Annals of Nutrition and Metabolism最新文献

{"title":"Evaluation of Deficient Nutrients in Infants and Toddlers Mainly Taking Amino Acid-Based Elemental Formulas: An Exploratory Study.","authors":"Ichiro Takeuchi, Rie Funayama, Hiromichi Shoji, Ryusuke Nambu, Keisuke Jimbo, Tomoko Hara, Hirotaka Shimizu, Ichiro Nomura, Itaru Iwama, Takahiro Kudo, Toshiaki Shimizu, Katsuhiro Arai","doi":"10.1159/000539146","DOIUrl":"10.1159/000539146","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated nutrient deficiencies in infants and toddlers with inflammatory bowel disease (IBD) and eosinophilic gastrointestinal disorders (EGIDs), whose primary nutritional source is elemental formulas (EFs).</p><p><strong>Methods: </strong>The nutrient status of children with IBD and EGID aged 6 months to 6 years was evaluated.</p><p><strong>Results: </strong>Twenty-one children fed with EFs (EF group) and 25 controls (CL group) were enrolled. The selenium level in the EF group was lower than that in the CL group (2.2 μg/dL vs. 9.3 μg/dL; p &lt; 0.01). Although fat-soluble vitamins were deficient in some EF group participants, no significant differences were observed in their concentration and insufficiency proportion. However, ascorbic acid deficiency was more frequent in the EF group, with significantly lower levels (8.6 μg/mL vs. 12.0 μg/mL; p &lt; 0.01). The triene:tetraene ratio was significantly higher in the EF group (0.046 vs. 0.010; p &lt; 0.01). Asparagine and taurine levels were significantly lower in the EF group (asparagine: p &lt; 0.01; taurine: p &lt; 0.01) and tyrosine and phenylalanine levels were higher in the EF group, resulting in a lower Fisher's ratio (p &lt; 0.01).</p><p><strong>Conclusion: </strong>Long-term feeding with EFs can cause deficiencies in essential fatty acids, selenium, and ascorbic acid and also carries a risk of amino acid imbalance in infants and toddlers.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"186-195"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition in Institutionalized and Non-Institutionalized Neurologically Impaired Children in Bulgaria.","authors":"Rouzha Pancheva, Albena Toneva, Silviya Nikolova, Koen Huysentruyt, Lyubomir Dimitrov, Nikoleta Yoncheva, Alexandra Nedelcheva, Desislava Zhelyazkova","doi":"10.1159/000533918","DOIUrl":"10.1159/000533918","url":null,"abstract":"<p><strong>Introduction: </strong>The nutritional status of children with neurological impairment affects their health and quality of life. Bulgaria has many abandoned disabled children in residential homes. Lack of parental care puts them at risk for poor growth, suboptimal nutrition, and physical and mental development. Our study aims to identify factors associated with poor nutrition in Bulgarian children with neurological impairment living in different environments.</p><p><strong>Methods: </strong>From January to December 2017, a cross-sectional study was conducted in northeastern Bulgaria. We recruited 109 residential and nonresidential children. The study included demographics, medical history, anthropometric measurements, biochemical tests, nutritional assessment, and gastrointestinal signs and symptoms. Data were analyzed with Jamovi 2.2.5 at a 0.05 significance level. Logistic regression was used to predict wasting in both environmental settings.</p><p><strong>Results: </strong>About 70% of the neurologically impaired children living in residential settings have malnutrition based on weight-for-age Z-score, compared to 25% of the non-residential children. Prematurity, low gross motor function (as measured by the gross motor function classification system), pureed food consumption, birth before 37 weeks, and living in residential care homes are linked to poor nutrition.</p><p><strong>Conclusion: </strong>Neurologically impaired children have a poor nutritional state, especially those living in residential homes. The study underscores the pressing need for the allocation of additional nutrition resources to effectively address the nutritional and developmental needs of children with neurological disabilities in Bulgaria.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"21-28"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000538351","DOIUrl":"10.1159/000538351","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"171"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data.","authors":"Kateřina Koudelková, Petr Waldauf, Petr Wohl, Michal Šenkyřík, Petr Beneš, Pavel Kohout, Jiří Vejmelka, Jan Maňák, Pavel Těšínský, František Novák, Eva Meisnerová, Filip Fencl, Jan Gojda","doi":"10.1159/000538232","DOIUrl":"10.1159/000538232","url":null,"abstract":"<p><strong>Introduction: </strong>Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the data collected on HPN patients in the Czech Republic over the past 30 years.</p><p><strong>Methods: </strong>National registry data were collected using a standardised online form based on the OASIS registry (Oley - A.S.P.E.N. Information System) across all centres providing HPN in the Czech Republic. Data collected prospectively from adult patients in the HPN program were analysed in the following categories: epidemiology, demographics, underlying syndrome, diagnosis, complications, and teduglutide therapy prevalence.