: </strong>Expert otorhinolaryngologists (n = 61) from India were invited to develop the consensus statements based on the modified Delphi method.</p><p><strong>Results: </strong>Several consensus statements were framed based on evidence from clinical trials and expert insights and experience. One crucial statement was regarding the additional subgrouping of patients with intermittent or persistent AR, or mild, moderate or severe AR into \"sneeze-runners\" (sneezing, anterior rhinorrhea, itchy nose, and itchy eyes; more sensitization to pollens) and \"blockers\" (severe nasal blockage and thick nasal mucus which often leads to postnasal drip and breathlessness; higher sensitization to polyvalent house dust, house dust mites and fungi) since they have distinct clinical profiles and different treatment approach. Another critical consensus was on the use of the fixed-dose combination of fluticasone furoate and oxymetazoline hydrochloride nasal spray for the persistent and moderate-severe blocker phenotype of AR.</p><p><strong>Conclusion: </strong>This expert consensus will help physicians in their clinical practice and complement effective diagnosis and management of AR.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"319-328"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil ETosis in severe non-IgE-mediated gastrointestinal food allergy, a neonatal necrotizing enterocolitis: A case report.","authors":"Aya Imaide, Shoichiro Taniuchi, Shuhei Dohi, Masatoshi Mitomori, Meguru Gouma, Masahiro Enomoto, Masamitsu Nishino, Yoshiyuki Yamada, Yuki Moritoki, Shigeharu Ueki, Yo Okizuka","doi":"10.5415/apallergy.0000000000000213","DOIUrl":"10.5415/apallergy.0000000000000213","url":null,"abstract":"<p><p>Non-IgE-mediated gastrointestinal food allergy is a hypersensitivity disorder that affects the gastrointestinal tract, operating independently of IgE. While eosinophilic inflammation has been implicated in the literature, its precise role in the pathophysiology of non-IgE-mediated gastrointestinal food allergy remains poorly understood. We report the first documented case of severe non-IgE-mediated gastrointestinal food allergy in which eosinophil infiltration, eosinophil extracellular traps, and Charcot-Lyden crystals were observed in the tissue. A 1-month-old female infant presented with fever, watery diarrhea, and poor weight gain associated with the ingestion of cow's milk-based formula. Despite transitioning to an extensively hydrolyzed formula, she developed necrotizing enterocolitis. Following a switch to an amino-acid-based infant formula, her abdominal symptoms resolved, and her weight gain normalized. However, 1 month later, bile-like vomiting led to the diagnosis of jejunal atresia, which was attributed to scarring from necrotizing enterocolitis. Surgical resection revealed histopathological findings of eosinophil infiltration, cytolytic eosinophil cell death (ETosis), extracellular traps, and Charcot-Lyden crystals. The necrotizing enterocolitis was ultimately diagnosed as a severe manifestation of non-IgE-mediated gastrointestinal food allergy triggered by cow's milk protein. After surgery, the patient resumed feeding with an amino-acid-based infant formula. During regular follow-up, she continued to gain weight well without any clinical symptoms while being fed an amino-acid-based infant formula. To our knowledge, this is the first report to identify a histopathological link between severe non-IgE-mediated gastrointestinal food allergy-related inflammation and eosinophil ETosis. This suggests a potential role of ETosis in the pathogenesis and its complications.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"346-349"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of emulsion bathing in adult patients with atopic dermatitis.","authors":"Duy Le Pham, Nguyet Doan Lam Nguyen, Quoc Quang Luu","doi":"10.5415/apallergy.0000000000000186","DOIUrl":"10.5415/apallergy.0000000000000186","url":null,"abstract":"<p><strong>Background: </strong>Emulsion bathing has been commonly advised in the management of atopic dermatitis (AD) to maintain skin hydration and reduce the negative effects of soaps on the skin barrier. However, there is limited scientific evidence from randomized controlled trials to support their effectiveness.</p><p><strong>Objectives: </strong>We aimed to compare the moisturizing effectiveness of 2 regimens: emulsion bathing combined with moisturization and moisturization after bathing with tap water only, in adults with AD.