Arthritis Care & Research最新文献

{"title":"Lower environmental temperature and higher relative humidity had significant associations with worsened Raynaud phenomenon in systemic sclerosis: comment on the article by Taylor et al.","authors":"Gang Wang, Zhichun Liu","doi":"10.1002/acr.25529","DOIUrl":"https://doi.org/10.1002/acr.25529","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placebo Effect Sizes are Larger in Clinical Trials of Knee Osteoarthritis using Intra-Articular Injections of Biologic Agents.","authors":"Johanna M Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian, Samuel R Ward","doi":"10.1002/acr.25526","DOIUrl":"https://doi.org/10.1002/acr.25526","url":null,"abstract":"<p><strong>Objective: </strong>Patients with knee osteoarthritis (KOA) rely on symptomatic treatments where up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (e.g., biologics vs. non-biologic injection) and route of administration (e.g., intra-articular vs. topical vs. oral). The placebo effect is an integral part of treatment effect size calculation; thus, network analyses comparing efficacies of different treatments may be inaccurate. The objective of this study was to test the hypothesis that placebo effects differ between treatment types and route of delivery.</p><p><strong>Methods: </strong>A systematic literature search was carried out in August 2019. Randomized trials comparing pain outcomes of oral, topical, or intra-articular placebo interventions to active treatments were included. The outcome measure of interest was change in pain scores from baseline. Data were stratified by length of follow up and treatment subcategory.</p><p><strong>Results: </strong>129 papers were included with 9218 patients receiving placebo treatments. Reduction in pain from baseline occurred in 93% of the subcategory data points. Biologic IA placebo injections had the greatest pain reduction at one month (VAS: -32.2 ± 24.6; WOMAC -16.3 ± 3.81). At one month and two months, placebo intra-articular injections had a greater pain reduction than oral placeboes (P ≤0.01).</p><p><strong>Conclusions: </strong>The robust placebo effect is influenced by the active treatment category and changes over time. The variation in placebo response despite analogous placebo methodologies implies using network meta-analyses to compare treatments from different active treatment categories by evaluating the change from placebo is inaccurate.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Pain During Exercise With Exercise-Induced Hypoalgesia in People With Knee Osteoarthritis.","authors":"Soyoung Lee, Tuhina Neogi, Benjamin M Senderling, S Reza Jafarzadeh, Mary Gheller, Pirinka G Tuttle, Charmaine Demanuele, Lars Viktrup, Paul Wacnik, Deepak Kumar","doi":"10.1002/acr.25524","DOIUrl":"10.1002/acr.25524","url":null,"abstract":"<p><strong>Objective: </strong>A paradoxical relationship between pain during exercise and the hypoalgesic effect of exercise has not been studied well in the knee osteoarthritis (OA) population. We sought to investigate the relation of pain evoked during exercise to exercise-induced hypoalgesia (EIH) and to determine if the efficiency of conditioned pain modulation (CPM), a proxy of the descending pain inhibitory system, mediates this relationship in people with knee OA.</p><p><strong>Methods: </strong>We used baseline data from two clinical trials for people with symptomatic knee OA (n = 68). The maximum pain rating (0-10) during a series of knee exercises was defined as the outcome. EIH was assessed as an increase (ie, improvement) in the pressure pain threshold (PPT) after a bout of exercises. Efficient CPM was defined as an increase (ie, improvement) in PPT after a painful conditioning stimulus (forearm ischemia). We performed a causal mediation analysis to examine the association between pain during exercise and EIH as well as the mediating role of CPM efficiency on the relation of pain during exercise with EIH.</p><p><strong>Results: </strong>People with knee OA who had at least a one-unit increase in pain with exercise were 43% more likely (odds ratio [OR] 1.43, 95% confidence interval [CI] 1.05-1.94) to experience subsequent EIH than those without pain increase. The efficiency of CPM did not mediate the relationship between pain during exercise and EIH (OR 1.00, 95% CI 0.96-1.04).</p><p><strong>Conclusion: </strong>Our finding suggests that some amount of discomfort or pain during exercise may have beneficial analgesic effects; however, this is not likely via activation of the descending pain inhibitory system.