Archivos De La Sociedad Espanola De Oftalmologia最新文献_第4页

Un estudio ambispectivo sobre la progresión fenotípica de los pacientes con enfermedad de Stargardt por mutación en el gen ABCA4 ABCA4基因突变引起的Stargardt病患者表型进展的双目研究

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-14 DOI: 10.1016/j.oftal.2025.06.005

V.A. Martel Ramirez, C.R. Pérez Montaño, A.Y. Hernández Vázquez, S. Rojas Juárez, J.A. Ramírez Estudillo

{"title":"Un estudio ambispectivo sobre la progresión fenotípica de los pacientes con enfermedad de Stargardt por mutación en el gen ABCA4","authors":"V.A. Martel Ramirez, C.R. Pérez Montaño, A.Y. Hernández Vázquez, S. Rojas Juárez, J.A. Ramírez Estudillo","doi":"10.1016/j.oftal.2025.06.005","DOIUrl":"10.1016/j.oftal.2025.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to describe the phenotypic progression of patients with Stargardt disease caused by mutations in the <em>ABCA4</em> gene and reports on the mutated allelic variants.</div></div><div><h3>Method</h3><div>We conducted an observational, ambispective, and descriptive study. Patients who had Stargardt disease by the <em>ABCA4</em> gene mutation were included. The study used the genetic report and the baseline examinations appearing on health records. To evaluate the phenotypic variation, a new ophthalmological evaluation was conducted using macular OCT, retinography, autofluorescence, and electroretinogram.</div></div><div><h3>Results</h3><div>The study identified a total of 32 cases with a mean follow-up of 6 years. The mean age of onset was 16 years. The mean initial and final VA were 0.79 and 0.95 logMAR, respectively. The mean initial and final CMT were 142.5 and 135 microns, respectively. The predominant degree of fundus involvement and autofluorescence pattern at the beginning and end was macular atrophy with flecks and the low signal of macular autofluorescence surrounded by a heterogeneous background, respectively. Initial electroretinography showed predominantly preserved function of rods and cones, while in the end most cases presented rod and cone system dysfunction. A total of 9 cases were homozygous, and 31 different mutant allelic variants were identified. The most common variant was p.Trp1618Cys, followed by p.Ala1773Val. Two new allelic variants, p.Leu634Pro, and p.Tyr665Serfs*5, were also discovered.</div></div><div><h3>Conclusions</h3><div>The study found that patients experienced structural and functional deterioration at the follow-up. The study also identified 2 predominant variants and 2 new variants. Homozygotes had an earlier onset of the disease.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 528-536"},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlación entre biomarcadores de mal pronóstico visual por tomografía de coherencia óptica en edema macular diabético y el nivel de albuminuria en pacientes con enfermedad renal crónica 糖尿病黄斑水肿的光学相干断层扫描视力预后差的生物标志物与慢性肾病患者白蛋白尿水平之间的相关性

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2025.03.008

S. Menchaca Gutiérrez, L.F. Yañez Ortega, E. Sánchez Hernández

{"title":"Correlación entre biomarcadores de mal pronóstico visual por tomografía de coherencia óptica en edema macular diabético y el nivel de albuminuria en pacientes con enfermedad renal crónica","authors":"S. Menchaca Gutiérrez, L.F. Yañez Ortega, E. Sánchez Hernández","doi":"10.1016/j.oftal.2025.03.008","DOIUrl":"10.1016/j.oftal.2025.03.008","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the correlation of poor visual prognosis biomarkers by Optical Coherence Tomography (OCT) in diabetic macular edema with the level of albuminuria in patients with Chronic Kidney Disease.</div></div><div><h3>Design</h3><div>This is a retrospective, observational, cross-sectional, and analytical study</div></div><div><h3>Participants</h3><div>All patients diagnosed with diabetic macular edema who attended the retina department of the Ophthalmology service and met the inclusion criteria between March 2021 and August 2022.</div></div><div><h3>Methods</h3><div>Data gathering was done through medical record reviews and the patients were divided based on 3 categories of albuminuria. OCT images of the affected eye, which was considered to be the one that was eligible for anti- VEGF treatment, were collected and analyzed, and the corresponding subdivision was made depending on the presence of poor visual prognosis OCT biomarkers.</div></div><div><h3>Results</h3><div>Chi-square goodness-of-fit tests were performed to analyze whether the proportion of biomarkers in each albuminuria category is due to chance or is related to each A1-A3 albuminuria level. A direct correlation was found between the absence of integrity in the outer retinal layers and the severity of albuminuria.</div></div><div><h3>Conclusions</h3><div>OCT may serve as a valuable tool for detecting kidney damage by considering the relationship between certain biomarkers and the presence of albuminuria, particularly the disruption of the outer retinal layers, which could serve as an OCT biomarker for advanced kidney disease.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 392-396"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Queratitis herpética después de crosslinkig corneal 角膜交叉连接后疱疹性角膜炎

