P.58遗传背景决定了高血压小鼠的主动脉纤维化

IF 0.9 4区医学 Q4 PERIPHERAL VASCULAR DISEASE

Artery Research Pub Date : 2020-12-01 DOI:10.2991/artres.k.201209.068

B. Spronck, M. Latorre, S. Mehta, A. Caulk, A. Ramachandra, Sae-Il Murtada, Alexia Rojas, Changyuan He, Bo Jiang, Mo Wang, M. Bersi, G. Tellides, J. Humphrey

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引用次数: 0

摘要

方法：在AngII输注（14天，1000纳克/千克/分钟）和安乐死后，使用等压血管活性和循环被动硬度测试对切除的胸主动脉进行功能表征。免疫组织化学定量了泛炎性CD45+细胞的内/外膜组成和浸润。进行了基于RNA测序的基因本体论、壁应力分析以及生长和重塑（G&R）模拟，以补充我们的机械发现。

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P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

Methods: After AngII infusion (14-day, 1000 ng/kg/min) and euthanasia, excised thoracic aortas were characterized functionally using isobaric vasoactive and cyclic passive stiffness tests. Immunohistochemistry quantified medial/adventitial composition and infiltration of pan-inflammatory CD45+ cells. RNA sequencing-based gene ontology, wall stress analyses, and growth and remodeling (G&R) simulations were performed to complement our mechanical findings.

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来源期刊

Artery Research Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

13 weeks

期刊介绍： Artery Research is the official journal of the Association for Research into Arterial Structure and Physiology (ARTERY) which promotes the advancement of knowledge and dissemination of information concerning the pathophysiology, epidemiology, detection, investigation and treatment of arterial structure and function. The journal publishes original research articles, review articles, perspectives, case-studies, letters to the Editor, short communications and images. All submitted material is subject to a strict peer-review process.