Archivos De La Sociedad Espanola De Oftalmologia最新文献

{"title":"La enfermedad del ojo seco: alimentación y genética nutricional. Una revisión narrativa","authors":"J. Salgado-Borges,&nbsp;S. Mora-Sáez,&nbsp;I. Andrés-Blasco,&nbsp;E. Bendala-Tufanisco,&nbsp;J. Benitez-del-Castillo,&nbsp;R. Machado-Soares,&nbsp;M.D. Pinazo-Durán,&nbsp;M. Labetoulle","doi":"10.1016/j.oftal.2026.502574","DOIUrl":"10.1016/j.oftal.2026.502574","url":null,"abstract":"<div><div>This narrative review deals with dry eye disease (DED), a multifactorial disorder with varied prevalence worldwide, affecting the ocular surface constituents, and commonly associated to inflammation. Changes induced by DED provoke tear-film instability and a range of clinical manifestations, from soreness, blurred vision, to severe complications and loss of quality-of-life. Diet, nutrition and nutraceuticals have been identified as intervention targets for better managing DED pathophysiology. To gain knowledge in nutritional requirements and how to modify the diet based on the necessities by means of nutritional genetics, is an excellent approach to the above issues.</div><div>Molecular-genetic tools, specifically omics sciences in relation to food, diet, and nutritional genetics in DED, are the main purpose of this work. Between July- November 2025 we accessed the following databases: PubMed®, Web of Science®, Scopus®, and Cochrane library®, by using the keywords.</div><div>diet OR natural food OR nutrition OR nutritional genetics OR nutrigenetics OR nutrigenomics OR omics sciences OR personalized diet AND dry eye disease OR dry eye disorder OR ocular surface disease. According to selection criteria, and a refined evaluation, 238 studies were finally found eligible for this review.</div><div>DED-related topics included in this work were: 1) Diets, food, and nutrients, 2) Nutritional genetics. 3) Dietary recommendations for DED, and 4) Final remarks and conclusions. Using new omics technologies, including nutrigenetics, nutrigenomics, epigenetics and epigenomics, and metabolomics, the influence of diet and nutrition on DEDs are becoming clearer. However, knowledge of the interplay between food, nutritional genetics and DED is just beginning to emerge.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 8","pages":"Article 502574"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coriorretinopatía exudativa hemorrágica periférica bilateral tratada con inyecciones intravítreas de ranibizumab","authors":"A.B. González Escobar,&nbsp;I.M. Baquero Aranda,&nbsp;J.C. Valera Ávila,&nbsp;E. Barco Moreno,&nbsp;J.M. Galván Cano,&nbsp;R. Luque Aranda","doi":"10.1016/j.oftal.2026.502539","DOIUrl":"10.1016/j.oftal.2026.502539","url":null,"abstract":"<div><div>Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is a rare entity consisting of lesions similar to those of age-related macular degeneration (AMD) and type 1 aneurysmal neovascularization (N1a), but located outside the macular region in the peripheral retina.</div><div>We present the case of an 89-year-old woman who presented to the emergency department with loss of visual acuity (VA) in both eyes (OU) due to a massive macular subretinal hemorrhage in the right eye (OD) and a vitreous hemorrhage in her left eye (OS), accompanied in both eyes by peripheral hemorrhagic retinal pigment epithelium detachments (HPED). Ophthalmological examination and multimodal imaging led to the diagnosis of PEHCR.</div><div>This case highlights the importance of the differential diagnosis of PEHCR from other vascular and neoplastic pathologies in order to avoid unnecessary tests and treatments. Early recognition and diagnosis are essential for establishing appropriate management, with intravitreal injections of anti-vascular endotelial groth factors (anti-VEGF) being recommended in cases with loss of VA or threat thereof. This case also contributes to the limited published literature on bilateral PEHCR, reinforcing the need to consider this pathology in elderly patients with peripheral hemorrhagic lesions.