Arthritis Care & Research最新文献

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Better Patient Care and Team Satisfaction Call for "Both-And" Approach. 更好的病人护理和团队满意度需要“双管齐下”的方法。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-03-03 DOI: 10.1002/acr.25516
Jennifer Brandt, S Sam Lim, Christie M Bartels
{"title":"Better Patient Care and Team Satisfaction Call for \"Both-And\" Approach.","authors":"Jennifer Brandt, S Sam Lim, Christie M Bartels","doi":"10.1002/acr.25516","DOIUrl":"10.1002/acr.25516","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of a Telephone-Delivered Walk With Ease Program on Arthritis-Related Symptoms, Function, and Activity: A Randomized Trial. 电话轻松行走计划对关节炎相关症状、功能和活动的有效性:一项随机试验
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-03-03 DOI: 10.1002/acr.25515
Christine A Pellegrini, Sara Wilcox, Yesil Kim, Scott Jamieson, Katherine DeVivo, Daniel Heidtke
{"title":"Effectiveness of a Telephone-Delivered Walk With Ease Program on Arthritis-Related Symptoms, Function, and Activity: A Randomized Trial.","authors":"Christine A Pellegrini, Sara Wilcox, Yesil Kim, Scott Jamieson, Katherine DeVivo, Daniel Heidtke","doi":"10.1002/acr.25515","DOIUrl":"10.1002/acr.25515","url":null,"abstract":"<p><strong>Objective: </strong>Walk With Ease (WWE) is a six-week arthritis-appropriate evidence-based physical activity program traditionally offered in a face-to-face format. Because many populations encounter participation barriers to in-person programs, WWE was modified for telephone delivery (WWE-T). The short- and long-term effects of this program on physical activity and arthritis-related outcomes were examined.</p><p><strong>Methods: </strong>Participants (n = 267) with arthritis were randomized to WWE-T or a wait list control. WWE-T participants received two telephone calls per week (one group and one individual call) for six weeks. Group calls focused on arthritis education and social support. Individual calls focused on problem-solving and goal setting. Physical function tests, patient-reported outcomes, and physical activity were assessed at baseline, 6 weeks, 6 months, and 12 months.</p><p><strong>Results: </strong>Participants were 92% female and 60% Black and had a mean ± SD age of 64.1 ± 9.4 years and a body mass index of 34.2 ± 7.7. Retention ranged from 93.6% at 6 weeks to 83.8% at 12 months. Participants attended a mean ± SD of 9.8 ± 2.6 calls. At six weeks, WWE-T participants had greater improvements in physical function (P = 0.03), fatigue (P = 0.03), self-efficacy (P ≤ 0.0001), and activity impairment due to health (P = 0.01) as compared to the control group. By 12 months, WWE-T participants had better physical function (P = 0.02), higher arthritis self-efficacy (P ≤ 0.0001), lower depression symptoms (P = 0.02), and lower impairment of daily activities (P = 0.02) than at baseline.</p><p><strong>Conclusion: </strong>A WWE-T program led to improvements in physical function, self-efficacy, and impairment related to daily activities in adults with arthritis. Although changes were not seen in all outcomes, this remotely delivered program may be an effective alternative for adults with arthritis who face barriers to in-person programs.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are we rheumatologists or just internists who also care for patients with rheumatologically related challenges?: comment on the article by Brandt et al. 我们是风湿病学家还是内科医生还要照顾风湿病相关疾病的患者?
