Archivos De La Sociedad Espanola De Oftalmologia最新文献_第10页

El rol de la OCT de segmento anterior en queratitis ulcerativa periférica 前段OCT在周围溃疡性角膜炎中的作用

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-10-01 Epub Date: 2025-06-17 DOI: 10.1016/j.oftal.2025.03.004

C. Parés-Alfonso, D. Oliver-Gutiérrez, E. Ros-Sanchez

引用次数: 0

Reconstrucción de párpado superior tras mordedura de perro mediante el uso de injerto compuesto en edad pediátrica 在狗咬伤后使用儿科复合移植重建上眼睑

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-10-01 Epub Date: 2025-06-12 DOI: 10.1016/j.oftal.2025.05.004

C.A. Gómez Lanz , B. Palmero Sánchez , M.V. Carmona Pérez , E. Nevado Sánchez

引用次数: 0

Osteoma primario gigante en la órbita: reporte de caso y revisión de la literatura 在轨的巨大原发性骨瘤：病例报告和文献综述

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-10-01 Epub Date: 2025-07-14 DOI: 10.1016/j.oftal.2025.06.011

M. Dorronsoro, C. Pagano Boza

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Evaluación de la efectividad del implante de válvula de Ahmed adicionando mitomicina C en pacientes con glaucoma refractario a un año de seguimiento 对Ahmed添加肌霉素C瓣膜植入物对难治性青光眼患者一年随访的有效性的评价

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1016/j.oftal.2025.06.003

O. Teherán , C. Parra , E. Ramos , M. Ochoa , W. Escobar

{"title":"Evaluación de la efectividad del implante de válvula de Ahmed adicionando mitomicina C en pacientes con glaucoma refractario a un año de seguimiento","authors":"O. Teherán , C. Parra , E. Ramos , M. Ochoa , W. Escobar","doi":"10.1016/j.oftal.2025.06.003","DOIUrl":"10.1016/j.oftal.2025.06.003","url":null,"abstract":"<div><h3>Introduction</h3><div>The Ahmed valve is indicated for glaucoma refractory to maximal pharmacologic therapy and properly performed filtering surgeries. Surgical success can be compromised by the formation of fibrotic tissue around the valve body; various strategies have been employed to prevent this, including the use of antimetabolites such as mitomycin C (MMC).</div></div><div><h3>Aim</h3><div>To evaluate the effectiveness and safety of mitomycin C (MMC) use when implanting Ahmed valve in patients with refractory glaucoma.</div></div><div><h3>Methods</h3><div>Cohort study involving 34 patients divided into 2 groups of 17 patients each: group 1 (MMC use) and group 2 (no MMC use), with a one-year follow-up. Complete success was defined as intraocular pressure (IOP) between 6-18mmHg without the use of antiglaucoma medications; qualified success referred to the same IOP range but associated with antiglaucoma medications, while failure was characterized by IOP outside this range, severe complications or reintervention.</div></div><div><h3>Results</h3><div>The overall success rate in group 1 was 88.2%, and in group 2, 94.2%. There was an average reduction in IOP of 18.0±11.5mmHg in group 1 and 11.3±5.0mmHg in group 2 (p=0.0352). The hypertensive phase occurred in 17.6% of the participants in the first group and the second, 70.6% (p=0.0048).</div></div><div><h3>Conclusions</h3><div>The use of MMC decreases the hypertensive phase observed in Ahmed valve implant surgery, thereby achieving better IOP control.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 521-527"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Un estudio ambispectivo sobre la progresión fenotípica de los pacientes con enfermedad de Stargardt por mutación en el gen ABCA4 ABCA4基因突变引起的Stargardt病患者表型进展的双目研究

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI: 10.1016/j.oftal.2025.06.005

V.A. Martel Ramirez, C.R. Pérez Montaño, A.Y. Hernández Vázquez, S. Rojas Juárez, J.A. Ramírez Estudillo

{"title":"Un estudio ambispectivo sobre la progresión fenotípica de los pacientes con enfermedad de Stargardt por mutación en el gen ABCA4","authors":"V.A. Martel Ramirez, C.R. Pérez Montaño, A.Y. Hernández Vázquez, S. Rojas Juárez, J.A. Ramírez Estudillo","doi":"10.1016/j.oftal.2025.06.005","DOIUrl":"10.1016/j.oftal.2025.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to describe the phenotypic progression of patients with Stargardt disease caused by mutations in the <em>ABCA4</em> gene and reports on the mutated allelic variants.</div></div><div><h3>Method</h3><div>We conducted an observational, ambispective, and descriptive study. Patients who had Stargardt disease by the <em>ABCA4</em> gene mutation were included. The study used the genetic report and the baseline examinations appearing on health records. To evaluate the phenotypic variation, a new ophthalmological evaluation was conducted using macular OCT, retinography, autofluorescence, and electroretinogram.</div></div><div><h3>Results</h3><div>The study identified a total of 32 cases with a mean follow-up of 6 years. The mean age of onset was 16 years. The mean initial and final VA were 0.79 and 0.95 logMAR, respectively. The mean initial and final CMT were 142.5 and 135 microns, respectively. The predominant degree of fundus involvement and autofluorescence pattern at the beginning and end was macular atrophy with flecks and the low signal of macular autofluorescence surrounded by a heterogeneous background, respectively. Initial electroretinography showed predominantly preserved function of rods and cones, while in the end most cases presented rod and cone system dysfunction. A total of 9 cases were homozygous, and 31 different mutant allelic variants were identified. The most common variant was p.Trp1618Cys, followed by p.Ala1773Val. Two new allelic variants, p.Leu634Pro, and p.Tyr665Serfs*5, were also discovered.</div></div><div><h3>Conclusions</h3><div>The study found that patients experienced structural and functional deterioration at the follow-up. The study also identified 2 predominant variants and 2 new variants. Homozygotes had an earlier onset of the disease.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 528-536"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuevos sistemas biotecnológicos de administración de fármacos para la degeneración macular asociada a la edad 为老年性黄斑变性提供药物的新生物技术系统