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2024.11.012

N. Laaribi, R. Mendes, K. Reda, A. Oubaaz

{"title":"Queratitis herpética después de crosslinkig corneal","authors":"N. Laaribi, R. Mendes, K. Reda, A. Oubaaz","doi":"10.1016/j.oftal.2024.11.012","DOIUrl":"10.1016/j.oftal.2024.11.012","url":null,"abstract":"<div><div>Corneal crosslinking is considered a safe procedure even if sight-threatening side effects have been reported. Other han our case report, few reports of herpetic keratitis (HK) after crosslinking have been published. We report a new onset HK after corneal crosslinking for keratoconus.</div><div>A 40-year-old woman underwent corneal collagen crosslinking in her right eye for progressive keratoconus. The patient returned with pain and photophobia. Infiltration in the corneal stroma was observed. Fluorescein staining specified epithelial defects overlying the corneal infiltrates.</div><div>The diagnostic of HK was confirmed with polymerase chain reaction for DNA detection of HSV type 1 of corneal swab. The epithelial defect healed with oral valacyclovir treatment.</div><div>Topical corticosteroid drops and preservative-free lubricant eye drops were, also, added to the antiviral treatment. Afterwards, a decrease in stromal infiltrate was observed.</div><div>This case report highlights the risk of HK after crosslinking and elucidates the importance of timely diagnosis of this unusual but important complication. The ophthalmologist should be aware of the possibility of HK in eyes after crosslinking, even in patients without a past medical history of <em>HSV</em> infection.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 435-438"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grabaciones con teléfonos móviles en consulta de oftalmología: límites legales 眼科诊所的移动电话录音：法律限制

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2025.01.005

M. Sanchidrián Mayo

引用次数: 0

Uveítis infecciosa: epidemiología, etiología, rendimiento de pruebas diagnósticas y tratamiento 传染病：流行病学、病因学、诊断结果和治疗

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2025.01.010

L.M. Méndez-Rodríguez , L.C. Nocua-Báez , G. Mejía-Salgado , A. de-la-Torre , C.A. Álvarez-Moreno

{"title":"Uveítis infecciosa: epidemiología, etiología, rendimiento de pruebas diagnósticas y tratamiento","authors":"L.M. Méndez-Rodríguez , L.C. Nocua-Báez , G. Mejía-Salgado , A. de-la-Torre , C.A. Álvarez-Moreno","doi":"10.1016/j.oftal.2025.01.010","DOIUrl":"10.1016/j.oftal.2025.01.010","url":null,"abstract":"<div><div>Infectious uveitis is an inflammation of the uveal tract, corresponding to the eye's middle layer, triggered by a response against an infectious agent. This condition is classified into anterior, intermediate, posterior and panuveitis. The most frequent infectious agents in anterior uveitis are viruses, mainly herpes simplex virus. However, it can also be caused by other pathogens such as <em>Bartonella</em> spp<em>., Mycobacterium tuberculosis</em> and <em>Fusarium</em> spp<em>.</em> In intermediate uveitis, syphilis plays a predominant role, while in posterior uveitis various microorganisms are involved, among them <em>Toxoplasma gondii, Cytomegalovirus, Plasmodium</em> spp<em>. and Candida</em> spp. In some instances, as in ocular toxoplasmosis, severe inflammation may involve the entire uvea, resulting in panuveitis.</div><div>Clinical manifestations of uveitis include ocular pain, redness, myodesopsias, blurred vision, and even vision loss. Direct identification of the causative agent is complex, and the diagnostic performance of available tests varies significantly. For example, polymerase chain reaction (PCR) on ocular specimens for Herpes simplex virus has a sensitivity of 91.3% and specificity of 98.8%, while for toxoplasmosis the sensitivity is 43.1% and specificity 98.5%. Another challenge in infectious uveitis is treatment, as systemic antimicrobials generally have a low penetration into ocular tissue, mostly less than 5%, mainly due to the blood-retinal and blood-aqueous barriers. The efficacy of the molecules in ocular tissue is favored by low protein binding and high liposolubility.</div><div>This review addresses the most frequent clinical manifestations of bacterial, viral, parasitic and fungal etiologies of infectious uveitis, as well as the diagnostic performance of available tests. In addition, emphasis is placed on the different therapeutic approaches depending on etiology.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 397-420"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frecuencia del cociente vertical copa-disco con relación al tamaño del disco óptico normal 杯盘垂直比与正常光盘尺寸之比的频率

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2024.11.011

Manuel Gonzalez de la Rosa, Marta Gonzalez Hernandez, Daniel Gonzalez-Hernandez

引用次数: 0

Análisis de la prevalencia de la retinopatía diabética en un programa de cribado por telemedicina durante el periodo 2018 a 2023 2018 - 2023年远程医疗筛查项目中糖尿病视网膜病变患病率分析

