Arthritis Care & Research最新文献

{"title":"Trends in Dermato-polymyositis Mortality, 1999-2022: A Nationwide Population-based Study, United States.","authors":"Elizabeth Matz, Ram R Singh","doi":"10.1002/acr.25609","DOIUrl":"https://doi.org/10.1002/acr.25609","url":null,"abstract":"<p><strong>Objective: </strong>We evaluated trends in dermato-polymyositis (DPM) mortality relative to all-cause mortality in the United States, 1999-2022.</p><p><strong>Methods: </strong>We used the Center for Disease Control and Prevention's databases (Multiple Causes of Death for 1999-2020 and Provisional Mortality Statistics for 2021 and 2022) to obtain death counts for DPM and non-DPM (all causes other than DPM). We calculated age-standardized mortality rates (ASMR) for both groups and computed the ratio of DPM-ASMR to non-DPM-ASMR for each of the 24 years. We performed joinpoint regression analysis to estimate annual percent change (APC) in DPM and non-DPM ASMRs and in the DPM-ASMR:non-DPM-ASMR ratios, overall and by sex, age, and race/ethnicity.</p><p><strong>Results: </strong>There were 12,882 DPM and 63,549,485 non-DPM deaths during 1999-2022. Mortality decreased at a higher APC (-3.8% [95% CI, -4.3%, -3.4%]) for DPM than non-DPM (-1.2% [95% CI, -1.5%, -0.9%]) until the start of the COVID-19 pandemic, when it increased for both at similar APCs. Consequently, the ratios of DPM-ASMRs to non-DPM-ASMRs decreased over these 24 years in all subgroups. The DPM-ASMR to non-DPM-ASMR ratios were higher in females than males, and in younger individuals (≤64 years) than those ≥65 years. The odds of premature death were higher for DPM than non-DPM. Non-Hispanic Black, Hispanic, and non-Hispanic others had higher DPM-ASMR to non-DPM-ASMR ratios than White individuals.</p><p><strong>Conclusion: </strong>DPM mortality decreased at a higher rate than all-cause mortality until the pandemic, when it proportionately increased for both DPM and all causes. Females, younger, Black, Hispanic, and non-Hispanic other individuals had higher DPM mortality relative to all-cause mortality. Findings highlight the need for improved screening, earlier intervention, and targeted efforts to address racial/ethnic disparities in DPM outcomes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-Onset Scleroderma Renal Crisis Does Occur - A Multi-Center Study.","authors":"Swati Mehta, Sumbal Wajid, Isam Albaba, Virginia Steen, Robyn T Domsic-Degazio, Alexa Luta, Paul J Feustel, Loay Salman, Lee Shapiro","doi":"10.1002/acr.25608","DOIUrl":"https://doi.org/10.1002/acr.25608","url":null,"abstract":"<p><strong>Objective: </strong>Scleroderma renal crisis (SRC) is historically described to occur within first 5 years of SSc diagnosis. However, it has been observed to occur beyond 5 years. In this analysis, we aim to describe the prevalence, clinical features and outcomes of late onset SRC and compare them to early onset SRC.</p><p><strong>Methods: </strong>This retrospective observational study included patients diagnosed with SRC between 1995 to 2018 at three university-affiliated hospitals. Late onset SRC was defined as SRC occurring 5 years after SSc diagnosis. After obtaining IRB approval, data including demographics, SRC onset, clinical characteristics, laboratory data, and outcomes were extracted. Continuous data were expressed as mean/median, and categorical as frequencies/percentages. Differences were analyzed via Pearson's chi-square.</p><p><strong>Results: </strong>A total of 223 SRC patients were identified, with 169 (75.8%) classified as early onset and 54 (24.2%) as late onset. Late onset group had a mean SRC onset at 12.2 years after SSc diagnosis. Male predominance was observed in late compared to early group (59% vs 9%). Steroid exposure was more common in late vs early group (56% vs 29%). There was no evidence of difference in autoantibodies profile and outcomes between early and late onset groups.