</p><p><strong>Method: </strong>Thirty-nine adult patients with AD (aged 20-63 years) were recruited. The right and left forearms of each subject were randomly assigned to be immersed and washed for 3 minutes with either moisturizing bath oil (dual-therapy group) or tap water alone (monotherapy group), followed by air drying for 30 minutes. Subsequently, a moisturizer was applied to the tested skin areas. Stratum corneum hydration (SCH) and transepidermal water loss (TEWL) were measured using a GP Skin Pro device (Gpower, South Korea) at five time points: before washing (baseline), after washing and air drying for 30 min (postwash), and after moisturization at 0, 30 and 60 minutes.</p><p><strong>Results: </strong>At the postwash time point, mean SCH levels in both groups decreased significantly; however, the mean SCH level of the dual-therapy group was significantly higher than that of the monotherapy group (20.9 ± 8.4 a.u. vs 14.4 ± 9.96 a.u., <i>P =</i> 0.006). Additionally, the mean TEWL level of the dual-therapy group was significantly lower than that of the monotherapy group (6.73 ± 2.7 g/m²/h vs 8.53 ± 3.1 g/m²/h, <i>P =</i> 0.009). After moisturizer application, both study groups demonstrated significant increases in SCH and decreases in TEWL levels. However, no significant differences in SCH and TEWL levels were observed between the 2 groups after moisturization at 0, 30, and 60 minutes.</p><p><strong>Conclusion: </strong>Emulsion bathing helped prevent epidermal damage induced by bathing. However, the combination of emulsion bathing and moisturization did not show superiority over moisturization alone in improving skin hydration after bathing.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"263-267"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145675900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency and predictability of switching biologic agents in severe asthma: A real-world perspective.","authors":"Ali Can, Özge Atik","doi":"10.5415/apallergy.0000000000000244","DOIUrl":"10.5415/apallergy.0000000000000244","url":null,"abstract":"<p><strong>Background: </strong>While phenotyping assists in selecting the right biologic agent for severe asthma, the frequency of patients transitioning to a different biologic is also significant.</p><p><strong>Objective: </strong>We sought to identify the factors that predict switching between biological agents.</p><p><strong>Methods: </strong>The study involved 165 adults with severe asthma and included a 3-year follow-up period. Clinical and spirometric data were evaluated alongside the demographic characteristics of the patients. In addition to skin prick tests and specific immunoglobulin E (IgE) tests, eosinophil counts and total IgE measurements were assessed.</p><p><strong>Results: </strong>The patient group comprised 124 female participants (75%); the average age was 48 ± 13 years. Over half of the patients had eosinophilic asthma (56%) and allergic asthma (52%). In the first-line treatment, 111 patients (68%) were started on omalizumab, 43 patients (26%) on mepolizumab, and 11 patients (6%) on benralizumab. A total of 37 patients required a change in their biologic treatment. The 2 key factors influencing this switch were the initial annual number of asthma attacks and the level of improvement in the asthma control test score assessed during the first evaluation after starting the biologic (odds ratio 2.23 [95% confidence interval: 1.49-3.33]; <i>P</i> < 0.001 and 0.42 [0.30-0.58]; <i>P</i> < 0.001, respectively).</p><p><strong>Conclusion: </strong>Patients with higher annual attacks at baseline and lower responsiveness at the first postbiologic efficacy assessment can be useful in predicting switching status. However, further well-designed studies involving a larger number of patients and conducted over a longer term are needed to identify additional factors that could assist in selecting the most appropriate biologic.