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-03-03 DOI: 10.1002/acr.25518
Bruce Rothschild
{"title":"Are we rheumatologists or just internists who also care for patients with rheumatologically related challenges?: comment on the article by Brandt et al.","authors":"Bruce Rothschild","doi":"10.1002/acr.25518","DOIUrl":"10.1002/acr.25518","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Metabolic Syndrome and Radiographic Changes in Psoriatic Arthritis: A Cohort Study. 银屑病关节炎代谢综合征与影像学改变的相关性:一项队列研究。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-03-02 DOI: 10.1002/acr.25513
Fadi Kharouf, Shangyi Gao, S Ercan Tunc, Justine Y Ye, Daniel Pereira, Dafna D Gladman, Vinod Chandran
{"title":"Association Between Metabolic Syndrome and Radiographic Changes in Psoriatic Arthritis: A Cohort Study.","authors":"Fadi Kharouf, Shangyi Gao, S Ercan Tunc, Justine Y Ye, Daniel Pereira, Dafna D Gladman, Vinod Chandran","doi":"10.1002/acr.25513","DOIUrl":"10.1002/acr.25513","url":null,"abstract":"<p><strong>Objective: </strong>Metabolic syndrome (MetS) is a known comorbidity of psoriatic arthritis (PsA) and is associated with PsA disease activity. We aimed to explore the association between MetS and radiographic features (peripheral and axial) in PsA.</p><p><strong>Methods: </strong>We included patients with PsA followed at our prospective observational cohort for the period between 1978 and 2024. We identified patients with MetS on longitudinal follow-up and used generalized estimating equations (GEE) analysis to define the radiographic features independently associated with MetS, adjusting for age, sex, PsA disease duration, calendar decade, and use of targeted disease-modifying antirheumatic drugs.</p><p><strong>Results: </strong>The study population consisted of 1,422 patients, out of which 400 (28.1%) had MetS at baseline (clinic entry) and 836 (58.79%) had a record of MetS (per the harmonized definition) over a median follow-up duration of 10.59 (interquartile range 4.52-18.28) years. The mean (SD) age of our cohort at baseline was 44.43 (12.98) years, with 789 patients (55.5%) identifying as men. Mean (SD) body mass index was 28.79 (6.36) kg/m<sup>2</sup>. In the GEE analysis, MetS was not significantly associated with axial disease or radiographic damage to peripheral joints, assessed as the presence of syndesmophytes or sacroiliitis and the radiographic damaged joint count, respectively. On the other hand, MetS was significantly associated with calcaneal spurs, diffuse idiopathic skeletal hyperostosis, and degenerative disc disease.</p><p><strong>Conclusion: </strong>MetS is associated with degenerative and metabolic changes in the spine and entheses but not with radiographic damage in PsA.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequence Analysis to Phenotype Healthcare Patterns in Adults with Musculoskeletal Conditions Using Primary Care Electronic Health Records. 使用初级保健电子健康记录对成人肌肉骨骼疾病的表型医疗模式进行序列分析。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-03-02 DOI: 10.1002/acr.25514
Smitha Mathew, George Peat, Emma Parry, Ross Wilkie, Kelvin P Jordan, Jonathan C Hill, Dahai Yu
{"title":"Sequence Analysis to Phenotype Healthcare Patterns in Adults with Musculoskeletal Conditions Using Primary Care Electronic Health Records.","authors":"Smitha Mathew, George Peat, Emma Parry, Ross Wilkie, Kelvin P Jordan, Jonathan C Hill, Dahai Yu","doi":"10.1002/acr.25514","DOIUrl":"https://doi.org/10.1002/acr.25514","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to apply sequence analysis (SA) to phenotype healthcare patterns of adult patients with musculoskeletal (MSK) conditions using primary care electronic health records and to investigate the association between these healthcare patterns and post-consultation patient's self-reported outcome.</p><p><strong>Methods: </strong>Data from the Multi-level Integrated Data for musculoskeletal health intelligence and ActionS (MIDAS) programme conducted in North Staffordshire and Stoke-on-Trent, UK was utilised. The study included patients aged ≥18 years who consulted primary care for MSK conditions between September 2021 and July 2022. SA was employed to categorise patients with similar healthcare patterns in primary care in the five years prior to their index consultation in respect to consultations, analgesic prescriptions, imaging, physiotherapy, and secondary care referrals. Association of socio-demographic characteristics and self-reported outcome with clusters were determined.