Asia Pacific Allergy最新文献

{"title":"The clinical course of nasal polyps in relation with histological and radiological findings.","authors":"Suh-Young Lee, Hee Young Na, Margaret Mbabazi Sebbale, Kyoung-Hee Sohn, Hye Sook Min, Chang Hyun Lee, Doo Hee Han, Hye-Ryun Kang","doi":"10.5415/apallergy.0000000000000285","DOIUrl":"https://doi.org/10.5415/apallergy.0000000000000285","url":null,"abstract":"<p><strong>Background: </strong>Nasal polyps (NPs) show distinct characteristics in histologic features with different inflammatory cells and stromal changes, but their clinical implications remain poorly understood.</p><p><strong>Objective: </strong>To determine the associations between NP histology, clinical characteristics, radiologic disease burden on osteomeatal unit computed tomography (OMU-CT) findings, and postoperative recurrence.</p><p><strong>Methods: </strong>We retrospectively reviewed 219 patients who underwent nasal polypectomy. NPs were histologically classified by predominant inflammatory cells (eosinophilic vs. lymphoplasmacytic) and stromal features (edematous, glandular, or dense). Clinical variables, preoperative OMU-CT scores, and recurrence rates were analyzed.</p><p><strong>Results: </strong>Overall, 62.6% (137/219) of NPs were eosinophilic. Edematous stroma was the most common stromal subtype (72.6%, 159/219), predominating in eosinophilic NPs (96.3%, 132/137). Patients with eosinophilic NPs showed higher CT severity scores (18.4 ± 0.7 vs. 15.5 ± 1.1; <i>P</i> = 0.021) and a higher prevalence of extended disease (78.3% vs. 60.0%; <i>P</i> = 0.010) than those with lymphoplasmacytic NPs. CT severity score correlated with blood eosinophil counts (<i>r</i> = 0.17, <i>P</i> = 0.018). Patients with asthma (11.9%) showed higher CT severity scores (22.4 ± 1.4 vs. 16.9 ± 0.6; <i>P</i> = 0.002) and a tendency toward extended disease (92.0% vs. 70.3%; <i>P</i> = 0.052) compared to those without asthma. Among 99 patients with follow-up, recurrence occurred in 16.2%. While recurrence rates did not differ by histologic type, recurrent cases had significantly higher preoperative CT scores than nonrecurrent cases (21.9 vs. 16.9; <i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Eosinophilic NPs are associated with greater CT disease burden and extent. Peripheral eosinophil counts reflect tissue eosinophilia and correlate with radiologic severity.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 5","pages":"253-259"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon yet critical: Immediate hypersensitivity reactions to Gadobutrol in magnetic resonance imaging procedures.","authors":"Cristina Coelho, José Ferreira, Daniela Malheiro","doi":"10.5415/apallergy.0000000000000240","DOIUrl":"10.5415/apallergy.0000000000000240","url":null,"abstract":"<p><p>Gadolinium-based contrast agents are widely used in magnetic resonance imaging due to their excellent safety profile and tolerability. Hypersensitivity reactions to gadolinium-based contrast agents are uncommon, but they may occur with varying severity. The authors present 2 confirmed cases of immediate hypersensitivity reactions to Gadobutrol, a macrocyclic nonionic gadolinium-based contrast agent. The first case involved a female patient with generalized pruritus, tachycardia, and nasal congestion following a magnetic resonance imaging scan, which resolved spontaneously. The second case involved a male patient with multiple comorbidities who experienced anaphylactic shock during a cardiac magnetic resonance imaging. In both cases, the diagnosis of hypersensitivity reaction was supported by the results of skin tests and basophil activation tests. The article discusses the importance of understanding the mechanisms of hypersensitivity reactions and the role of allergy work-up. It highlights the importance of thorough patient evaluation, considering the impact of comorbidities and medications on hypersensitivity reactions and treatment. Further research is needed to improve diagnostic approaches and understand the immunological mechanisms involved in gadolinium-based contrast agent-induced hypersensitivity reactions.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 4","pages":"244-247"},"PeriodicalIF":2.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13440942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mast cells: The forgotten players in type 2 inflammation - From nasal cytology to chronic rhinosinusitis with nasal polyps and beyond.","authors":"Matteo Gelardi, Rossana Giancaspro, Andrea Marzullo, Michele Cassano","doi":"10.5415/apallergy.0000000000000284","DOIUrl":"10.5415/apallergy.0000000000000284","url":null,"abstract":"<p><p>Mast cells represent key regulators within type 2 inflammation and contribute significantly to the pathophysiology of chronic inflammatory airway diseases. Nasal cytology has enabled their consistent identification, highlighting how their interaction with eosinophils influences inflammatory persistence, tissue remodeling, and disease severity in chronic rhinosinusitis with nasal polyps (CRSwNP). In