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial, Ethnic, Sex, and Geographical Diversity in Myositis Clinical Trials.","authors":"Raisa Lomanto Silva, Manuel Carpio Tumba, Sneha Gupta, Diana Louden, Latika Gupta, Pedro M Machado, Julie J Paik, Lesley Ann Saketkoo, Sebastian E Sattui, Didem Saygin","doi":"10.1002/acr.25525","DOIUrl":"https://doi.org/10.1002/acr.25525","url":null,"abstract":"<p><strong>Background: </strong>The number of randomized clinical trials (RCTs) in idiopathic inflammatory myopathies (IIMs) has grown exponentially over the last decade. Race, ethnicity, and sex reporting and representation of participants and the geographic distribution of enrolling sites in IIM RCTs are unknown. This information can provide critical insights into the current state of enrollment practices and generalizability in IIM trials.</p><p><strong>Methods: </strong>A systematic literature review assessed IIM RCTs published between 2010-2023. Sex/gender reporting was analyzed per SAGER guidelines. Appropriate reporting of race and ethnicity was defined as reporting them for all trial participants. Countries were categorized based on the Human Development Index. U.S. enrollment sites were grouped using the Urban-Rural Classification Scheme and Medically Underserved Areas (MUA).</p><p><strong>Results: </strong>Of the 19 RCTs included, race was appropriately reported in 58%. Black, Asian, and Hispanic/Latino participants represented 3%, 7%, and 2% of the enrollees, respectively. Ethnicity was only reported in 26% of RCTs and 16% conflated race and ethnicity. Temporal trends showed encouraging results for race/ethnicity representation. Most trials (90%) had greater than 45% female participants. Geographic regions of sites included North America, Europe, Asia, and Australasia, with no sites in South America or Africa. The majority of U.S. sites were located in large metropolitan areas, while none were in non-metropolitan areas and only 31% in medically underserved areas.</p><p><strong>Conclusion: </strong>Racial, ethnic, and geographic representation in IIM RCTs remains a critical issue. Inadequate reporting of race and ethnicity and limited sociodemographic and geographic representation of participants raise concerns about the generalizability of findings of IIM RCTs.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile Idiopathic Arthritis, Earnings and Work Loss: A Nationwide Matched Cohort Study.","authors":"Heather Miller, Martin Neovius, Erik Sundberg, Johan Askling, Gustaf Bruze","doi":"10.1002/acr.25522","DOIUrl":"https://doi.org/10.1002/acr.25522","url":null,"abstract":"<p><strong>Objective: </strong>This study compares trajectories of earnings and work loss in individuals with juvenile idiopathic arthritis (JIA) versus matched comparators from the general population.</p><p><strong>Methods: </strong>Patients with JIA (n=4737) were identified in the Swedish National Patient Register (2001-2017) and individually matched to up to 5 general population comparators on birth year, sex, and residence county (n=23,645). Earnings and work loss data were retrieved from nationwide registers from age 18y. Differences between patients with JIA and general population comparators were estimated using linear regression, adjusted for sex, age, age at identification, calendar year, as well as parental education, work loss and earnings.</p><p><strong>Results: </strong>During a median of 11 years follow-up, patients with JIA had 5.5% lower earnings than matched comparators (mean annual difference -€736 [95%CI -1026, -445]. The difference in earnings was larger before than after age 26y. Beyond age 26y, the difference in earnings was less than 4%. Patients with JIA had more work loss than matched comparators throughout follow-up (mean difference 11 days/year [95%CI 8-13]). This difference was consistent throughout follow-up, but significant effect modification with calendar period of entry (<2005 vs ≥2005) was found, with later entry associated with lower work loss.</p><p><strong>Conclusion: </strong>Patients with JIA had lower mean annual earnings and higher work loss than matched general population comparators, but earnings differences diminished in magnitude with age and work loss diminished with calendar period of identification. In JIA, a minority of patients accounts for the majority of the negative impact on economic outcomes, which persists into adulthood.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multicenter Study of Associations between Area-Level Child Opportunity, Initial Disease Severity and Outcomes among Children with Lupus.","authors":"Joyce C Chang, Jessica P Liu, Emily A Smitherman, Pooja N Patel, Gabrielle Alonzi, Livie Timmerman, Gabrielle A Morgan, Francesca T deFaria, Laura M Berbert, Edie A Weller, Karen H Costenbader, Mary Beth F Son","doi":"10.1002/acr.25523","DOIUrl":"https://doi.org/10.1002/acr.25523","url":null,"abstract":"<p><strong>Objective: </strong>Child opportunity encompasses neighborhood resources and conditions that influence healthy childhood development. We determined whether area-level opportunity associates with disease severity or disease control in a geographically and socioeconomically diverse, multi-center cohort of patients with childhood-onset systemic lupus erythematosus (cSLE).