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Endogenous lipoid pneumonia in adult autoinflammatory disease. 成人自身炎症性疾病的内源性脂质性肺炎。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-05-14 DOI: 10.1002/acr.25570
Katrien Slabbynck, Jo Van Dorpe, Isabelle Peene, Karin Melsens, Cedric Bosteels, Rik Joos, Dirk Elewaut, Peggy Jacques, Hans Slabbynck, Gaëlle Varkas
{"title":"Endogenous lipoid pneumonia in adult autoinflammatory disease.","authors":"Katrien Slabbynck, Jo Van Dorpe, Isabelle Peene, Karin Melsens, Cedric Bosteels, Rik Joos, Dirk Elewaut, Peggy Jacques, Hans Slabbynck, Gaëlle Varkas","doi":"10.1002/acr.25570","DOIUrl":"https://doi.org/10.1002/acr.25570","url":null,"abstract":"<p><p>We describe one of the first cases of endogenous lipoid pneumonia (ELP) in an adult patient with the clinical picture of adult-onset Still disease (AOSD) and a low penetrance genetic background of tumour necrosis factor receptor-associated periodic syndrome (TRAPS). This case highlights the complex pathophysiology of lung involvement in autoinflammatory diseases, operating at the interface of the innate and adaptive immune system. This case presents a 53-year-old immunocompromised woman with treatment refractory autoinflammatory disease and history of macrophage activation syndrome (MAS), presenting to the emergency room with progressive dyspnea and fever. Upon evaluation, chest-CT showed diffuse lung disease. Extensive work-up, including bronchoscopy with bronchoalveolar lavage remained negative. Lung biopsy revealed an ELP with intra-alveolar accumulation of cholesterol crystals and foamy macrophages. In the years preceding the event, her autoinflammatory disease had shown to be refractory to both conventional systemic disease-modifying antirheumatic drugs, as well as biologic treatments including tocilizumab, anakinra and canakinumab. Because of new onset respiratory failure in the context of uncontrolled inflammation, after exclusion of infectious origin, pulse doses of systemic corticosteroids were administered before induction with cyclophosphamide, followed by maintenance therapy with tacrolimus. Upon treatment, our patient recovered, but retained severe interstitial lung disease. Only one case of ELP in adult autoinflammatory disease has been depicted in a patient diagnosed with AOSD, although the entity is more recognized in paediatric literature on systemic onset juvenile idiopathic arthritis (soJIA). METHODS: Literature review on ELP in autoinflammatory diseases was performed in PubMed, without language restrictions, and comprised publications from January 1953 until November 2024. The literature search addressed lung disease in AOSD, TRAPS and soJIA using the following MESH terms: endogenous lipoid pneumonia, pulmonary alveolar proteinosis, parenchymal lung disease, macrophage activation syndrome, adult-onset Still disease, tumour necrosis factor receptor-associated periodic syndrome and systemic onset juvenile idiopathic arthritis.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sleep disturbance and subsequent pain interference in patients with early rheumatoid arthritis. 早期类风湿关节炎患者睡眠障碍与随后疼痛干扰的关系
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-05-12 DOI: 10.1002/acr.25568
Burcu Aydemir, Orit Schieir, Marie-France Valois, Lutfiyya N Muhammad, Jing Song, Dorothy Dunlop, Rowland W Chang, Susan J Bartlett, Louis Bessette, Gilles Boire, Glen Hazlewood, Carol Hitchon, Janet Pope, Carter Thorne, Diane Tin, Vivian P Bykerk, Yvonne C Lee
