Archivos De La Sociedad Espanola De Oftalmologia最新文献

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Encuesta poblacional sobre salud visual en España 西班牙人口视力健康调查
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-14 DOI: 10.1016/j.oftal.2026.502467
B. Benito-Pascual , C. Fernández-Pérez , A. Medina , D. Rojo , P. Arriola-Villalobos
{"title":"Encuesta poblacional sobre salud visual en España","authors":"B. Benito-Pascual ,&nbsp;C. Fernández-Pérez ,&nbsp;A. Medina ,&nbsp;D. Rojo ,&nbsp;P. Arriola-Villalobos","doi":"10.1016/j.oftal.2026.502467","DOIUrl":"10.1016/j.oftal.2026.502467","url":null,"abstract":"<div><h3>Background and objective</h3><div>Conducting a national visual health survey and comparing results after 5 years.</div></div><div><h3>Materials and methods</h3><div>Cross-sectional study using a computer-assisted telephone interview with a representative sample of Spaniards over 18 years of age (except Ceuta and Melilla). The survey was designed by ophthalmologists, the selection of the sample and the conduct of the interviews (April 2017 and May 2023) was carried out through the company Metroscopia and the analysis of the anonymous data was carried out by researchers. Demographic data, knowledge about glaucoma, use of glasses, perceived visual quality, ophthalmological pathology and ocular treatments were collected.</div></div><div><h3>Results</h3><div>1209 and 600 people were interviewed in 2017 and 2023, respectively. The level of glaucoma awareness went from 80 to 87%. The perceived visual quality was reduced (8.2<!--> <!-->±<!--> <!-->1.6 to 6.9<!--> <!-->±<!--> <!-->1.8) and the frequency of access to the ophthalmologist. The prevalence of glasses use increased (50 to 62%), dry eye (13 to 28%), cataract (9.7 to 12.4%), glaucoma (1.9 to 4.6%), age-related macular degeneration (7 to 11.3%), and diabetic retinopathy (1.2 to 1.7%). The use of artificial tears and glaucoma drops also increased (16.9 to 32.9% and 1.6 to 6%, respectively).</div></div><div><h3>Conclusions</h3><div>The study shows that there has been an increase in self-reporting of eye diseases in recent years in Spain. These types of population surveys can serve to encourage the development of visual health programs aimed at the needs of our country.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502467"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Terapia con láser argón para el tratamiento de pterigión tipo 1, ensayo clínico aleatorizado: seguimiento a los 6 meses 氩激光治疗1型翼龙,随机临床试验:6个月随访
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-20 DOI: 10.1016/j.oftal.2026.502499
Y. Quintana-Beltrán, N. Santiago-Rea, J.L. Tovilla-Canales, L. Garnica-Hayashi, D.B. Mejía-Llanes, Á. Nava-Castañeda
{"title":"Terapia con láser argón para el tratamiento de pterigión tipo 1, ensayo clínico aleatorizado: seguimiento a los 6 meses","authors":"Y. Quintana-Beltrán,&nbsp;N. Santiago-Rea,&nbsp;J.L. Tovilla-Canales,&nbsp;L. Garnica-Hayashi,&nbsp;D.B. Mejía-Llanes,&nbsp;Á. Nava-Castañeda","doi":"10.1016/j.oftal.2026.502499","DOIUrl":"10.1016/j.oftal.2026.502499","url":null,"abstract":"<div><h3>Background and objective</h3><div>Pterygium is a wing-shaped degenerative growth of the bulbar conjunctiva that extends onto the cornea. Its treatment can be medical, surgical, or a combination of both. Argon laser therapy has been reported as an initial treatment option. The effectiveness of argon laser use as a first-line treatment for primary T1 or grade 1 pterygium was evaluated in comparison with a control group.</div></div><div><h3>Materials and methods</h3><div>Randomized, double-blind, single-center trial. Subjects were divided into two groups using a randomized block design. Group 1 received argon laser treatment along the vessels of the head and body of the pterygium, and group 2 received placebo treatment. Symptoms of dry eye, signs of conjunctivitis, best corrected visual acuity, and pterygium size were evaluated at one week, one month, three months, and six months after treatment.</div></div><div><h3>Results</h3><div>Thirty-two subjects were included. There was a statistically significant reduction in the length of the pterygium between the first and third month after laser treatment. All symptoms, except for itching, improved after the third month of argon laser treatment and continued to improve until the end of the follow-up period.</div></div><div><h3>Conclusions</h3><div>Argon laser therapy can be a safe and effective method for the treatment of T1 or grade 1 pterygium, significantly reducing the size of the pterygium and improving the signs and symptoms of the ocular surface.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502499"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Más allá de la órbita: celulitis odontogénica con inusual complicación retiniana 超越轨道:牙源性蜂窝组织炎伴有不寻常的视网膜并发症