</p><p><strong>Methods: </strong>We linked medical records of patients with cSLE at 3 tertiary centers (2016-2022) to the Child Opportunity Index (COI) 2.0 (29 indicators across education, health and environment, socioeconomics). Primary outcomes included severe initial disease presentation (composite of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) ≥10, intensive care, or dialysis) and acute care (inpatient/emergency) visits. Associations between nationally ranked COI levels and outcomes were estimated using mixed effects models clustered by site, adjusted for age, sex, race and ethnicity, language and insurance status.</p><p><strong>Results: </strong>Among 538 cSLE patients, living in areas with low vs. very high COI associated with 1.93 higher adjusted odds of severe disease presentation (95% CI [1.05-3.57]) and 2.03 higher adjusted incidence of acute care visits within the first year ([1.29-3.18]). At most recent follow-up, living in low vs. very high COI areas associated with higher disease activity (aβ 1.69 [0.54-2.84]) and lower odds of concurrent achievement of SLEDAI-2K≤4 and ≤7.5 mg/day of prednisone, adjusted for initial disease severity and disease duration (aOR 0.44 [0.22-0.88]).</p><p><strong>Conclusion: </strong>Structural inequities in area-level child opportunity may contribute to disparities in both cSLE severity and disease control. Tailoring interventions for communities with low levels of child opportunity may improve access to pediatric subspecialty care and cSLE outcomes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ageism in Rheumatologic Care: Ensuring Equity and Quality for Older Adults.","authors":"Jiha Lee, Devyani Misra, Una E Makris","doi":"10.1002/acr.25521","DOIUrl":"https://doi.org/10.1002/acr.25521","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American College of Rheumatology (ACR) Guidance Statements for Addressing Mental Health Concerns in Youth with Pediatric Rheumatologic Diseases.","authors":"Natoshia R Cunningham, Ashley N Danguecan, Samantha L Ely, Yaa Amponsah, Alaina Davis, Suzanne Edison, Julia Harris, Jordan T Jones, Alana Goldstein-Leever, Alison Manning, Anne McHugh, Crystal Mui, Ekemini Ogbu, Nikki Reitz, Martha Rodriguez, Natalie Rosenwasser, Alyse Tankanow, Erin Treemarcki, Katherine Winner, Tamar B Rubinstein, Andrea M Knight","doi":"10.1002/acr.25519","DOIUrl":"10.1002/acr.25519","url":null,"abstract":"<p><p>The accepted version of this article was posted prematurely on March 6, 2025. The final version of record will be made fully available at a later date.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Trends in Risk Factors for Low Back Pain: An Analysis of the Global Burden of Disease Study Data From 1990 to 2021.","authors":"Katharine E Roberts, Manuela L Ferreira, Paula R Beckenkamp, Sneha Nicholson, Lyn March, Paulo H Ferreira","doi":"10.1002/acr.25520","DOIUrl":"10.1002/acr.25520","url":null,"abstract":"<p><strong>Objective: </strong>The increasing burden associated with low back pain (LBP) is a critical issue. This is a novel analysis of trends in risk factors for LBP aiming to identify risk factors that require further attention or consideration in global policies to reduce the burden of LBP.</p><p><strong>Methods: </strong>The Global Burden of Disease study metadata were used to describe the trends in three modifiable categories of risk factors that contribute to the burden associated with LBP. The trends in occupational/ergonomic, behavioral (smoking), and metabolic (high body mass index [BMI]) risk factors for LBP between 1990 and 2021 have been described with attention to global areas, high sociodemographic index (SDI) areas, and low SDI areas.</p><p><strong>Results: </strong>The number of years lived with disability (YLDs) caused by LBP increased globally, in high and low SDI areas between 1990 and 2021. The impact of smoking and occupational/ergonomic risk factors have decreased; however, the impact of high BMI has increased markedly in the same time frame, with a particularly concerning impact in high SDI areas and on women.</p><p><strong>Conclusion: </strong>The burden of LBP is increasing globally, with a significant proportion of the YLDs caused by LBP attributed to three modifiable lifestyle factors: occupation/ergonomics, smoking, and high BMI. Of significant concern is the rapidly increasing impact of high BMI on YLDs caused by LBP, with the greatest impact seen among women in low and high SDI areas. The role of additional risk factors (eg, physical inactivity) still needs to be determined in the context of the global burden of LBP.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatology Medical Education Year in Review, 2023 to 2024.","authors":"Ann Cameron Barr, David Leverenz","doi":"10.1002/acr.25517","DOIUrl":"10.1002/acr.25517","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}