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2025.02.008

Ó. García-Espinilla , P. Arlanzón-Lope , A. Novo-Díez , D.R. Llanos Ferraris , S. Ortiz-Toquero , P. de la Iglesia Rodríguez , M. López-Gálvez , J.C. Pastor

{"title":"Análisis de la prevalencia de la retinopatía diabética en un programa de cribado por telemedicina durante el periodo 2018 a 2023","authors":"Ó. García-Espinilla , P. Arlanzón-Lope , A. Novo-Díez , D.R. Llanos Ferraris , S. Ortiz-Toquero , P. de la Iglesia Rodríguez , M. López-Gálvez , J.C. Pastor","doi":"10.1016/j.oftal.2025.02.008","DOIUrl":"10.1016/j.oftal.2025.02.008","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Diabetic retinopathy (DR) is the most common ocular complication of diabetes. Screening programmes using fundus examination with retinal imaging are a useful tool for early diagnosis of DR and an improved disease prognosis. The purpose of this study is to analyse the number of patients attended in the DR screening programme of the Castilla y León health system and to estimate DR prevalence and severity.</div></div><div><h3>Material and methods</h3><div>An observational study of patients previously registered as diabetic who participated in the screening programme between 2018 and 2028 was conducted. Patients were classified according to their diagnosis in non-evaluable test, non-evaluable patient, no DR, DR (mild, moderate, severe, proliferative, and suspected diabetic macular oedema) and other pathologies.</div></div><div><h3>Results</h3><div>The total number of consultations in the program up to the present date has been 31,901, increasing from 3,934 in 2018 to 9,508 in 2023. The estimated prevalence of DR is 15.41%. 1.58% of patients were referred to their reference hospitals due to DR or other pathologies requiring urgent treatment. The remaining patients were managed by the program.</div></div><div><h3>Conclusions</h3><div>The prevalence of DR appears to be slightly lower than that reported in other published series, but no significant differences were observed between different program years, overall assessment, or different forms of DR or suspected diabetic macular oedema.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 377-385"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurorretinopatía macular aguda asociada a infección por el virus del dengue 与登革热病毒感染相关的急性黄斑视网膜病变

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2025.02.002

F. Calleja Casado , B. Juan Ribelles , S.A. Maugard Tepper , A. Caro Ortega , E. Gracia Rovira , A. Duch Samper

{"title":"Neurorretinopatía macular aguda asociada a infección por el virus del dengue","authors":"F. Calleja Casado , B. Juan Ribelles , S.A. Maugard Tepper , A. Caro Ortega , E. Gracia Rovira , A. Duch Samper","doi":"10.1016/j.oftal.2025.02.002","DOIUrl":"10.1016/j.oftal.2025.02.002","url":null,"abstract":"<div><div>Acute macular neuroretinopathy (AMN) is a rare retinal condition characterized by paracentral scotomas and typical wedge-shaped lesions in the outer retina, often affecting young, otherwise healthy individuals. We report a case of AMN associated with dengue virus infection in a 48-year-old female doctor presenting with sudden onset of visual disturbances during a febrile illness after working away in Africa. Ophthalmologic examination and multimodal imaging, including optical coherence tomography and fundus autofluorescence, revealed characteristic outer retinal changes consistent with AMN. Dengue infection was confirmed through serologic testing, and no other systemic or ocular conditions were identified, apart from fever and myalgias.</div><div>The pathophysiology of AMN in the context of dengue virus remains unclear, though it may involve ischemic damage to the deep retinal capillary plexus due to systemic inflammation, endothelial dysfunction, or immune-mediated mechanisms. This case underscores the importance of considering dengue virus infection in the differential diagnosis of AMN and/or foveolitis, particularly in endemic regions. Early recognition and diagnosis are critical for appropriate management and follow up, though no specific treatment for AMN exists. This case adds to the growing body of literature on the ocular manifestations of viral infections, specifically dengue, and highlights the need for further research into the underlying mechanisms and potential therapeutic interventions.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 421-425"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lente intraocular fáquica de colámero tórica implantada en piggyback: manejo de la ametropía pseudofáquica y la disfotopsia negativa 托聚物假眼内背囊植入晶状体：处理假眼畸变和负性畸变

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2024.10.014

F. Gonzalez-Lopez, S. Delgado-Tirado, E. Sevillano, E. Corral-Carrasquilla, D. Medel

引用次数: 0

La noche estrellada: turbulencias de pigmento tras iridotomía periférica en iris bombé 繁星点点的夜晚：大虹膜周围虹膜切除术后的色素紊乱

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-07-01 DOI: 10.1016/j.oftal.2024.12.006

A. Arnaiz-Camacho, C. Parés-Alfonso, L. Sánchez-Vela

引用次数: 0