</p><p><strong>Results: </strong>In total, 1,875 patients consulting primary care for MSK conditions were available for analysis. SA identified five clusters of prior healthcare patterns among patients with MSK conditions, including \"increasing consultation and analgesia\" (5.60%), \"low consultation and healthcare use\" (57.39%), \"high consultation and healthcare use\" (8.32%), \"low consultation but high analgesia\" (13.01%), and \"low consultation but moderate healthcare use\" (15.68%). Patients in the \"high consultation and healthcare use\" group were predominantly female, older, obese, had more comorbidities and lived in the most deprived areas compared to those in the \"low consultation and healthcare use\" group. Additionally, self-reported outcome varied significantly between clusters, with patients in the \"high consultation and healthcare use\" group reporting worse self- reported outcome.</p><p><strong>Conclusion: </strong>This analysis identified five distinct clusters of healthcare patterns for patients with MSK conditions in primary care and observed substantial variations in patient's self-reported outcome and socio-demographic profiles across these different groups of patients.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta-Analysis. 轴型脊柱炎随机临床试验中疗效和安全性结果的性别差异:系统文献综述和荟萃分析
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-02-24 DOI: 10.1002/acr.25512
Angel Gao, Jordi Pardo Pardo, Steven Dang, Lianne S Gensler, Philip Mease, Lihi Eder
{"title":"Sex-Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta-Analysis.","authors":"Angel Gao, Jordi Pardo Pardo, Steven Dang, Lianne S Gensler, Philip Mease, Lihi Eder","doi":"10.1002/acr.25512","DOIUrl":"10.1002/acr.25512","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to assess differences in baseline characteristics, efficacy, and safety of advanced therapies between male and female patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>We conducted a systematic literature search for RCTs assessing the efficacy of advanced therapies in patients with axSpA until March 19, 2023. We extracted the following outcomes by sex: baseline participant characteristics, Assessment in Spondylarthritis International Society (ASAS) 20/40 criteria, and Axial Spondyloarthritis Disease Activity Score low disease activity or inactive disease (ASDAS-LDA/ID). Random-effects models were used to calculate pooled effects for responses in men versus women for different medication classes.</p><p><strong>Results: </strong>We included 79 RCTs (n = 23,748 patients, 69.7% male). Only 9 trials (11.4%), 22 trials (28%), and 9 trials (11.4%) reported baseline characteristics, efficacy end points, and safety end points by sex, respectively. At baseline, women were significantly older and had higher pain scores, whereas men had higher C-reactive protein levels. Overall, male patients were more likely to achieve an ASAS40 response compared to female patients for all advanced therapies (odds ratio [OR] 1.88, 95% confidence interval [CI] 1.44-2.46) and for interleukin-17A (IL-17A) inhibitors (IL-17Ai) (OR 1.82) and tumor necrosis factor inhibitor (TNFi) (OR 2.42), and male patients had numerically higher values for IL-17A/Fi. Male patients were also more likely to achieve an ASDAS-LDA/ID (OR 2.19, 95% CI 1.47-3.26) across all advanced therapies and for IL-17Ai (OR 2.08) and TNFi (OR 2.42) individually.</p><p><strong>Conclusion: </strong>Female patients with axSpA are less likely to achieve efficacy outcomes on advanced therapies compared to their male counterparts, with similar differences across medication classes. Future studies should study the biologic (sex-related) and sociocultural (gender-related) mechanisms underlying these differences.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Community-Level Social Determinants of Health With Patient Race in Total Hip Arthroplasty Outcomes. 比较全髋关节置换术结果中社区水平的健康社会决定因素与患者种族。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-02-24 DOI: 10.1002/acr.25511
Bella Mehta, Yi Yiyuan, Diyu Pearce-Fisher, Kaylee Ho, Susan M Goodman, Michael L Parks, Fei Wang, Mark A Fontana, Said Ibrahim, Peter Cram, Rich Caruana
{"title":"Comparing Community-Level Social Determinants of Health With Patient Race in Total Hip Arthroplasty Outcomes.","authors":"Bella Mehta, Yi Yiyuan, Diyu Pearce-Fisher, Kaylee Ho, Susan M Goodman, Michael L Parks, Fei Wang, Mark A Fontana, Said Ibrahim, Peter Cram, Rich Caruana","doi":"10.1002/acr.25511","DOIUrl":"10.1002/acr.25511","url":null,"abstract":"<p><strong>Objective: </strong>Social determinants of health (SDOH), including race, have a key role in total hip arthroplasty (THA) disparities. We compared the collective influence of community-level SDOH to the influence of individual factors such as race, on THA outcomes.