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1016/j.oftal.2026.502489
V.M. Asensio-Sánchez
{"title":"Más allá de la órbita: celulitis odontogénica con inusual complicación retiniana","authors":"V.M. Asensio-Sánchez","doi":"10.1016/j.oftal.2026.502489","DOIUrl":"10.1016/j.oftal.2026.502489","url":null,"abstract":"<div><div>We present an unusual clinical case of odontogenic orbital cellulitis (OOC) complicated by a serous macular detachment (SMD), an extremely rare association. A 61-year-old patient presented with blurred vision, severe ocular pain, and proptosis. Imaging studies revealed orbital cellulitis secondary to an apical abscess of an upper molar. Although retinal involvement is uncommon in OOC, in this case the SMD represented an atypical and striking manifestation, highlighting the importance of considering unusual retinal complications in orbital infections. Combined treatment with intravenous antibiotics and corticosteroids, along with dental extraction of the infectious focus, led to resolution of both the orbital inflammation and the SMD. A multidisciplinary approach between ophthalmology and dentistry was crucial, with complete visual and anatomical recovery observed at 18<!--> <!-->months of follow-up.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502489"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cirugía de la catarata en el glaucoma crónico de ángulo cerrado aposicional sola frente a asociada a cirugía angular con iStent W inject 使用iStent W输注对慢性闭合位置角型青光眼进行白内障手术
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-20 DOI: 10.1016/j.oftal.2026.502491
M. Cerdá Ibáñez , N. Burguera Giménez , L. Rial Álvarez , J.M. Vilaplana Mora , C. Peris Martínez
{"title":"Cirugía de la catarata en el glaucoma crónico de ángulo cerrado aposicional sola frente a asociada a cirugía angular con iStent W inject","authors":"M. Cerdá Ibáñez ,&nbsp;N. Burguera Giménez ,&nbsp;L. Rial Álvarez ,&nbsp;J.M. Vilaplana Mora ,&nbsp;C. Peris Martínez","doi":"10.1016/j.oftal.2026.502491","DOIUrl":"10.1016/j.oftal.2026.502491","url":null,"abstract":"<div><h3>Background and objectives</h3><div>To evaluate intraocular pressure (IOP) and the number of hypotensive medications in patients with mild-to-moderate appositional primary angle-closure glaucoma (PACG) after phacoemulsification surgery (phaco-only group) versus phacoemulsification combined with the implantation of two iStent® W inject trabecular stents (Glaukos Corporation, CA, USA) (phaco-iStent group).</div></div><div><h3>Materials and methods</h3><div>A retrospective cohort study including 28 eyes from 28 patients with appositional PACG, divided into two groups (phaco-only and phaco-iStent). The number of medications and IOP values were recorded, at baseline, as well as, at one month, six months, and twelve months postoperatively.</div></div><div><h3>Results</h3><div>Baseline and one-month postoperative mean IOP were similar in both groups (p<!--> <!-->&gt;<!--> <!-->0.05). The phaco-iStent group exhibited significantly lower IOP at six and twelve months postoperatively compared to the phaco-only group (p<!--> <!-->=<!--> <!-->0.024 at six months and p<!--> <!-->=<!--> <!-->0.018 at twelve months). The number of active agents was significantly lower at twelve months in the phaco-iStent group (p<!--> <!-->=<!--> <!-->0.01).</div></div><div><h3>Conclusions</h3><div>There is greater efficacy in lowering blood pressure over time in patients with appositional PACG if phacoemulsification is accompanied by trabecular surgery. This could be useful in patients in whom we suspect that lowering IOP with phacoemulsification alone will not be sufficient to control the disease.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502491"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suplementación neuroprotectora en las distrofias hereditarias de la retina 遗传性视网膜营养不良中的神经保护性补充
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1016/j.oftal.2026.502475
I. Pinilla , M. Sopeña-Pinilla , R.M. Coco
