Arthritis Care & Research最新文献

{"title":"Higher levels of high-sensitivity CRP are associated with future development of Psoriatic Arthritis in Psoriasis: A prospective cohort study.","authors":"Lihi Eder, Xianwei Li, Vinod Chandran, Cheryl F Rosen, Richard J Cook, Dafna D Gladman","doi":"10.1002/acr.25539","DOIUrl":"https://doi.org/10.1002/acr.25539","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to assess whether high sensitivity c-reactive protein (hsCRP) could predict the development of psoriatic arthritis (PsA) in patients with psoriasis.</p><p><strong>Methods: </strong>We analyzed data from a prospective cohort of patients with psoriasis without PsA at enrollment. Participants were assessed annually by a rheumatologist for signs and symptoms of PsA. Information on patient demographics, psoriasis features, medications and musculoskeletal symptoms was collected. hsCRP levels were measured in serum samples collected at baseline using standard commercial assays. The association between hsCRP levels and risk of development of PsA was assessed using multivariable Cox proportional hazards model adjusted for age, sex, psoriasis severity and duration, nail lesions, body mass index (BMI), fatigue, and medication use.</p><p><strong>Results: </strong>A total of 589 patients with psoriasis followed from 2006 to 2019 were analyzed. 57 patients developed PsA during the follow up period. Mean level of hsCRP was 3.1±5.5 mg/L (hsCRP levels in incident PsA cases: 5.4±13.1). Significantly higher levels of hs-CRP at baseline were found in patients with arthralgia, obesity and in females. Higher hs-CRP levels were associated with future development of PsA in multivariable analysis (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.01, 1.07, p=0.007). Similar effect size was seen in males and females. No significant interaction was found between hsCRP and sex or BMI.</p><p><strong>Conclusion: </strong>Higher levels of systemic inflammation, as measured by hsCRP, are associated with future development of PsA.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Longitudinal Behavior of Serum Levels of Soluble Flt1 and Placental Growth Factor in Pregnant Patients With Systemic Lupus Erythematosus.","authors":"Nilson R de Jesús, Guilherme R de Jesús, Marcela I Lacerda, Flávia C Dos Santos, Jeane de S Nogueira, Luiz Cristóvão Porto, Evandro S F Coutinho, Evandro M Klumb","doi":"10.1002/acr.25536","DOIUrl":"10.1002/acr.25536","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed longitudinal trajectories of soluble Flt1 (sFlt1) levels, placenta growth factor (PlGF) levels, and sFlt1:PlGF ratios in a cohort of pregnant patients with systemic lupus erythematosus (SLE).</p><p><strong>Methods: </strong>Blood samples were collected (14-18, 24-26, 30-32, 34-36, and 38-40 weeks), stored at -80°C, and evaluated for serum levels of sFlt1, PlGF, and sFlt1:PlGF ratios. Patients were classified as inactive SLE (Systemic Lupus Erythematosus Pregnancy Disease Activity Index [SLEPDAI] <4), active disease (SLEPDAI ≥4), or preeclampsia (PE). Medians and interquartile ranges were calculated for each group, and linear models with random effects were used.</p><p><strong>Results: </strong>A total of 527 samples were obtained from 163 patients, and all patients were subsequently classified as having inactive disease (109 patients [66.9%]), active disease (33 patients [20.2%]), and inactive disease with PE (21 patients [12.9%]). In exploratory analysis, patients with PE had higher mean serum levels of sFlt1 and sFlt1:PlGF ratios and lower PlGF levels than patients with inactive and active SLE (P = 0.01 to P < 0.001). Using linear models with random effects, there was no significant differences in mean serum levels of these angiogenic markers comparing inactive and active disease. Patients with PE showed a marked increase in sFlt1 levels from the 24th week, constantly low PlGF levels from the 14th week, and progressive increase of sFlt1:PlGF ratio during pregnancy. All these differences were statistically significant compared to the groups without PE.</p><p><strong>Conclusion: </strong>Pregnant patients with SLE who developed PE had higher sFlt1 levels and sFlt1:PlGF ratios and lower PlGF levels, and these last two changes were detected at the beginning of second trimester, before clinical manifestation. SLE activity did not interfere with longitudinal behavior of these angiogenic markers.