Archives of Women's Mental Health最新文献

{"title":"Neuroactive steroid levels are elevated in the follicular phase and predict premenstrual depression and anxiety symptom severity in women with menstrually related mood disorder.","authors":"Allison Kimball, Jenna Bourassa, Mark L Chicote, Anu V Gerweck, Laura E Dichtel, Karen K Miller","doi":"10.1007/s00737-024-01532-3","DOIUrl":"10.1007/s00737-024-01532-3","url":null,"abstract":"<p><strong>Purpose: </strong>Menstrually related mood disorder (MRMD) is marked by severe affective symptoms in the late luteal phase of the menstrual cycle. We hypothesized that women with MRMD experience relative neuroactive steroid deficiency, specifically low allopregnanolone levels due to reduced conversion of progesterone, in association with the onset of affective symptoms in the late luteal phase.</p><p><strong>Methods: </strong>Nine subjects with MRMD and 14 healthy controls were studied. Daily Record of Severity of Problems was used to diagnose MRMD by DSM-5 criteria for premenstrual dysphoric disorder. Depression and anxiety symptom severity (16-Item Quick Inventory of Depressive Symptomatology Self Report, Generalized Anxiety Disorder 7-Item Scale) and levels of plasma neuroactive steroids by mass spectrometry were assessed at the mid-follicular, mid-luteal, and late luteal phases.</p><p><strong>Results: </strong>Depression severity was greater in women with MRMD than healthy controls in the late luteal phase only, as expected. In the mid-follicular phase, the mean allopregnanolone level and allopregnanolone/progesterone ratio were higher in women with MRMD than healthy controls. There were no differences between groups in luteal phase allopregnanolone levels. Higher follicular phase allopregnanolone sulfate and allopregnanolone levels were associated with greater depression severity in the mid-luteal and late luteal phases and greater anxiety severity in the late luteal phase.</p><p><strong>Conclusion: </strong>Levels of allopregnanolone, which have antidepressant effects, were higher in the mid-follicular phase in women with MRMD compared to healthy controls. In MRMD, increased conversion of progesterone to allopregnanolone in the mid-follicular phase may be a compensatory response to luteal phase depression and anxiety, or increased allopregnanolone levels could paradoxically trigger depression and anxiety.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"771-780"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of work hours on sleep quality: a non-linear and gendered disparity.","authors":"Tinh Doan, Liana Leach, Lyndall Strazdins","doi":"10.1007/s00737-024-01535-0","DOIUrl":"10.1007/s00737-024-01535-0","url":null,"abstract":"<p><strong>Purpose: </strong>Quality sleep is vital for good health. Although it is known that workhours affect sleep quality, it is not known at what point workhours begin to compromise sleep. Few studies consider workhours in the 'other job' (domestic and care work) or address reverse causality between sleep quality and how long people work. This study aimed to estimate the point at which weekly workhours harm sleep, among employed Australians aged 25-64.</p><p><strong>Methods: </strong>Using Australian data (19,453 observations from 9,826 adults assessed 2013, 2017, and 2021), a maximum likelihood instrumental variable approach modelled the influence of domestic and care hours on workhours and then the effect of workhours on sleep. We tested for a non-linear pattern and a potential tipping point or limit at which sleep quality declines. Sleep quality scores were constructed from sleep duration (hours), quality rating, medications, and problems with onset.</p><p><strong>Results: </strong>We estimated a population tipping point of 42 workhours per week, beyond which sleep quality deteriorated. Notably, women demonstrated a lower tipping point (36 h) beyond which their sleep quality deteriorated compared to men (47 h), likely linked to their greater care and domestic workhours in the home.</p><p><strong>Conclusions: </strong>Our methods allowed us to specify the point at which weekly workhours were optimal for sleep quality and the point beyond which they become harmful. By considering unequal hours worked in care and domestic work, we were able to identify distinct gender differences in this relationship.