</p><p><strong>Results: </strong>The registry identified a total of 1,838 adult patient records, reflecting almost 1.5 million individual catheter days. The prevalence of HPN has risen considerably over the last few decades, currently reaching 5.5 per 100,000 population. The majority of patients have short bowel syndrome and GI obstruction, with cancer being the most prevalent underlying disease. Catheter-related bloodstream infections have been the most prevalent acute complication. However, the incidence in 2022 was only 0.15 per 1,000 catheter days. The study also observed an increase in the prevalence of patients on palliative HPN over the last decade.</p><p><strong>Conclusion: </strong>This study presents a thorough analysis of data from the Czech REgistr Domaci NUtricni Podpory (REDNUP) registry. It shows an increasing prevalence of HPN, namely, in the palliative patient group. The sharing of national data can improve understanding of this rare condition and facilitate the development of international guidelines.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"143-152"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140108978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Diet before Bariatric Surgery on Ghrelin Level through DNA Methylation.","authors":"Duygu Güçlü, Nilgün Işıksaçan, Hakan Seyit, Asuman Gedikbaşı, Mehmet Karabulut, İrem Erdil, Tamay Seda Taşçı, Mustafa Yaman","doi":"10.1159/000538406","DOIUrl":"10.1159/000538406","url":null,"abstract":"<p><strong>Introduction: </strong>The ghrelin system, which generates the appetite hormone, is harmed by obesity, a problem of worldwide public health. An efficient way to cure obesity is through bariatric surgery. This randomized controlled study's objective was to assess preoperative diet-related DNA methylation of Ghrelin (GHRL) levels in patients undergoing bariatric surgery.</p><p><strong>Methods: </strong>The 50 patients who volunteered to participate in the trial were randomly divided into two groups. The study group followed the very low-calorie diet for 2 weeks. The control group did not follow any diet. The physiological parameters, weight, and DNA methylation levels of the patients were assessed.</p><p><strong>Results: </strong>The percentage of excess weight loss (EWL) in the control and study groups was determined as 47.1% and 51.5%, respectively. The study group's GHRL percentage of methylated reference was 76.8%, whereas the control group's was 67.3%. It was concluded that the EWL and GHRL gene DNA methylation of the diet-treated study group were significantly higher than the control group (p &lt; 0.05).</p><p><strong>Conclusion: </strong>According to the findings, the pre-op diet had a favorable effect on the patient's behavior modification. It has also been shown to increase postoperative weight loss and DNA methylation of the Ghrelin gene. The ghrelin gene has been muted by methylation, making hunger regulation more manageable.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"153-160"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 33rd Annual Congress of ECOG, Ghent, Belgium, October 8-10, 2024, Abstracts.","authors":"","doi":"10.1159/000540849","DOIUrl":"10.1159/000540849","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"337-353"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Protein Intake after Intensive Care Unit on Discharge Destination for Critically Ill Patients: A Single-Center Prospective Observational Study.","authors":"Yoshifumi Katsumata, Tomoaki Yatabe, Hajime Kuroiwa, Hideki Iwata, Shota Oda, Takashi Kawano","doi":"10.1159/000540301","DOIUrl":"10.1159/000540301","url":null,"abstract":"<p><strong>Introduction: </strong>Although nutritional therapy may be able to enable intensive care unit (ICU) survivors to return home instead of being discharged to a rehabilitation facility, post-ICU discharge nutritional therapy lacks investigation. This study evaluated the impact of nutritional therapy after ICU on discharge destination in critically ill patients.</p><p><strong>Methods: </strong>We enrolled consecutive adult patients who spent &gt;72 h in the ICU from December 2020 to March 2023. The primary outcome was discharge destination. Energy and protein intake during the ICU stay and on days 7 and 14 after ICU discharge were evaluated. The target protein intake during the intensive treatment and general ward phases were 0.8 and 1.0 g/kg/day, respectively. Patients were categorized into home discharge (group A) and rehabilitation transfer (group B) groups. Factors affecting the discharge destination were evaluated using logistic regression analysis.</p><p><strong>Results: </strong>Of the 183 patients included, 134 belonged to group A and 49 to group B. In group A, more patients reached the protein intake target than in group B. Logistic regression analysis identified achieving the protein intake target as an independent predictor of home discharge.</p><p><strong>Conclusion: </strong>Further studies are required to confirm the relationship between nutritional therapy during general ward and patient outcomes.