{"title":"Association between sleep disturbance and subsequent pain interference in patients with early rheumatoid arthritis.","authors":"Burcu Aydemir, Orit Schieir, Marie-France Valois, Lutfiyya N Muhammad, Jing Song, Dorothy Dunlop, Rowland W Chang, Susan J Bartlett, Louis Bessette, Gilles Boire, Glen Hazlewood, Carol Hitchon, Janet Pope, Carter Thorne, Diane Tin, Vivian P Bykerk, Yvonne C Lee","doi":"10.1002/acr.25568","DOIUrl":"https://doi.org/10.1002/acr.25568","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated whether sleep disturbance can predict the extent to which pain interferes with daily functioning in patients with early rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>Data were from adults with early RA (joint symptoms ≤12 months) enrolled in the Canadian Early Arthritis Cohort between 2016-2023. Participants underwent standardized clinical assessments and completed PROMIS-29 (Patient-Reported Outcomes Measurement Information System) measures at 0, 6-, 12-, 18-, and 24-months to assess sleep disturbance (primary predictor) and pain interference (primary outcome). Linear mixed effects models were used to estimate crude and adjusted (age, sex, BMI, education, income, smoking status, comorbidities, disease activity, treatment, and depression) effects of sleep disturbance on pain interference over the 24-month study period. The analysis was lagged so that repeat measures of sleep disturbance at 0-, 6-, 12- and 18-months were evaluated as predictors of pain interference 6-months later at 6-,12-, 18- and 24-months follow up.</p><p><strong>Results: </strong>The analysis included 502 patients with early RA. At baseline, the sample was 68% female, 81% White, with a mean (SD) age of 56 (14) years, and disease duration of 5.4 (2.9) months. The unadjusted and adjusted linear mixed effects models revealed a significant association between sleep disturbance and subsequent pain interference scores, indicating that worse sleep 6-months prior was associated with greater pain interference at the following 6-month evaluation.</p><p><strong>Conclusion: </strong>These findings underscore the importance of addressing sleep disturbances as part of pain management strategies soon after RA diagnosis. Identifying and targeting problematic sleep disturbances early on may help improve long-term pain outcomes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Pain and Factors Associated with Pain in Patients with Idiopathic Inflammatory Myopathies. 特发性炎性肌病患者疼痛发生率及疼痛相关因素
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-05-12 DOI: 10.1002/acr.25571
Didem Saygin, Anne-Marie Malfait, Ethan M Ritz, Kristin Wipfler, Kaleb Michaud, Yvonne C Lee
{"title":"Prevalence of Pain and Factors Associated with Pain in Patients with Idiopathic Inflammatory Myopathies.","authors":"Didem Saygin, Anne-Marie Malfait, Ethan M Ritz, Kristin Wipfler, Kaleb Michaud, Yvonne C Lee","doi":"10.1002/acr.25571","DOIUrl":"https://doi.org/10.1002/acr.25571","url":null,"abstract":"<p><strong>Objective: </strong>Pain is an often overlooked and understudied symptom in inflammatory myopathies (IIM). In this study, our goal is to examine the prevalence of pain and factors associated with pain in adults with IIM.</p><p><strong>Methods: </strong>FORWARD is a US-based prospective registry of adults with rheumatic diseases recruited from rheumatology clinics. Participants had physician diagnosis of IIM and completed questionnaires on pain, fatigue, physical function, disease activity, and sociodemographic variables. Pain prevalence was examined in demographic and disease subgroups. Regression models were performed to identify any factors associated with higher levels of pain (>3 pain on visual analog scale). The relationship between pain and outcome variables was examined through Pearson correlations, t-test and chi-square test.</p><p><strong>Results: </strong>A total of 189 IIM patients (age 55 years ± 14, 78% women) from FORWARD Databank were included in the study. Approximately 86% reported pain with an average of 3.5 on a 10-point visual analog scale. One in four patients were on opioids. Approximately 62-63% reported joint and muscle pain, respectively. Pain prevalence was similar across subgroups of disease subtype, sex, race, smoking, and obesity. Patient global disease activity was significantly associated with higher pain levels in multivariable models. Pain was significantly associated with worse physical function, fatigue, quality of life and health satisfaction.