Arthritis Care & Research最新文献_第3页

Proportion of acceptable symptom state nearly tripled with improvements in patient-reported outcomes for all symptom state subgroups: A registry study of over 15,000 osteoarthritis patients in a digital education and exercise therapy. 在所有症状状态亚组中，可接受症状状态的比例几乎增加了两倍，患者报告的结果有所改善：一项对超过15,000名骨关节炎患者进行数字教育和运动治疗的登记研究。

IF 3.3 2区医学

Arthritis Care & Research Pub Date : 2025-07-01 DOI: 10.1002/acr.25594

Ali Kiadaliri, L Stefan Lohmander, Amanda E Nelson, Leif E Dahlberg

{"title":"Proportion of acceptable symptom state nearly tripled with improvements in patient-reported outcomes for all symptom state subgroups: A registry study of over 15,000 osteoarthritis patients in a digital education and exercise therapy.","authors":"Ali Kiadaliri, L Stefan Lohmander, Amanda E Nelson, Leif E Dahlberg","doi":"10.1002/acr.25594","DOIUrl":"10.1002/acr.25594","url":null,"abstract":"Objective: This study investigated trajectories of patient acceptable symptom state (PASS) among participants of a digital education and exercise therapy for knee and hip osteoarthritis.Methods: A longitudinal observational study among individuals aged 40+ years who participated in the digital program. Participants completed PASS (yes/no) at enrolment and at least one follow-up during one year after enrolment (n=15,253). Group-based trajectory modelling was used to identify groups with distinct PASS trajectories. We used multinomial logistic regression and linear random intercept models to explore predictors and compare changes in patient-reported outcome measures (PROMs) across trajectory subgroups.Results: The proportion of participants reporting acceptable symptom state rose from 17.4% (95%CI 16.8, 18.1) at enrolment to 42.4% (41.6, 43.1) and 48.9% (47.5, 50.2) at 3- and 12-month follow-ups, respectively. We identified four PASS trajectories: 1) \"persistently not achieving PASS (PNAP)\" (45.1%), 2) \"early sustained PASS (ESP)\" (34.8%), 3) \"gradually increasing satisfaction (GIS)\" (10.8%) and 4) \"early PASS, later unacceptable PASS (EPLUP)\" (9.3%). Among baseline variables, female sex, older age, non-metropolitan residence, lower education, knee OA, fear of movement, no walking difficulties, no wish for surgery and better PROMs were generally associated with higher odds of following trajectories other than the \"PNAP\". All trajectories experienced improvements in PROMs, with generally larger improvements in the ESP and GIS groups than the other two groups.Conclusions: The percentage of participants achieving PASS almost tripled at 12 months. Improvements in PROMs across all PASS trajectories highlights the importance of distinction between \"feeling better\" and \"feeling good\".","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer risk in patients with systemic sclerosis: A nationwide cohort study in South Korea 2004-2021. 系统性硬化症患者的癌症风险：2004-2021年韩国全国队列研究

IF 3.7 2区医学

Arthritis Care & Research Pub Date : 2025-07-01 DOI: 10.1002/acr.25595

Jihyun Na, Su Jin Choi, Sojeong Park, Minae Park, Doo-Ho Lim

{"title":"Cancer risk in patients with systemic sclerosis: A nationwide cohort study in South Korea 2004-2021.","authors":"Jihyun Na, Su Jin Choi, Sojeong Park, Minae Park, Doo-Ho Lim","doi":"10.1002/acr.25595","DOIUrl":"https://doi.org/10.1002/acr.25595","url":null,"abstract":"Objective: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by tissue fibrosis, vasculopathy, and immune dysregulation. Our objectives were to quantify the overall and site-specific cancer risks in SSc patients compared to the general population, examine temporal trends in cancer incidence following SSc diagnosis, and explore potential associations with immunosuppressive agent use.Methods: Using data from the Korean National Health Insurance Service, we identified 6,386 patients newly diagnosed with SSc between 2004 and 2020. Standardized incidence ratios (SIRs) were calculated to compare the risk of cancer between SSc patients and the general population. Subgroup analyses were performed based on age at diagnosis, follow-up duration, and immunosuppressive agents use.Results: Most patients (80.2%) were women, with a mean age at diagnosis of 53.1 ± 13.4 years. SSc patients had higher risks of overall cancer (SIR 3.12, 95% CI 2.92-3.33), solid cancer (SIR 3.07, 95% CI 2.86-3.28), and hematologic cancer (SIR 5.70, 95% CI 4.50-7.11) compared to the general population. Myelodysplastic syndrome (SIR 12.52, 95% CI 7.00-20.65) had the highest risk, followed by multiple myeloma, eye, Hodgkin lymphoma, larynx cancers. Cancer risk peaked among patients aged 20-39 years (SIR 5.27, 95% CI 4.31-6.38) and during the first year after diagnosis (SIR 4.44, 95% CI 3.81-5.14).Conclusion: In this study, we revealed that the incidence of cancer is higher in patients with SSc in South Korea compared to general population. The strong association between SSc and cancer occurrence prompts clinicians to conduct careful cancer screening for SSc patients.","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Concerns Regarding PTX-3 Specificity and ROC Interpretation in the Study on Endothelial Biomarkers of SSc-Associated Pulmonary Hypertension". 对“对ssc相关性肺动脉高压内皮生物标志物研究中PTX-3特异性和ROC解释的关注”的回应。