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"751-758"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation of the Yale-Brown Obsessive-Compulsive Scale in pregnant women.","authors":"Catherine E Rast, Rashelle Musci, Jonathan S Abramowitz, Gerald Nestadt, Paul Nestadt, Mary C Kimmel, Tracey Dibbs, Lauren M Osborne, Jack Samuels, Janice Krasnow, Eric A Storch","doi":"10.1007/s00737-024-01548-9","DOIUrl":"10.1007/s00737-024-01548-9","url":null,"abstract":"<p><strong>Purpose: </strong>Although many women experience obsessive-compulsive symptoms during the perinatal period, the Yale-Brown Obsessive Compulsive Scale (YBOCS) has not yet been psychometrically evaluated in this population. This study examined the internal consistency, convergent and divergent validity, and factor structure of the YBOCS among pregnant women.</p><p><strong>Methods: </strong>256 Women who were 20 to 24 weeks pregnant completed the clinician-administered YBOCS and Mini International Neuropsychiatric Interview (MINI) along with a series of self-report questionnaires including the Edinburgh Postnatal Depression Scale (EPDS), Perinatal Anxiety Screening Scale (PASS) and Obsessive-Compulsive Inventory-Revised (OCI-R).</p><p><strong>Results: </strong>Internal consistency of the YBOCS was excellent, and there were strong inter-scale correlations between the YBOCS Total Score, YBOCS Obsessions and Compulsions Severity Scales. The YBOCS demonstrated good known-groups validity differentiating women with and without OCD. Convergent validity with the OCI-R was demonstrated while relations with divergent validity were more mixed.</p><p><strong>Conclusion: </strong>The YBOCS possesses strong psychometric properties in pregnant women.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"919-926"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational diabetes and mental health: longitudinal analysis of data from the GEMS randomized trial.","authors":"Phyllis Ohene-Agyei, Greg D Gamble, Thach Tran, Jane E Harding, Caroline A Crowther","doi":"10.1007/s00737-024-01551-0","DOIUrl":"10.1007/s00737-024-01551-0","url":null,"abstract":"<p><strong>Purpose: </strong>There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and health-related quality of life comparing women with gestational diabetes and those without among a contemporary cohort of pregnant women.</p><p><strong>Methods: </strong>Prospective cohort study of participants in the GEMS Trial. Women with a singleton pregnancy were eligible if they had a 75-g diagnostic oral glucose-tolerance test between 24 and 32 weeks' gestation, provided written informed consent, and completed questionnaires about anxiety, depression, and health-related quality of life at the study time points.</p><p><strong>Results: </strong>There were no differences in risk for anxiety (RR 1.13, 95% CI 0.86, 1.49; p = 0.39) or depression (RR 1.08, 95% CI 0.78, 1.50; p = 0.64) between the two groups at 36 weeks' gestation or 6 months postpartum [anxiety: (RR 1.21, 95% CI 0.90, 1.63; p = 0.21); depression: (RR 0.84, 95% CI 0.55, 1.28; p = 0.43]. However, at 36 weeks' gestation participants with gestational diabetes reported better physical functioning, and at 6 months postpartum, better mental functioning (mean difference (MD) in scores 1.28, 95% CI 0.25, 2.30; p = 0.01) although worse physical functioning (MD -2.99, 95% CI -3.90, -2.07; p = < 0.001) compared to participants without.</p><p><strong>Conclusion: </strong>The risk for poor mental health during the perinatal period does not differ importantly among women diagnosed and treated for gestational diabetes compared to the general pregnant population.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"819-830"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pregnant moms' empowerment program - Mexico enhances mental health for women exposed to intimate partner violence: a pilot randomized controlled trial.","authors":"Cecilia Martinez-Torteya, Laura E Miller-Graff, Jessica R Carney, Sandra P Esparza-Dávila, Jessica C Acuapa-Juárez, Kathryn H Howell","doi":"10.1007/s00737-024-01549-8","DOIUrl":"10.1007/s00737-024-01549-8","url":null,"abstract":"<p><strong>Purpose: </strong>Given the lack of available and effective interventions to address the detrimental consequences of perinatal exposure to intimate partner violence (IPV) on maternal mental health, and reported very low access to IPV-related mental health services in Mexico, we examined the feasibility and efficacy of a culturally adapted, virtual, brief group psychosocial intervention designed to improve maternal mental and physical health and reduce IPV revictimization for pregnant women exposed to IPV. In this pilot randomized controlled trial, we evaluated maternal outcomes after participation in the Pregnant Moms' Empowerment Program (PMEP) in Mexico.