Arthritis Care & Research最新文献

{"title":"Chronic Kidney Disease Is Associated with Increased Glucose Uptake-Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Gout Patients.","authors":"Shunya Kaneshita, Sho Fukui, Soheil Niku, Kwanghoon Lee, Ernest Belezzuoli, Robert Terkeltaub, Monica Guma","doi":"10.1002/acr.25540","DOIUrl":"https://doi.org/10.1002/acr.25540","url":null,"abstract":"<p><strong>Objective: </strong>We evaluate the ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG) PET standardized uptake value (SUV) by PET/CT in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in patients with and without gout. Additionally, we investigate whether glucose uptake in these tissues predicts the progression of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>We used ICD-10 codes from the University of California San Diego patient database to identify patients with gout and controls, forming a cohort of individuals who underwent PET/CT scans. The mean VAT and SAT SUVmax were measured using PET/CT and adjusted for potential confounders using inverse probability weighting analysis. We also employed multivariable linear regression to analyze changes in estimated glomerular filtration rate (eGFR) after PET/CT.</p><p><strong>Results: </strong>The study included 221 patients, with 120 diagnosed with gout. After the inverse probability of weighting adjustment, the mean VAT and SAT SUVmax were higher in patients with gout (mean VAT SUVmax: β=0.09, 95% CI=0.04 to 0.15; mean SAT SUVmax: β=0.06, 95% CI=0.01 to 0.12). Additionally, in gout patients with CKD stage 3 or higher, higher mean VAT and SAT SUVmax were associated with decreased eGFR in the five years following PET/CT (mean VAT SUVmax: β=-1.76, 95% CI=-3.50 to -0.01; mean SAT SUVmax: β=-2.97, 95% CI=-5.61 to -0.32) CONCLUSIONS: Elevated glucose uptake-associated metabolic activity in both VAT and SAT was observed in gout patients, which may contribute to CKD progression among patients with both gout and CKD.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of juvenile idiopathic arthritis associated uveitis in long-term disease remission: consensus based recommendations from MIWGUC.","authors":"Ivan Foeldvari, Ameenat Solebo, Harry Petrushkin, Sheila T Angeles-Han, Regitze Bangsgaard, Joan Calzada-Hernández, Tamas Constantin, Joke de Boer, Jesus Díaz-Cascajosa, Mia Glerup, Helene Ingels, Sebastian Kramer, Elisabetta Miserocchi, Ellen Nordal, Rotraud K Saurenmann, Gabriele Simonini, Joost F Swart, Jan Titz, Jordi Antón","doi":"10.1002/acr.25542","DOIUrl":"https://doi.org/10.1002/acr.25542","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to develop consensus-based recommendations for the monitoring of children with Juvenile Idiopathic Arthritis-associated uveitis (JIAU) in long-term remission, addressing the absence of international guidance on monitoring schedules for these children and young people.</p><p><strong>Methods: </strong>The Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC) convened experts from ten countries, including paediatric rheumatologists and ophthalmologists, alongside parents of affected children. A review of key longitudinal cohort studies informed a structured consensus process comprising discussion, recommendation development, and voting for adoption, with a consensus threshold of ≥80% needed for adoption. Recommendation development focused on three principal questions: stratification of the risk of poor outcomes, the natural history of JIAU post-remission, and the impact of delayed examination.</p><p><strong>Results: </strong>The group established several key recommendations including: a standard monitoring frequency of every 4 months for the first four years following medication cessation; ongoing assessments for patients with structural complications; and low-frequency monitoring every 6 months for those in stable, drug-free remission for over four years. There was unanimous agreement on these recommendations.</p><p><strong>Conclusions: </strong>These consensus-based recommendations provide a framework for monitoring children with JIAU in remission, enhancing the quality of care and optimizing resource use in eye health services. Ongoing research is essential to refine these guidelines as new evidence emerges regarding biomarkers and imaging techniques for disease recurrence.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Tuberculosis Screening Practices among New Users of Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs: A Call for Individualized Approaches.","authors":"Yuting Wang, Guiyao Jin, Fanzhang Meng, Chen Li, Wenlong Wang","doi":"10.1002/acr.25534","DOIUrl":"https://doi.org/10.1002/acr.25534","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comments on Tuberculosis Screening Practices among New Users of Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs: A Call for Individualized Approaches.","authors":"Eric T Roberts, Matthew Murrill, Gabriela Schmajuk, Jinoos Yazdany","doi":"10.1002/acr.25533","DOIUrl":"https://doi.org/10.1002/acr.25533","url":null,"abstract":"<p><p>We argue for universal latent tuberculosis infection (LTBI) screening prior to administration of biologic or targeted synthetic DMARDs (b/tsDMARDs). First, though evidence about the risk of LTBI reactivation for newer b/tsDMARDs is accumulating these studies are conducted in populations in which patients have been screened and treated for LTBI meaning the true risk of reactivation is difficult to assess with current studies. Second, while there are algorithms to predict the risk of active TB in non-endemic populations, these models use a broad category of immunosuppression and the result of LTBI screening limiting their utility for identifying who to screen. Critically, there are limits to screening based on demographic characteristics alone. Third, Center for Medicare and Medicaid Services has a stated goal of zero preventable harm in patients and the U.S. is experiencing increasing rates of TB since COVID. Immunosuppression is a strong risk factor suggesting screening should be universal.