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P.65 Increased Biomarkers of Endothelial Dysfunction and Thrombotic Microenvironment in Patients with Autoimmune Rheumatic Disorders Free from Cardiovascular Comorbidities P.65无心血管合并症的自身免疫性类风湿性疾病患者内皮功能障碍和血栓微环境的生物标志物增加
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.074
E. Gavriilaki, P. Anyfanti, S. Douma, E. Gkaliagkousi
{"title":"P.65 Increased Biomarkers of Endothelial Dysfunction and Thrombotic Microenvironment in Patients with Autoimmune Rheumatic Disorders Free from Cardiovascular Comorbidities","authors":"E. Gavriilaki, P. Anyfanti, S. Douma, E. Gkaliagkousi","doi":"10.2991/artres.k.201209.074","DOIUrl":"https://doi.org/10.2991/artres.k.201209.074","url":null,"abstract":"Purpose/Background/Objectives: Cardiovascular risk is increased in patients with autoimmune rheumatic disorders [1]. Endothelial and platelet MVs (EMVs, PMVs) are small vesicles (0.1–1 μm) released from plasma membrane and represent novel markers of endothelial dysfunction and thrombosis. Their levels increase substantially in patients with cardiovascular diseases [2,3]. We tested whether EMVs and PMVs are increased in patients with autoimmune rheumatic disorders in the absence of cardiovascular comorbidities.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49129811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice P.58遗传背景决定了高血压小鼠的主动脉纤维化
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.068
B. Spronck, M. Latorre, S. Mehta, A. Caulk, A. Ramachandra, Sae-Il Murtada, Alexia Rojas, Changyuan He, Bo Jiang, Mo Wang, M. Bersi, G. Tellides, J. Humphrey
{"title":"P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice","authors":"B. Spronck, M. Latorre, S. Mehta, A. Caulk, A. Ramachandra, Sae-Il Murtada, Alexia Rojas, Changyuan He, Bo Jiang, Mo Wang, M. Bersi, G. Tellides, J. Humphrey","doi":"10.2991/artres.k.201209.068","DOIUrl":"https://doi.org/10.2991/artres.k.201209.068","url":null,"abstract":"Methods: After AngII infusion (14-day, 1000 ng/kg/min) and euthanasia, excised thoracic aortas were characterized functionally using isobaric vasoactive and cyclic passive stiffness tests. Immunohistochemistry quantified medial/adventitial composition and infiltration of pan-inflammatory CD45+ cells. RNA sequencing-based gene ontology, wall stress analyses, and growth and remodeling (G&R) simulations were performed to complement our mechanical findings.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49663116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
YI 1.2 Ideal Cardiovascular Health Score Declines from Adolescence to Emerging Adulthood YI 1.2理想心血管健康评分从青春期到成年期下降
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.002
Chloe M. Park, Siana Jones, Suzanne Williams, A. Rapala, H. Taylor, L. Howe, A. Fraser, N. Chaturvedi, A. Hughes
{"title":"YI 1.2 Ideal Cardiovascular Health Score Declines from Adolescence to Emerging Adulthood","authors":"Chloe M. Park, Siana Jones, Suzanne Williams, A. Rapala, H. Taylor, L. Howe, A. Fraser, N. Chaturvedi, A. Hughes","doi":"10.2991/artres.k.201209.002","DOIUrl":"https://doi.org/10.2991/artres.k.201209.002","url":null,"abstract":"Methods: 3142 participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) study attended clinical investigations at 17.8 ± 0.4 yrs and 24.0 ± 0.8 yrs (38% male). CV health was assessed using smoking status, body mass index (BMI), plasma glucose, cholesterol, sitting brachial blood pressure, left ventricle (LV) hypertrophy, arterial stiffness (carotid-tofemoral pulse wave velocity) and atherosclerosis (carotid intima-media thickness) metrics. Prevalence was stratified into poor (0_points), intermediate (1_point) and ideal (2_points) health categories and a composite, individual-level CHS for all 8 metrics was calculated (total range, 0–16 points). Prevalence of ideal health was assessed using ANOVA and linear mixed modelling assessed age##sex modifications.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45903175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation P.66肾移植后桡动脉收缩期-舒张期脉搏传递时间
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.075
E. Philibert, H. Obeid, M. Paré, N. Côté, C. Fortier, R. Goupil, M. Agharazii