</p><p><strong>Conclusions: </strong>Late onset SRC was seen in up to 25% of SRC patients, with a mean of 12 years after SSc diagnosis. Our findings reveal comparable clinical characteristics and outcomes between early and late onset SRC, underlying the importance of recognizing SRC regardless of disease duration to optimize outcomes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor: Validation of Lung Ultrasound Interpretation Criteria for Interstitial Lung Disease in Systemic Sclerosis and Inflammatory Myopathy.","authors":"Robert M Fairchild, Lorinda Chung","doi":"10.1002/acr.25607","DOIUrl":"https://doi.org/10.1002/acr.25607","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A twist in the diagnosis: Chronic arthropathy without inflammation.","authors":"María Á Puche-Larrubia, Inmaculada C Aranda-Valera, Alejandro Escudero-Contreras, Rosa Roldán Molina","doi":"10.1002/acr.25597","DOIUrl":"https://doi.org/10.1002/acr.25597","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria, Phase III-C Report: Assessment of Patient Scenarios (Derivation Cohort) and Refinement of Definitions.","authors":"Medha Barbhaiya, Stephane Zuily, Deanna Jannat-Khah, Mary-Carmen Amigo, Danieli Andrade, Tadej Avcin, Maria L Bertolaccini, D Ware Branch, Nathalie Costedoat-Chalumeau, Guilherme Ramires de Jesús, Katrien M J Devreese, David Garcia, Jose A Gomez Puerta, Francis Guillemin, Steven R Levine, Roger A Levy, Michael D Lockshin, Thomas L Ortel, Michelle Petri, Giovanni Sanna, Savino Sciascia, Surya V Seshan, Maria Tektonidou, Denis Wahl, Rohan Willis, Cecile Yelnik, Alison Hendry, Ray Naden, Karen H Costenbader, Doruk Erkan","doi":"10.1002/acr.25599","DOIUrl":"https://doi.org/10.1002/acr.25599","url":null,"abstract":"<p><strong>Objective: </strong>The 2023 ACR/EULAR Antiphospholipid Syndrome (APS) Classification criteria aim to identify patients with high likelihood of APS for research. Phases I/II of our four-phase methodological approach resulted in 27 candidate criteria organized in clinical and laboratory domains. Here, we summarize Phase III efforts to reduce and refine criteria using patient scenarios.</p><p><strong>Methods: </strong>Using standardized definitions for candidate criteria, the Steering Committee collected antiphospholipid antibody (aPL)-positive cases referred for \"suspected APS\". Treating physicians assessed APS case likelihood using a Likert Scale. Poisson regression calculated risk ratios (RR) and 95% confidence intervals to quantify the direction and size of the association of candidate criteria with \"highly likely\" versus \"equivocal or unlikely\" APS, which guided Steering Committee candidate criteria refinement and organization.</p><p><strong>Results: </strong>We collected 314 suspected APS cases (137 [44%] highly likely, 177 [56%] equivocal/unlikely APS). Provoking venous thromboembolism (VTE) or arterial thromboses (AT) risk factors reduced the size of the association with highly likely APS (RR 4.31 [95%CI 2.11-8.78] to RR 1.56 [95%CI 0.89-2.75] for VTE, and RR 3.48 [95%CI 1.91-6.32] to RR 1.64 [95%CI 0.77-3.51] for AT). Persistent lupus anticoagulant, anticardiolipin IgG antibody >40U, and anti-β₂-glycoprotein-I IgG antibody >40U were positively associated with highly likely APS (all p<0.05). Eventually, items within eight additive and independent clinical and laboratory domains were refined.</p><p><strong>Conclusion: </strong>Referred suspected APS cases provided insight into associations of individual candidate criteria with APS likelihood. Risk ratio analyses helped refine items and organize the draft classification system into eight additive and independent clinical and laboratory domains.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term lignan intake, whole grain foods, and the risk of gout: results from two prospective cohort studies.","authors":"Sharan K Rai, Yang Hu, Ming Ding, Frank B Hu, Molin Wang, Jorge E Chavarro, Natalie McCormick, Hyon K Choi, Qi Sun","doi":"10.1002/acr.25596","DOIUrl":"https://doi.org/10.1002/acr.25596","url":null,"abstract":"<p><strong>Objective: </strong>Multiple plant-based dietary patterns are inversely associated with gout, although the individual constituents driving this association remain unclear. Dietary lignans, a major group of phytoestrogens abundant in plant foods, are metabolized by the gut microflora and may modulate gout risk. We examined the associations between dietary lignan intake, certain whole grain foods rich in lignans, and incident gout.