</p><p><strong>Methods: </strong>Women were recruited from social service agencies and health centers in the community, as well as social media advertisements that targeted pregnant women living in Mexico. Women were randomized to receive the intervention (n = 43) or a control condition (i.e., referrals to local services; n = 47). Women completed questionnaires at baseline, post-intervention, and 3-months postpartum that assessed their exposure to IPV, depression, posttraumatic stress symptoms (PTSS), physical health symptoms, and resilience, as these were our primary outcomes of interest. Women in the intervention condition participated in ten, 60-minute virtual group sessions. Multilevel models were used to evaluate effects of treatment over time.</p><p><strong>Results: </strong>On average, women in the intervention condition participated in six treatment sessions. Compared to the control group, intervention participants reported significantly fewer symptoms of depression at both the post-intervention and 3-month postpartum assessments (d = 0.64, d = 0.59, respectively) and fewer physical health symptoms at the post-intervention assessment (d = 0.77). Trend-level improvements in PTSS scores for post-intervention (d = 0.56) and 3-months postpartum (d = 0.56), as well as physical health at 3-months postpartum (d = 0.59), were also observed. There were no group differences in exposure to IPV over time.</p><p><strong>Conclusion: </strong>The current study adds to the evidence base for the PMEP intervention while also expanding it to a new cultural context by suggesting promise of its clinical utility in targeting Mexican women's perinatal depression, PTSS, and physical health symptoms.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"947-959"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avertible filicide: a call to action for early intervention and mental health support in India.","authors":"Simran Arora, Satish Suhas, Guru S Gowda, Venkata Senthil Kumar Reddi, John P John","doi":"10.1007/s00737-025-01559-0","DOIUrl":"10.1007/s00737-025-01559-0","url":null,"abstract":"<p><strong>Purpose: </strong>Maternal filicide is a deeply distressing and potentially preventable phenomenon that demands priority attention. This study aims toshed light on the psychological, social and systemic factors contributing to maternal filicide. It calls for robust early intervention strategies and the establishment of comprehensive mental health support systems to mitigate the risk and prevent the occurence of such tragedies..</p><p><strong>Methods: </strong>A detailed evaluation of a mother who committed filicide was undertaken The assessments included in-depth psychiatric evaluations, interviews with family members, review of the individual's medical history, prior social circumstances, and existing legal records. This comprehensive approach allowed for the identification of potential warning signs and gaps in intervention. Additionally, a review of existing literature and national frameworks related to maternal mental health was undertaken to contextualize the findings within the broader socio-cultural and healthcare landscape of India.</p><p><strong>Results: </strong>The case highlights a complex interplay of untreated mental health disorders, social stigma, lack of accessible mental health services, and a failure to recognize warning signs by family members and professionals. The analysis reveals missed opportunities for intervention that might have prevented the act of filicide. Key contributing factors included postpartum mental health issues, socio-economic stressors, and inadequate social and legal support for the mother. This case underscores the need for systemic changes, including improved mental health screening during the perinatal period and the establishment of crisis intervention services.</p><p><strong>Conclusion: </strong>Maternal filicide is not solely a legal issue but also a multifaceted public health and social problem that warrants a multidisciplinary response. The findings emphasize the need for an integrated approach involving healthcare professionals, social workers, and law enforcement agencies to address the mental health challenges faced by mothers in distress. Early identification of at-risk individuals, destigmatization of mental health care, and the provision of timely interventions are pivotal in preventing such tragedies. This study underscores the urgency of implementing mental health policies that prioritize maternal mental health, enhance public awareness, and ensure the availability of accessible, culturally sensitive support systems for at-risk families.