Disfunción visual progresiva y neurodegeneración retiniana en pacientes con fibromialgia

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-10-01 DOI:10.1016/j.oftal.2025.06.015

E. Garcia-Martin , M.J. Vicente Altabás , E. Vilades Palomar , E. Orduna Hospital , B. Cordon Ciordia , J. Garcia-Campayo , M. Puebla-Guedea , M. Satue Palacian

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引用次数: 0

Abstract

Background

Pathophysiology of fibromyalgia is still not well known. There are certain theories than point out a possible neurodegeneration component.

Objectives

To evaluate variations in visual function parameters and in the macular ganglion cell layer (CGR) of patients with Fibromyalgia (FM) over a period of 5 years, and compare these results with controls.

Method

85 patients with FM and 41 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity (VA) with ETDRS, contrast sensitivity vision (CSV) with Pelli Robson, color vision with Farnsworth and Lanthony D15 tests and retinal evaluation using Cirrus HD-OCT 3000 (Carl Zeiss, California). All subjects were re-evaluated after 5 years. It was also analysed the association between progressive structural, functional and disease severity changes. Furthermore, patients were classified into three groups (1, atypical; 2, depressive; 3, biologic).

Results

Progressive changes were detected in visual function parameters and CGR thickness in FM patients after 5 years. Patients with FM presented worse low contrast VA (p = 0.022), color discrimination (Lanthony's C index, p = 0.006) and decreased CGR thickness (nasal inferior, p < 0.001) over the follow up time, compared with controls. Changes in color vision were associated with CGR thinning, but no correlations with disease severity were observed.

Conclusions

It has been noticed progressive visual dysfunction and CGR loss in patients suffering from FM. The analysis of visual function parameters and CGR thickness using Cirrus OCT could be of value to control FM disease.

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纤维肌痛患者的进行性视力障碍和视网膜神经退行性变

背景纤维肌痛的病理生理机制尚不清楚。有一些理论指出了可能的神经变性成分。目的评价纤维肌痛（FM）患者5年内视觉功能参数和黄斑神经节细胞层（CGR）的变化，并与对照组进行比较。方法对85例FM患者和41名健康受试者进行全面的眼科检查，包括ETDRS视力评估（VA）、Pelli Robson对比敏感度评估（CSV）、Farnsworth和Lanthony D15色差评估和Cirrus HD-OCT 3000 （Carl Zeiss, California）视网膜评估。所有受试者在5年后重新评估。还分析了进行性结构、功能和疾病严重程度变化之间的关系。此外，将患者分为三组（1，非典型；2，抑郁；3，生物学）。结果FM患者5年后视功能参数及CGR厚度呈进行性变化。与对照组相比，FM患者的低对比度VA （p = 0.022）、颜色辨别（Lanthony's C指数，p = 0.006）和CGR厚度（鼻下区，p < 0.001）随随访时间变差。色觉变化与CGR变薄有关，但与疾病严重程度无相关性。结论FM患者存在进行性视觉功能障碍和CGR下降。利用卷云OCT分析视觉功能参数和CGR厚度，对FM病的防治有一定的参考价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archivos De La Sociedad Espanola De Oftalmologia Medicine-Ophthalmology

CiteScore

1.20

自引率

0.00%

发文量

109

审稿时长

78 days

期刊介绍： La revista Archivos de la Sociedad Española de Oftalmología, editada mensualmente por la propia Sociedad, tiene como objetivo publicar trabajos de investigación básica y clínica como artículos originales; casos clínicos, innovaciones técnicas y correlaciones clinicopatológicas en forma de comunicaciones cortas; editoriales; revisiones; cartas al editor; comentarios de libros; información de eventos; noticias personales y anuncios comerciales, así como trabajos de temas históricos y motivos inconográficos relacionados con la Oftalmología. El título abreviado es Arch Soc Esp Oftalmol, y debe ser utilizado en bibliografías, notas a pie de página y referencias bibliográficas.