Arthritis Care & Research最新文献

{"title":"Analysis of the longitudinal behavior of serum levels of Soluble Flt-1 and Placental Growth Factor in pregnant women with Systemic Lupus Erythematosus.","authors":"Nilson R de Jesús, Guilherme R de Jesús, Marcela I Lacerda, Flávia C Dos Santos, Jeane de S Nogueira, Luiz Cristóvão Porto, Evandro S F Coutinho, Evandro M Klumb","doi":"10.1002/acr.25536","DOIUrl":"https://doi.org/10.1002/acr.25536","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed longitudinal trajectories of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) and sFlt-1/PlGF ratio in a cohort of pregnant patients with systemic lupus erythematosus (SLE).</p><p><strong>Methods: </strong>Blood samples were collected (14-18, 24-26, 30-32, 34-36 and 38-40 weeks), stored at -80°C and evaluated for serum levels of sFlt-1, PlGF and sFlt1/PlGF ratios. Patients were classified as inactive SLE (SLEPDAI < 4), active disease (SLEPDAI > 4), or preeclampsia (PE). Medians and interquartile ranges (IQR) were calculated for each group, and linear models with random effects were used.</p><p><strong>Results: </strong>A total of 527 samples were obtained from 163 patients and all cases were subsequently classified as inactive disease [109 (66.9%)], active disease [33 (20.2%)], and inactive disease with PE [21 (12.9%)]. In exploratory analysis, patients with PE had higher mean serum levels of sFlt-1 and sFlt-1/PlGF ratios and lower PlGF levels than patients with inactive and active SLE (p=0.01 to p<0.001). Using linear models with random effects, there was no significant differences in mean serum levels of these angiogenic markers comparing inactive and active disease. Patients with PE showed a marked increase in sFlt-1 from the 24th week, constantly low PlGF levels from the 14th week and progressive increase of sFlt-1/ PlGF ratio during pregnancy. All these differences were statistically significant compared to the groups without PE.</p><p><strong>Conclusion: </strong>Pregnant SLE patients who developed PE had higher sFlt-1 levels and sFlt-1/PlGF ratios, and lower PlGF levels, and these last two changes were detected at the beginning of second trimester, before clinical manifestation. SLE activity did not interfere with longitudinal behavior of these angiogenic markers.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher levels of high-sensitivity CRP are associated with future development of Psoriatic Arthritis in Psoriasis: A prospective cohort study.","authors":"Lihi Eder, Xianwei Li, Vinod Chandran, Cheryl F Rosen, Richard J Cook, Dafna D Gladman","doi":"10.1002/acr.25539","DOIUrl":"https://doi.org/10.1002/acr.25539","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to assess whether high sensitivity c-reactive protein (hsCRP) could predict the development of psoriatic arthritis (PsA) in patients with psoriasis.</p><p><strong>Methods: </strong>We analyzed data from a prospective cohort of patients with psoriasis without PsA at enrollment. Participants were assessed annually by a rheumatologist for signs and symptoms of PsA. Information on patient demographics, psoriasis features, medications and musculoskeletal symptoms was collected. hsCRP levels were measured in serum samples collected at baseline using standard commercial assays. The association between hsCRP levels and risk of development of PsA was assessed using multivariable Cox proportional hazards model adjusted for age, sex, psoriasis severity and duration, nail lesions, body mass index (BMI), fatigue, and medication use.</p><p><strong>Results: </strong>A total of 589 patients with psoriasis followed from 2006 to 2019 were analyzed. 57 patients developed PsA during the follow up period. Mean level of hsCRP was 3.1±5.5 mg/L (hsCRP levels in incident PsA cases: 5.4±13.1). Significantly higher levels of hs-CRP at baseline were found in patients with arthralgia, obesity and in females. Higher hs-CRP levels were associated with future development of PsA in multivariable analysis (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.01, 1.07, p=0.007). Similar effect size was seen in males and females. No significant interaction was found between hsCRP and sex or BMI.</p><p><strong>Conclusion: </strong>Higher levels of systemic inflammation, as measured by hsCRP, are associated with future development of PsA.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Consequences of Rheumatoid Arthritis.","authors":"Stevie Barry, Emily Sheng, Joshua F Baker","doi":"10.1002/acr.25537","DOIUrl":"https://doi.org/10.1002/acr.25537","url":null,"abstract":"<p><p>Patients with rheumatoid arthritis (RA) may have metabolic disruption for multiple reasons that can contribute to adverse long-term outcomes. RA patients appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes, metabolic syndrome and hypertension. Systemic inflammation in RA can cause a 'lipid paradox' with reduced low-density lipoprotein being associated with higher rates of cardiovascular disease. In this review, we discuss changes to body composition, insulin resistance, lipids and blood pressure that often occur in patients with RA. We examine the current understanding of the mechanisms underlying disruptions in metabolic pathways in RA, their clinical effects, and how treatment affects these changes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoidable Hospitalizations in Persons with Rheumatoid Arthritis: A Population-Based Study Using Administrative Data.","authors":"Dani G Contreras, Claire E H Barber, J Antonio Aviña-Zubieta, Hude Quan, Seungwon Lee, James A King, Cheryl Barnabe","doi":"10.1002/acr.25541","DOIUrl":"https://doi.org/10.1002/acr.25541","url":null,"abstract":"<p><strong>Objective: </strong>We estimated incidence rates of avoidable hospitalizations by persons with rheumatoid arthritis (RA) relative to the general population.