Oral contraceptive treatment improves cognitive performance in polycystic ovarian syndrome (PCOS) patients.

IF 2.7 3区 医学 Q2 PSYCHIATRY
Saloni Kumari, Soumen Manna, Sheeba Marwah, Himani Ahluwalia, Shweta Panwar
{"title":"Oral contraceptive treatment improves cognitive performance in polycystic ovarian syndrome (PCOS) patients.","authors":"Saloni Kumari, Soumen Manna, Sheeba Marwah, Himani Ahluwalia, Shweta Panwar","doi":"10.1007/s00737-025-01628-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Oral contraceptives (OCs) are commonly used for the treatment of polycystic ovarian syndrome (PCOS). However, the therapeutic effects of OCs on cognitive function have not been explored extensively. This study aimed to determine the changes in cognitive function in PCOS patients treated with three cycles of combined oral contraceptives (COCs) containing estrogen and progesterone.</p><p><strong>Methods: </strong>Drug-naive PCOS patients (N = 35), aged 18-35 years, were evaluated at baseline and three months after treatment with COC containing levonorgestrel (0.15 mg) plus ethinyl estradiol (30 µg). Working memory (WM), attention, and executive function domains of cognition were assessed using the auditory and visual digit span test (DST), continuous performance test-identical pair (CPT-IP), and trail-making test (TMT), respectively.</p><p><strong>Results: </strong>The DST results showed improvements in the maximal digit span (ML) of the auditory (p = 0.0039) and visual (p = 0.0005) WM tasks after treatment. Improvements were also observed in the mean span (MS) of the auditory (Cohen's d = 0.94, p = 0.0009) and visual (Cohen's d = 0.90, p < 0.0001) DST after treatment. In CPT-IP test, the mean reaction time (RT) of hit rate (Cohen's d = 0.64, p = 0.01) and random errors (Cohen's d = 0.64, p = 0.01) showed a significant decrease after treatment. After treatment, TMT showed a significant decrease in all parameters, except trail 1 errors (p = 0.1079).</p><p><strong>Conclusions: </strong>This preliminary study suggests that three months of COCs treatment in PCOS patients improves cognitive performance in the domains of WM, attention, and executive function. However, the lack of a control group and short follow-up period limits the strength of our findings.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Women's Mental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00737-025-01628-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: Oral contraceptives (OCs) are commonly used for the treatment of polycystic ovarian syndrome (PCOS). However, the therapeutic effects of OCs on cognitive function have not been explored extensively. This study aimed to determine the changes in cognitive function in PCOS patients treated with three cycles of combined oral contraceptives (COCs) containing estrogen and progesterone.

Methods: Drug-naive PCOS patients (N = 35), aged 18-35 years, were evaluated at baseline and three months after treatment with COC containing levonorgestrel (0.15 mg) plus ethinyl estradiol (30 µg). Working memory (WM), attention, and executive function domains of cognition were assessed using the auditory and visual digit span test (DST), continuous performance test-identical pair (CPT-IP), and trail-making test (TMT), respectively.

Results: The DST results showed improvements in the maximal digit span (ML) of the auditory (p = 0.0039) and visual (p = 0.0005) WM tasks after treatment. Improvements were also observed in the mean span (MS) of the auditory (Cohen's d = 0.94, p = 0.0009) and visual (Cohen's d = 0.90, p < 0.0001) DST after treatment. In CPT-IP test, the mean reaction time (RT) of hit rate (Cohen's d = 0.64, p = 0.01) and random errors (Cohen's d = 0.64, p = 0.01) showed a significant decrease after treatment. After treatment, TMT showed a significant decrease in all parameters, except trail 1 errors (p = 0.1079).

Conclusions: This preliminary study suggests that three months of COCs treatment in PCOS patients improves cognitive performance in the domains of WM, attention, and executive function. However, the lack of a control group and short follow-up period limits the strength of our findings.

口服避孕药治疗可改善多囊卵巢综合征(PCOS)患者的认知能力。
目的:口服避孕药是治疗多囊卵巢综合征(PCOS)的常用药物。然而,OCs对认知功能的治疗作用尚未得到广泛的探讨。本研究旨在确定PCOS患者服用含雌激素和黄体酮的联合口服避孕药(COCs)三个周期后认知功能的变化。方法:35例年龄在18-35岁的PCOS患者,在基线和治疗3个月后接受含左炔诺孕酮(0.15 mg) +炔雌醇(30µg)的COC治疗。工作记忆(WM)、注意力和执行功能领域的认知分别采用听觉和视觉数字广度测试(DST)、连续性能测试-相同对(CPT-IP)和轨迹测试(TMT)进行评估。结果:DST结果显示,治疗后听觉(p = 0.0039)和视觉(p = 0.0005) WM任务的最大数字广度(ML)有所改善。听觉(Cohen’s d = 0.94, p = 0.0009)和视觉(Cohen’s d = 0.90, p)的平均跨度(MS)也有改善。结论:本初步研究表明,COCs治疗三个月后,PCOS患者在WM、注意力和执行功能领域的认知表现得到改善。然而,缺乏对照组和较短的随访期限制了我们研究结果的强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Archives of Women's Mental Health
Archives of Women's Mental Health 医学-精神病学
CiteScore
8.00
自引率
4.40%
发文量
83
审稿时长
6-12 weeks
期刊介绍: Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信