Annals of Nutrition and Metabolism最新文献

Erratum. 勘误表。

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-10-20 DOI: 10.1159/000548195

Marta Raposo

引用次数: 0

Metabolomic markers for dietary carbohydrate, fat, and protein consumption: a two-sample Mendelian randomization study. 饮食碳水化合物、脂肪和蛋白质消耗的代谢组学标记：一项双样本孟德尔随机研究。

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-10-03 DOI: 10.1159/000548523

Tung Hoang, Jeongseon Kim

{"title":"Metabolomic markers for dietary carbohydrate, fat, and protein consumption: a two-sample Mendelian randomization study.","authors":"Tung Hoang, Jeongseon Kim","doi":"10.1159/000548523","DOIUrl":"https://doi.org/10.1159/000548523","url":null,"abstract":"Introduction: Observational studies have raised questions regarding the comprehensive metabolomic markers associated with dietary macronutrient intake. This study aimed to identify metabolites that are causally linked to dietary macronutrient consumption using a robust analytical framework.Methods: This genetic association study employed a two-sample Mendelian randomization approach. Genetic proxies for metabolites and their summary statistics were sourced from 64 genome-wide association studies, and a meta-analysis provided summary statistics for 3,362 metabolites. Summary statistics for dietary carbohydrate, fat, and protein intakes were obtained from the UK Biobank. Mendelian randomization associations were assessed using inverse variance-weighted, weighted median, and Egger's regression models to enhance robustness. Significant metabolites were subjected to enrichment analysis to identify relevant metabolic pathways. Associations were expressed as odds ratios with 95% confidence intervals, and enrichment analysis was used to identify key KEGG pathways based on p-values.Results: Mendelian randomization analysis identified 540 metabolite-macronutrient associations: 186 for carbohydrate intake, 217 for fat intake, and 137 for protein intake. Metabolites inversely associated with carbohydrate and protein intake, but positively linked to fat intake, were enriched in KEGG pathways, particularly those governing the biosynthesis and metabolism of aromatic amino acids (tryptophan and phenylalanine) and branched-chain amino acids (tyrosine, valine, leucine, and isoleucine).Conclusion: This study comprehensively mapped the metabolite associations with dietary macronutrient intake using extensive genetic data. These findings highlight the critical roles of aromatic and branched-chain amino acid biosynthesis and metabolism as key metabolic pathways in macronutrient regulation.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-17"},"PeriodicalIF":2.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential contribution of plant-based milk alternatives to the nutrient supply in sustainable diets. 植物性牛奶替代品对可持续饮食中营养供应的潜在贡献。

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-09-25 DOI: 10.1159/000548487

Margrit Richter, Alessa Klug, Christina Breidenassel, Anne Carolin Schäfer, Johanna Conrad, Bernhard Watzl

引用次数: 0

Interactions between total energy, and protein intake, and the MC4R rs17782313 variant on lipid levels in Saudi adults: A cross-sectional study. 沙特成年人总能量和蛋白质摄入与MC4R rs17782313变异对脂质水平的相互作用：一项横断面研究

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-09-19 DOI: 10.1159/000548524

Israa M Shatwan, Maha S Al-Odinan, Najlaa M Aljefree, Noha M Almoraie, Basma Tariq Jamal, Marwan A Bakarman, Hani A Alhadrami

{"title":"Interactions between total energy, and protein intake, and the MC4R rs17782313 variant on lipid levels in Saudi adults: A cross-sectional study.","authors":"Israa M Shatwan, Maha S Al-Odinan, Najlaa M Aljefree, Noha M Almoraie, Basma Tariq Jamal, Marwan A Bakarman, Hani A Alhadrami","doi":"10.1159/000548524","DOIUrl":"https://doi.org/10.1159/000548524","url":null,"abstract":"Introduction: Genetic variations, including rs17782313 (C/T) in the MC4R gene, are associated with lipid levels. Gene-diet interactions contribute to disease development. This study aimed to investigate the effects of interactions between total energy intake, protein intake, and MC4R rs17782313 on lipid parameters in Saudi adults.Methods: In a cross-sectional study of 268 Saudi adults (aged 20-55 years), dietary data were assessed using a 136-item validated semiquantitative food frequency questionnaire, and MC4R (rs17782313) was genotyped using real-time polymerase chain reaction.Results: Total energy and protein calorie intake interacted with the MC4R rs17782313 polymorphism to influence total cholesterol (TC) (P interaction= 0.036 and P interaction=0.021, respectively). Low total energy and protein intake was associated with decreased TC levels in all genotypes at rs17782313. The interaction between total energy intake and MC4R rs17782313 affected triglyceride levels (P interaction=0.039). Protein calorie intake significantly interacted with MC4R rs17782313 in determining low-density lipoprotein (P interaction= 0.042).Conclusion: Low total energy and protein intake is associated with low lipid levels among all genotypes at rs17782313 in Saudi adults. Further validation in larger cohorts is warranted to confirm these findings and explore their clinical implications.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-16"},"PeriodicalIF":2.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECONOMIC BURDEN OF OBESITY IN HUNGARY. 匈牙利肥胖的经济负担。