contrast, conventional hematoxylin-eosin histopathology does not reliably visualize mast cells, potentially limiting comprehensive cellular characterization. Through cytological assessment, distinct inflammatory endotypes have been defined, including nonallergic rhinitis with mast cells and nonallergic rhinitis with eosinophils and mast cells, which may represent stages along a continuum progressing toward CRSwNP. The Clinical-Cytological Grading integrates cellular patterns with clinical parameters, identifying eosinophil-mast cell coinfiltration as a marker associated with increased disease severity and recurrence risk. Evidence from both sinonasal and extra-nasal mucosae, including eosinophilic esophagitis, further supports the relevance of mast cells within the broader network of type 2 inflammation. As therapeutic strategies increasingly target specific inflammatory pathways, accurate cellular endotyping becomes essential for refining risk stratification and optimizing biologic therapy selection. Integrating nasal cytology with histological and molecular approaches offers a pragmatic framework for advancing precision medicine in type 2 inflammatory diseases.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 4","pages":"232-239"},"PeriodicalIF":2.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13440944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, associated factors, and temporal variation of allergic rhinitis among 13 to 14-year-old adolescents from rural Sri Lanka: An analytical cross-sectional study.","authors":"Thiweda Subhanee, Sajeewa Thennakoon, Periyasami Sivabalan Sridharan, Tharusha Chamanthi Siriwardhana, Savithri Sulakkhana, Vimansha Sumanapala, Lahiru Wijayarathna, Janith Warnasekara, Shashanka Rajapakse","doi":"10.5415/apallergy.0000000000000252","DOIUrl":"10.5415/apallergy.0000000000000252","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis is often underdiagnosed despite its high prevalence and considerable impact on academic achievement and quality of daily living. The study aims to describe the epidemiological patterns of allergic rhinitis among adolescents aged 13-14 years in Anuradhapura, Sri Lanka.</p><p><strong>Methods: </strong>An analytical cross-sectional study was conducted in 2023 among adolescents from 32 grade 8 classes in 6 government secondary schools located in the Anuradhapura municipal council area and randomly selected via multistage sampling. The prevalence and associated factors were assessed using the validated and translated International Study of Asthma and Allergy in Childhood questionnaire.</p><p><strong>Results: </strong>The study sample included 1,029 participants, of whom 528 (51.3%) were males. The prevalence of lifetime and current allergic rhinitis and eye symptoms was 37.6% (n = 387; 95% confidence interval [CI], 34.6-40.6), 25.9% (n = 266; 95% CI, 23.2-28.6), and 13.8% (n = 142; 95% CI, 11.8-16.0), respectively. Nasal symptoms negatively affected the activities of daily living in 195(18.9%; 95% CI, 16.6-21.5) adolescents, with moderate-to-severe disruption reported by 54 of them (20.3%; 95% CI, 15.6-25.6). Nasal symptoms were more common from October to February, with monthly precipitation significantly affecting the temporal variation (<i>P</i> = 0.003). Severe asthma (<i>P</i> < 0.01, adjusted odds ration [OR] 5.75; 95% CI, 3.79-8.72) was independently associated with allergic rhinitis, while sleeping on a rubber-mixed-coir mattress (adjusted OR 1.61; 95% CI, 0.95-2.74), and playing 4-6 times per week (adjusted OR 1.50; 95% CI 0.98-2.29) had higher odds for allergic rhinitis.</p><p><strong>Conclusions: </strong>Over a quarter of adolescents had current allergic rhinitis, and their symptom exacerbation followed a temporal pattern predicted by monthly precipitation. Severe asthma was an independent determinant of allergic rhinitis.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 3","pages":"145-151"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate allergy against glucagon-like peptide-1 receptor agonist liraglutide.","authors":"Öner Özdemir","doi":"10.5415/apallergy.0000000000000196","DOIUrl":"10.5415/apallergy.0000000000000196","url":null,"abstract":"","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 3","pages":"198"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tick bite prevention and management: integrating patient perspectives to shape patient education.","authors":"Katherine Duong, Melanie Burk, David Boettiger, Bronte Cross, Ayesha Owen, Jordan Symons, Andrew Ratchford, Sheryl van Nunen","doi":"10.5415/apallergy.0000000000000267","DOIUrl":"10.5415/apallergy.0000000000000267","url":null,"abstract":"<p><strong>Background: </strong>The rise in tick anaphylaxis (TA) in Australia and worldwide underscores the need for effective tick bite prevention and management strategies.</p><p><strong>Objectives: </strong>This retrospective survey of a clinical TA cohort aimed to determine prevention and management strategies employed by patients who had received education following diagnosis of TA and identify areas for improvement in patient education.