Quality of life in patients with hereditary angioedema correlates with angioedema control: Our experience at Chandigarh, India.

IF 1.6 Q3 ALLERGY

Asia Pacific Allergy Pub Date : 2025-03-01 Epub Date: 2025-01-13 DOI:10.5415/apallergy.0000000000000172

Rajni Sharma, Suprit Basu, Reva Tyagi, Sangeetha Siniah, Prabal Barman, Archan Sil, Sanghamitra Machhua, Sanchi Chawla, Vignesh Pandiarajan, Rakesh Kumar Pilania, Saniya Sharma, Manpreet Dhaliwal, Deepti Suri, Amit Rawat, Sendhil M Kumaran, Sunil Dogra, Surjit Singh, Ankur Kumar Jindal

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引用次数: 0

Abstract

Background: Hereditary angioedema (HAE) is characterized by unpredictable acute attacks that impair the patient's quality of life (QoL) not only due to the impact on functional abilities caused by edema but also due to pain and other symptoms, including fatigue, nausea, and vomiting.

Objectives: QoL studies in patients with HAE have not been carried out in the Indian subcontinent. Hence, we carried out this study to assess the QoL and to identify factors associated with impaired QoL in patients with HAE.

Methods: This was a cross-sectional observational study carried out in confirmed cases of HAE, aged >18 years, using angioedema QoL score and angioedema control test.

Results: We enrolled 135 patients with HAE (aged 18-80 years) with a mean age of 40.93 years. We observed that the QoL directly correlates with angioedema control and is also affected by other factors such as gender, duration of follow-up, and the frequency of episodes. Genitalia swelling, positive family history, and presence of mortality due to HAE in the family also significantly impact the QoL of patients with HAE. In addition, patients with type 1 HAE reported a poorer QoL as compared to patients with type 2 HAE.

Conclusion: We report the QoL of patients with HAE from settings where none of the first-line medications are available. Results of the study suggest that disease control is the most important factor that influences the QoL.

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遗传性血管性水肿患者的生活质量与血管性水肿的控制相关：我们在印度昌迪加尔的经验。

背景：遗传性血管性水肿（遗传性血管性水肿）的特点是不可预测的急性发作，不仅由于水肿引起的功能能力的影响，而且由于疼痛和其他症状，包括疲劳、恶心和呕吐，损害患者的生活质量（QoL）。目的：在印度次大陆尚未开展HAE患者的生活质量研究。因此，我们开展了这项研究，以评估HAE患者的生活质量，并确定与生活质量受损相关的因素。方法：采用血管性水肿生活质量评分和血管性水肿控制试验，对年龄在bb0 ~ 18岁的确诊HAE患者进行横断面观察性研究。结果：我们纳入了135例HAE患者（年龄18-80岁），平均年龄40.93岁。我们观察到生活质量与血管性水肿的控制直接相关，也受到其他因素的影响，如性别、随访时间和发作频率。生殖器肿胀、阳性家族史和家族中因HAE死亡的存在也显著影响HAE患者的生活质量。此外，与2型HAE患者相比，1型HAE患者的生活质量较差。结论：我们报告了在没有一线药物可用的情况下HAE患者的生活质量。研究结果表明，疾病控制是影响患者生活质量的最重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific Allergy ALLERGY-

CiteScore

2.50

自引率

5.90%

发文量

期刊介绍： Asia Pacific Allergy (AP Allergy) is the official journal of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI). Although the primary aim of the journal is to promote communication between Asia Pacific scientists who are interested in allergy, asthma, and clinical immunology including immunodeficiency, the journal is intended to be available worldwide. To enable scientists and clinicians from emerging societies appreciate the scope and intent of the journal, early issues will contain more educational review material. For better communication and understanding, it will include rational concepts related to the diagnosis and management of asthma and other immunological conditions. Over time, the journal will increase the number of original research papers to become the foremost citation journal for allergy and clinical immunology information of the Asia Pacific in the future.