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Consequences of Rheumatoid Arthritis.","authors":"Stevie Barry, Emily Sheng, Joshua F Baker","doi":"10.1002/acr.25537","DOIUrl":"10.1002/acr.25537","url":null,"abstract":"<p><p>Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long-term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a \"lipid paradox,\" with reduced low-density lipoprotein being associated with higher rates of cardiovascular disease. In this review, we discuss changes to body composition, insulin resistance, lipids, and blood pressure that often occur in patients with RA. We examine the current understanding of the mechanisms underlying disruptions in metabolic pathways in RA, their clinical effects, and how treatment affects these changes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoidable Hospitalizations in Persons With Rheumatoid Arthritis: A Population-Based Study Using Administrative Data.","authors":"Dani G Contreras, Claire E H Barber, J Antonio Aviña-Zubieta, Hude Quan, Seungwon Lee, James A King, Cheryl Barnabe","doi":"10.1002/acr.25541","DOIUrl":"10.1002/acr.25541","url":null,"abstract":"<p><strong>Objective: </strong>We estimated incidence rates of avoidable hospitalizations by persons with rheumatoid arthritis (RA) relative to the general population.</p><p><strong>Methods: </strong>We identified individuals meeting a validated case definition for RA based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and ICD-10-CA codes in years 2002 to 2023. Four general population controls were matched to each RA case by age and sex. We identified hospitalizations for ambulatory care sensitive conditions (ACSCs), including grand mal seizures, chronic lower respiratory diseases, asthma, diabetes, heart failure and pulmonary edema, hypertension, and angina, from 2007 to 2023 by established diagnostic codes. Incidence rate ratios (IRRs) three and five years from the date of diagnosis were calculated using a multivariable regression model adjusting for age, sex, and location of residence. A Cox proportional hazards model was used to identify predictors of avoidable hospitalizations among patients with RA.</p><p><strong>Results: </strong>Persons with RA (n = 83,811) had 1.12 times the risk of hospitalization for heart failure and pulmonary edema compared to those without RA (n = 190,304) (IRR 1.12, 95% confidence interval [CI] 1.01-1.25). Significant predictors of ACSC hospitalizations for RA cases were increasing age, prolonged exposure to glucocorticoids, and having comorbid conditions, especially if the comorbid condition was an ACSC (hazard ratio 10.1, 95% CI 7.8-13.0).</p><p><strong>Conclusion: </strong>Persons with RA are at a higher risk of potentially avoidable hospitalizations three and five years after diagnosis compared to those without RA. Improved ambulatory care access and quality, inclusive of primary care and subspecialty care, is proposed to prevent unnecessary hospitalizations and reduce burden on the acute care system.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Chronic Kidney Disease With Increased Glucose Uptake-Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Patients With Gout.","authors":"Shunya Kaneshita, Sho Fukui, Soheil Niku, Kwanghoon Lee, Ernest Belezzuoli, Robert Terkeltaub, Monica Guma","doi":"10.1002/acr.25540","DOIUrl":"10.1002/acr.25540","url":null,"abstract":"<p><strong>Objective: </strong>We evaluate the ¹⁸F-fluorodeoxyglucose positron emission tomography (PET) standardized uptake value (SUV) by PET/computed tomography (CT) scans in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in patients with and without gout. Additionally, we investigate whether glucose uptake in these tissues predicts the progression of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>We used International Classification of Diseases, Tenth Revision codes from the University of California San Diego patient database to identify patients with gout and controls, forming a cohort of individuals who underwent PET/CT scans. The mean VAT and SAT maximum SUV (SUVmax) were measured using PET/CT scans and adjusted for potential confounders using inverse probability of weighting analysis. We also employed multivariable linear regression to analyze changes in estimated glomerular filtration rate (eGFR) after PET/CT scans.</p><p><strong>Results: </strong>The study included 221 patients, with 120 diagnosed with gout. After the inverse probability of weighting adjustment, the mean VAT and SAT SUVmax were higher in patients with gout (mean VAT SUVmax: β = 0.09, 95% confidence interval [CI] 0.04-0.15; mean SAT SUVmax: β = 0.06, 95% CI 0.01-0.12). Additionally, in patients with gout with CKD stage ≥3, higher mean VAT and SAT SUVmax were associated with decreased eGFR in the 5 years following PET/CT scans (mean VAT SUVmax: β = -1.76, 95% CI -3.50 to -0.01; mean SAT SUVmax: β = -2.97, 95% CI -5.61 to -0.32).</p><p><strong>Conclusion: </strong>Elevated glucose uptake-associated metabolic activity in both VAT and SAT was observed in patients with gout, which may contribute to CKD progression among patients with both gout and CKD.