</p><p><strong>Methods: </strong>This retrospective cohort study of the Pennsylvania Health Care Cost Containment Council Database (2012-2018) included 105,336 patients undergoing unilateral primary elective THA. We extracted \"community\" factors from the US census by geocoding patient zip codes, including walkability index, household income, foreign-born individuals, English proficiency, computer and internet access, unpaid family workers, those lacking health insurances, and education. We trained an explainable boosting machine, a modern form of generalized additive models, to predict 90-day readmission, 90-day mortality, one-year revision, and length of stay (LOS). Mean absolute scores were aggregated to measure variable importance (ie, variables that contributed most to the prediction).</p><p><strong>Results: </strong>The rates of readmission, revision, and mortality were 8%, 1.5%, and 0.3%, respectively, with a median LOS of two days. Predictive performance measured by area under the receiver operating characteristic curve was 0.76 for mortality, 0.66 for readmission, and 0.57 for one-year revision. For LOS, the root mean squared error was 0.41 (R<sup>2</sup> = 0.2). The top three predictors of mortality were community, discharge location, and age; for readmission, they were discharge location, age, and comorbidities; for revision, they were community, discharge location, and comorbidities; and for LOS, they were discharge location, community, and comorbidities.</p><p><strong>Conclusion: </strong>Community-level SDOH were significantly more important than individual race in contributing to the prediction of THA outcomes, especially for 90-day mortality.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Outcomes of Children Born to Anti-Ro Antibody-Positive Mothers With and Without Rheumatic Disease. 抗ro抗体阳性母亲所生儿童的长期预后(有或无风湿病)
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-02-21 DOI: 10.1002/acr.25510
Talia Diaz, Ashely Danguecan, Daniela Dominguez, Andrea Knight, Carl A Laskin, Deborah M Levy, Edgar Jaeggi, Melissa Misztal, Piushkumar Mandhane, Theo Moraes, Lawrence Ng, Franklin Silverio, Earl D Silverman, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, Linda T Hiraki
{"title":"Long-Term Outcomes of Children Born to Anti-Ro Antibody-Positive Mothers With and Without Rheumatic Disease.","authors":"Talia Diaz, Ashely Danguecan, Daniela Dominguez, Andrea Knight, Carl A Laskin, Deborah M Levy, Edgar Jaeggi, Melissa Misztal, Piushkumar Mandhane, Theo Moraes, Lawrence Ng, Franklin Silverio, Earl D Silverman, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, Linda T Hiraki","doi":"10.1002/acr.25510","DOIUrl":"10.1002/acr.25510","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to estimate the prevalence of allergy, and/or neurodevelopmental and autoimmune diagnoses in children born to anti-Ro antibody-positive mothers.</p><p><strong>Methods: </strong>We conducted a cohort study of children born to anti-Ro antibody-positive mothers observed in the neonatal lupus erythematosus (NLE) clinic at The Hospital for Sick Children. Participants one year of age or older were invited to complete a health status questionnaire. Prevalence of allergic, neurodevelopmental, and autoimmune disease diagnoses was compared between the NLE cohort and the non-NLE population-based CHILD Cohort Study cohort. Descriptive statistics were used for demographics, NLE manifestations, and outcomes. Fisher's exact test compared the prevalence of diagnoses between subgroups. We tested the association between allergies and neurodevelopmental conditions and NLE with logistic regression models. A P-value < 0.006 was considered significant.</p><p><strong>Results: </strong>We included 321 participants born to anti-Ro antibody-positive mothers. The median age at survey completion was six years, 51% of participants were female, and 50% (n = 162) had NLE. We found no significant difference in any disease prevalence between children with and without NLE manifestations (P = 0.57) or between children born to mothers with and without a rheumatic disease (P = 0.11). Disease prevalence was similar between the NLE and CHILD cohorts (allergic disease 30% vs 22% [P= 0.25], neurodevelopmental conditions 5% vs 2% [P = 0.45], autoimmune disease 4% vs 2% [P = 0.68]).</p><p><strong>Conclusion: </strong>In a large multiethnic cohort of infants born to anti-Ro antibody-positive mothers, there was no significant difference in the prevalence of allergic, neurodevelopmental, or autoimmune diseases between children with and without NLE or between those born to anti-Ro antibody-positive mothers and a population-based non-NLE cohort.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Perceptions of Medication Therapy for Prevention of Posttraumatic Osteoarthritis Following Anterior Cruciate Ligament Injury: A Qualitative Content Analysis. 前十字韧带损伤后患者对预防创伤后骨关节炎药物疗法的看法:定性内容分析。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-02-12 DOI: 10.1002/acr.25508
Lily M Waddell, Donald P Mitchener, Kelly C Frier, Morgan H Jones, Elena Losina, Nick Bansback, Liana Fraenkel, Jason S Kim, Jeffrey N Katz, Faith Selzer, Adam Easterbrook