{"title":"Suplementación neuroprotectora en las distrofias hereditarias de la retina","authors":"I. Pinilla ,&nbsp;M. Sopeña-Pinilla ,&nbsp;R.M. Coco","doi":"10.1016/j.oftal.2026.502475","DOIUrl":"10.1016/j.oftal.2026.502475","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502475"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalencia de Demodex en pacientes con blefaritis y su asociación con la enfermedad de ojo seco 蠕形螨在眼睑炎患者中的流行及其与干眼病的关联
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-16 DOI: 10.1016/j.oftal.2026.502464
D.L. Serrano Ramírez , J.M. Carrillo Martinez , R. Gútierrez Gómez , M.P. Serrano Ramírez , A. Carrasco Quiroz
{"title":"Prevalencia de Demodex en pacientes con blefaritis y su asociación con la enfermedad de ojo seco","authors":"D.L. Serrano Ramírez ,&nbsp;J.M. Carrillo Martinez ,&nbsp;R. Gútierrez Gómez ,&nbsp;M.P. Serrano Ramírez ,&nbsp;A. Carrasco Quiroz","doi":"10.1016/j.oftal.2026.502464","DOIUrl":"10.1016/j.oftal.2026.502464","url":null,"abstract":"<div><h3>Background and objective</h3><div>To determine the prevalence of <em>Demodex</em> in patients with blepharitis, its clinical characteristics, as well as its association with systemic conditions, and the type and severity of dry eye disease (DED).</div></div><div><h3>Materials and methods</h3><div>A cross-sectional, observational, and analytical study was conducted. 302 patients with signs of blepharitis were evaluated from December 2024 to April 2025 at a Mexican ophthalmology referral center.</div></div><div><h3>Results</h3><div>The prevalence of <em>Demodex</em> was 49.3%, with significant differences between age groups, observing a higher prevalence with advanced ages: 39.7% in &lt;<!--> <!-->60<!--> <!-->years, and 49.3% in ≥<!--> <!-->60<!--> <!-->years (χ<sup>2</sup> <!-->=<!--> <!-->0.009). Type 2 diabetes (T2D) was associated with a significant risk of developing demodicosis (OR: 2.456 (95%<!--> <!-->CI: 1.457-4.141), <em>P</em> <!-->≤<!--> <!-->.001). Regarding clinical characteristics, patients with <em>Demodex</em> had a higher presence of collarettes, a higher prevalence of mixed blepharitis (58.4%), and mixed dry eye disease (DED). Regarding tests for dry eye type and severity, there were only differences in the Van Bijsterveld score (χ<sup>2</sup> <!-->=<!--> <!-->0.009), but not for the TBUT, Schirmer, or OSDI scores.</div></div><div><h3>Conclusion</h3><div>Ocular demodicosis has a high prevalence in our population; its presence is associated with age, with no differences by gender. T2D increases the likelihood of developing <em>Demodex</em>. The anatomical and functional alterations caused by this ocular infection can promote or worsen the symptoms and severity of DED.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502464"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granulomatosis con poliangeítis orbitaria. Un reto diagnóstico en pacientes pediátricos 肉芽肿伴轨道多面体。儿科患者的诊断挑战
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-13 DOI: 10.1016/j.oftal.2026.502488
A.M. Blanco López , A. García Vázquez
{"title":"Granulomatosis con poliangeítis orbitaria. Un reto diagnóstico en pacientes pediátricos","authors":"A.M. Blanco López ,&nbsp;A. García Vázquez","doi":"10.1016/j.oftal.2026.502488","DOIUrl":"10.1016/j.oftal.2026.502488","url":null,"abstract":"<div><div>Granulomatosis with polyangiitis is a systemic autoimmune disease characterized by the presence of granulomatous necrotizing vasculitis with kidney, respiratory, and vascular involvement, whose peak incidence is in the fifth and sixth decades of life. Its localized presentation without systemic involvement is infrequent. We present the case of a 10-year-old patient with recurrent eyelid edema as the initial symptom in the setting of granulomatosis with systemic polyangiitis.</div><div>Although rare, this disease can affect children, as in the case we present, and given its low incidence and atypical presentation it is sometimes a diagnostic challenge.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502488"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Binimetinib y edema macular quístico: un dilema terapéutico en los pacientes con melanoma metastásico 比米替尼与囊性黄斑水肿:转移性黑色素瘤患者的治疗困境
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-08 DOI: 10.1016/j.oftal.2026.502472
M. Moro-Muniz , C. Martinez Rubio , J. Cañas Costa , D. Martinez Tormo , A. Avendaño Flores , D. Salom