</p><p><strong>Methods: </strong>Patients diagnosed with TA by a consultant immunologist between 2005 and 2021 in NSW, Australia, completed a survey in 2021 assessing tick bite recurrence, life stage identification, removal methods, need for medical assistance, prevention strategies, and geographic tick bite locations. Relationships between tick bite occurrence and prevention methods, such as the use of permethrin-treated clothing and backyard pest control, were analyzed with Kaplan-Meier curves and log-rank tests.</p><p><strong>Results: </strong>Despite receiving education at the time of their previous TA, 59% of patients experienced further tick bites, and 50% struggled to identify the tick life stage. Preferred prevention methods included avoidance, untreated clothing, and repellents, with some using backyard insecticides. We observed a trend towards reduced tick bite recurrence among patients who treated their backyards and wore permethrin-treated clothing. Almost 46% of bites occurred in patients' backyards. Adherence to tick removal advice was highly variable. Only 30% of patients sought medical help when bitten again.</p><p><strong>Conclusion: </strong>The recurrence of tick bite in TA patients despite education at first diagnosis indicates a need for clearer and more frequent education to encourage adherence to prevention strategies, targeting high-risk groups, to prevent further fatalities.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 3","pages":"174-180"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and influencing factors of allergic rhinitis in Xi'an: A 2022 survey.","authors":"Xu Zhang, YunBo Gao, Jingyun Li, Lin Xi, Luo Zhang, Yuan Zhang","doi":"10.5415/apallergy.0000000000000246","DOIUrl":"10.5415/apallergy.0000000000000246","url":null,"abstract":"<p><strong>Background: </strong>The incidence of allergic rhinitis (AR) has been rising annually in China, correlating with the ongoing intensification of global climate change and industrialization.</p><p><strong>Objectives: </strong>This study aimed to investigate the self-reported prevalence of AR among adults in Xi'an, as well as the relevant influencing factors.</p><p><strong>Methods: </strong>The prevalence of AR was assessed among adult residents across 11 districts of Xi'an from June to October 2022. Additionally, an analysis was conducted to determine the relevant influencing factors associated with AR in these patients.</p><p><strong>Results: </strong>In total, 3,350 individuals from 11 districts in Xi'an participated in this survey, with a self-reported prevalence of 10.0%. Among AR patients, 20.1% had a family history of allergies, compared with 5.1% in those without AR. The prevalence of AR was 30.3% in patients with a family history of allergies and 8.5% in those without. Urban residents had a higher prevalence of AR (11.0%) than suburban residents (8.3%) (<i>P</i> = 0.002). Among the patients, 22.8% had perennial AR and 77.2% had seasonal AR, mainly due to pollen. In terms of diagnosis and treatment, 38.0% of the patients underwent allergen testing, 55.4% received medication, and 66.4% achieved symptom control.</p><p><strong>Conclusion: </strong>The incidence of AR in Xi'an remained high. This study will enhance the understanding of AR patterns in Xi'an and inform public health policies, prevention strategies, and AR control systems.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 3","pages":"167-173"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced anaphylaxis: Molecular pathophysiology, diagnosis, and management.","authors":"Deasy Fetarayani, Mega Kahdina, Debi Yulia Sandra, Henry Sutanto","doi":"10.5415/apallergy.0000000000000233","DOIUrl":"10.5415/apallergy.0000000000000233","url":null,"abstract":"<p><p>Drug-induced anaphylaxis is a severe, potentially fatal hypersensitivity reaction triggered by various pharmacologic agents, including antibiotics, nonsteroidal anti-inflammatory drugs, and biologics. It involves a spectrum of immunologic and nonimmunologic mechanisms, ranging from classical IgE-mediated pathways to complement activation and direct mast cell stimulation via receptors such as Mas-related G-protein-coupled receptor member X2 (MRGPRX2). The clinical heterogeneity of anaphylaxis presents significant diagnostic challenges, often requiring a combination of clinical evaluation, laboratory biomarkers (eg, serum tryptase and histamine), in vitro tests (eg, basophil activation test and specific IgE test), skin testing, and in some cases, a gold-standard drug provocation test, to establish a definitive diagnosis. Emerging insights into phenotypes and endotypes-such as cytokine-release reactions and bradykinin-mediated responses-enable a more complex understanding of pathophysiological mechanisms, facilitating precision diagnostics and targeted interventions. Accurate risk stratification considers both drug-related and patient-related factors, including genetic polymorphisms and comorbidities. Management hinges on the prompt administration of intramuscular epinephrine, with supportive therapies tailored to the underlying mechanism. In select patients, desensitization and delabeling strategies may allow continued treatment with essential medications. This review provides a comprehensive synthesis of the current knowledge on the pathogenesis, clinical features, diagnostic approaches, and management strategies for drug-induced anaphylaxis and highlights areas for future research aimed at improving patient safety and therapeutic outcomes.