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-09-15 DOI: 10.1159/000547338

Emese Antal, Péter Torzsa, Imre Rurik

{"title":"ECONOMIC BURDEN OF OBESITY IN HUNGARY.","authors":"Emese Antal, Péter Torzsa, Imre Rurik","doi":"10.1159/000547338","DOIUrl":"https://doi.org/10.1159/000547338","url":null,"abstract":"Background: Obesity is a significant threat to national and global public health in terms of its prevalence and economic burden due to obesity-related complications (ORCs) and morbidities. The aim of this study is to calculate obesity-related public expenditures in Hungary in order to estimate the expenses and contribution of patients in 2019 and in 2022, before and after the COVID-19 pandemic, respectively.Method: Expenditures related to patients with obesity, who suffered from more frequent co-morbidities, were requested from the national database of the National Health Insurance Fund. Financial information related to the inpatient and the outpatient providers and reimbursement for the prescription of medicines and healing aids was collected.Results: Obesity-related morbidities represent 10-12 % of all cases in the public health care system. National public health care expenses were reported to be close to HUF 144 billion (EUR 444 million) for 2019 and HUF 133 billion (EUR 393 million) for 2022. These sums represent 7-11% of the total national spending for health care provision, not accounting for sick leave expenditures. The co-payment of patients was estimated to be around HUF 34 billion (EUR 104 million) for 2019 and HUF 43 billion (EUR 109 million) for 2022. Public expenditures and co-payments related to Type 2 diabetes and hypertension were the highest. Public and individual expenditures represent 0.3-0.4% of the GDP, which is equivalent to EUR 56 and EUR 52 per capita, respectively, for all inhabitants of the country.Conclusion: Reducing these high expenses is possible through the introduction of appropriate education and public health policies to prevent obesity at an individual level and enable weight reduction among persons living with obesity. To calculate the cost of obesity, an international consensus on standardized methods is required to improve homogeneity and comparability.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-18"},"PeriodicalIF":2.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin Profile of the Patients with Chronic Kidney Disease Receiving a Novel Total Parenteral Nutrition Formula: Multicenter Randomized Controlled Phase III Trial. 接受一种新型全肠外营养配方的慢性肾病患者的维生素概况：多中心随机对照III期试验

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-09-04 DOI: 10.1159/000547656

Ken Tsuchiya, Tatsukuni Kawakami, Yusuke Maniwa, Yoshiyuki Kawauchi, Motofusa Katayama

{"title":"Vitamin Profile of the Patients with Chronic Kidney Disease Receiving a Novel Total Parenteral Nutrition Formula: Multicenter Randomized Controlled Phase III Trial.","authors":"Ken Tsuchiya, Tatsukuni Kawakami, Yusuke Maniwa, Yoshiyuki Kawauchi, Motofusa Katayama","doi":"10.1159/000547656","DOIUrl":"10.1159/000547656","url":null,"abstract":"Introduction: Efficacy and safety of a novel total parenteral nutrition formula for chronic kidney disease patients, OPF-109, containing multivitamins based on the FDA2000 recommendation were investigated.Methods: We conducted a phase III clinical trial administering OPF-109 (n = 63) or the control solutions (combination of marketed products including multivitamin based on American Medical Association 1975 guidelines) (n = 61) to the chronic kidney disease patients for 8 days. Blood concentrations of proteins and vitamins and safety were evaluated. The primary efficacy endpoint was protein concentration (serum T-P, ALB, pre-ALB, transferrin) on day 8. Safety endpoints were hematological data, blood biochemistry data, vital signs, and adverse events.Results: Values of blood protein until day 8 were similar in 2 groups although those of vitamins B1, B6, C, and folic acid (contained more in OPF-109) were higher in the OPF-109 group. For both groups, vitamin C concentration of day 1 was below the normal range, which restored to within the range in the OPF-109 group but decreased in the control group on day 8. Vitamin K concentration (contained less in OPF-109) was over the normal range on day 1 in both groups and decreased to slightly higher than the normal range in the OPF-109 group while increased to higher than day 1 value in the control group on day 8. Safety was similar in 2 groups.Conclusion: Efficacy and safety of OPF-109 and usefulness of multivitamins based on the FDA2000 recommendation formula were confirmed in chronic kidney disease patients.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-15"},"PeriodicalIF":2.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Patient Sleep before Surgery: The Case for Sleep Prehabilitation. 术前改善患者睡眠：睡眠预适应的案例。

