Arthritis Care & Research最新文献

{"title":"Correction to \"Effects of Social Vulnerability and Environmental Burden on Care Fragmentation and Social Needs Among Individuals with Rheumatic Conditions\".","authors":"","doi":"10.1002/acr.25585","DOIUrl":"https://doi.org/10.1002/acr.25585","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time trends and predictors of gout remission over six years.","authors":"Adwoa Dansoa Tabi-Amponsah, Sarah Stewart, Greg Gamble, Lisa K Stamp, William J Taylor, Nicola Dalbeth","doi":"10.1002/acr.25584","DOIUrl":"https://doi.org/10.1002/acr.25584","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to describe the trends in remission rates over six years of follow-up among people with gout taking urate-lowering therapy (ULT), and to identify variables that predict remission.</p><p><strong>Methods: </strong>A post hoc analysis was conducted using data from the Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES) trial, which enrolled people with gout and cardiovascular disease randomised to febuxostat or allopurinol. Gout remission over six years of follow-up was measured in participants with at least one year of follow-up data using the simplified gout remission definition, requiring the fulfilment of three domains, a) no gout flares during the past year, b) at least two serum urate measurements <0.36mmol/l during the past year, and c) no tophus. Logistic regression was used to identify baseline predictors of remission.</p><p><strong>Results: </strong>Achievement of remission increased from 37.4% of participants (1593/4259) at year 1 to 63.1% (322/510) at year 6. Across the six years, 59.4% of participants achieved remission at least once. More participants on febuxostat achieved remission during the first two years, primarily due to a higher number achieving the serum urate remission domain. In multivariable analysis, baseline age, race, greater disease severity, presence of comorbidities, and febuxostat treatment were variables significantly associated with remission.</p><p><strong>Conclusion: </strong>On ULT, fulfilment of remission increases over time and remission can be achieved in the majority of patients. Baseline predictors, including demographics, comorbidities and disease severity, may be useful to identify people with gout who need more proactive management to achieve remission.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid arthritis and risk of thyroid cancer: A nationwide cohort study.","authors":"Mi Hee Cho, Jinhyung Jung, Tae Hyuk Kim, Kyungdo Han, Dagyeong Lee, Keun Hye Jeon, In Young Cho, Dong Wook Shin","doi":"10.1002/acr.25582","DOIUrl":"https://doi.org/10.1002/acr.25582","url":null,"abstract":"<p><strong>Objective: </strong>Despite extensive cancer-related research in patients with rheumatoid arthritis (RA), there remains a paucity of studies on thyroid cancer in RA patients. We investigated risk of thyroid cancer in RA patients using updated definitions to identify RA patients and incident cases of thyroid cancer with consideration of RA serologic status.</p><p><strong>Methods: </strong>Using a nationwide database, we identified 40,895 patients with newly diagnosed RA between 2010 and 2017, and matched them by sex and age at a 1:5 ratio to a control population of 204,475 non-RA individuals. The association of thyroid cancer and RA with consideration of serostatus was investigated using Cox regression analyses. Stratified analysis by sex and age were conducted using the same Cox modeling.</p><p><strong>Results: </strong>During 5.5 years of follow-up, compared to the matched control group, the adjusted hazard ratio (aHR) of thyroid cancer in overall RA patients was 0.98 (95% confidence interval [CI] 0.85-1.13). Compared to the seronegative RA patients, seropositive RA patients did not show a significantly different risk of thyroid cancer (aHR 1.03, 95% CI 0.78-1.36). Stratified analyses by age or sex showed no statistical interaction.</p><p><strong>Conclusion: </strong>Patients with newly diagnosed RA did not show a different risk of thyroid cancer compared to a matched control group. The risk of thyroid cancer incidence was not affected by serologic status of RA, sex, or age.