</p><p><strong>Methods: </strong>We analyzed data from 122,680 individuals in the Health Professionals Follow-up Study and Nurses' Health Study. We administered a food frequency questionnaire every 2-4 years. We used Cox models to evaluate associations between dietary lignans, whole grain foods, and confirmed gout.</p><p><strong>Results: </strong>Higher intakes of matairesinol (hazard ratio [HR] and 95% confidence interval [CI] comparing extreme quintiles: 0.78 [0.69, 0.90]; P trend=0.002) and secoisolariciresinol (0.78 [0.68, 0.89]; P trend=0.002) were both associated with lower gout risk, while pinoresinol and lariciresinol were not associated with gout. We found inverse associations of whole grain cold breakfast cereals (HR for those consuming ≥1 serving/day 0.62 [0.53, 0.73]), cooked oatmeal/oat bran (HR for those consuming ≥2 servings/week 0.78 [0.70, 0.86]), and bran added to food (HR for those consuming ≥2 servings/week 0.84 [0.74, 0.95]), but not dark breads or other cooked breakfast cereals, with gout.</p><p><strong>Conclusion: </strong>Higher intakes of matairesinol and secoisolariciresinol, as well as whole grain cold breakfast cereals, oatmeal, and added bran, were each significantly associated with lower gout risk. These findings support adherence to healthful plant-based diets for gout and suggest a potential role of the gut microbiome in gout pathogenesis.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of pincer morphology in early adolescents from the general population: a population-based study (Generation R).","authors":"Delong Chen, Fleur Boel, Suzanne de Vos-Jakobs, Pim van Klij, Michiel M A van Buuren, Sita M A Bierma-Zeinstra, Rintje Agricola","doi":"10.1002/acr.25601","DOIUrl":"https://doi.org/10.1002/acr.25601","url":null,"abstract":"<p><strong>Objective: </strong>Pincer morphology can lead to femoroacetabular impingement syndrome (FAIS) and may be a modifiable risk factor for hip osteoarthritis (OA). Currently, no studies investigate the prevalence of pincer morphology in early adolescence-the period when this bony shape likely develops. The purpose of this study was to estimate the prevalence and birth-assigned sex distribution of pincer morphology in early adolescents from the general population in the Netherlands.</p><p><strong>Methods: </strong>This study was embedded in the Generation R study, a population-based prospective cohort in Rotterdam, the Netherlands. Around the age of 13 years, participants underwent high-resolution dual-energy x-ray absorptiometry (DXA) of their full-body and right hip. The lateral center edge angle (LCEA) was automatically determined based on landmarks outlining the hip contour, and pincer morphology was defined as a LCEA ≥ 40°. The overall and birth-assigned sex-specific prevalence was presented as a percentage with 95% confidence interval (CI).</p><p><strong>Results: </strong>A total of 3,986 adolescents (median age 13.5 years [2.5th - 97.5th percentile, 13.2 - 14.6]; 46.8% males) were included. The overall prevalence of pincer morphology was 3.1% (95% CI 2.6% - 3.6%). The prevalence in male and female adolescents was 3.0% (95% CI 2.2% - 3.7%) and 3.3% (95% CI 2.5% - 4.0%), respectively.</p><p><strong>Conclusion: </strong>Among early adolescents from the general population in the Netherlands, the estimated prevalence of pincer morphology was 3.1%. Male and female adolescents had a similar prevalence of pincer morphology. These findings could inform the timing of prevention strategies for pincer morphology, potentially reducing the risk of FAIS and hip OA.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Still's lung disease: Time to recognize this complication in adults.","authors":"Lauren A Henderson","doi":"10.1002/acr.25598","DOIUrl":"https://doi.org/10.1002/acr.25598","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and incidence of Sjögren's disease in Alaska Native and American Indian peoples of Alaska.","authors":"Tessalyn Morrison, Peter Holck, Tammy L Choromanski, Amy Wilson, Flora Lee, Elizabeth D Ferucci","doi":"10.1002/acr.25600","DOIUrl":"10.1002/acr.25600","url":null,"abstract":"<p><strong>Objective: </strong>Our objective was to determine the prevalence, incidence, and clinical characteristics of Sjögren's disease in Alaska Native and American Indian (AN/AI) peoples of Alaska.