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review.","authors":"Natasha Cox, Saeed Farooq, Helen Twohig, Ian C Scott","doi":"10.1002/acr.25532","DOIUrl":"https://doi.org/10.1002/acr.25532","url":null,"abstract":"<p><p>As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Co-morbid depression is prevalent in adults with IA, affecting 15 to 39% of people. Whilst pain and depression are thought to be associated in IA, this concept is largely based on cross-sectional data. To better understand potential causality, longitudinal studies are required. This narrative review examines the relationship between pain and depression in patients with IA participating in observational longitudinal studies (spanning association strengths, direction of effect, and causal factors) and summarises the literature on causal pathways in general populations alongside guideline recommendations/systematic reviews on assessing pain/depression in IA. 14 longitudinal studies in IA largely indicate an association between pain and depression, albeit with a small-to-modest effect size, and a focus on pain intensity. This relationship appears to be bidirectional. Evidence on causal pathways is sparse in IA and limited in non-IA populations (with structural/function brain changes, altered sensory/pain thresholds, and sleep disturbance implicated) highlighting a need for further research. Whilst many patient-reported outcome measures exist to assess pain and depression in IA, evidence for their psychometric properties is often limited, and IA guidelines offer incomplete advice on pain/depression assessment. A simple approach of using a single-item pain intensity score (e.g. a numeric rating scale, which has strong clinimetric properties) in routine IA consultations, with screening for depression where relevant, appears appropriate. Further research is needed to understand how this could be achieved in different healthcare settings.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withholding acetaminophen for older adults with osteoarthritis? Not so fast.","authors":"Ali Ahmed, Gail Kerr, Hans J Moore, Janani Rangaswami, Charles Faselis, Richard M Allman","doi":"10.1002/acr.25538","DOIUrl":"https://doi.org/10.1002/acr.25538","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Withholding acetaminophen for older adults with osteoarthritis? Not so fast.\"","authors":"Jaspreet Kaur, Georgina Nakafero, Abhishek Abhishek, Christian Mallen, Michael Doherty, Weiya Zhang","doi":"10.1002/acr.25535","DOIUrl":"https://doi.org/10.1002/acr.25535","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis.","authors":"Lisa R Sammaritano, Anca Askanase, Bonnie L Bermas, Maria Dall'Era, Alí Duarte-García, Linda T Hiraki, Brad Rovin, Mary Beth F Son, Anthony Alvarado, Cynthia Aranow, April Barnado, Anna Broder, Hermine I Brunner, Vaidehi Chowdhary, Gabriel Contreras, Christele Felix, Elizabeth D Ferucci, Keisha L Gibson, Aimee O Hersh, Peter M Izmirly, Kenneth Kalunian, Diane Kamen, Brandi Rollins, Benjamin J Smith, Asha Thomas, Homa Timlin, Daniel J Wallace, Michael Ward, Muayad Azzam, Christie M Bartels, Joanne S Cunha, Kimberly DeQuattro, Andrea Fava, Gabriel Figueroa-Parra, Shivani Garg, Jessica Greco, Maria C Cuéllar-Gutiérrez, Priyanka Iyer, Andrew S Johannemann, April Jorge, Shanthini Kasturi, Hassan Kawtharany, Jana Khawandi, Kyriakos A Kirou, Alexandra Legge, Kelly V Liang, Megan M Lockwood, Alain Sanchez-Rodriguez, Marat Turgunbaev, Jessica N Williams, Amy S Turner, Reem A Mustafa","doi":"10.1002/acr.25528","DOIUrl":"10.1002/acr.25528","url":null,"abstract":"<p><p>The accepted version of this article was posted prematurely on March 24, 2025. The final version of record will be made fully available at a later date.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply to \"Lower environmental temperature and higher relative humidity had significant associations with worsened Raynaud phenomenon in systemic sclerosis: comment on the article by Taylor et al.\"","authors":"Alicia Calderone, Dylan Hansen, Laura Taylor, Mandana Nikpour","doi":"10.1002/acr.25530","DOIUrl":"https://doi.org/10.1002/acr.25530","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse Treatment Goals in Psoriatic Arthritis: Insights from participants in the PARC cohort.","authors":"Astia Allenzara, Kat Bush, M Elaine Husni, Soumya M Reddy, Jose U Scher, Ethan Craig, Joelle Koplin, Jessica A Walsh, Alexis Ogdie","doi":"10.1002/acr.25527","DOIUrl":"https://doi.org/10.1002/acr.25527","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to examine patient-reported treatment goals among individuals with psoriatic arthritis (PsA).</p><p><strong>Methods: </strong>Participants in the Psoriatic Arthritis Research Consortium (PARC) completed standardized assessments including patient-reported outcome (PROs) instruments between 2017-2020. Additionally, participants were asked two open-ended questions at enrollment or therapy initiation \"If you could improve one thing about your disease, what would it be?\" and \"What would an effective treatment change for you?\" to identify patients' top improvement priority and their treatment impact goals, respectively. We categorized each response into a theme. The themes were matched to constructs measured by PRO items (i.e., pain, fatigue, skin, etc.). We describe themes and scores from matched PRO items.</p><p><strong>Results: </strong>Assessments were completed by 193 participants. Decreasing pain (56%) and improving skin (12%) were the most common improvement priorities. Impact goals were more diverse and included decreasing pain (24%), general improvement in life (18%), the ability to be more active (15%), participate in recreational activities (9%), function at work (11%) and exercise (5%). Of note, responses were often matched to more than one PRO item or instrument. The scores for PRO items that matched the patient's improvement priority, or the impact goal were higher than scores for the remainder of the population (i.e., fatigue item scores were higher among individuals identifying fatigue as their improvement priority).</p><p><strong>Conclusions: </strong>The heterogeneity of treatment goals underscores the importance of eliciting patient treatment goals to guide personalized management. Specific items within PROs may be helpful in identifying and following patient-specific treatment goals.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}