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-steroidal anti-inflammatory drugs reduce sacroiliac joint inflammation, as seen on MRI, in axial spondyloarthritis.","authors":"Gareth T Jones, Alexander N Bennett, Raj Sengupta, Pedro M Machado, Helena Marzo-Ortega, Lorna Aucott, Margaret A Hall-Craggs, Timothy Jp Bray, Alan Bainbridge, Ruaridh M Gollifer, Gary J Macfarlane","doi":"10.1002/acr.25581","DOIUrl":"https://doi.org/10.1002/acr.25581","url":null,"abstract":"<p><strong>Objective: </strong>Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, is no consistent guidance whether patients should temporarily stop Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) prior to MRI.</p><p><strong>Aim: </strong>to determine whether NSAIDs lead to an underestimation of active sacroiliitis, as observed using MRI.</p><p><strong>Methods: </strong>Adults with axSpA were recruited from rheumatology clinics and undertook NSAID washout for 1-2wks prior to a sacroiliac joint MRI. Images were read by two independent readers, adjudicated by a third if required. Those who scored positive for active sacroiliitis, as per internationally recognised criteria, underwent a second scan 6wks after recommencing daily NSAIDs. We determined the proportion of participants who scanned negative on NSAIDs, having previously scanned positive when NSAID-free. Images were also scored using semi-quantitative methods comprising lesion size and intensity, and a sub-set of participants underwent quantitative MRI (qMRI) to provide an objective evaluation of any inflammatory changes.</p><p><strong>Results: </strong>From 34 centres across the UK 311 participants (median age 42yrs; 62% male) were recruited; 286 (92%) completed the NSAID washout and underwent the first MRI. From 146 participants with active sacroiliitis, follow-up scans (on NSAIDs) were obtained from 124 (85%), at which point 25 scanned negative (20.2%; 95%CI: 13.5 to 28.3%). Semi-quantitative and qMRI methods supported these findings.</p><p><strong>Conclusion: </strong>One-fifth of patients show full resolution of active sacroiliitis lesions when NSAIDs were present. In clinical practice, if patients with axSpA are willing to attempt a 1-2 week NSAID washout prior to MRI, this should be considered.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the Impact of Air Quality Index on Rheumatoid Arthritis Disease Activity.","authors":"Ahmad Alsaber, Adeeba Al-Herz, Maryam Al-Mazedi, Iyad Abu Doush, Afsah Abdullah, Dhary Alkandary, Ahmad T Al-Sultan, Parul Setiya, Jiazhu Pan","doi":"10.1002/acr.25583","DOIUrl":"https://doi.org/10.1002/acr.25583","url":null,"abstract":"<p><strong>Aim and objective: </strong>This study explored the relationship between air pollution and rheumatoid arthritis (RA), focusing on how specific air quality components affect RA disease activity as measured by Disease Activity Score 28 (DAS28).</p><p><strong>Methods: </strong>The research involved Data were obtained from six air-monitoring stations across Kuwait, and RA patient information was obtained from the Kuwait Registry for Rheumatic Diseases (KRRD). This study analyzed the impact of pollutants such as sulfur dioxide (SO₂), nitrogen dioxide (NO₂), ozone (O₃), particulate matter (PM₁₀), nitrogen oxide (NO), and carbon monoxide (CO) on the DAS28.</p><p><strong>Results: </strong>The results highlighted that NO₂ and O₃ were the most significant air quality index (AQI) components influencing DAS28 scores. NO₂ had a lag effect of two months (p < 0.01, effect score = 0.43), while O₃ exhibited a lag effect of three months (p < 0.05, effect score = 0.31), both correlating with increased RA disease activity. The study utilized a Vector Error Correction Model (VECM) and co-integration analysis to examine short- and long-term associations between predicted and actual DAS28 scores was corrected over the following year, indicating that strong long-term cointegration with the Error Correction (EC1) term was negative and significant (-0.54, p < 0.001).</p><p><strong>Conclusions: </strong>These findings emphasize the importance of air quality management in mitigating the impact of environmental factors on RA, suggesting that exposure to elevated levels of NO₂ and O₃ beyond regulatory standards could exacerbate RA symptoms. This study provides a foundation for future public health interventions aimed at improving disease prognosis in patients with RA by addressing environmental factors, such as air pollution.