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 8","pages":"Article 502539"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148646861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hacia una nueva era en la biometría ocular: innovación en tecnología de medición y cálculo de la potencia de la lente intraocular","authors":"M. Puzo Bayod,&nbsp;F.J. Castro Alonso","doi":"10.1016/j.oftal.2026.502468","DOIUrl":"10.1016/j.oftal.2026.502468","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 8","pages":"Article 502468"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regresión espontánea de un nevus coroideo con factores de riesgo para crecimiento","authors":"M. Prat Dot,&nbsp;D. Lorenzo Parra,&nbsp;J.M. Caminal Mitjana","doi":"10.1016/j.oftal.2026.502536","DOIUrl":"10.1016/j.oftal.2026.502536","url":null,"abstract":"<div><div>We report the case of a 41-year-old woman with a choroidal nevus exhibiting recognized risk factors for malignant transformation who demonstrated spontaneous and progressive regression over a 6-year follow-up period. Spontaneous involution is a well-established phenomenon in cutaneous lesions, including melanocytic nevi and cutaneous malignant melanoma, and has occasionally been described in choroidal melanoma. However, spontaneous regression of choroidal nevus is exceedingly rare, with only two cases previously reported in the literature. The underlying mechanism is presumed to involve an immune-mediated response driven by melanocyte-specific T<!--> <!-->lymphocytes, predominantly cytotoxic CD8+ T<!--> <!-->cells.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 8","pages":"Article 502536"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148646860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la recesión bilateral gradual del músculo oblicuo inferior en la torsión ocular en pacientes con hiperfunción primaria del músculo oblicuo inferior: un estudio prospectivo","authors":"K.B. Mallik,&nbsp;A. Singh,&nbsp;S.K. Mittal,&nbsp;P.K. Pandey,&nbsp;B. Kumar","doi":"10.1016/j.oftal.2026.502599","DOIUrl":"10.1016/j.oftal.2026.502599","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>The impact of inferior oblique (IO) weakening on ocular torsion is well documented. This study aimed to evaluate objective and subjective torsional changes using fondo photography and the Double Maddox rod test (DMRT) after bilateral IO recession in cases of primary inferior oblique overaction.</div></div><div><h3>Materials and methods</h3><div>This prospective, hospital-based observational cohort study included 82 eyes from 41 patients with primary inferior oblique overaction who underwent IO recession using the Apt and Call technique between December 2023 and March 2025. Pre- and postoperative subjective and objective torsion were analyzed using the DMRT and fundus photography to assess torsional changes at 1, 4, and 12 weeks.</div></div><div><h3>Results</h3><div>The mean age was 13.93<!--> <!-->±<!--> <!-->8 years; 58.5% of patients were male. Preoperative DMRT showed no subjective torsion, with a mean objective torsion of 9.32<!--> <!-->±<!--> <!-->5.25̊. Mean IOOA grade and V-pattern were 2.74<!--> <!-->±<!--> <!-->0.98 and 28.66<!--> <!-->±<!--> <!-->9.08 prism diopters, respectively. Postoperatively, DMRT findings remained unchanged, whereas objective torsion decreased significantly to 5.82<!--> <!-->±<!--> <!-->3.95, 5.51<!--> <!-->±<!--> <!-->3.8, and 5.08<!--> <!-->±<!--> <!-->3.77̊ at 1, 4, and 12 weeks, respectively. The overall change in torsion at 12 weeks was 4.24<!--> <!-->±<!--> <!-->3.14̊. Additionally, significant improvements in IOOA grading and V-pattern were observed at 12 weeks, with values of 0.09<!--> <!-->±<!--> <!-->0.28 grades and 6.05<!--> <!-->±<!--> <!-->2.95 prism diopters, respectively (<em>P</em> <!-->&lt;<!--> <!-->.001).</div></div><div><h3>Conclusions</h3><div>Bilateral graded IO recession significantly reduces objective ocular extorsion, without a corresponding change in subjective torsion as assessed by DMRT. The reduction in torsion was accompanied by significant improvements in IOOA grading and V-pattern deviation, confirming the functional efficacy of IO recession.