</p><p><strong>Methods: </strong>We identified individuals meeting a validated case definition for RA based on ICD-9-CM and ICD-10-CA codes in years 2002-2023. Four general population controls were matched to each RA case by age and sex. We identified hospitalizations for ambulatory care sensitive conditions (ACSCs) including grand mal seizures, chronic lower respiratory diseases, asthma, diabetes, heart failure and pulmonary edema, hypertension, and angina from 2007-2023 by established diagnostic codes. Incidence rate ratios 3 and 5 years from date of diagnosis were calculated using a multivariable regression model adjusting for age, sex, and location of residence. A Cox proportional hazards model was used to identify predictors of avoidable hospitalizations among RA patients.</p><p><strong>Results: </strong>Cases (n=83,811) had 1.12 times the risk of hospitalization for heart failure and pulmonary edema compared to those without RA (n=190,304) (IRR 1.12, 95% 1.01, 1.25). Significant predictors of ACSC hospitalizations for RA cases were increasing age, prolonged exposure to corticosteroids, and having comorbid conditions, especially if the comorbid condition is an ACSC (HR 10.1, 95% CI 7.8, 13.0).</p><p><strong>Conclusion: </strong>Persons with RA are at a higher risk of potentially avoidable hospitalizations 3 and 5 years after diagnosis compared to those without RA. Improved ambulatory care access and quality, inclusive of primary care and contributing role of subspecialty care, is proposed to prevent unnecessary hospitalizations and reduce burden on the acute care system.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Kidney Disease Is Associated with Increased Glucose Uptake-Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Gout Patients.","authors":"Shunya Kaneshita, Sho Fukui, Soheil Niku, Kwanghoon Lee, Ernest Belezzuoli, Robert Terkeltaub, Monica Guma","doi":"10.1002/acr.25540","DOIUrl":"https://doi.org/10.1002/acr.25540","url":null,"abstract":"<p><strong>Objective: </strong>We evaluate the ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG) PET standardized uptake value (SUV) by PET/CT in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in patients with and without gout. Additionally, we investigate whether glucose uptake in these tissues predicts the progression of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>We used ICD-10 codes from the University of California San Diego patient database to identify patients with gout and controls, forming a cohort of individuals who underwent PET/CT scans. The mean VAT and SAT SUVmax were measured using PET/CT and adjusted for potential confounders using inverse probability weighting analysis. We also employed multivariable linear regression to analyze changes in estimated glomerular filtration rate (eGFR) after PET/CT.</p><p><strong>Results: </strong>The study included 221 patients, with 120 diagnosed with gout. After the inverse probability of weighting adjustment, the mean VAT and SAT SUVmax were higher in patients with gout (mean VAT SUVmax: β=0.09, 95% CI=0.04 to 0.15; mean SAT SUVmax: β=0.06, 95% CI=0.01 to 0.12). Additionally, in gout patients with CKD stage 3 or higher, higher mean VAT and SAT SUVmax were associated with decreased eGFR in the five years following PET/CT (mean VAT SUVmax: β=-1.76, 95% CI=-3.50 to -0.01; mean SAT SUVmax: β=-2.97, 95% CI=-5.61 to -0.32) CONCLUSIONS: Elevated glucose uptake-associated metabolic activity in both VAT and SAT was observed in gout patients, which may contribute to CKD progression among patients with both gout and CKD.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of juvenile idiopathic arthritis associated uveitis in long-term disease remission: consensus based recommendations from MIWGUC.","authors":"Ivan Foeldvari, Ameenat Solebo, Harry Petrushkin, Sheila T Angeles-Han, Regitze Bangsgaard, Joan Calzada-Hernández, Tamas Constantin, Joke de Boer, Jesus Díaz-Cascajosa, Mia Glerup, Helene Ingels, Sebastian Kramer, Elisabetta Miserocchi, Ellen Nordal, Rotraud K Saurenmann, Gabriele Simonini, Joost F Swart, Jan Titz, Jordi Antón","doi":"10.1002/acr.25542","DOIUrl":"https://doi.org/10.1002/acr.25542","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to develop consensus-based recommendations for the monitoring of children with Juvenile Idiopathic Arthritis-associated uveitis (JIAU) in long-term remission, addressing the absence of international guidance on monitoring schedules for these children and young people.