{"title":"P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation","authors":"E. Philibert, H. Obeid, M. Paré, N. Côté, C. Fortier, R. Goupil, M. Agharazii","doi":"10.2991/artres.k.201209.075","DOIUrl":"https://doi.org/10.2991/artres.k.201209.075","url":null,"abstract":"Methods: Before and three months after KTx, we obtained radial pressure waveforms using applanation tonometry, in a group of 61 patients with restored renal function (eGFR > 45 ml/min/1,73 m2). Radial waveforms were recorded over a 10 seconds period and ensemble-averaged (using in house-MATLAB program) to obtain a single waveform and then modelled using two Gaussian functions, was then determined as the transit time between the first systolic peak T1 and the early diastolic peak T2.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47641190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound P.41使用无图像快速超声测量颈动脉脉搏波速度的压力依赖性搏动内变化
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.053
K. Raj, P. Nabeel, J. Joseph, Dinu S. Chandran, M. Sivaprakasam
{"title":"P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound","authors":"K. Raj, P. Nabeel, J. Joseph, Dinu S. Chandran, M. Sivaprakasam","doi":"10.2991/artres.k.201209.053","DOIUrl":"https://doi.org/10.2991/artres.k.201209.053","url":null,"abstract":"Background: The clinical significance of pressure-dependent intra-beat changes in local pulse-wave velocity (C) has recently come to light [1]. While reported methods require arterial pressure and diameter measurements from a single site to assess intrabeat changes in C, we present an image-free fast ultrasound device that performs this by capturing diameter waveforms from two proximal locations on an artery.. Methods: The functionality was assessed on eight normotensive participants (26 ± 4 years). By perturbing blood pressure through a short duration moderate lower body negative pressure intervention [2], CD and CF pulse wave velocities corresponding to diastolic and 80% of peak pressure were measured from the carotid artery. Human NIBP system (ADInstruments, India) was used for monitoring continuous pressure.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42777069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P.27 Mechanisms of NADPH Oxidase Participation in the Regulation of Diaphragm Artery Contractile Responses P.27 NADPH氧化酶参与调节膈动脉收缩反应的机制
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.040
A. A. Borzykh, I. Kuzmin, O. Vinogradova, O. Tarasova
{"title":"P.27 Mechanisms of NADPH Oxidase Participation in the Regulation of Diaphragm Artery Contractile Responses","authors":"A. A. Borzykh, I. Kuzmin, O. Vinogradova, O. Tarasova","doi":"10.2991/artres.k.201209.040","DOIUrl":"https://doi.org/10.2991/artres.k.201209.040","url":null,"abstract":"Reactive oxygen species (ROS) produced by NADPH-oxidase (NOX) participate in vascular tone control, but their effects in the arteries of respiratory muscles is poorly understood. Possible targets of vasoregulatory ROS influence are NO-pathway in the endothelium and Rho-kinase pathway in smooth muscle cells. Therefore, the aim of this study was to evaluate the interaction of NOX-dependent control with NOand Rho-kinase signaling pathways in rat diaphragm arteries (DA).","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47986936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
YI 1.3 Retinal Microvascular Calibers and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis 视网膜微血管直径与抑郁症状:动脉粥样硬化的多民族研究
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.003
April C E van Gennip, Sanaz Sedeghat, M. Carnethon, N. Allen, B. Klein, M. Cotch, D. Chirinos, C. Stehouwer, T. Sloten
{"title":"YI 1.3 Retinal Microvascular Calibers and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis","authors":"April C E van Gennip, Sanaz Sedeghat, M. Carnethon, N. Allen, B. Klein, M. Cotch, D. Chirinos, C. Stehouwer, T. Sloten","doi":"10.2991/artres.k.201209.003","DOIUrl":"https://doi.org/10.2991/artres.k.201209.003","url":null,"abstract":"Background: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is scarce. The retina allows for direct visualisation of a microvascular bed that shares anatomical and physiological similarities with the cerebral microvasculature. We investigated the association between baseline central retinal arteriolar and venular calibers (CRAE and CRVE) and 7.8-year change of CRAE and CRVE and incident depressive symptoms.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48158659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P.60 Improvement in Muscular Strength Within One Year is Associated with Increased Arterial Stiffness in Young Male Soccer Players P.60年轻男子足球运动员一年内肌肉力量的提高与动脉硬化有关
