Arthritis Care & Research最新文献

{"title":"Development of Patient-Reported Outcome Measures for Early Systemic Sclerosis Across Disease Subtypes.","authors":"George J Greene, Chelsea Rose Perschon, Emilie Jaeger, Alain Lescoat, David Cella, Dinesh Khanna","doi":"10.1002/acr.80190","DOIUrl":"https://doi.org/10.1002/acr.80190","url":null,"abstract":"<p><strong>Objective: </strong>Existing patient-reported outcome (PRO) measures for systemic sclerosis (SSc) have important limitations, including inadequate coverage of early disease and limited inclusion of diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) subtypes. This paper reports on the development of two PRO measures for early SSc in the Clinical Outcome Assessments for Systemic Sclerosis Clinical Trials (COAST) study, following regulatory guidance for clinical outcome assessments.</p><p><strong>Methods: </strong>Concept elicitation interviews were conducted with 42 individuals with dcSSc or lcSSc within 7 years of disease onset. Data were analyzed using a constant comparative approach. The concept prioritization scheme integrated symptom frequency, bother and health-related quality of life ratings, subgroup analyses, and clinical expert input. Priority concepts were mapped to items from item libraries (PROMIS®, FACIT) and SSc-specific measures, with new items developed during measure refinement. The item pool was reduced through expert consensus.</p><p><strong>Results: </strong>Across SSc subtypes, participants reported 52 symptoms and treatment side effects, spanning 16 domains. Raynaud's phenomenon was the most frequently reported symptom (81.0%), followed by swelling and pain (66.7% each); among the five most frequently reported symptoms, fatigue was rated most bothersome (mean=7.20, 0-10 scale). Participants also reported 57 physical function impacts across 8 domains, and 16 socioemotional concerns across 4 domains. Two candidate measures were constructed: COAST Scleroderma Symptom Questionnaire (33 items) and COAST Scleroderma Function and Mood Questionnaire (20 items).</p><p><strong>Conclusions: </strong>The COAST measures address important gaps in SSc measurement, with content validity established through systematic patient input. The measures were designed for use in clinical trials to assess treatment benefit in early SSc.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the roles of community pharmacies in supporting adults with osteoarthritis and other chronic (non-malignant) pain: a systematic review and narrative synthesis.","authors":"Adrian Chudyk, Joanna Simkins, Opeyemi Babatunde, Nicola O'Brien, Emma Healey, Simon White, Adam Todd, Angela Long, Elaine Nicholls, Colin Stanford, Christine Walker, Elizabeth Cottrell, Tania Cork, Christian Mallen, Krysia Dziedzic, Melanie Holden","doi":"10.1002/acr.80187","DOIUrl":"https://doi.org/10.1002/acr.80187","url":null,"abstract":"<p><strong>Objective: </strong>Synthesise the existing evidence exploring the roles of community pharmacies in supporting adults with osteoarthritis and other chronic (non-malignant) pain.</p><p><strong>Methods: </strong>Systematic review with narrative synthesis Data sources MEDLINE(OVID), MEDLINE, EMBASE(Ovid), CINAHL(EBSCO), HMIC(OVID), EMCARE(OVID), PsychINFO(OVID), AMED(All Allied and Complementary Medicine), Cochrane Database of Systematic Reviews-CDSR, Web of Science. Eligibility Any primary study referring to care delivered to adults with osteoarthritis or other chronic non-malignant pain by community pharmacies, regardless of care content or duration. Data extraction Relevant studies were screened and data extracted. Quality was assessed using the Critical Appraisal Skills Programme (CASP) or Appraisal Tool for Cross-Sectional Studies (AXIS) criteria.