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 3","pages":"181-197"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating montelukast-second-generation antihistamine combinations versus monotherapy in allergic rhinitis: A network meta-analysis.","authors":"Angelina Wandana, Joyceline Chika Tanely, Robby Malik Chandra Sudrajat, Jeanne Alexandra, Naja Nurilhaqqi Araz Albani, Euphemia Seto Anggraini Widyastuti, Stevent Sumantri","doi":"10.5415/apallergy.0000000000000236","DOIUrl":"10.5415/apallergy.0000000000000236","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is an atopic condition affecting over 400 million people worldwide, impairing quality of life and often leading to complications such as asthma and sinusitis. Montelukast, a leukotriene receptor antagonist, is often used in combination with second-generation antihistamines (sgAHs) to enhance symptom control. However, the relative efficacy of different montelukast-sgAH combinations remains unclear.</p><p><strong>Objective: </strong>To evaluate and compare the efficacy of montelukast combined with various sgAHs versus montelukast monotherapy in patients with AR.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) comparing montelukast-sgAH combinations to montelukast alone were identified from 5 electronic databases up to 2025. Outcomes included Total Nasal Symptom Score (TNSS; 0-12), Daytime and Nighttime Nasal Symptom Scores (DNSS, NNSS; 0-3), and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ; 0-6). Risk of bias (RoB) was assessed using Cochrane RoB 2.0. A frequentist network meta-analysis with subgroup analysis and meta-regression was performed using RStudio and Jeffreys's Amazing Statistics Program.</p><p><strong>Results: </strong>Seventeen RCTs involving 2,655 participants were included. For TNSS improvement, montelukast + desloratadine combination is significantly better than monotherapy in adults (mean difference [MD] = -0.92 [-1.15 to -0.69]) and children (MD = -1.95 [-3.46 to -0.44]). Effects on RQLQ and DNSS were inconsistent, while NNSS improved with montelukast-levocetirizine (<i>P</i> = 0.0384). Heterogeneity was high, but most studies showed low risk of bias. No serious adverse events were reported.</p><p><strong>Conclusion: </strong>Montelukast-sgAH combinations may improve symptoms over monotherapy, especially with desloratadine in both adults and children. However, variability across outcomes and high heterogeneity warrant cautious interpretation and further research.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 3","pages":"152-166"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of bronchial asthma and results of asthma control in patients after 3 months of treatment: A longitudinal follow-up study.","authors":"Dan Bui Van, Oanh Nguyen Thi, Ha Nguyen Le, Lan Nguyen Thi Thu, Huong Nguyen Thi Mai, Mui Tran Thi, Quan Nguyen Van Hong, Trinh Cao Thi, Hanh Hong Chu, Phuong Nguyen Hoang, Tung Le Dinh","doi":"10.5415/apallergy.0000000000000238","DOIUrl":"10.5415/apallergy.0000000000000238","url":null,"abstract":"<p><strong>Background: </strong>Bronchial asthma (BA) is a chronic respiratory disease that significantly affects patients' quality of life if not well managed. The Global Initiative for Asthma (GINA) 2022 guidelines open a new, more effective direction in controlling asthma attacks for patients.</p><p><strong>Objective: </strong>The study was conducted to describe the current status of BA and the results of asthma control in patients after 3 months of treatment.</p><p><strong>Methods: </strong>A prospective longitudinal study was conducted on 47 patients over 12 years old with BA treated at the Department of Allergy, Immunology and Dermatology, Hospital E, from July 2023 to September 2024. The current study assessed BA control after treatment for patients according to GINA 2022 guidelines and the Asthma Control Test (ACT) score.</p><p><strong>Results: </strong>Before treatment, the majority of patients' BA attacks were severe (55.3%) with moderate obstructive ventilatory disorder (42.6%). After treatment, patients' asthma was completely controlled at 93.6%, while respiratory function was significantly improved.</p><p><strong>Conclusion: </strong>After treatment, patients' asthma was well controlled on all 3 assessment scales: GINA 2022 symptom control, ACT score, and respiratory function. Widespread application of GINA 2022 guidelines in BA control in Vietnam is recommended.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"16 2","pages":"100-106"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}