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"831-839"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of traumatic exposure in women with premenstrual dysphoric disorder (PMDD): a systematic review.","authors":"Jasleen Kaur Grewal, Eveline Mu, Qi Li, Elizabeth H X Thomas, Jayashri Kulkarni, Leo Chen","doi":"10.1007/s00737-024-01536-z","DOIUrl":"10.1007/s00737-024-01536-z","url":null,"abstract":"<p><strong>Background and purpose: </strong>Premenstrual dysphoric disorder (PMDD) is a debilitating illness that affects 3-8% of women worldwide. There are multiple factors underlying the aetiology of PMDD, ranging from neuroendocrine changes to psychosocial factors such as exposure to trauma. This systematic review aims to assess the prevalence of traumatic exposure in women with PMDD.</p><p><strong>Methods: </strong>A literature search of MEDLINE, EMBASE and PsycInfo was conducted following PRISMA guidelines. Of the 369 studies identified for abstract and full-text screening, 27 were included for review and 16 studies for the quantitative calculation of average prevalence and 95% confidence intervals. Data extracted included study details, sampling details, demographic details, type of traumatic exposure reported, diagnostic tools used, the prevalence of PMDD (total) and the prevalence of self-reported traumatic exposure in PMDD patients.</p><p><strong>Results: </strong>The reported prevalence of traumatic exposure in PMDD ranged from 18.03 to 90.5%. Using a random effects model, the pooled prevalence was 61% (95%CI, 46-74%). The level of heterogeneity (I²) was 95%, showing considerable variability in the data. Amongst only those studies with a control group, it was shown that those with PMDD are 1.99 times more likely to have a history of traumatic exposure than those without PMDD.</p><p><strong>Conclusion: </strong>Our findings suggest that a history of traumatic exposure is highly represented in women living with PMDD. Trauma exposure may be a risk factor for PMDD and could inform this condition's aetiology. A trauma-informed approach should be considered when assessing and managing women presenting with PMDD.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"723-740"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and social determinants of self-reported health status among reproductive age women in Nepal.","authors":"Ashfikur Rahman, Mortuja Mahamud Tohan, Amirul Islam, Bristi Rani Saha, Satyajit Kundu","doi":"10.1007/s00737-024-01528-z","DOIUrl":"10.1007/s00737-024-01528-z","url":null,"abstract":"<p><strong>Purpose: </strong>The self-reported health status (SRHS) is a subjective evaluation of an individual's health and has been connected to mortality and future health outcomes in numerous studies. However, the determinants of SRHS among women in Nepal remain largely unclear. In Nepal, traditional gender norms often result in women bearing greater responsibilities in terms of household chores, child-rearing, and taking care of elderly family members, all of which may potentially contribute to lower self-perceived health. Therefore, this study aims to identify the factors influencing SRHS among women in Nepal.</p><p><strong>Methods: </strong>The study utilized data from 7,442 women aged between 15 and 49 who participated in the Nepal Demographic and Health Survey (NDHS) 2022. Both univariate and multiple linear regression analyses were employed to ascertain the factors influencing self-rated health status (SRHS) among women in Nepal.</p><p><strong>Result: </strong>Women in the age groups 15-24 years (AOR: 5.14, 95% CI: 3.07-8.62) and 25-34 years (AOR: 2.71, 95% CI: 1.99-3.68) were more likely to report good health status compared to older age groups. Additionally, women who were never married (AOR: 4.89, 95% CI: 3.62-5.32) or currently married (AOR: 1.46, 95% CI: 1.11-2.20) and those from wealthy families (AOR: 1.54, 95% CI: 1.07-2.21), also had a higher likelihood of reporting good health status. Other factors associated with a higher probability of reporting good health included not having a history of terminated pregnancy (AOR: 1.48, 95% CI: 1.11-1.97), having no history of genital discharge (AOR: 1.75, 95% CI: 1.29-2.38), not visiting a health facility in the last 12 months (AOR: 2.03, 95% CI: 1.43-2.88), and having no genital ulcers in the previous 12 months (AOR: 2.02, 95% CI: 1.24-3.28). Conversely, women with mild to severe depression and anxiety were less likely to report good health status compared to those with no depression or anxiety.</p><p><strong>Conclusion: </strong>This study identified several social determinants of SRHS among Nepalese women. These socioeconomic determinants of health should be included in future research and health policy activities in Nepal and other comparable contexts.