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.069
M. Baumgartner, H. Weberruss, Katharina Appel, T. Engl, R. Oberhoffer-Fritz, T. Schulz
{"title":"P.60 Improvement in Muscular Strength Within One Year is Associated with Increased Arterial Stiffness in Young Male Soccer Players","authors":"M. Baumgartner, H. Weberruss, Katharina Appel, T. Engl, R. Oberhoffer-Fritz, T. Schulz","doi":"10.2991/artres.k.201209.069","DOIUrl":"https://doi.org/10.2991/artres.k.201209.069","url":null,"abstract":"Methods: 30 male soccer players were examined twice (age t0: 13.3 ± 2.0 years, age t1: 14.2 ± 2.0 years). cSBP and aPWV were measured oscillometrically (Mobil-O-Graph®) and z-scores were calculated. The MoMo physical activity questionnaire recorded the weekly training load and the hand dynamometer measured muscular strength. Height and weight were examined and body surface area (BSA) was computed.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41925697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P.54 Biomarkers and Haemodynamic Predictors of Left Atrial Strain in Early Hypertension P.54早期高血压左心房应变的生物标志物和血流动力学预测因子
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.064
M. Bukhamseen, Nada Al-Saileek, A. Alsaileek, Mohammad Ghormalla Ghamdi, Tahlil Wasame, A. Omran, Azra Mahmud
{"title":"P.54 Biomarkers and Haemodynamic Predictors of Left Atrial Strain in Early Hypertension","authors":"M. Bukhamseen, Nada Al-Saileek, A. Alsaileek, Mohammad Ghormalla Ghamdi, Tahlil Wasame, A. Omran, Azra Mahmud","doi":"10.2991/artres.k.201209.064","DOIUrl":"https://doi.org/10.2991/artres.k.201209.064","url":null,"abstract":"Methods: We studied 34 patients, mean age 47.5 ± 11.6 years, 56% females. All parameters for arterial stiffness including 24 hour central systolic pressure, augmentation index and pulse wave velocity were measured non–invasively using Mobil-Ograph PWA. All patients underwent standard two-dimensional echocardiography with Spackle tracking analysis for left atrium (LA). Circulating biomarkers including renin, aldosterone and morning cortisol were measured using ELISA.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46734548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P.49 Aortic Root Longitudinal Strain by Speckle-Tracking Echocardiography: Comparison with Cardiac Magnetic Resonance and Predictive Value in Marfan Syndrome Patients P.49斑点跟踪超声心动图主动脉根部纵向应变与心脏磁共振的比较及其对马凡氏综合征的预测价值
IF 0.6 4区 医学
Artery Research Pub Date : 2020-12-01 DOI: 10.2991/artres.k.201209.061
A. Guala, M. Pons, A. Ruiz-Muñoz, L. Dux-Santoy, L. Madrenas, M. Gandara, F. Valente, Á. López-Sainz, L. Galián, L. Gutiérrez, A. Sao-Avilés, T. González‐Alujas, I. Ferreira, A. Evangelista, J. Rodríguez-Palomares, G. Teixidó-Tura
{"title":"P.49 Aortic Root Longitudinal Strain by Speckle-Tracking Echocardiography: Comparison with Cardiac Magnetic Resonance and Predictive Value in Marfan Syndrome Patients","authors":"A. Guala, M. Pons, A. Ruiz-Muñoz, L. Dux-Santoy, L. Madrenas, M. Gandara, F. Valente, Á. López-Sainz, L. Galián, L. Gutiérrez, A. Sao-Avilés, T. González‐Alujas, I. Ferreira, A. Evangelista, J. Rodríguez-Palomares, G. Teixidó-Tura","doi":"10.2991/artres.k.201209.061","DOIUrl":"https://doi.org/10.2991/artres.k.201209.061","url":null,"abstract":"Background: Low longitudinal strain of the ascending aorta (AAo) by cardiac magnetic resonance (CMR) predicts dilation and aortic events in Marfan syndrome (MFS) [1], possibly reflecting aortic stiffness [2]. Speckle-tracking is established for cardiac deformation, but proximal aorta applications are challenging due to wall thickness and substantial motion. We aimed to validate a purpose-specific speckle-tracking tool for root longitudinal strain analysis by comparison with CMR-derived AAo longitudinal strain and as predictor of dilation in MFS patients.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":"26 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69871966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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