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-08-20 DOI: 10.1159/000547974

Daniel Sibley, Marc Sicova, Mandeep Singh, Ian Randall, Daniel Santa Mina

引用次数: 0

Pre- and Post-Operative Exercise and Nutrition Therapy in Patients with Esophageal Cancer Undergoing Esophagectomy: A Prospective Interventional Study. 食管癌切除术患者术前和术后运动和营养治疗：一项前瞻性介入研究。

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-08-18 DOI: 10.1159/000547965

Kohei Ueno, Tatsuto Nishigori, Shinya Yoshida, Koya Hida, Shigeru Tsunoda, Hisahiro Hosogi, Shigeo Hisamori, Ryosuke Okamura, Shintaro Okumura, Seiichiro Kanaya, Ami Kobayashi, Yukiko Nobori, Kenichiro Shide, Yuji Yoshioka, Yohei Oshima, Yoshihito Goto, Kentaro Goto, Nobuya Inagaki, Shuichi Matsuda, Kazutaka Obama

{"title":"Pre- and Post-Operative Exercise and Nutrition Therapy in Patients with Esophageal Cancer Undergoing Esophagectomy: A Prospective Interventional Study.","authors":"Kohei Ueno, Tatsuto Nishigori, Shinya Yoshida, Koya Hida, Shigeru Tsunoda, Hisahiro Hosogi, Shigeo Hisamori, Ryosuke Okamura, Shintaro Okumura, Seiichiro Kanaya, Ami Kobayashi, Yukiko Nobori, Kenichiro Shide, Yuji Yoshioka, Yohei Oshima, Yoshihito Goto, Kentaro Goto, Nobuya Inagaki, Shuichi Matsuda, Kazutaka Obama","doi":"10.1159/000547965","DOIUrl":"10.1159/000547965","url":null,"abstract":"Introduction: This study aimed to evaluate safety and feasibility of perioperative exercise and nutrition therapy and to explore perioperative changes in skeletal muscle mass (SMM) in patients with esophageal cancer.Methods: Patients scheduled for curative esophagectomy at two hospitals were enrolled. Exercise and nutrition therapy were performed for 3 weeks preoperatively and 4 weeks postoperatively. Outcomes included SMM, which was the sum of both mid-thigh cross-sectional area on computed tomography and physical function, assessed at T1 (intervention start), T2 (just before surgery), and T3 (1-month postoperatively). The SMM change rate between T1 and T3 was compared with the hypothesized value (-7.5%) from our previous study.Results: Thirty-six patients underwent intervention and esophagectomy (intervention completion rate: 94.4%, no serious adverse events). The SMM increased by 4.9% for T1-T2 (p < 0.001) but decreased by 10.1% for T1-T3 (p < 0.001), suggesting that the primary outcome was not achieved. Physical function results were significantly better at T3 than at T1. Postoperative SMM loss was lower in patients who maintained postoperative caloric intake and physical activity than in those who could not (-8.3% vs. -15.4%, p = 0.011).Conclusions: Perioperative exercise and nutrition therapy were safe and feasible. An increase in preoperative SMM and postoperative physical function were observed, although SMM decreased after surgery. Further investigation is warranted to evaluate the efficacy of this intervention.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Value of Fat-Related Body Composition in Early Pregnancy for Macrosomia Using Propensity Score Matching. 使用倾向评分匹配分析妊娠早期脂肪相关体成分对巨大儿的预测价值。

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-08-05 DOI: 10.1159/000547740