{"title":"Binimetinib y edema macular quístico: un dilema terapéutico en los pacientes con melanoma metastásico","authors":"M. Moro-Muniz ,&nbsp;C. Martinez Rubio ,&nbsp;J. Cañas Costa ,&nbsp;D. Martinez Tormo ,&nbsp;A. Avendaño Flores ,&nbsp;D. Salom","doi":"10.1016/j.oftal.2026.502472","DOIUrl":"10.1016/j.oftal.2026.502472","url":null,"abstract":"<div><div>We present the case of a woman with metastatic BRAF-mutated melanoma and a history of type 1 diabetes mellitus, who developed ocular toxicity secondary to binimetinib treatment. She was initially treated with vemurafenib and cobimetinib, achieving complete remission. However, due to cumulative toxicities, therapy was switched to encorafenib and binimetinib in February 2023. After three months, she developed cystoid macular edema (CME), confirmed by optical coherence tomography (OCT). Management included binimetinib dose reduction and topical ketorolac, resulting in initial improvement, although the CME recurred several months later. The rapid progression of metastatic melanoma in January 2024, with peritoneal carcinomatosis, massive ascites, and a left adrenal metastasis, limited further treatment options such as intravitreal anti-VEGF or dexamethasone. The patient ultimately began immunotherapy with nivolumab and ipilimumab, but died in February 2024 due to refractory abdominal septic shock. This case highlights the importance of early ophthalmologic monitoring and interdisciplinary collaboration in patients receiving MEK inhibitors.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502472"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Un caso de síndrome de múltiples puntos blancos evanescentes (SMPBE) secundario a coriorretinopatía hemorrágica exudativa periférica 1例继发于外周性出血性脉络膜视网膜病的多白点消失综合征(SMPBE)
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-28 DOI: 10.1016/j.oftal.2026.502517
G. O’Dwyer, G. de la Mata
{"title":"Un caso de síndrome de múltiples puntos blancos evanescentes (SMPBE) secundario a coriorretinopatía hemorrágica exudativa periférica","authors":"G. O’Dwyer,&nbsp;G. de la Mata","doi":"10.1016/j.oftal.2026.502517","DOIUrl":"10.1016/j.oftal.2026.502517","url":null,"abstract":"<div><div>We describe a case of the recently described MEWDS like retinopathy in a patient with active PEHCR and history of bilateral non-arteritic ischaemic optic neuropathy (NAION). This patient was an 83-year-old man with a known history of PEHCR not requiring treatment and sequential NAION. He presented to the emergency eye services complaining of left eye (LE) reduced vision. Cystoid macular oedema (EMC) was noted. There were multiple hyper-autofluorescent dots within the macula which corresponded to subretinal hyper-reflective deposits on optical coherence tomography (OCT). The patient was observed with partial resolution of deposits and complete resolution of EMC noted 4 months following his initial presentation.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502517"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
El potencial de la metilación del ADN como biomarcador de la degeneración macular asociada a la edad: una revisión sistemática DNA甲基化作为与年龄相关的黄斑变性生物标志物的潜力:系统综述
Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-03-14 DOI: 10.1016/j.oftal.2026.502521
S. Ghannai , E. Ribeiro , B. Pereira , M. Brito , P. Camacho
{"title":"El potencial de la metilación del ADN como biomarcador de la degeneración macular asociada a la edad: una revisión sistemática","authors":"S. Ghannai ,&nbsp;E. Ribeiro ,&nbsp;B. Pereira ,&nbsp;M. Brito ,&nbsp;P. Camacho","doi":"10.1016/j.oftal.2026.502521","DOIUrl":"10.1016/j.oftal.2026.502521","url":null,"abstract":"<div><div>Age-related macular degeneration (AMD) is a multifactorial disease influenced by genetic and environmental factors, yet its pathogenesis remains incompletely understood. DNA methylation, increasingly recognized as a disease indicator, has been linked to AMD and may represent a promising biomarker or therapeutic target. This systematic review, conducted according to PRISMA 2020 guidelines, analyzed 13 studies addressing DNA methylation in AMD populations (2012-2025). Results revealed that 25% reported hypermethylation, 8% hypomethylation, and 41% both patterns, while 15% found no significant differences. Notably, one study described downregulation of DNA methyltransferases in advanced stages compared with early or intermediate AMD. Despite the limited evidence, findings support the relevance of methylation in AMD prognosis and therapy. Further research with robust methodologies is essential to clarify the role of epigenetic mechanisms in disease progression and to explore their potential for guiding targeted therapeutic strategies.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502521"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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