{"title":"Patient Perceptions of Medication Therapy for Prevention of Posttraumatic Osteoarthritis Following Anterior Cruciate Ligament Injury: A Qualitative Content Analysis.","authors":"Lily M Waddell, Donald P Mitchener, Kelly C Frier, Morgan H Jones, Elena Losina, Nick Bansback, Liana Fraenkel, Jason S Kim, Jeffrey N Katz, Faith Selzer, Adam Easterbrook","doi":"10.1002/acr.25508","DOIUrl":"10.1002/acr.25508","url":null,"abstract":"<p><strong>Objective: </strong>Posttraumatic osteoarthritis (PTOA) accounts for nearly 12% of osteoarthritis incidences and often occurs after anterior cruciate ligament (ACL) tear. Ensuring the uptake of preventive treatments for PTOA requires that investigators and clinicians understand factors influencing patients to seek preventive therapies. This qualitative, descriptive study aimed to assess individuals' willingness to adopt a medication therapy for PTOA prevention following ACL injury.</p><p><strong>Methods: </strong>We enrolled participants who had an ACL tear within two years of enrollment. Study individuals participated in a semistructured interview or focus group. We reviewed audio transcriptions for accuracy, and then organized the data inductively, beginning with open coding of audio transcriptions using NVivo 12. Finally, using a qualitative content analysis approach, we identified, revised, and constructed themes and subthemes.</p><p><strong>Results: </strong>Twenty-five individuals (mean age 25 years, 60% women) participated. Participants were an average of 10 months after injury (mean 310 days, 95% confidence interval [CI] 249-371) and reported a mean Knee Injury and Osteoarthritis Outcome Score pain score of 80.3 (95% CI 74.5-86.2). We identified three main themes related to general treatment for PTOA (eg, unwanted side effects), medication treatment for PTOA (eg, concern about pill size and dose frequency), and clinical trial attributes (eg, time commitment).</p><p><strong>Conclusion: </strong>Although participants expressed great interest in trying medication therapy for PTOA prevention, there was variability in which components of treatment mattered to them. Our results stress the importance of using qualitative approaches such as this one to inform the design of trials and treatments that real-world patients will pursue with enthusiasm.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Clinical Characteristics of Vasculitis in the Alaska Native and American Indian Peoples of Alaska. 阿拉斯加原住民和美洲印第安人血管炎的患病率和临床特征。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-02-12 DOI: 10.1002/acr.25506
Ben A Henderson, Vivek R Mehta, Peter Holck, Tammy L Choromanski, Amy Wilson, Flora Lee, Elizabeth D Ferucci
{"title":"Prevalence and Clinical Characteristics of Vasculitis in the Alaska Native and American Indian Peoples of Alaska.","authors":"Ben A Henderson, Vivek R Mehta, Peter Holck, Tammy L Choromanski, Amy Wilson, Flora Lee, Elizabeth D Ferucci","doi":"10.1002/acr.25506","DOIUrl":"10.1002/acr.25506","url":null,"abstract":"<p><strong>Objective: </strong>Our objective was to determine the prevalence and clinical characteristics of vasculitis in Alaska Native and American Indian (AN/AI) peoples of Alaska.</p><p><strong>Methods: </strong>We queried the electronic health records of participating tribal health organizations within the Alaska Tribal Health System (ATHS) to identify adults with diagnostic codes related to vasculitis. Medical record abstraction was performed for all adults with potential vasculitis to confirm fulfillment of inclusion criteria, subtype, and clinical characteristics. The denominator for prevalence was the 2019 ATHS user population ≥ 18 (except giant cell arteritis [GCA], defined for persons ≥ 50).</p><p><strong>Results: </strong>The age-adjusted prevalence per 1,000,000 AN/AI adults was 752 (95% confidence interval [CI] 581-959) for all vasculitis, with systemic vasculitis being the most common at 518 (95% CI 379-695). The most prevalent types of systemic vasculitis were antineutrophil cytoplasmic antibody-associated vasculitis (AAV) at 340 per million adults (95% CI 230-488) and GCA at 28 per 100,000 ≥ 50 (95% CI 12-56). The most prevalent subtype of AAV was granulomatosis with polyangiitis (GPA) at 244 per million adults (95% CI 148-380). AAV was diagnosed at a mean age of 54.2 years (SD 17), often with high markers of inflammation and renal involvement. GCA was diagnosed at a mean age of 69.6 years (SD 9.2).</p><p><strong>Conclusion: </strong>The prevalence of AAV (especially GPA) in AN/AI peoples is high. GCA prevalence is lower than White populations, but higher than many other populations. AN/AI peoples with AAV and GCA may present at younger ages with more severe disease than other populations.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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