IF 3.7 2区医学

Arthritis Care & Research Pub Date : 2025-07-01 DOI: 10.1002/acr.25589

Matthew Lammi, Kathleen D Kolstad, Lesley Ann Saketkoo, Avani Khatri, Paul J Utz, Virginia Steen, Lorinda Chung

引用次数: 0

Concerns Regarding PTX-3 Specificity and ROC Interpretation in the Study on Endothelial Biomarkers of SSc-Associated Pulmonary Hypertension. ssc相关性肺动脉高压内皮生物标志物研究中PTX-3特异性及ROC解释的关注

IF 3.7 2区医学

Arthritis Care & Research Pub Date : 2025-06-30 DOI: 10.1002/acr.25586

D Ashwant Kumar, Sabarinath Mahadevan

引用次数: 0

Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis. 类风湿关节炎疼痛遗传风险评分的开发和外部验证。

IF 3.7 2区医学

Arthritis Care & Research Pub Date : 2025-06-30 DOI: 10.1002/acr.25588

Katie J McMenamin, Thomas R Riley, Kristin Wipfler, Kaleb Michaud, Austin Wheeler, Bryant R England, Brian Sauer, Katherine D Wysham, Rui Xiao, Michael March, Grant W Cannon, Sylvanus Toikumo, Henry R Kranzler, Rachel L Kember, Ted R Mikuls, Joshua F Baker

{"title":"Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.","authors":"Katie J McMenamin, Thomas R Riley, Kristin Wipfler, Kaleb Michaud, Austin Wheeler, Bryant R England, Brian Sauer, Katherine D Wysham, Rui Xiao, Michael March, Grant W Cannon, Sylvanus Toikumo, Henry R Kranzler, Rachel L Kember, Ted R Mikuls, Joshua F Baker","doi":"10.1002/acr.25588","DOIUrl":"https://doi.org/10.1002/acr.25588","url":null,"abstract":"Objective: Several single-nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA).Methods: Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic Diseases, training dataset) and VARA (Veterans Affairs RA registry, validation dataset). Multivariable linear regression was used to estimate the relationship between cross-sectional pain scores and 36 FM-associated SNPs8 in FORWARD. SNP alleles were summed and weighted by these regression coefficients to generate a genetic risk score (GRS) for pain for each participant in both cohorts. Linear regressions and generalized estimating equations were used to determine the relationship between this GRS, an existing pain intensity GRS,10 and pain and self-reported disease activity.Results: The sample comprised 756 participants from FORWARD (mean age 56.8 years, 89.4% female) and 2,176 participants from VARA (mean age 64.3 years, 11.0% female) who had pain and genotyping data. Participants in the validation dataset (VARA) with FM GRS in the highest quartile had more baseline pain than those in the lowest quartile [+0.55 (95% CI: 0.16, 0.93), p=0.006]. This was also true for the existing pain intensity GRS. VARA participants in the highest quartile of both GRS had more pain throughout follow-up and higher disease activity scores.Conclusion: Genetic risk scores based on pain-related SNPs were associated with RA pain and disease activity, suggesting that the genetic risk of pain may have clinical impacts in RA, such as likelihood of achieving remission.","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to "Febuxostat use is associated with a significantly greater risk of mild to moderate perturbation of liver function compared to benzbromarone in patients with gout: comment on the article by Sun et al". 回复“与苯溴马隆相比，痛风患者使用非布司他与轻度至中度肝功能紊乱的风险显著更高：对Sun等人文章的评论”。

IF 3.7 2区医学

Arthritis Care & Research Pub Date : 2025-06-30 DOI: 10.1002/acr.25590

Wenyan Sun, Lingling Cui, Changgui Li

引用次数: 0

In Response to Risk of hepatotoxicity in use of febuxostat or benzbromarone. 对使用非布司他或苯溴马龙的肝毒性风险的反应。

IF 3.7 2区医学

Arthritis Care & Research Pub Date : 2025-06-30 DOI: 10.1002/acr.25592

Lingling Cui, Wenyan Sun, Changgui Li

引用次数: 0

TITLE: Risk of hepatotoxicity in use of febuxostat or benzbromarone. 题目：使用非布司他或苯溴马龙的肝毒性风险。