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Sensitivity and Chronic Pain as a Link Between Analgesic Use and Cardiovascular/Gastrointestinal Risk: comment on the article by Kaur et al.","authors":"Ryuichi Minoda Sada","doi":"10.1002/acr.25577","DOIUrl":"https://doi.org/10.1002/acr.25577","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of administrative pharmacy dispensing with self-reported use of oral prednisone in US Veterans with rheumatoid arthritis.","authors":"Beth I Wallace, Bryant R England, Joshua F Baker, Michael D George, Brian C Sauer, Jorge Rojas, Punyasha Roul, Katherine D Wysham, Hannah Brubeck, Isaac Smith, Liron Caplan, Paul A Monach, Gail S Kerr, Gary Kunkel, Tawnie Braaten, Ted R Mikuls, Grant W Cannon","doi":"10.1002/acr.25580","DOIUrl":"https://doi.org/10.1002/acr.25580","url":null,"abstract":"<p><strong>Objective: </strong>Administrative claims are used to evaluate oral glucocorticoid use in rheumatoid arthritis (RA), despite limited evidence to support accuracy. We aimed to evaluate the performance of claims-based algorithms for glucocorticoid use compared to self-report in an RA population.</p><p><strong>Methods: </strong>Participants with RA enrolled at 7 VA Rheumatoid Arthritis (VARA) registry sites were asked six questions as part of clinical care assessing current prednisone use and dose, recent use, \"stockpiling\", and receiving prednisone outside VA. Algorithms using VA prescription claims operationalized current use (active prescription on date of self-report assessment), current dose (that prescription's mean dose), and recent use (active course overlapping the prior 30 or 90 days). We assessed performance characteristics and agreement, benchmarked on self-report.</p><p><strong>Results: </strong>Of 284 participants, 13% reported current prednisone use and 20% reported 90-day use. Sensitivity, specificity, PPV and NPV were 0.70, 0.98, 0.84, and 0.96 for current use, and 0.71, 0.92, 0.72, and 0.92 for 90-day use. Cohen's kappa was 0.68 for current use and 0.63 for 90-day use. Among participants reporting ≤5mg/day, agreement for dose was high (weighted kappa 0.67). One in 4 participants reported a stockpile, and 1 in 4 reported receiving prednisone from a non-VA provider.</p><p><strong>Conclusions: </strong>Algorithms derived from VA claims detecting prednisone prescriptions have high validity compared to patient self-report. The modest sensitivity of these algorithms may reflect stockpiling and non-VA prescriptions. These findings form a basis for contextualizing real-world studies of glucocorticoid use in RA and improve clinical estimation of glucocorticoid use not captured in claims.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are the On-Ramps to Predict Psoriatic Arthritis? Does Monitoring C-Reactive Protein Levels Help?","authors":"Zheni Stavre, Michael H Weisman","doi":"10.1002/acr.25578","DOIUrl":"10.1002/acr.25578","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Matters: Exploring the Link Between Sleep Disturbances and Fatigue in Rheumatoid Arthritis.","authors":"Natalia V Chalupczak, Burcu Aydemir, Ariel Isaacs, Lutfiyya N Muhammad, Jing Song, Kathryn J Reid, Daniela Grimaldi, Mary Carns, Kathleen Dennis-Aren, Dorothy D Dunlop, Beth I Wallace, Phyllis C Zee, Yvonne C Lee","doi":"10.1002/acr.25579","DOIUrl":"https://doi.org/10.1002/acr.25579","url":null,"abstract":"<p><strong>Objective: </strong>Fatigue is a prevalent and debilitating symptom for patients with rheumatoid arthritis (RA). While patients and rheumatologists often attribute fatigue to inflammation, other factors such as sleep disturbances are frequently overlooked. This study aims to explore the relationship between subjective (self-reported) and objective (actigraphy-based) sleep parameters and self-reported fatigue in patients with RA.