</p><p><strong>Conclusion: </strong>Pain is prevalent and associated with poor outcomes in patients with IIM. Pain is closely linked with patient global disease activity. Results highlight the critical need to better understand the pain experienced by these patients to best address their needs.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avoidant Restrictive Food Intake Disorder Symptoms in Adults with Systemic Sclerosis: A Nationwide Study in Spain. 成人系统性硬化症患者的回避性限制性食物摄入障碍症状:西班牙的一项全国性研究
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-05-12 DOI: 10.1002/acr.25569
Luis G Alcala-Gonzalez, Helen Burton-Murray, Micaela Atkins, Alfredo Guillen-Del-Castillo, Carolina Malagelada, Michael Hughes, Zsuzsanna H McMahan, Carmen P Simeón-Aznar
{"title":"Avoidant Restrictive Food Intake Disorder Symptoms in Adults with Systemic Sclerosis: A Nationwide Study in Spain.","authors":"Luis G Alcala-Gonzalez, Helen Burton-Murray, Micaela Atkins, Alfredo Guillen-Del-Castillo, Carolina Malagelada, Michael Hughes, Zsuzsanna H McMahan, Carmen P Simeón-Aznar","doi":"10.1002/acr.25569","DOIUrl":"https://doi.org/10.1002/acr.25569","url":null,"abstract":"<p><strong>Objective: </strong>Patients with systemic sclerosis (SSc) may restrict food intake to manage their symptoms (particularly gastrointestinal). Whether some patients may develop nutritional and/or quality of life impairments indicative of an eating disorder, avoidant/restrictive food intake disorder (ARFID), is unknown. We aimed to: (1)identify the prevalence and characteristics of ARFID symptoms in patients with SSc and, (2)explore the relationship between ARFID symptoms, GI symptom burden and health-related quality of life METHODS: Cross-sectional internet survey nationwide in Spain, patients with SSc completed the Spanish Nine-Item ARFID Screen and assessments of gastrointestinal symptom burden (UCLA SCTC GIT 2.0) and health-related quality of life (SF-12).</p><p><strong>Results: </strong>Of 200 patients with SSc, 99 (49.5%) screened positive for ARFID. Just over half of those who screened positive for ARFID (n=53) screened positive based on having a fear of aversive consequences around eating (e.g., GI discomfort). A positive ARFID screen was associated with a greater frequency of self-reported enteral nutrition, weight loss, and self-initiated (vs provider-monitored) diet restrictions. ARFID symptoms were moderately associated with worse GI symptom severity by UCLA GIT 2.0 total score (r=0.408, p<0.001), but not for the reflux subscale (r=0.058, p=0.420) and constipation subscale (r=0.090, p=0.209). worse health-related quality of life, in all domains and both the physical and mental components of by SF-12 (all p<0.05).</p><p><strong>Conclusions: </strong>ARFID symptoms were relatively common in patients with SSc. Future research is needed to identify when a positive screen for ARFID reflects an adaptive response to disease or versus pathological restriction indicative of ARFID warranting behavioral treatment.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carpal Tunnel Syndrome (CTS) is an Early Underrecognized Feature of Rheumatoid Arthritis (RA): A Population-Based Study of CTS Occurrence Before and After RA Incidence. 腕管综合征(Carpal Tunnel Syndrome, CTS)是类风湿关节炎(RA)的早期未被充分认识的特征:一项基于人群的RA发病前后CTS发生的研究
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-05-05 DOI: 10.1002/acr.25566
Roslin Jose George, Noah Frechette, Manuela Oviedo, Iqra Javed, Sara J Achenbach, Ryan J Lennon, Bradley Alex Kimbrough, Elena K Joerns, Vanessa L Kronzer, Anne Gingery, John M Davis, Cynthia S Crowson, Elena Myasoedova
