Características demográficas y clínicas de pacientes con orbitopatía tiroidea en un hospital de tercer nivel a lo largo de 5 años

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2025-03-01 DOI:10.1016/j.oftal.2024.10.006

A. Fernández Fernández De Castro, H. Sánchez Tocino, A. Galindo-Ferreiro

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引用次数: 0

Abstract

Objective

To describe the demographic and clinical characteristics of thyroid orbitopathy (TO) in a population in Spain.

Method

It is a retrospective observational study of patients with TO treated at a tertiary hospital center. We gathered demographic data, ophthalmological symptoms, laterality, symmetry, recurrences, activity according to the Clinical Activity Score scale, severity according to the European Group On Graves’ Orbitopathy (EUGOGO), thyroid function and antibody levels. Statistical significance was defined for p values <0.05.

Results

One hundred fifty-six patients with TO were included. One hundred twenty eight (82.1%) women, the female/male sex ratio was 4.57:1. The cumulative incidence was 7.47 cases per 100,000 inhabitants/year. The mean age was 50.7 ± 13.2 years. Seventy (44.9%) patients were smokers. Sixty two (39.7%) patients had a family history of thyroid dysfunction. Hyperthyroidism occurred in 90 (57.7%) patients, hypothyroidism in 34 (21.8%) patients, and euthyroidism in 32 (20.5%) patients. Thyroid-stimulating immunoglobulin was elevated in 107 (68.5%) patients. The TO was bilateral in 149 (95.51%) and symmetrical in 99 (66%). Active TO occurred in 28 (17.9%) patients. One hundred ten (70.5%) TO were mild, 41 (26.3%) moderate-severe and 5 (3.2%) very severe. Moderate-severe TO was higher in smokers compared to non-smokers (32.9% vs. 20.9%, p = 0.524).

Conclusions

TO in our population follows similar patterns to other countries: female sex, mild, bilateral and symmetrical. In smokers, TO may present more severely.

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三级医院甲状腺眼疾患者5年的人口统计和临床特征

目的探讨西班牙人群甲状腺眼窝病（TO）的人口学特征和临床特点。方法对某三级医院收治的急性脑梗死患者进行回顾性观察研究。我们收集了人口统计学数据、眼科症状、侧边、对称性、复发、根据临床活动评分量表进行的活动、根据欧洲格雷夫斯眼病组织（EUGOGO）进行的严重程度、甲状腺功能和抗体水平。p值为<；0.05，具有统计学意义。结果共纳入156例TO患者。女性128人（82.1%），男女性别比为4.57:1。累计发病率为7.47例/ 10万居民/年。平均年龄50.7±13.2岁。70例（44.9%）患者为吸烟者。62例（39.7%）患者有甲状腺功能障碍家族史。甲状腺功能亢进90例（57.7%），甲状腺功能减退34例（21.8%），甲状腺功能正常32例（20.5%）。107例（68.5%）患者促甲状腺免疫球蛋白升高。149例（95.51%）为双侧，99例（66%）为对称。28例（17.9%）患者发生活动性TO。其中轻度110例（70.5%），中重度41例（26.3%），极重度5例（3.2%）。吸烟者中重度TO的发生率高于非吸烟者（32.9%比20.9%,p = 0.524）。结论我国人群的发病模式与其他国家相似：女性、轻度、双侧、对称。在吸烟者中，TO的表现可能更为严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archivos De La Sociedad Espanola De Oftalmologia Medicine-Ophthalmology

CiteScore

1.20

自引率

0.00%

发文量

109

审稿时长

78 days

期刊介绍： La revista Archivos de la Sociedad Española de Oftalmología, editada mensualmente por la propia Sociedad, tiene como objetivo publicar trabajos de investigación básica y clínica como artículos originales; casos clínicos, innovaciones técnicas y correlaciones clinicopatológicas en forma de comunicaciones cortas; editoriales; revisiones; cartas al editor; comentarios de libros; información de eventos; noticias personales y anuncios comerciales, así como trabajos de temas históricos y motivos inconográficos relacionados con la Oftalmología. El título abreviado es Arch Soc Esp Oftalmol, y debe ser utilizado en bibliografías, notas a pie de página y referencias bibliográficas.