</p><p><strong>Methods: </strong>This cross-sectional analysis included data from 48 adult RA patients from a single academic rheumatology practice. Sleep data were obtained daily over 14 days with actigraphy (objective) and the Karolinska Sleep Diary (subjective). Fatigue was assessed using the Patient-Reported Outcome Measurement Information System (PROMIS) fatigue computerized adaptive test. Spearman's correlations and linear regression analyses were used to examine associations between sleep parameters and fatigue, adjusting for swollen joint count, pain intensity, and symptoms of depression.</p><p><strong>Results: </strong>Subjective sleep parameters showed significant correlations with PROMIS fatigue. Longer total sleep time (ρ = -0.4, p < 0.01), higher sleep efficiency (ρ = -0.42, p < 0.01), and better sleep quality (ρ = -0.5, p < 0.01) were associated with lower levels of fatigue. Objective actigraphy-based sleep parameters were not significantly associated with PROMIS fatigue. Separate linear regression models demonstrated that each subjective sleep parameter remained significantly associated with fatigue after adjusting for covariates.</p><p><strong>Conclusion: </strong>Self-reported poor sleep duration, efficiency, and quality were significantly associated with fatigue in patients with RA, whereas objective actigraphy-based sleep parameters were not, supporting the integration of self-reported assessment of sleep disturbances into RA treatment plans to improve patient outcomes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review of Inequitable Population Representation in Systemic Lupus Erythematosus Clinical Trials.","authors":"Seth Sims, Kaylyn Rowsey, Christian Hemmerich, Haley Howard, Jay Babek, Garrett Jones, Simran Demla, Alicia Ito Ford, Matt Vassar","doi":"10.1002/acr.25576","DOIUrl":"https://doi.org/10.1002/acr.25576","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aims to evaluate the participation of historically marginalized populations in systemic lupus erythematosus (SLE) clinical trials conducted in the US.</p><p><strong>Background: </strong>SLE, a complex autoimmune disease characterized by a dysregulated immune response leading to inflammation and tissue damage in multiple organ systems, exhibits a mortality rate four times higher in historically marginalized populations compared to the general population. It is essential for clinical trials to accurately represent the disease population to effectively evaluate treatment modalities. However, the current trial design lacks appropriate representation of historically marginalized populations, limiting the generalizability of results. Our study addresses this research gap by evaluating the participant demographics in SLE clinical trials.</p><p><strong>Methods: </strong>Relevant clinical trials were obtained in a comprehensive search of MEDLINE (PubMed) and Embase (Elsevier) in May of 2024. Included trials were published in the United States between January 1, 2018, and December 31, 2023. Two reviewers independently performed screening and data extraction via a standardized Google Form.</p><p><strong>Results: </strong>Having met our inclusion criteria, 18 U.S. SLE clinical trials were evaluated for participant sex, age, racial, and ethnic data. Analysis of sex/gender revealed that the included population accurately represented the disease population. Regarding race/ethnicity participation, 11/18 (61.1%) received an overall Poor rating, and none received a Good rating. Analysis revealed that 14/18 (77.8%) of studies demonstrated statistically insignificant underrepresentation of Black, Asian, and Hispanic populations. No studies reported the inclusion of older adults in their sample, suggesting a significant need for better age representation.</p><p><strong>Conclusion: </strong>The results of this study reveal disparities in the representation of the SLE disease population in clinical trials, emphasizing insufficient inclusion of Black, Asian, and Hispanic/Latinx participants and the disproportionate overrepresentation of white participants. Our study highlights the need for the initiation of effective strategies to engage historically marginalized populations in SLE clinical trials. Addressing these gaps is necessary to prioritize the participation of inequitable populations, increase standardization of SLE treatments, and improve the relevance of SLE research.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}