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 8","pages":"Article 502599"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnóstico molecular dual de albinismo oculocutáneo tipo 1 relacionado con TYR y síndrome de Marfan asociado a FBN1: un caso novedoso con correlaciones oculares y sistémicas","authors":"M. Moro-Muniz,&nbsp;A. Ortiz Seller,&nbsp;E. Sanz Marco","doi":"10.1016/j.oftal.2026.502537","DOIUrl":"10.1016/j.oftal.2026.502537","url":null,"abstract":"<div><div>We report the first pediatric case with molecular confirmation of <em>TYR</em>-related oculocutaneous albinism type 1 and <em>FBN1</em>-associated Marfan syndrome. The patient exhibited high myopia, diffuse myopic chorioretinopathy, bilateral foveal hypoplasia, and electrophysiologic evidence of optic pathway misrouting. Systemic findings included tall stature, mild scoliosis, and marfanoid features. Pathogenic variants were confirmed in both <em>TYR</em> and <em>FBN1</em>. The coexistence of these traditionally unrelated disorders broadens the phenotypic spectrum of both oculocutaneous albinism type 1 and Marfan syndrome and suggests the potential involvement of shared or interacting pathways linking melanogenesis and extracellular matrix biology. This case highlights the importance of comprehensive genomic testing and multidisciplinary evaluation in patients with atypical ocular presentations and supports consideration of dual genetic diagnoses when a single gene defect does not adequately account for the clinical phenotype.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 8","pages":"Article 502537"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148646862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coloboma aislado del cristalino","authors":"N. Taouri,&nbsp;H. Alami,&nbsp;L.O. Cherkaoui","doi":"10.1016/j.oftal.2026.502552","DOIUrl":"10.1016/j.oftal.2026.502552","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 7","pages":"Article 502552"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mejora en la calidad de vida y los síntomas de la superficie ocular después de la escisión de pterigión con autoinjerto conjuntival y pegamento tisular: un estudio prospectivo","authors":"A.D. Alarcón García,&nbsp;B. Burgos-Blasco,&nbsp;P. Robles Amor,&nbsp;A. Miranda Sánchez,&nbsp;P. Pérez García,&nbsp;P. Arriola Villalobos","doi":"10.1016/j.oftal.2026.502598","DOIUrl":"10.1016/j.oftal.2026.502598","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>To evaluate changes in quality of life in patients with pterygium before and after pterygium excision with conjunctival autograft using standardized questionnaires.</div></div><div><h3>Materials and methods</h3><div>A prospective observational study including patients scheduled for pterygium surgery was conducted. Patients completed the Ocular Surface Disease Index (OSDI) and the Visual Function Questionnaire 25 (NEI VFQ-25) before surgery and at 2 and 6 months postoperatively. Sex, age, prior treatments, visual acuity, and corneal and limbal pterygium extension were recorded. A standard surgical procedure was performed by experienced ocular surface surgeons under topical anaesthesia, consisting of pterygium excision via avulsion followed by superior conjunctival autograft fixation using tissue adhesive.</div></div><div><h3>Results</h3><div>Twenty eyes were included in this study: mean age 50.0<!--> <!-->±<!--> <!-->11.5 years, and 12 patients (60%) were male. Visual acuity was 0.8<!--> <!-->±<!--> <!-->0.2 (decimal scale), and the mean pterygium size was 3.3<!--> <!-->±<!--> <!-->1.0<!--> <!-->mm of corneal invasion and 3.3<!--> <!-->±<!--> <!-->1.1<!--> <!-->mm of limbal invasion. The mean preoperative OSDI score was 47.6<!--> <!-->±<!--> <!-->20.6 (no differences between sexes; P<!--> <!-->=<!--> <!-->.650), which decreased significantly to 35.8<!--> <!-->±<!--> <!-->18.1 at 2 months (11.8 [95%CI, 4.5 to 19.1]; P<!--> <!-->=<!--> <!-->.001) and to 29.0<!--> <!-->±<!--> <!