</p><p><strong>Results: </strong>13,294 papers were identified and 27 studies (28 papers) included, incorporating clinical trials, observational studies, qualitative studies and economic evaluation. Studies' quality was mixed. Five studies focused specifically on OA, and the others addressed chronic pain more broadly. Fourteen studies (52%) focused on the current role of community pharmacies in care delivery, nine (33%) (ten papers) on intervention effectiveness and fifteen (56%) on attitudes and beliefs. Findings revealed that current community pharmacy care for OA and other chronic pain predominantly focuses on pharmacological management, with evidence supporting an extended role in non-pharmacological and self-management. Attitudes and beliefs about this role were mixed, with barriers that could hinder its effectiveness and implementation.</p><p><strong>Conclusions: </strong>Existing evidence on the role of community pharmacies in managing chronic pain is diverse and of varying quality. This makes implementation across different healthcare systems difficult.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis: An External Validation in the BRASS Registry.","authors":"Misti L Paudel, Katherine Liao, Jon T Giles, Joan M Bathon, Hongshu Guan, Brendan M Everett, Leah M Santacroce, Nancy Shadick, Michael Weinblatt, Pamela Rist, Daniel H Solomon","doi":"10.1002/acr.80188","DOIUrl":"10.1002/acr.80188","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular (CV) disease occurs more frequently in rheumatoid arthritis (RA) than in the general population and is difficult to predict. The expanded risk score for RA (ERS-RA) has demonstrated good discrimination and calibration in prior studies, but additional external validation studies are needed to understand clinical utility.</p><p><strong>Methods: </strong>Data from a single center RA registry was integrated with electronic health records (EHR) and linked to Medicare/Medicaid administrative claims data. A less restrictive CV outcome was defined as an event identified in any of the three data sources (questionnaires/EHR/claims), and a more restrictive outcome included events in EHR and claims. External validation of the ERS-RA examined model discrimination and calibration.</p><p><strong>Results: </strong>The longitudinal RA registry has 1,332 participants aged 20-80 years without prior evidence of CVD, followed for a mean of 6.8 years. The mean age was 54 years and 84% were female. We observed 164 (12.3%) and 69 (5.2%) participants with a CV event with the less and more restrictive CV definitions, respectively. The mean ERS-RA predicted score was 7.1%, and 424 (32%) participants had a predictive score ≥7.5%. We observed c-statistics of 0.66 (95% CI 0.62-0.71; less restrictive) and 0.80 (95% CI 0.76-0.85; more restrictive). The ERS-RA also demonstrated good calibration, with better performance for the more restrictive CV event definition.</p><p><strong>Conclusions: </strong>The ERS-RA demonstrated good discrimination and calibration for CV risk prediction in an external validation RA cohort. It also highlights the importance of using multiple sources of data to find CV events in a non-CV registry.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Independent and Combined Effects of Mindfulness Meditation and Transcranial Direct Current Stimulation on Central Pain Processing in Adults with Knee Osteoarthritis.","authors":"Angela M Mickle, Jared J Tanner, Samuel S Wu, Yunfeng Dai, Selenia Rubio, Pavithra A Thomas, Daniel A Kusko, Steven D Pratscher, Song Lai, Kevin R Riggs, Hyochol Ahn, Adam J Woods, Roland Staud, Kimberly T Sibille, Robert E Sorge, Fadel Zeidan, Roger B Fillingim, Burel R Goodin","doi":"10.1002/acr.80189","DOIUrl":"https://doi.org/10.1002/acr.80189","url":null,"abstract":"<p><strong>Objective: </strong>The Pain Relief for OsteoArthritis through Combined Treatment (PROACT) was a proof-of-principle mechanistic randomized controlled trial to examine the effects of Breathing and Attention Training (BAT), and transcranial direct current stimulation (tDCS) on pain modulatory balance, pain-related brain function, and clinical pain in middle-aged to older adults with knee osteoarthritis (OA).