P.27 Mechanisms of NADPH Oxidase Participation in the Regulation of Diaphragm Artery Contractile Responses

IF 0.9 4区医学 Q4 PERIPHERAL VASCULAR DISEASE

Artery Research Pub Date : 2020-12-01 DOI:10.2991/artres.k.201209.040

A. A. Borzykh, I. Kuzmin, O. Vinogradova, O. Tarasova

引用次数: 0

Abstract

Reactive oxygen species (ROS) produced by NADPH-oxidase (NOX) participate in vascular tone control, but their effects in the arteries of respiratory muscles is poorly understood. Possible targets of vasoregulatory ROS influence are NO-pathway in the endothelium and Rho-kinase pathway in smooth muscle cells. Therefore, the aim of this study was to evaluate the interaction of NOX-dependent control with NOand Rho-kinase signaling pathways in rat diaphragm arteries (DA).

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P.27 NADPH氧化酶参与调节膈动脉收缩反应的机制

NADPH氧化酶（NOX）产生的活性氧（ROS）参与血管张力控制，但它们在呼吸肌动脉中的作用尚不清楚。血管调节性ROS影响的可能靶点是内皮中的NO通路和平滑肌细胞中的Rho激酶通路。因此，本研究的目的是评估大鼠膈动脉（DA）中NOX依赖性控制与NO和Rho激酶信号通路的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artery Research Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

13 weeks

期刊介绍： Artery Research is the official journal of the Association for Research into Arterial Structure and Physiology (ARTERY) which promotes the advancement of knowledge and dissemination of information concerning the pathophysiology, epidemiology, detection, investigation and treatment of arterial structure and function. The journal publishes original research articles, review articles, perspectives, case-studies, letters to the Editor, short communications and images. All submitted material is subject to a strict peer-review process.