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"759-769"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of disasters on women: the case of Kahramanmaras Earthquake sequence : Post-traumatic stress disorder and other problems among women after the Kahramanmaras Earthquake sequence.","authors":"Cigdem Samanci Tekin, Gamze Aydin","doi":"10.1007/s00737-024-01543-0","DOIUrl":"10.1007/s00737-024-01543-0","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to uncover difficulties, living conditions, and post-traumatic stress disorder (PTSD) symptoms among women victims of the Kahramanmaras earthquake sequence on February 6, 2023.</p><p><strong>Methods: </strong>The data was collected from 388 participants using an online survey between November 1-30, 2023. We collected the data using a survey form with a 48-question sociodemographic information form and the 9-item Post-Traumatic Stress Disorder (PTSD)-Short Scale.We analyzed the data using independent samples t-test, Chi-square test, and binary logistic regression analysis.</p><p><strong>Results: </strong>While 59.5% of participants reported post-earthquake headaches, 77.8% had difficulty sleeping. Apart from the primary impacts of the disaster, 53.6% of participants reported post-earthquake financial difficulties, and 53.4% had to be employed to generate income. Besides, 22.2% of participants experienced violence, and 38.1% had PTSD symptoms. Furthermore, having to work in a paid job increased their probability of developing PTSD symptoms by 3.4 times. Our analysis showed that singles, smokers, those with a disaster-damaged home and financial difficulties, those who had to work, those receiving psychological support, and those with anxiety had significantly higher PTSD scores (p < 0.05). Despite all such difficulties, 43.3% of them participated in aid activities.</p><p><strong>Conclusion: </strong>It seems imperative to devise and implement efficient strategies to address women's physical and mental health challenges in the wake of the disaster. Moreover, it is of the utmost importance to integrate gender-sensitive approaches into disaster preparedness plans by fostering collaborations among all relevant bodies.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"795-804"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new perspective on the causal pathway between maternal mental health and neonatal adversity.","authors":"Emma Lin, Elah Wilson, Arad Kodesh, Stephen Z Levine, Abraham Reichenberg, Nathan Fox, Nina Zaks, Magdalena Janecka","doi":"10.1007/s00737-024-01541-2","DOIUrl":"10.1007/s00737-024-01541-2","url":null,"abstract":"<p><strong>Purpose: </strong>Substantial evidence suggests a downstream impact of maternal mental health on birth outcomes. The roles of comorbid maternal physical health and familial confounding underlying this association remain unclear.</p><p><strong>Methods: </strong>This cohort study included a random sample of children born 1997-2008 within a health maintenance organization (HMO) in Israel, their parents, and siblings. Outcomes were ICD-9 diagnoses of neonatal adversities (birth complications and congenital anomalies) and exposures were maternal diagnoses of mental health disorders. Odds ratios (ORs) and their 95% confidence intervals for the associations between maternal mental health diagnoses and measures of neonatal adversity were calculated using logistic regression, adjusting for maternal age, child's year of birth, socioeconomic status, and maternal physical morbidity burden. We examined potential familial confounding using a negative control approach based on paternal exposure.</p><p><strong>Results: </strong>In our sample of 74,533 children, 6,674 (9.1%) were born after birth complications and 14,569 (19.9%) with a congenital anomaly. Maternal mental health diagnosis around pregnancy was significantly associated with these measures of neonatal adversity after adjustment for potential confounders (birth complications: OR = 1.3 (1.2-1.4), p < 0.001; congenital anomalies: OR = 1.2 (1.1-1.3), p < 0.001). These associations became attenuated and non-significant after further adjustment for maternal physical morbidity burden. In a joint model, maternal and paternal diagnosis of a mental health disorder were independently associated with neonatal adversity (birth complications: OR_mat=1.3 (1.1-1.4), p < 0.001; OR_pat=1.2 (1.1-1.3), p = 0.004; congenital anomalies: OR_mat=1.2 (1.1-1.3), p < 0.001; OR_pat=1.1 (1.0-1.2), p = 0.01).</p><p><strong>Conclusion: </strong>Physical health and familial factors play a role in the associations between maternal mental health and neonatal adversity.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":"903-910"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}