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1016/j.oftal.2025.03.009

S. Amatha , R. Das , M.K. Gautam , S. Mondal

{"title":"Nuevos sistemas biotecnológicos de administración de fármacos para la degeneración macular asociada a la edad","authors":"S. Amatha , R. Das , M.K. Gautam , S. Mondal","doi":"10.1016/j.oftal.2025.03.009","DOIUrl":"10.1016/j.oftal.2025.03.009","url":null,"abstract":"<div><div>Recent years have witnessed remarkable advancements in biotechnological ocular drug delivery systems, introducing novel strategies such as gene therapy, cell-based systems, and targeted carriers. This article focuses specifically on age-related macular degeneration, the most prevalent ocular condition. While gene therapy holds promise for age-related macular degeneration treatment, it also presents significant challenges, leading to the exploration of cell-based therapy as a complementary or alternative approach. To address these hurdles and ensure successful market translation, new companies often form collaborative expert teams encompassing all relevant fields, including regulatory affairs. As medical science continues to evolve, a comprehensive understanding of gene therapy, cell-based delivery, biocompatibility, safety considerations, regulatory aspects, and ongoing clinical trials is essential to fully grasp the safety and effectiveness of these novel ocular therapies. Consequently, this paper primarily explores these key areas. The successful evolution of biotechnological ocular delivery signals a positive shift towards personalized medicine, which is expected to significantly improve the quality of life for age-related macular degeneration patients in the near future.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 537-548"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoftalmitis atípica por Streptococcus pneumoniae

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1016/j.oftal.2025.04.004

M. Moro-Muniz , J. Raga Cervera , G. Genovés , A. Adloff-Alonso , A. Janicka-Caulineau , D. Salom

{"title":"Endoftalmitis atípica por Streptococcus pneumoniae","authors":"M. Moro-Muniz , J. Raga Cervera , G. Genovés , A. Adloff-Alonso , A. Janicka-Caulineau , D. Salom","doi":"10.1016/j.oftal.2025.04.004","DOIUrl":"10.1016/j.oftal.2025.04.004","url":null,"abstract":"<div><div>Endogenous endophthalmitis is a serious intraocular infection resulting from hematogenous spread of microorganisms. Although <em>Streptococcus pneumoniae</em> is an uncommon cause, its aggressiveness can lead to severe complications.</div><div>We present the case of a 48-year-old male who presented to the emergency department with blurred vision and periorbital pain in the right eye. Examination revealed hypertensive panuveitis with vitreous hemorrhage. Broad-spectrum topical and systemic antibiotics were initiated.</div><div>Imaging studies showed signs of orbital cellulitis without venous thrombosis, and aqueous humor culture confirmed the presence of <em>S. pneumoniae</em>, prompting hospital admission. Despite treatment, clinical progression led to the development of an intraorbital abscess requiring evisceration, after which the patient evolved favorably, allowing for later prosthesis placement.</div><div>This case highlights the aggressiveness of pneumococcal endogenous endophthalmitis and the importance of early, multidisciplinary management.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 553-557"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papilitis parainfecciosa bilateral superpuesta a seudoedema de papila por drusas del nervio óptico 双侧副脓疱性乳头炎，再加上视神经上的眼睑伪水肿

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-09-01 Epub Date: 2025-06-17 DOI: 10.1016/j.oftal.2025.04.005

Javier Garulo Nicolás , Laura Manfreda Domínguez , Patricia Bayo Calduch , Sergio Obiol Ferrando , Andrea Català Nadal , Antonio Miguel Duch Samper

引用次数: 0

Éxito quirúrgico en el desprendimiento de retina regmatógeno: nuevas consideraciones en 2025 手术成功切除regmatorgenos视网膜：2025年的新考虑因素

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1016/j.oftal.2025.06.001

L. López Guajardo , P. Carnota Méndez , F. González del Valle

引用次数: 0

Enfermedad de Stargardt por mutación en ABCA4 en un adulto joven: reporte de caso y alternativas actuales de tratamientos ópticos y médicos 青少年中ABCA4突变引起的Stargardt病：病例报告及目前的光学和医学治疗方案

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-09-01 Epub Date: 2025-06-24 DOI: 10.1016/j.oftal.2025.05.001

D.V. Rey-Rodriguez , M.I. Gómez-Buitrago , M.J. Mateus Parra , L.A. Pazmiño La Rotta , L.F. Aguilar-Serrano

引用次数: 0