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"281-285"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145675919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Milk oral immunotherapy for adult-onset cow's milk-induced anaphylaxis.","authors":"Jae-Hyuk Jang, Sooyoung Lee, Young-Min Ye","doi":"10.5415/apallergy.0000000000000218","DOIUrl":"10.5415/apallergy.0000000000000218","url":null,"abstract":"<p><p>While food allergies affect individuals across all age groups, oral immunotherapy (OIT) has been widely studied and implemented in pediatric populations. Here, we report a successful case of cow's milk (CM) OIT in a 60-year-old male with adult-onset cow milk allergy. The patient who was previously tolerated with CM initially presented with generalized pruritus, rash, dyspnea, urticaria, and dizziness occurring 4 hours after consuming milk-containing foods. The patient was positive on the skin prick test and for specific IgEs to milk (24.4 kU/L) and casein (31.2 kU/L). After diagnosis, CM OIT was initiated using bread containing milk protein. The protocol began with a 1/4 slice of milk bread (1.55 g of milk protein) and gradually increased to 1 full slice (6.2 g of milk protein) over the course of 4 years. Throughout the period, the patient's immunological markers consistently improved, with his CM-specific IgE level decreasing from 24.40 to 1.50 kU/L and his casein-specific IgE level decreasing from 31.20 to 2.24 kU/L. The patient successfully completed an oral food challenge with 190 mL of cow milk and currently maintains a daily consumption of 200 mL of CM without adverse reactions. This case demonstrates that CM OIT can be successfully implemented in elderly patients with adult-onset CM allergy. The clinical and immunological responses suggest that immune modulation remains possible even in older adults, suggesting potential therapeutic options for adult-onset food allergies.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"343-345"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal cytology: Cornerstone and future directions in precision nasal disease management.","authors":"Yuan Zhang, Luo Zhang","doi":"10.5415/apallergy.0000000000000239","DOIUrl":"10.5415/apallergy.0000000000000239","url":null,"abstract":"","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 4","pages":"245-246"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of treatment control in severe chronic urticaria treated with omalizumab.","authors":"Miguel Proença, João Marcelino, João Vieira, Joana Guimarães, Carlota Dias, Elza Tomaz","doi":"10.5415/apallergy.0000000000000162","DOIUrl":"10.5415/apallergy.0000000000000162","url":null,"abstract":"<p><strong>Background: </strong>Real-life clinical research on biomarkers that predict therapy outcomes of severe chronic spontaneous urticaria patients receiving omalizumab (OMA) therapy is still limited. For this reason, we aimed to identify biomarkers that predict the response to OMA treatment.</p><p><strong>Methods: </strong>A single-center, observational, retrospective review of patients with severe chronic urticaria treated with OMA from January 2015 to January 2023 in a Portuguese Immunology and Allergy Department. One-way ANOVA and linear regression were used.</p><p><strong>Results: </strong>Data on 56 OMA-treated chronic spontaneous urticaria patients shows patients can be divided into 3 groups according to their response to OMA. The first group of 26 patients (46.4%) successfully reduced their IMA dose without experiencing any rebound effects. The second group of 19 (33.9%) patients achieved disease control but could not tolerate a progressive dose reduction, and the third group of 11 (19.6%) patients, required a higher dose to achieve disease control. In group 1, patient age and a favorable clinical response had a positive correlation (<i>P</i> = 0.008). The patient's age was also correlated to the time interval until a dose reduction was tolerated (<i>r</i> = 0.69; <i>P</i> = 0.005). There was also a negative correlation between the ratio: thyroid peroxidase antibodies/total-IgE and a favorable clinical response (<i>r</i> = -0.74; <i>P</i> = 0.021). In group 2, thyroid peroxidase antibodies were negatively correlated with a favorable clinical response (<i>r</i> = -0.55; <i>P</i> = 0.027). In group 3, anti-double-stranded DNA was negatively correlated with a favorable clinical response (<i>r</i> = -0,97; <i>P</i> = 0,007).</p><p><strong>Conclusion: </strong>Our study suggests that older patients experience higher success rates with OMA compared to younger individuals, but increasing age is also associated with a longer interval before achieving successful dose reduction. Potential markers of resistance to OMA identified in our cohort included elevated levels of IgG-antithyroid peroxidase antibodies, positive anti-dsDNA antibodies, and a higher IgG-antithyroid peroxidase/total-IgE ratio.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 3","pages":"159-165"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}