{"title":"Carpal Tunnel Syndrome (CTS) is an Early Underrecognized Feature of Rheumatoid Arthritis (RA): A Population-Based Study of CTS Occurrence Before and After RA Incidence.","authors":"Roslin Jose George, Noah Frechette, Manuela Oviedo, Iqra Javed, Sara J Achenbach, Ryan J Lennon, Bradley Alex Kimbrough, Elena K Joerns, Vanessa L Kronzer, Anne Gingery, John M Davis, Cynthia S Crowson, Elena Myasoedova","doi":"10.1002/acr.25566","DOIUrl":"https://doi.org/10.1002/acr.25566","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to assess the occurrence of Carpal Tunnel Syndrome (CTS) before and after rheumatoid arthritis (RA) incidence and by serological status.</p><p><strong>Methods: </strong>This population-based study included residents of a geographically defined area meeting the 1987 ACR classification criteria for RA in 1980-2019, matched 1:1 with non-RA individuals. At least two diagnosis codes ≥ 30 days apart were used to identify CTS. Cumulative incidence of CTS adjusting for competing risk of death was assessed. Logistic regression and Cox proportional hazard models were used, adjusting for age, sex, calendar year, smoking, obesity, diabetes, and hypothyroidism.</p><p><strong>Results: </strong>We included 1335 patients with RA and 1331 individuals without RA. The overall prevalence of CTS prior to or on RA incidence/index was 179 (13%) and 85 (6%), respectively: OR 2.23; 95% CI 1.69-2.94. Most prior incidence of CTS occurred ≥ 2 years prior to index date (112 and 75 events, respectively). Following RA incidence/index, individuals with RA (versus without RA) had ~80%-higher risk of CTS (HR 1.78; 95%CI 1.38-2.30). The risk estimates of CTS in patients with seronegative (vs seropositive) RA were OR 1.33; 95%CI 0.96-1.84 prior to RA incidence and HR: 1.37, 95%CI 0.99-1.88 after RA incidence. In RA, obesity (HR 1.42, 95% CI 1.02-1.99) and seronegative CCP-antibody status (HR 1.79, 95% CI 1.07-2.99), but not other risk factors, were associated with increased CTS risk.</p><p><strong>Conclusion: </strong>We found an over 2-fold increase in risk of CTS in years preceding RA, and 1.8-fold increased risk of incident CTS following RA onset.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of Lung Ultrasound Interpretation Criteria for Interstitial Lung Disease in Systemic Sclerosis and Inflammatory Myopathy. 系统性硬化症和炎性肌病肺间质性肺病超声诊断标准的验证。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-05-04 DOI: 10.1002/acr.25567
Robert M Fairchild, Diane A Mar, Mariani D Deluna, Melody Chung, Srijana Davuluri, Yumeko Kawano, Henry Guo, Matthew C Baker, David Fiorentino, Lorinda Chung
{"title":"Validation of Lung Ultrasound Interpretation Criteria for Interstitial Lung Disease in Systemic Sclerosis and Inflammatory Myopathy.","authors":"Robert M Fairchild, Diane A Mar, Mariani D Deluna, Melody Chung, Srijana Davuluri, Yumeko Kawano, Henry Guo, Matthew C Baker, David Fiorentino, Lorinda Chung","doi":"10.1002/acr.25567","DOIUrl":"https://doi.org/10.1002/acr.25567","url":null,"abstract":"<p><strong>Objectives: </strong>Interstitial lung disease (ILD) has a high prevalence in systemic sclerosis (SSc) and inflammatory myopathy (IM) and early identification reduces associated morbidity and mortality. We previously developed LUS interpretation criteria for ILD detection in 2020 (LUS-ILD-20) showing excellent sensitivity and specificity in SSc-ILD; herein, we sought to validate revised LUS-ILD-24 in a large SSc and IM cohort.</p><p><strong>Methods: </strong>Patients meeting criteria for SSc and IM, with planned CT chest imaging underwent LUS imaging interpreted with LUS-ILD-24 by 3 blinded readers. The sensitivity and specificity for LUS-ILD detection as noted on CT was analyzed for SSc, IM, and possible incident ILD subgroups. Inter- and intra-rater agreement was calculated. Correlations between LUS-ILD-24 severity, CT imaging severity, and pulmonary function tests (PFTs) were assessed.