{"title":"口服避孕药治疗可改善多囊卵巢综合征(PCOS)患者的认知能力。","authors":"Saloni Kumari, Soumen Manna, Sheeba Marwah, Himani Ahluwalia, Shweta Panwar","doi":"10.1007/s00737-025-01628-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Oral contraceptives (OCs) are commonly used for the treatment of polycystic ovarian syndrome (PCOS). However, the therapeutic effects of OCs on cognitive function have not been explored extensively. This study aimed to determine the changes in cognitive function in PCOS patients treated with three cycles of combined oral contraceptives (COCs) containing estrogen and progesterone.</p><p><strong>Methods: </strong>Drug-naive PCOS patients (N = 35), aged 18-35 years, were evaluated at baseline and three months after treatment with COC containing levonorgestrel (0.15 mg) plus ethinyl estradiol (30 µg). Working memory (WM), attention, and executive function domains of cognition were assessed using the auditory and visual digit span test (DST), continuous performance test-identical pair (CPT-IP), and trail-making test (TMT), respectively.</p><p><strong>Results: </strong>The DST results showed improvements in the maximal digit span (ML) of the auditory (p = 0.0039) and visual (p = 0.0005) WM tasks after treatment. Improvements were also observed in the mean span (MS) of the auditory (Cohen's d = 0.94, p = 0.0009) and visual (Cohen's d = 0.90, p < 0.0001) DST after treatment. In CPT-IP test, the mean reaction time (RT) of hit rate (Cohen's d = 0.64, p = 0.01) and random errors (Cohen's d = 0.64, p = 0.01) showed a significant decrease after treatment. After treatment, TMT showed a significant decrease in all parameters, except trail 1 errors (p = 0.1079).</p><p><strong>Conclusions: </strong>This preliminary study suggests that three months of COCs treatment in PCOS patients improves cognitive performance in the domains of WM, attention, and executive function. However, the lack of a control group and short follow-up period limits the strength of our findings.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oral contraceptive treatment improves cognitive performance in polycystic ovarian syndrome (PCOS) patients.\",\"authors\":\"Saloni Kumari, Soumen Manna, Sheeba Marwah, Himani Ahluwalia, Shweta Panwar\",\"doi\":\"10.1007/s00737-025-01628-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Oral contraceptives (OCs) are commonly used for the treatment of polycystic ovarian syndrome (PCOS). However, the therapeutic effects of OCs on cognitive function have not been explored extensively. This study aimed to determine the changes in cognitive function in PCOS patients treated with three cycles of combined oral contraceptives (COCs) containing estrogen and progesterone.</p><p><strong>Methods: </strong>Drug-naive PCOS patients (N = 35), aged 18-35 years, were evaluated at baseline and three months after treatment with COC containing levonorgestrel (0.15 mg) plus ethinyl estradiol (30 µg). Working memory (WM), attention, and executive function domains of cognition were assessed using the auditory and visual digit span test (DST), continuous performance test-identical pair (CPT-IP), and trail-making test (TMT), respectively.</p><p><strong>Results: </strong>The DST results showed improvements in the maximal digit span (ML) of the auditory (p = 0.0039) and visual (p = 0.0005) WM tasks after treatment. Improvements were also observed in the mean span (MS) of the auditory (Cohen's d = 0.94, p = 0.0009) and visual (Cohen's d = 0.90, p < 0.0001) DST after treatment. In CPT-IP test, the mean reaction time (RT) of hit rate (Cohen's d = 0.64, p = 0.01) and random errors (Cohen's d = 0.64, p = 0.01) showed a significant decrease after treatment. After treatment, TMT showed a significant decrease in all parameters, except trail 1 errors (p = 0.1079).</p><p><strong>Conclusions: </strong>This preliminary study suggests that three months of COCs treatment in PCOS patients improves cognitive performance in the domains of WM, attention, and executive function. 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引用次数: 0
摘要
目的:口服避孕药是治疗多囊卵巢综合征(PCOS)的常用药物。然而,OCs对认知功能的治疗作用尚未得到广泛的探讨。本研究旨在确定PCOS患者服用含雌激素和黄体酮的联合口服避孕药(COCs)三个周期后认知功能的变化。方法:35例年龄在18-35岁的PCOS患者,在基线和治疗3个月后接受含左炔诺孕酮(0.15 mg) +炔雌醇(30µg)的COC治疗。工作记忆(WM)、注意力和执行功能领域的认知分别采用听觉和视觉数字广度测试(DST)、连续性能测试-相同对(CPT-IP)和轨迹测试(TMT)进行评估。结果:DST结果显示,治疗后听觉(p = 0.0039)和视觉(p = 0.0005) WM任务的最大数字广度(ML)有所改善。听觉(Cohen’s d = 0.94, p = 0.0009)和视觉(Cohen’s d = 0.90, p)的平均跨度(MS)也有改善。结论:本初步研究表明,COCs治疗三个月后,PCOS患者在WM、注意力和执行功能领域的认知表现得到改善。然而,缺乏对照组和较短的随访期限制了我们研究结果的强度。
Purpose: Oral contraceptives (OCs) are commonly used for the treatment of polycystic ovarian syndrome (PCOS). However, the therapeutic effects of OCs on cognitive function have not been explored extensively. This study aimed to determine the changes in cognitive function in PCOS patients treated with three cycles of combined oral contraceptives (COCs) containing estrogen and progesterone.
Methods: Drug-naive PCOS patients (N = 35), aged 18-35 years, were evaluated at baseline and three months after treatment with COC containing levonorgestrel (0.15 mg) plus ethinyl estradiol (30 µg). Working memory (WM), attention, and executive function domains of cognition were assessed using the auditory and visual digit span test (DST), continuous performance test-identical pair (CPT-IP), and trail-making test (TMT), respectively.
Results: The DST results showed improvements in the maximal digit span (ML) of the auditory (p = 0.0039) and visual (p = 0.0005) WM tasks after treatment. Improvements were also observed in the mean span (MS) of the auditory (Cohen's d = 0.94, p = 0.0009) and visual (Cohen's d = 0.90, p < 0.0001) DST after treatment. In CPT-IP test, the mean reaction time (RT) of hit rate (Cohen's d = 0.64, p = 0.01) and random errors (Cohen's d = 0.64, p = 0.01) showed a significant decrease after treatment. After treatment, TMT showed a significant decrease in all parameters, except trail 1 errors (p = 0.1079).
Conclusions: This preliminary study suggests that three months of COCs treatment in PCOS patients improves cognitive performance in the domains of WM, attention, and executive function. However, the lack of a control group and short follow-up period limits the strength of our findings.
期刊介绍:
Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.