-->13.9 at 6 months postoperatively (18.6 [95%CI, 9.6 to 27.5]; P &lt;<!--> <!-->.001). The mean preoperative NEI VFQ-25 score was 71.8<!--> <!-->±<!--> <!-->6.8, with no significant differences between males and females (P<!--> <!-->=<!--> <!-->.928). Mean VFQ scores differed significantly across time points (F(1.5, 29.1)<!--> <!-->=<!--> <!-->3.7; P<!--> <!-->=<!--> <!-->.047), although posthoc analysis showed no significant pairwise differences.</div></div><div><h3>Conclusions</h3><div>Pterygium surgery significantly improves ocular symptomatology in most patients, with improvement observed within the first 6 months postoperatively.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 7","pages":"Article 502598"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148559012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOIANA bilateral simultánea tras inicio de semaglutida a dosis elevadas: comunicación de un caso","authors":"V.M. Asensio-Sánchez,&nbsp;J. Rodríguez-Espinosa,&nbsp;S. Silva-Schultz,&nbsp;G. González-Fernández,&nbsp;S. Lallana-Serrano","doi":"10.1016/j.oftal.2026.502490","DOIUrl":"10.1016/j.oftal.2026.502490","url":null,"abstract":"<div><div>We report a case of simultaneous bilateral non-arteritic anterior ischemic optic neuropathy (NAION) in a 68-year-old man with poorly controlled type<!--> <!-->2 diabetes mellitus and significant hyperopia (+5<!--> <!-->diopters). Visual loss began 14<!--> <!-->days after initiating semaglutide at a relatively high dose (0.5<!--> <!-->mg/week), progressing to functional blindness within four weeks. Ophthalmologic examination revealed bilateral optic disc edema with hemorrhages, exudates, and subretinal fluid. Infectious and autoimmune causes were ruled out, and cerebrospinal fluid analysis was normal. Following the high dose of semaglutide, glycated hemoglobin decreased, although the magnitude and speed of this decline should be interpreted with caution, and the association between the drug and the optic nerve event must be considered purely temporal, with no evidence of direct causality. Despite drug discontinuation and corticosteroid treatment, visual loss persisted. The simultaneous bilateral presentation, rapid progression, and predisposing anatomical factors — crowded optic discs and possible scleral rigidity — highlight extreme vulnerability. This case illustrates a possible temporal association, representing one of the few such cases reported to date, and underscores the importance of baseline ophthalmic evaluation, close monitoring, and careful consideration of initial dosing in patients treated with GLP-1 receptor agonists.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 7","pages":"Article 502490"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148559015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis biomicroscópico, gonioscópico y tomográfico de un anillo de Kayser-Fleischer: comunicación de un caso","authors":"V.J. Altares-Mateos,&nbsp;M. Castro Rebollo,&nbsp;J. González Martín-Moro","doi":"10.1016/j.oftal.2026.502535","DOIUrl":"10.1016/j.oftal.2026.502535","url":null,"abstract":"<div><div>The Kayser- Fleischer Ring (KFR) is a characteristic, though not pathognomonic, feature of Wilson's disease (WD). It arises from copper deposition in Descemet's membrane and may exhibit a range of hues, including yellow-green, dull red, bright green, or blue. We report the case of a 58-year-old female patient in whom, in addition to copper deposition, optical coherence tomography (OCT) revealed leucomatous alterations in the corneal stroma adjacent to the deposit.</div><div>Early recognition of this clinical sign plays a crucial role in the diagnosis of WD, in which timely identification is essential to reducing morbidity. In this study, we discuss the value of different diagnostic modalities for the detection and monitoring of this clinical sign and propose that copper toxicity may induce irreversible changes in the peripheral corneal stroma.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 7","pages":"Article 502535"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}