</p><p><strong>Results: </strong>Ninety-five patients were included in the analyses. Sensitivity and specificity for ILD detection ranged from 92.4% to 95.5% and 82.8% to 86.2% across readers with similar accuracy in all subgroups. Inter- and intra-reader reliability showed near perfect agreement (κ = 0.92 and κ = 0.90 to 1, respectively). LUS severity correlated with CT imaging severity and inversely correlated with diffusion capacity for carbon monoxide (%DLCO) and forced vital capacity.</p><p><strong>Conclusion: </strong>We validated our revised LUS-ILD-24 in SSc and IM cohorts and found excellent sensitivity, specificity, and reliability for detection of ILD identified on CT. LUS severity correlated with CT and PFT markers of ILD severity. Validation of the revised LUS-ILD-24 supports the implementation of LUS in screening algorithms for ILD in SSc and IM patients.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Core Set of Responsive and Discriminatory Measures for Use in Pragmatic Trials of Youth with Axial Juvenile Spondyloarthritis. 核心反应性和歧视性措施用于青少年轴型幼年脊柱炎的实用试验。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-05-02 DOI: 10.1002/acr.25565
Timothy G Brandon, Rui Xiao, Daniel J Lovell, Edward Oberle, Matthew L Stoll, Nancy A Chauvin, Michael L Francavilla, Walter P Maksymowych, Pamela F Weiss
{"title":"Core Set of Responsive and Discriminatory Measures for Use in Pragmatic Trials of Youth with Axial Juvenile Spondyloarthritis.","authors":"Timothy G Brandon, Rui Xiao, Daniel J Lovell, Edward Oberle, Matthew L Stoll, Nancy A Chauvin, Michael L Francavilla, Walter P Maksymowych, Pamela F Weiss","doi":"10.1002/acr.25565","DOIUrl":"https://doi.org/10.1002/acr.25565","url":null,"abstract":"<p><strong>Objective: </strong>To determine a core set of measures for youth with spondyloarthritis and axial disease (axJSpA), using the juvenile arthritis working group Outcome Measures in Rheumatology framework.</p><p><strong>Methods: </strong>This was a prospective multicenter study of youth with axJSpA. Participants (8-18 years) all initiated tumor necrosis factor inhibitor (TNFi) therapy and completed questionnaires, exam, and MRI at baseline and 12 weeks. Responsiveness and discrimination were assessed using standardized response mean (SRM) and standardized mean difference (SMD). For highly correlated (r>|0.80|) items within domains, larger SRM and SMD were prioritized, and minimal clinically important improvement was determined for each.</p><p><strong>Results: </strong>Of the evaluable cohort (N=57), 68.4% were male, median age was 15.3 years. 70.2% of youth treated with TNFi had clinical response (change ≥2 in patient global assessment). Although 58% had continued MRI inflammation, 77% of those patients reported moderate clinical improvement. The final axJSpA core set contained: Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference (SRM: 0.77, SMD: 0.5), the sacroiliac joint inflammation score (SIS; SRM: 1.02, SMD: 0.52), PROMIS mobility (SRM: 0.83, SMD: 0.75), and patient global well-being (SRM: 0.88, SMD: n/a). All overall/composite disease activity measures tested, except the physician global, had high SRM and SMD. Subgroup analysis demonstrated differences by biological sex and overweight status. Improvement in the MRI inflammation score was greater in males. Improvement in the PROMIS pain interference and mobility measures were greater in those with normal BMI.</p><p><strong>Conclusions: </strong>A set of measures was developed for youth with axJSpA.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moderators and mediators of pain and function outcomes in a new service delivery model for management of knee osteoarthritis in primary care (PARTNER): Secondary exploratory analysis of a randomized controlled trial. 初级保健中膝关节骨关节炎管理的新服务交付模式(PARTNER)疼痛和功能结局的调节因子和中介因子:一项随机对照试验的二次探索性分析。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-04-29 DOI: 10.1002/acr.25564