</p><p><strong>Methods: </strong>The Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC) convened experts from ten countries, including paediatric rheumatologists and ophthalmologists, alongside parents of affected children. A review of key longitudinal cohort studies informed a structured consensus process comprising discussion, recommendation development, and voting for adoption, with a consensus threshold of ≥80% needed for adoption. Recommendation development focused on three principal questions: stratification of the risk of poor outcomes, the natural history of JIAU post-remission, and the impact of delayed examination.</p><p><strong>Results: </strong>The group established several key recommendations including: a standard monitoring frequency of every 4 months for the first four years following medication cessation; ongoing assessments for patients with structural complications; and low-frequency monitoring every 6 months for those in stable, drug-free remission for over four years. There was unanimous agreement on these recommendations.</p><p><strong>Conclusions: </strong>These consensus-based recommendations provide a framework for monitoring children with JIAU in remission, enhancing the quality of care and optimizing resource use in eye health services. Ongoing research is essential to refine these guidelines as new evidence emerges regarding biomarkers and imaging techniques for disease recurrence.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Tuberculosis Screening Practices among New Users of Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs: A Call for Individualized Approaches.","authors":"Yuting Wang, Guiyao Jin, Fanzhang Meng, Chen Li, Wenlong Wang","doi":"10.1002/acr.25534","DOIUrl":"https://doi.org/10.1002/acr.25534","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comments on Tuberculosis Screening Practices among New Users of Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs: A Call for Individualized Approaches.","authors":"Eric T Roberts, Matthew Murrill, Gabriela Schmajuk, Jinoos Yazdany","doi":"10.1002/acr.25533","DOIUrl":"https://doi.org/10.1002/acr.25533","url":null,"abstract":"<p><p>We argue for universal latent tuberculosis infection (LTBI) screening prior to administration of biologic or targeted synthetic DMARDs (b/tsDMARDs). First, though evidence about the risk of LTBI reactivation for newer b/tsDMARDs is accumulating these studies are conducted in populations in which patients have been screened and treated for LTBI meaning the true risk of reactivation is difficult to assess with current studies. Second, while there are algorithms to predict the risk of active TB in non-endemic populations, these models use a broad category of immunosuppression and the result of LTBI screening limiting their utility for identifying who to screen. Critically, there are limits to screening based on demographic characteristics alone. Third, Center for Medicare and Medicaid Services has a stated goal of zero preventable harm in patients and the U.S. is experiencing increasing rates of TB since COVID. Immunosuppression is a strong risk factor suggesting screening should be universal.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review.","authors":"Natasha Cox, Saeed Farooq, Helen Twohig, Ian C Scott","doi":"10.1002/acr.25532","DOIUrl":"https://doi.org/10.1002/acr.25532","url":null,"abstract":"<p><p>As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Co-morbid depression is prevalent in adults with IA, affecting 15 to 39% of people. Whilst pain and depression are thought to be associated in IA, this concept is largely based on cross-sectional data. To better understand potential causality, longitudinal studies are required. This narrative review examines the relationship between pain and depression in patients with IA participating in observational longitudinal studies (spanning association strengths, direction of effect, and causal factors) and summarises the literature on causal pathways in general populations alongside guideline recommendations/systematic reviews on assessing pain/depression in IA. 14 longitudinal studies in IA largely indicate an association between pain and depression, albeit with a small-to-modest effect size, and a focus on pain intensity. This relationship appears to be bidirectional. Evidence on causal pathways is sparse in IA and limited in non-IA populations (with structural/function brain changes, altered sensory/pain thresholds, and sleep disturbance implicated) highlighting a need for further research. Whilst many patient-reported outcome measures exist to assess pain and depression in IA, evidence for their psychometric properties is often limited, and IA guidelines offer incomplete advice on pain/depression assessment. A simple approach of using a single-item pain intensity score (e.g. a numeric rating scale, which has strong clinimetric properties) in routine IA consultations, with screening for depression where relevant, appears appropriate. Further research is needed to understand how this could be achieved in different healthcare settings.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withholding acetaminophen for older adults with osteoarthritis? Not so fast.","authors":"Ali Ahmed, Gail Kerr, Hans J Moore, Janani Rangaswami, Charles Faselis, Richard M Allman","doi":"10.1002/acr.25538","DOIUrl":"https://doi.org/10.1002/acr.25538","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}