</p><p><strong>Methods: </strong>Participants completed baseline health screening, clinical knee pain assessment, quantitative sensory testing (QST), and functional magnetic resonance imaging (fMRI) in response to mechanical pain evocation of the index knee. They were randomized to receive concurrent sham BAT/sham tDCS, active BAT/sham tDCS, sham BAT/active tDCS or active BAT/active tDCS. Participants completed 20-minute interventions for five consecutive days. After, participants repeated the clinical knee pain assessment, QST, and fMRI.</p><p><strong>Results: </strong>Adjusted analyses of 226 completers revealed no significant main effects of treatment on clinical pain or pain modulatory balance. However, average pain-evoked cerebral blood flow across pain-related regions of interest was significantly lower for active tDCS (-3.14 [CI:-4.83- -1.45]) vs. sham tDCS (-0.51 [CI:-2.19-1.17]), though this finding did not survive multiple correction. Pre-planned follow-up comparisons revealed that the active BAT/active tDCS group showed lower post-intervention pain-evoked cerebral blood flow than the sham BAT/sham tDCS group.</p><p><strong>Conclusions: </strong>The PROACT study found that mindfulness meditation in combination with tDCS may reduce pain-evoked cerebral blood flow in adults with knee OA. Future research is needed to determine if a longer duration of exposure to the combined active BAT/active tDCS treatment beneficially influences pain modulatory balance and clinical knee pain in this population.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial.","authors":"Ashley N Buck, J Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M Golightly, Richard F Loeser, Leigh F Callahan, Stephen P Messier, Brian Pietrosimone, Amanda E Nelson, James S Marron","doi":"10.1002/acr.80186","DOIUrl":"https://doi.org/10.1002/acr.80186","url":null,"abstract":"<p><strong>Objective: </strong>High body mass index (BMI≥27 kg/m²) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and characterize the shared and individual variation between vGRF profiles and clinical features in individuals with KOA and high BMI.</p><p><strong>Methods: </strong>Baseline gait and clinical data from the Intensive Diet and Exercise for Arthritis (IDEA) trial (n=431; 29% male; 65±6 years; 34±4 kg/m²) were analyzed. vGRF waveforms (n=2,394) were represented using three functional data analysis methods: time- and bodyweight-normalization; elastic shape analysis; and optimal transport (OT). Principal component analysis extracted the dominant vGRF modes of variation, and Data Integration Via Analysis of Subspaces (DIVAS) quantified shared and individual variation among vGRF profiles and 40 clinical features.</p><p><strong>Results: </strong>A sustained loading phenotype emerged across all vGRF representations (lesser early and late stance vGRF; greater midstance vGRF). DIVAS identified shared variation between sustained loading and higher BMI, elevated inflammatory biomarkers, greater pain, worse KL grade, and slower walking speed. OT identified a temporal loading phenotype that shared variation with female sex.</p><p><strong>Conclusions: </strong>Unsupervised ML identified a sustained loading biomechanical phenotype that shared variation with greater BMI, increased inflammation, worse radiographic severity, and slower walking speed. These data highlight the complex interplay among gait biomechanics and clinical KOA features in individuals with high BMI and may help to guide future work evaluating targeted gait retraining interventions.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Modification of Cigarette Smoking on the Relationship between Post-traumatic Stress Disorder, Other Mental Health Conditions and Rheumatoid Arthritis Risk: A Large Case-Control Study in U.S. Veterans.","authors":"Kelsey Coziahr, Harlan Sayles, Tate M Johnson, Joshua F Baker, Punyasha Roul, Grant W Cannon, Gary A Kunkel, Katherine D Wysham, Gail S Kerr, Amir A Razmjou, Isaac Smith, Jennifer L Barton, Maria I Danila, Jonathan S Richards, Bryant R England, Ted R Mikuls","doi":"10.1002/acr.80184","DOIUrl":"https://doi.org/10.1002/acr.80184","url":null,"abstract":"<p><strong>Objective: </strong>We examined associations of post-traumatic stress disorder (PTSD) and other mental health disorders (OMH) with rheumatoid arthritis (RA), accounting for effects of smoking.