Association of Dermatophagoides pteronyssinus-specific immunoglobulin epsilon with atopy, age, and gender in a Filipino population.

IF 2.1 Q3 ALLERGY
Asia Pacific Allergy Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI:10.5415/apallergy.0000000000000212
Ian John P Alberba, Sean Maynard M Solis, Jill Mae Marie R Base, Nicole O Julia, Janelle Ranee F Villanueva, Chanie Y Patanindagat, Maureen B Sabit, John Donnie A Ramos
{"title":"<i>Association of Dermatophagoides pteronyssinus</i>-specific immunoglobulin epsilon with atopy, age, and gender in a Filipino population.","authors":"Ian John P Alberba, Sean Maynard M Solis, Jill Mae Marie R Base, Nicole O Julia, Janelle Ranee F Villanueva, Chanie Y Patanindagat, Maureen B Sabit, John Donnie A Ramos","doi":"10.5415/apallergy.0000000000000212","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>Dermatophagoides pteronyssinus</i> (Dp), with its major allergen Der p 2, triggers allergy symptoms in various populations worldwide, but their IgE-binding properties among Filipinos remain limited.</p><p><strong>Objectives: </strong>This study investigated the IgE reactivity of Dp and its major allergen rDer p 2 in a cohort of allergic and nonallergic Filipinos from Ilocos Norte, Philippines.</p><p><strong>Methods: </strong>Using enzyme-linked immunosorbent assay, total IgE (n = 960), Dp-specific IgE (n = 247), and rDer p 2-specific IgE (n = 90) levels were determined. The odds ratio was used to determine the association between Dp and rDer p 2 specific IgE among selected demographic variables. An inhibition enzyme-linked immunosorbent assay was used to measure the inhibition of rDer p 2 against Dp allergen extract.</p><p><strong>Results: </strong>Among 171 allergic cases, mean IgE levels were significantly higher (<i>P</i> < 0.01) than in 76 nonallergic controls. Of the allergic cases, 85 individuals (49.71%) were sensitized to Dp allergens, with 68.89% of these also displaying sensitization to rDer p 2. On average, rDer p 2 inhibited IgE binding to Dp allergens by approximately 36%. Significant associations were found between Dp sensitization and age (<i>P</i> < 0.01), male gender (<i>P</i> = 0.01), and between rDer p 2-sensitization and atopy (<i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>This study has shown the importance of Dp extract and its major allergen rDer p 2 as a source of allergen that sensitizes atopic Filipino individuals. Consequently, the inclusion of Dp and rDer p 2 in the panel of reagents utilized in immunodiagnostic and immunotherapeutic strategies and interventions for the local Filipino population sensitized to house dust mites is highly recommended.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 3","pages":"124-131"},"PeriodicalIF":2.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419349/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia Pacific Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5415/apallergy.0000000000000212","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Dermatophagoides pteronyssinus (Dp), with its major allergen Der p 2, triggers allergy symptoms in various populations worldwide, but their IgE-binding properties among Filipinos remain limited.

Objectives: This study investigated the IgE reactivity of Dp and its major allergen rDer p 2 in a cohort of allergic and nonallergic Filipinos from Ilocos Norte, Philippines.

Methods: Using enzyme-linked immunosorbent assay, total IgE (n = 960), Dp-specific IgE (n = 247), and rDer p 2-specific IgE (n = 90) levels were determined. The odds ratio was used to determine the association between Dp and rDer p 2 specific IgE among selected demographic variables. An inhibition enzyme-linked immunosorbent assay was used to measure the inhibition of rDer p 2 against Dp allergen extract.

Results: Among 171 allergic cases, mean IgE levels were significantly higher (P < 0.01) than in 76 nonallergic controls. Of the allergic cases, 85 individuals (49.71%) were sensitized to Dp allergens, with 68.89% of these also displaying sensitization to rDer p 2. On average, rDer p 2 inhibited IgE binding to Dp allergens by approximately 36%. Significant associations were found between Dp sensitization and age (P < 0.01), male gender (P = 0.01), and between rDer p 2-sensitization and atopy (P = 0.01).

Conclusion: This study has shown the importance of Dp extract and its major allergen rDer p 2 as a source of allergen that sensitizes atopic Filipino individuals. Consequently, the inclusion of Dp and rDer p 2 in the panel of reagents utilized in immunodiagnostic and immunotherapeutic strategies and interventions for the local Filipino population sensitized to house dust mites is highly recommended.

Abstract Image

Abstract Image

Abstract Image

在菲律宾人群中,蝶翼棘球绦虫特异性免疫球蛋白ε与特应性、年龄和性别的关系。
背景:翼状蝶食螨(Dp)以其主要过敏原Der p2在世界各地的不同人群中引发过敏症状,但其在菲律宾的ige结合特性仍然有限。目的:本研究调查了菲律宾北伊洛科斯岛一组过敏和非过敏菲律宾人Dp及其主要过敏原rderp2的IgE反应性。方法:采用酶联免疫吸附法测定总IgE (n = 960)、dp特异性IgE (n = 247)和rDer p2特异性IgE (n = 90)水平。比值比用于确定在选定的人口统计学变量中,Dp和rDer p2特异性IgE之间的关系。采用抑制酶联免疫吸附法测定rderp2对Dp变应原提取物的抑制作用。结果:171例过敏患者的平均IgE水平显著高于76例非过敏对照组(P < 0.01)。在过敏病例中,85例(49.71%)对Dp过敏原敏感,其中68.89%对rderp2也敏感。平均而言,orderp2抑制IgE与Dp过敏原的结合约36%。Dp致敏与年龄(P < 0.01)、男性(P = 0.01)、rDer 2致敏与特应性(P = 0.01)有显著相关性。结论:本研究表明,Dp提取物及其主要过敏原rderp2是菲律宾特应性个体致敏的过敏原来源。因此,强烈建议将Dp和rderp2纳入菲律宾当地尘螨敏感人群的免疫诊断和免疫治疗策略和干预措施中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.50
自引率
5.90%
发文量
33
期刊介绍: Asia Pacific Allergy (AP Allergy) is the official journal of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI). Although the primary aim of the journal is to promote communication between Asia Pacific scientists who are interested in allergy, asthma, and clinical immunology including immunodeficiency, the journal is intended to be available worldwide. To enable scientists and clinicians from emerging societies appreciate the scope and intent of the journal, early issues will contain more educational review material. For better communication and understanding, it will include rational concepts related to the diagnosis and management of asthma and other immunological conditions. Over time, the journal will increase the number of original research papers to become the foremost citation journal for allergy and clinical immunology information of the Asia Pacific in the future.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信