Xiaoyue Zhu, Ran Tao, Zhouxing Liao

{"title":"Predictive Value of Fat-Related Body Composition in Early Pregnancy for Macrosomia Using Propensity Score Matching.","authors":"Xiaoyue Zhu, Ran Tao, Zhouxing Liao","doi":"10.1159/000547740","DOIUrl":"10.1159/000547740","url":null,"abstract":"Introduction: This prospective cohort study aimed to assess the predictive capacity of fat-related body composition in early pregnancy for macrosomia and facilitate early screening.Methods: We analyzed 949 women who delivered at Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital) between March 2021 and March 2022, categorized into 54 macrosomia, 869 normal-weight, and 26 low-weight deliveries. At 13 weeks gestation, maternal adiposity indices, including fat mass index (FMI) and percent body fat, were measured. Propensity score matching (PSM) was performed at a 1:2 ratio to compare 53 macrosomic mothers with 106 normal mothers, controlling for maternal height, gestational age, and neonatal sex. Multivariate logistic regression identified independent risk factors for macrosomia.Results: The macrosomia group exhibited significantly higher prepregnancy BMI (22.44 vs. 20.95 kg/m2), body fat percentage (32.41% vs. 29.58%), and FMI (7.16 vs. 6.09 kg/m2, all p < 0.001) than the control group. Notably, FMI (OR = 1.428, 95% CI: 1.017, 2.003, p = 0.039) and gestational age (OR = 1.619, 95% CI: 1.095, 2.395, p = 0.016) emerged as independent risk factors for macrosomia. The diagnostic accuracy of FMI for predicting macrosomia was moderate, with an area under the curve of 73.2%.Conclusion: FMI during early pregnancy can serve as a predictive marker for macrosomia. Due to the objectivity and simplicity, FMI can be incorporated into prenatal care, which enables targeted lifestyle interventions, such as dietary counseling and exercise, reducing adverse pregnancy outcomes.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-9"},"PeriodicalIF":2.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Liraglutide 3.0 mg on Metabolic Dysfunction-Associated Steatotic Liver Disease in Individuals with Obesity: A Real-World Study. 利拉鲁肽3.0 mg对肥胖患者代谢功能障碍相关脂肪变性肝病的影响：一项现实世界研究

IF 2.9 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-07-17 DOI: 10.1159/000547347

Jungha Park, Jin-Wook Kim, Soo Lim

{"title":"Impact of Liraglutide 3.0 mg on Metabolic Dysfunction-Associated Steatotic Liver Disease in Individuals with Obesity: A Real-World Study.","authors":"Jungha Park, Jin-Wook Kim, Soo Lim","doi":"10.1159/000547347","DOIUrl":"10.1159/000547347","url":null,"abstract":"Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), a prevalent condition, can progress to liver cirrhosis and hepatocellular carcinoma. This study evaluated the efficacy of liraglutide 3.0 mg in treating MASLD in patients with obesity in real-world clinical settings.Methods: Adults aged 18 years or older with BMI ≥27 kg/m2 and obesity-related diseases were enrolled from ten tertiary hospitals across South Korea. Initially, 503 participants were included, with follow-up at 2, 4, and 6 months involving 244, 190, and 101 participants, respectively. Anthropometric and biochemical parameters, particularly MASLD-related ones, were assessed.Results: In this cohort, liver enzymes, which serve as surrogate markers for MASLD, decreased continuously: aspartate aminotransferase from 33.2 ± 18.5 IU/L at baseline to 27.4 ± 12.8 IU/L at 6 months (p < 0.001); alanine aminotransferase from 41.6 ± 29.9 IU/L to 30.6 ± 18.0 IU/L at 6 months (p < 0.001). Hepatic steatosis index (HSI) and nonalcoholic fatty liver disease (NAFLD) liver fat score also decreased significantly (HSI: 44.7 ± 6.2 to 42.2 ± 5.8, p < 0.001; NAFLD liver fat score: 2.12 ± 2.90 to 0.43 ± 1.91, p < 0.001). Single-point insulin sensitivity estimator, which indicates insulin sensitivity, steadily increased from 4.38 ± 0.93 to 4.72 ± 1.06 (p < 0.001). No serious adverse events were reported.Conclusion: Liraglutide 3.0 mg improved surrogate markers of MASLD in individuals with obesity, suggesting it may be a promising approach to address both conditions concurrently.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0