</p><p><strong>Methods: </strong>We conducted a matched case-control study, identifying incident RA cases and controls using national Veteran Health Administration data (2006-2019). PTSD/OMH exposures prior to RA diagnosis were identified using administrative/diagnostic codes. Conditional logistic regression examined associations of RA (vs. no-RA) with PTSD (±OMH) and OMH. Relative Excess Risk of Interaction was calculated between OMH/PTSD and smoking using standard multivariable logistic regression with standard errors clustered within match groups stratified by ever/never smoking. Analyses were repeated excluding individuals without a visit in the previous year.</p><p><strong>Results: </strong>A total of 357,361 Veterans (mean age 53 years, 87% male, 70% ever smoked) were studied. Both PTSD (19% vs. 13%) and OMH (31% vs. 26%) were more frequent in RA than controls. Multivariable analyses demonstrated associations of PTSD and OMH with RA with evidence of PTSD/OMH-smoking interactions; associations were stronger in never (aORs 1.54/1.40, respectively) vs. ever smokers (aORs 1.20/1.08). Excluding individuals without a healthcare visit, PTSD and OMH remained associated with seronegative RA in ever (aOR 1.17; 95% CI 1.09-1.26 and aOR 1.14; 95% CI 1.06-1.21) and never smokers (aOR 1.37; 95% CI 1.16-1.62 and aOR 1.27; 95% CI 1.10-1.47); similar associations of PTSD/OMH with seropositive RA were not observed.</p><p><strong>Conclusion: </strong>This study demonstrates that the relationships of PTSD (and OMH) with RA differ by smoking status. The strongest associations between PTSD/OMH and incident RA were among never smokers and in seronegative disease.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the prevalence and incidence of symptomatic hand OA in the Netherlands using primary care electronic health records.","authors":"Onur Kaya, Jacoline van den Driest, Laura Struik, Margreet Kloppenburg, Ruud Selles, Daniel Prieto Alhambra, Sita Bierma-Zeinstra, Dieuwke Schiphof","doi":"10.1002/acr.80183","DOIUrl":"https://doi.org/10.1002/acr.80183","url":null,"abstract":"<p><strong>Objective: </strong>This study estimated the incidence and prevalence of symptomatic hand osteoarthritis (OA) in the Dutch population using a validated algorithm that integrates free-text data from primary care electronic health records (EHRs).</p><p><strong>Methods: </strong>This retrospective cohort study used the Integrated Primary Care Information (IPCI) database, including EHRs from approximately 1.8 million Dutch patients aged ≥30 years between 2013 and 2023. As the International Classification of Primary Care 1 (ICPC-1) lacks a specific code for hand OA, cases were identified using an algorithm combining ICPC-1 codes for hand or wrist complaints and general OA with hand- and OA-related keywords from free-text notes. The algorithm was iteratively refined and validated through manual record review.</p><p><strong>Results: </strong>Manual review of 100 algorithm-identified records yielded a positive predictive value of 90%. Between 2013 and 2023, 152,900 unique patients with symptomatic hand OA were identified (mean age 68.4 years; 72% female). The age- and sex-standardized prevalence increased by 65% from 5.7% in 2013 to 9.4% in 2023, while incidence rose by 20% from 7.1 to 8.5 per 1,000 person-years. Both measures were consistently higher in women than in men, although the relative increase over time was greater in men.</p><p><strong>Conclusion: </strong>The prevalence and incidence of symptomatic hand OA increased substantially over the past decade in the Netherlands, with the highest absolute burden among women and older adults. These trends underline the rising burden of hand OA and call for greater recognition in healthcare policy, emphasizing the need for targeted management strategies and appropriate allocation of healthcare resources.