Identifying key risk factors for severe pediatric anaphylaxis in children aged 0 to 15: Evidence from a Thai study.

IF 2.1 Q3 ALLERGY

Asia Pacific Allergy Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI:10.5415/apallergy.0000000000000210

Treesupak Kawsomboon, Pasuree Sangsupawanich, Vanlaya Koosakulchai, Pornruedee Ratchatawiriyakul, Bunrat Srisuk, Araya Yuenyongviwat

{"title":"Identifying key risk factors for severe pediatric anaphylaxis in children aged 0 to 15: Evidence from a Thai study.","authors":"Treesupak Kawsomboon, Pasuree Sangsupawanich, Vanlaya Koosakulchai, Pornruedee Ratchatawiriyakul, Bunrat Srisuk, Araya Yuenyongviwat","doi":"10.5415/apallergy.0000000000000210","DOIUrl":null,"url":null,"abstract":"Background: Anaphylaxis is a life-threatening condition with significant global health implications. Understanding its risk factors in children across diverse populations is crucial for effective prevention and management strategies.Objective: The aim is to identify risk factors for severe anaphylaxis in children, using data from a Southeast Asian population.Methods: A retrospective study was conducted at a tertiary care hospital, Thailand, from 2015 to 2023. Data from 335 pediatric patients with anaphylaxis, classified into severe and nonsevere groups, were analyzed. Risk factors were identified using multivariable logistic regression.Results: Severe anaphylaxis occurred in 24 patients (7.2%). Males (58%) and food allergens, particularly shellfish and wheat, were the predominant factors. Severe cases were associated with an age greater than 12 years (adjusted odds ratio [aOR]: 5.67, P < 0.05), cardiovascular manifestations (aOR: 129.94, P < 0.01), and an early onset of symptoms (aOR: 0.96, P < 0.05).Conclusion: Age >12 years, cardiovascular symptoms, and early symptom onset were significant risk factors for severe anaphylaxis in children. These findings highlight the need for heightened vigilance and tailored management strategies in older children and those with cardiovascular involvement. Future studies in diverse populations are needed to confirm the generalizability of these risk factors.","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 3","pages":"192-197"},"PeriodicalIF":2.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419435/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia Pacific Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5415/apallergy.0000000000000210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Anaphylaxis is a life-threatening condition with significant global health implications. Understanding its risk factors in children across diverse populations is crucial for effective prevention and management strategies.

Objective: The aim is to identify risk factors for severe anaphylaxis in children, using data from a Southeast Asian population.

Methods: A retrospective study was conducted at a tertiary care hospital, Thailand, from 2015 to 2023. Data from 335 pediatric patients with anaphylaxis, classified into severe and nonsevere groups, were analyzed. Risk factors were identified using multivariable logistic regression.

Results: Severe anaphylaxis occurred in 24 patients (7.2%). Males (58%) and food allergens, particularly shellfish and wheat, were the predominant factors. Severe cases were associated with an age greater than 12 years (adjusted odds ratio [aOR]: 5.67, P < 0.05), cardiovascular manifestations (aOR: 129.94, P < 0.01), and an early onset of symptoms (aOR: 0.96, P < 0.05).

Conclusion: Age >12 years, cardiovascular symptoms, and early symptom onset were significant risk factors for severe anaphylaxis in children. These findings highlight the need for heightened vigilance and tailored management strategies in older children and those with cardiovascular involvement. Future studies in diverse populations are needed to confirm the generalizability of these risk factors.

Abstract Image

查看原文本刊更多论文

确定0至15岁儿童严重儿科过敏反应的关键危险因素：来自泰国研究的证据。

背景：过敏反应是一种危及生命的疾病，具有重要的全球健康影响。了解不同人群中儿童的风险因素对于有效预防和管理战略至关重要。目的：目的是确定儿童严重过敏反应的危险因素，使用来自东南亚人群的数据。方法：2015 - 2023年在泰国一家三级医院进行回顾性研究。对335例儿童过敏反应患者的数据进行分析，分为严重组和非严重组。使用多变量逻辑回归确定危险因素。结果：发生严重过敏反应24例（7.2%）。男性（58%）和食物过敏原（尤其是贝类和小麦）是主要因素。严重者与年龄大于12岁（校正优势比[aOR]: 5.67, P < 0.05）、心血管表现（aOR: 129.94, P < 0.01）、早发症状（aOR: 0.96, P < 0.05）相关。结论：年龄0 ~ 12岁、心血管症状和早期症状发作是儿童发生严重过敏反应的重要危险因素。这些发现强调了对年龄较大的儿童和心血管疾病患者提高警惕和量身定制管理策略的必要性。未来需要在不同人群中进行研究，以确认这些风险因素的普遍性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asia Pacific Allergy ALLERGY-

CiteScore

2.50

自引率

5.90%

发文量

期刊介绍： Asia Pacific Allergy (AP Allergy) is the official journal of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI). Although the primary aim of the journal is to promote communication between Asia Pacific scientists who are interested in allergy, asthma, and clinical immunology including immunodeficiency, the journal is intended to be available worldwide. To enable scientists and clinicians from emerging societies appreciate the scope and intent of the journal, early issues will contain more educational review material. For better communication and understanding, it will include rational concepts related to the diagnosis and management of asthma and other immunological conditions. Over time, the journal will increase the number of original research papers to become the foremost citation journal for allergy and clinical immunology information of the Asia Pacific in the future.