Abdolhay Farivar, Jocelyn L Bowden, Kim L Bennell, Andrew M Briggs, Stephen J Bunker, Rana S Hinman, Thorlene Egerton, Simon D French, Marie Pirotta, Karen Schuck, Venkatesha Venkatesha, Nicholas A Zwar, David J Hunter
{"title":"Moderators and mediators of pain and function outcomes in a new service delivery model for management of knee osteoarthritis in primary care (PARTNER): Secondary exploratory analysis of a randomized controlled trial.","authors":"Abdolhay Farivar, Jocelyn L Bowden, Kim L Bennell, Andrew M Briggs, Stephen J Bunker, Rana S Hinman, Thorlene Egerton, Simon D French, Marie Pirotta, Karen Schuck, Venkatesha Venkatesha, Nicholas A Zwar, David J Hunter","doi":"10.1002/acr.25564","DOIUrl":"https://doi.org/10.1002/acr.25564","url":null,"abstract":"<p><strong>Objective: </strong>Explore moderators and mediators influenced changes in pain and function in people with knee osteoarthritis (OA) receiving a new model of primary care service delivery (PARTNER), at 12 months (ACTRN12617001595303).</p><p><strong>Methods: </strong>Secondary analyses of a cluster randomized controlled trial comparing PARTNER to usual general practitioner-delivered care (n=217, 112 PARTNER, 105 usual care) on knee pain/function. Pain was measured using a Numerical Rating Scale (range 0-10, higher= worse) and the function measured using the function subscale of the Knee Injury and Osteoarthritis Outcome Score (range 0-100, higher= better). Baseline variables selected as potential moderators included age, sex, body mass index, pain duration, residential state, living arrangements, education, employment status, back pain and other joint issues. Mediation variables included physical activity, fear of movement, pain catastrophizing, OA self-management, self-efficacy, sleep, fatigue, quality-of-life, depression, and satisfaction.</p><p><strong>Results: </strong>For change in pain, no moderators influenced the intervention effect. However, age moderated change in function, with intervention participants <50 years demonstrating greater functional improvement than older counterparts, compared to the control group (50-69 years: coefficient -32.88 [95% confidence interval (95% CI): -45.02, -20.74], >=70 years: coefficient -24.28 [95%CI: -36.53, -12.02]). Mediation analysis revealed significant indirect effects of overall, treatment-related, and symptom-related satisfaction on mean change in pain (-0.10, -0.06, and -0.08, respectively) and function (0.09, 0.05, and 0.07, respectively).</p><p><strong>Conclusion: </strong>Younger PARTNER participants showed greater functional improvement compared to older age groups (moderating effect). Additionally, indirect mediation effects suggest increased satisfaction across the three satisfaction domains led to reduced knee pain and enhanced function.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 27-Year-Old Woman with Acute Encephalopathy and Painful, Bilateral Cervical Lymphadenopathy. 一个27岁的女性急性脑病和疼痛,双侧颈淋巴肿大。
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-04-28 DOI: 10.1002/acr.25563
Aakash V Patel, Eli Miloslavsky, Haatem Reda, James R Stone, Marcy B Bolster
{"title":"A 27-Year-Old Woman with Acute Encephalopathy and Painful, Bilateral Cervical Lymphadenopathy.","authors":"Aakash V Patel, Eli Miloslavsky, Haatem Reda, James R Stone, Marcy B Bolster","doi":"10.1002/acr.25563","DOIUrl":"https://doi.org/10.1002/acr.25563","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: "Acetaminophen Safety in Older Adults with OA: Key considerations." 回复:“对乙酰氨基酚在老年OA患者中的安全性:关键考虑因素。”
IF 3.7 2区 医学
Arthritis Care & Research Pub Date : 2025-04-28 DOI: 10.1002/acr.25560
Jaspreet Kaur, Georgina Nakafero, Abhishek Abhishek, Christian Mallen, Michael Doherty, Weiya Zhang
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