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of Juvenile Idiopathic Arthritis-Associated Uveitis in Long-Term Disease Remission: Consensus-Based Recommendations From the Multinational Interdisciplinary Working Group for Uveitis in Childhood.","authors":"Ivan Foeldvari, Ameenat Solebo, Harry Petrushkin, Sheila T Angeles-Han, Regitze Bangsgaard, Joan Calzada-Hernández, Tamas Constantin, Joke de Boer, Jesus Díaz-Cascajosa, Mia Glerup, Helene Ingels, Sebastian Kramer, Elisabetta Miserocchi, Ellen Nordal, Rotraud K Saurenmann, Gabriele Simonini, Joost F Swart, Jan Titz, Jordi Antón","doi":"10.1002/acr.25542","DOIUrl":"10.1002/acr.25542","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to develop consensus-based recommendations for the monitoring of children with juvenile idiopathic arthritis-associated uveitis (JIAU) in long-term remission, addressing the absence of international guidance on monitoring schedules for these children and young people.</p><p><strong>Methods: </strong>The Multinational Interdisciplinary Working Group for Uveitis in Childhood convened experts from 10 countries, including pediatric rheumatologists and ophthalmologists, alongside parents of affected children. A review of key longitudinal cohort studies informed a structured consensus process comprising discussion, recommendation development, and voting for adoption, with a consensus threshold of ≥80% needed for adoption. Recommendation development focused on three principal questions: stratification of the risk of poor outcomes, the natural history of JIAU postremission, and the impact of delayed examination.</p><p><strong>Results: </strong>The group established several key recommendations, including a standard monitoring frequency of every 4 months for the first four years following medication cessation, ongoing assessments for patients with structural complications, and low-frequency monitoring every 6 months for those in stable, drug-free remission for over four years. There was unanimous agreement on these recommendations.</p><p><strong>Conclusion: </strong>These consensus-based recommendations provide a framework for monitoring children with JIAU in remission, enhancing the quality of care and optimizing resource use in eye health services. Ongoing research is essential to refine these guidelines as new evidence emerges regarding biomarkers and imaging techniques for disease recurrence.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call for individualized approaches to tuberculosis screening practices among new users of biologic or targeted synthetic disease-modifying antirheumatic drugs: comment on the article by Roberts et al.","authors":"Yuting Wang, Guiyao Jin, Wenlong Wang, Fanzhang Meng, Chen Li","doi":"10.1002/acr.25534","DOIUrl":"10.1002/acr.25534","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Eric T Roberts, Matthew Murrill, Gabriela Schmajuk, Jinoos Yazdany","doi":"10.1002/acr.25533","DOIUrl":"10.1002/acr.25533","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review.","authors":"Natasha Cox, Saeed Farooq, Helen Twohig, Ian C Scott","doi":"10.1002/acr.25532","DOIUrl":"10.1002/acr.25532","url":null,"abstract":"<p><p>As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross-sectional data. To better understand potential causality, longitudinal studies are required. This narrative review examines the relationship between pain and depression in patients with IA participating in observational longitudinal studies (spanning association strengths, direction of effect, and causal factors) and summarizes the literature on causal pathways in general populations alongside guideline recommendations/systematic reviews on assessing pain/depression in IA. Fourteen longitudinal studies in IA largely indicate an association between pain and depression, albeit with a small-to-modest effect size and a focus on pain intensity. This relationship appears to be bidirectional. Evidence on causal pathways is sparse in IA and limited in non-IA populations (with structural/function brain changes, altered sensory/pain thresholds, and sleep disturbance implicated) highlighting a need for further research. Although many patient-reported outcome measures exist to assess pain and depression in IA, evidence for their psychometric properties is often limited, and IA guidelines offer incomplete advice on pain/depression assessment. A simple approach of using a single-item pain intensity score (eg, a Numeric Rating Scale, which has strong clinimetric properties) in routine IA consultations, with screening for depression where relevant, appears appropriate. Further research is needed to understand how this could be achieved in different health care settings.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withholding acetaminophen for older adults with osteoarthritis? Not so fast: comment on the article by Kaur et al.","authors":"Ali Ahmed, Gail Kerr, Hans J Moore, Janani Rangaswami, Charles Faselis, Richard M Allman","doi":"10.1002/acr.25538","DOIUrl":"10.1002/acr.25538","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}