</p><p><strong>Methods: </strong>We identified adults with Sjögren's disease by querying electronic health records from participating tribal health organizations within the Alaska Tribal Health System (ATHS). Medical records were abstracted for adults with diagnostic codes for Sjogren's disease. Individuals were included if they were diagnosed with Sjogren's disease by a rheumatologist). Prevalence and incidence were calculated using the ATHS user population in 2019 (point prevalence) and from 2012-2019 (incidence), with direct age-adjustment to the U.S. 2000 standard population. We evaluated whether adults met modified criteria (positive Ro/SSA antigen with sicca symptoms), 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR), and 2012 ACR criteria.</p><p><strong>Results: </strong>The age-adjusted prevalence of Sjögren's disease was 199 per 100,000 adults (95% confidence interval 170, 231); for primary Sjögren's disease it was 129 (106, 155), and for secondary Sjögren's disease it was 70 (54, 91). The age-adjusted incidence over the period was 16.6 (13.7, 20.0) per 100,000 person years. Two-thirds (66%) of adults met modified criteria. Only 5% had a salivary gland biopsy performed and only 3% met 2016 ACR/EULAR or 2012 ACR criteria. The most common associated conditions in secondary Sjögren's disease were rheumatoid arthritis and systemic lupus erythematosus.</p><p><strong>Conclusion: </strong>The prevalence and incidence of Sjögren's disease in AN/AI peoples is higher than other populations. These results may help clinicians to identify and treat this condition.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An assessment of rheumatology fellows' skills as clinical teachers through self-assessment and direct observation.","authors":"David Leverenz, Marcy B Bolster, Lisa Criscione-Schreiber, Jon Golenbiewski, Faye Hant, Rumey Ishizawar, Jennifer Schmidt, Amanda Snyder, Rachel Wolfe, Eli M Miloslavsky","doi":"10.1002/acr.25593","DOIUrl":"https://doi.org/10.1002/acr.25593","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to assess rheumatology fellows' teaching skills through an Observed Structured Teaching Exercise (OSTE), self-assessment, and a survey of fellows' teaching experiences.</p><p><strong>Methods: </strong>Rheumatology fellows from 5 institutions participated in an in-person OSTE, involving a simulated teaching encounter with a standardized learner. Trained faculty observers rated each OSTE encounter to assess the fellows' proficiency as a clinical teacher in the following domains: learning environment, learner assessment, presenting material, feedback, and overall teaching ability. Prior to the OSTE, fellows completed a self-assessment of their teaching skills according to those same five domains. In addition, they completed a post-OSTE survey assessing their experience with teaching during rheumatology fellowship training and their experience with the OSTE station itself.</p><p><strong>Results: </strong>A total of 25 fellows completed the OSTE and self-assessment. According to preceptor ratings on the OSTE, the domain with the highest average proficiency was presenting material (4.16, SD 0.46) and the lowest was learner assessment (3.06, SD 1.56). There was no significant correlation between OSTE ratings and fellow self-assessment in any domain. Of the 23 (92%) fellows who completed the post-OSTE survey, only 57% agreed they had received high-quality feedback on their teaching skills during fellowship training, and 100% agreed they received effective feedback during the OSTE.</p><p><strong>Conclusion: </strong>Fellows' self-assessed teaching ability does not correlate with direct observation. Interventions such as this OSTE are useful for providing high-quality feedback on fellows' teaching skills.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}