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"287-294"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Shifting Sands of Infant Feeding Policy.","authors":"Stewart Forsyth","doi":"10.1159/000541712","DOIUrl":"10.1159/000541712","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"334-336"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial Effects of Ketoanalogues on the Evolution of Renal Function and Bone Mineral Disorders in Patients with Advanced Chronic Kidney Disease: A Pilot Study.","authors":"Georgios Kosmadakis, Aura Necoara, Fanny Fuentes, Nathalie Ramade, Julien Baudenon, Clemence Deville, Ioana Enache, Claudine Gueret, Abraham Haskour","doi":"10.1159/000540472","DOIUrl":"10.1159/000540472","url":null,"abstract":"<p><strong>Introduction: </strong>The supplementation with Ketoanalogues in patients on very low-protein diets has shown a favorable effect on the evolution of renal function. The aim of the present study was to evaluate the progression of renal function in advanced chronic kidney disease patients on a low-protein diet (<0.8 g/kg/d) with or without additional Ketoanalogues.</p><p><strong>Methods: </strong>The primary criterion is the evolution of the renal function at 6, 12, and 24 months for the two groups. The secondary criteria comprise the evolution of the body weight, mean blood pressure, 24-h proteinuria, salt and protein consumption, energy consumption, hemoglobin levels, serum albumin, prealbumin, C-reactive protein, liver function tests, serum electrolyte and phosphate levels, parathormone as well as calcium levels at the same time periods.</p><p><strong>Results: </strong>There was a significant nephroprotective effect of the Ketoanalogues after 12 and 24 months with no differences in the protein consumption between the two groups. Mean blood pressure, hemoglobin levels, 24-hour proteinuria, serum electrolyte, liver function tests, salt and protein consumption, and serum albumin and prealbumin did not present any significant differences. Serum bicarbonate and calcium levels were higher while serum phosphate and parathormone levels were lower in the Ketoanalogue group at all follow-up time points. During the 24-month follow-up period, 4 patients from the Ketoanalogue group and 8 patients from the control group quit the study.</p><p><strong>Conclusion: </strong>A low-protein diet supplemented with Ketoanalogues exerts significant nephroprotective effects and better bone mineral metabolism parameters compared to a low-protein diet only.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"315-322"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FINUT 2024 Conference Abstracts.","authors":"","doi":"10.1159/000541491","DOIUrl":"https://doi.org/10.1159/000541491","url":null,"abstract":"<p><p>This supplement compiles most of the special lectures, symposia sessions, oral communications, and poster communications abstracts of the FINUT 2024 Conference, taking place in Medellin Colombia on October 24-26, 2024, under the motto \"Nutrition at the forefront of a sustainable planet\" This third edition of the FINUT Conference has as a specific objective the continuity of the space for the exchange and discussion of ideas and integration of new teams in which all the stakeholders that influence the areas of food, nutrition, health, and sustainability in Ibero-America participate to face the main challenges of the region, and thus offer solutions aimed at improving the health status of the population, considering the impact of social inequalities in Ibero-America. The scientific program of the FINUT 2024 Conference includes 45 parallel symposia, 10 special lectures, 4 \"with-science\" meals, and the presentations of 41 oral communications and 210 poster communications. The four main thematic areas of the Conference are: • Healthy nutrition in the life cycle and clinical nutrition • Nutritional epidemiology and public health challenges in Ibero-America • Safe, healthy, sustainable, and social nutrition • Methods and tools in nutrition The Ibero-American Nutrition Foundation (FINUT) which was established in 2011. FINUT is a non-profit and financially self-supporting entity; our vision is to promote research and training, identify problems of public interest and provide scientific answers; and involve all stakeholders in our cause. Every other year the FINUT Conference allows us to meet in person with the FINUT community and continue the education, information, and research activities in food sciences, nutrition, and health that are carried out virtually daily. We are deeply grateful to the Organizing Committee, the Local Committee, and all the entities represented therein, for their commitment and effort, the Scientific Committee members for their dedicated work and participation in the scientific program, and the University of Antioquia for their interest in hosting this event in Medellin and for all the support received by its authorities, directors, and professors during the organization and execution of the event. We thank all the sponsors who have supported and participated in carrying out this science-based, international event. Our most sincere thanks to the delegates (professionals, academics, researchers, clinicians, and students) who have once again trusted FINUT and who, with their participation, have made it possible to showcase scientific development in food, nutrition, health, and sustainability of the Ibero-American region at the FINUT Conference. ¡See you at the FINUT 2026 Conference!</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"80 Suppl 2 ","pages":"8-183"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}