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The range of Clinical Disease Activity (CDAI) Low Disease Activity (LDA) at baseline is associated with marked differences with time in patients with Rheumatoid Arthritis (RA).","authors":"Joel M Kremer, Kevin Kane, George Reed, Michael E Weinblatt","doi":"10.1002/acr.80177","DOIUrl":"https://doi.org/10.1002/acr.80177","url":null,"abstract":"<p><strong>Objective: </strong>We sought to determine if the range of clinical outcomes across rheumatoid arthritis patients exposed to biologic, or JAK disease-modifying antirheumatic drugs (b/tsDMARDs) remained consistent with time using the low clinical disease activity index (CDAI;range of 2.8-10) and remission (CDAI 0-2.8), along with patient-reported outcomes (PROs).</p><p><strong>Methods: </strong>We used baseline and prospective follow-up scores from the CorEvitas registry. All patients had measurement of the CDAI and validated PROs at baseline. We examined the evolution of these outcomes to determine if there were meaningful clinical differences with time based on the range of baseline CDAI scores.</p><p><strong>Results: </strong>6,856 patients with RA had baseline CDAI scores that were in CDAI Remission or LDA (0-10). 19.5% and 19.6% of patients whose baseline CDAI was between 2.8 and 6 (\"very low\" VLDA) vs. 31.2% and 31.0% of patients with a baseline CDAI >6-10 (\"High LDA; HLDA) exhibited a CDAI >10 at 1 and 2 years respectively (p<0.001for change in CDAI from baseline in the LDA subgroups). In both crude and adjusted models, patients with a CDAI between >6 and 10 were almost twice as likely to have a CDAI in the moderate disease activity range at 1 and 2 years compared with patients in the range of 2.8-6.</p><p><strong>Conclusion: </strong>The definition of CDAI so-called low disease activity is likely overly broad and includes patients in the upper range of LDA with an inferior prognosis. These differences in outcomes across the range of LDA should be incorporated into therapeutic recommendations that recognize these disparate outcomes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Ellen Romich, Alexis Ogdie, Nora Sandorfi","doi":"10.1002/acr.80180","DOIUrl":"10.1002/acr.80180","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Outcomes in Older Adults With Axial Spondyloarthritis and Concomitant Cancer.","authors":"Savannah Bowman, Mei Li, Xiudong Lei, Hui Zhao, Juan I Ruiz, Sharon H Giordano, Alexis R Ogdie, Maria E Suarez-Almazor","doi":"10.1002/acr.80178","DOIUrl":"10.1002/acr.80178","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer.</p><p><strong>Methods: </strong>We conducted a population-based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer-specific survival (CSS) in patients aged ≥66 years with in situ, localized, regional, or distant breast cancer (BC), prostate cancer (PCa), lung cancer (LC), or colorectal cancer (CRC), with and without axSpA, diagnosed January 2006 to December 2019, using International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3) site and histology codes. Patients with axSpA were matched to two to five controls without axSpA using cancer type, age at cancer diagnosis, sex, stage, and year of cancer diagnosis. We censored OS and CSS at five years and estimated rates using Kaplan-Meier analyses with log-rank tests. Stratified Cox proportional hazard regression models were performed for each cancer type, with CSS analyzed under the competing risks framework.</p><p><strong>Results: </strong>We included 6,095 patients (2,061 BC, 1,988 PCa, 1,229 LC, 817 CRC) with axSpA and 30,386 controls. Mean ages ranged from 74 (BC, PCa, LC) to 77 (CRC) years. No statistically significant differences in OS or CSS rates were observed between patients with BC, PCa, or LC and axSpA compared to controls. Patients with CRC and axSpA had higher five-year OS (adjusted hazard ratio [aHR] 0.78, 95% confidence interval [CI] 0.67-0.91, P = 0.002) and CSS (aHR 0.76, 95% CI 0.59-0.99, P = 0.04) compared to controls.</p><p><strong>Conclusion: </strong>Older patients with axSpA and BC, PCa, or LC had similar OS and CSS compared to controls. Among patients with CRC, axSpA was associated with higher OS and CSS.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}