Annals of Nutrition and Metabolism最新文献

Dietary intake of branched chain amino acids in relation to metabolic health status in adolescents with overweight and obesity.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-29 DOI: 10.1159/000544937

Pegah Hadi Sichani, Donya Poursalehi, Saeideh Mirzaei, Ali Asadi, Masoumeh Akhlaghi, Parvane Saneei

{"title":"Dietary intake of branched chain amino acids in relation to metabolic health status in adolescents with overweight and obesity.","authors":"Pegah Hadi Sichani, Donya Poursalehi, Saeideh Mirzaei, Ali Asadi, Masoumeh Akhlaghi, Parvane Saneei","doi":"10.1159/000544937","DOIUrl":"https://doi.org/10.1159/000544937","url":null,"abstract":"Introduction: The link between dietary branched-chain amino acids (BCAAs) intake and metabolic health, particularly in adolescents, is not well established. In this investigation, the metabolic health of adolescents with overweight and obesity in Iran was studied in relation to their intake of dietary BCAAs.Methods: This cross-sectional study included 203 adolescents from the general population who had either overweight or obesity. The consumption of BCAAs and other nutrients were calculated using a valid food frequency questionnaire. Blood pressure and anthropometric measurements were taken. Serum insulin, glucose, and lipid profile were determined from blood samples taken while the subjects were fasting. Subjects were categorized considering having metabolically healthy overweight/obesity (MHO) and metabolically unhealthy overweight/obesity (MHO) using two distinct approaches (International Diabetes Federation (IDF) criteria and IDF/Homeostasis Model Assessment Insulin Resistance (HOMA-IR) criteria).Results: Considering IDF criteria, increased consumption of dietary BCAAs was associated with significantly decreased odds of MUO (OR=0.38; 95% CI: 0.18-0.77) in crude model; but in the fully-adjusted model, the association became insignificant (OR=0.49; 95% CI: 0.22-1.09). Based on IDF/HOMA-IR criteria, this association was completely significant in crude model (OR=0.33; 95% CI: 0.15-0.69), and slightly significant in fully-adjusted model (OR=0.43; 95% CI: 0.18-1.00). Participants with overweight, as opposed to obesity, had considerably lower odds of MUO. Valine, one of the BCAAs, was negatively linked with odds of MUO in maximally-adjusted model (OR=0.43; 95% CI: 0.20-0.96).Conclusions: Among BCAAs, increased consumption of valine via food could reduce the odds of MUO in Iranian adolescents with overweight/obesity.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-21"},"PeriodicalIF":3.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-reactive protein and metabolic syndrome in obese and normal weight Hungarian children.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-28 DOI: 10.1159/000545201

Dalma Béres, Regina Felso, Róbert Herczeg, Attila Gyenesei, Szilvia Bokor, Dénes Molnár

{"title":"C-reactive protein and metabolic syndrome in obese and normal weight Hungarian children.","authors":"Dalma Béres, Regina Felso, Róbert Herczeg, Attila Gyenesei, Szilvia Bokor, Dénes Molnár","doi":"10.1159/000545201","DOIUrl":"https://doi.org/10.1159/000545201","url":null,"abstract":"Introduction: It is well known that obese children frequently have high C- reactive protein (CRP) values. There are controversies about the association of the CRP and components of the metabolic syndrome (MetS). The aim of this study was to determine among children and adolescents the link between the most routinely used inflammation marker, CRP, and components of the MetS.Methods: The study recruited 506 obese/overweight and 249 normal weight participants (ages 4-18 years) with complete fasting laboratory and anthropometric data. Statistical analyses, including multinomial logistic regression, were conducted in R, with significance set at p<0.05.Results: Children were divided into three groups according to CRP concentration (low <1 mg/l, medium: 1-3 mg/l, high >3 mg/l). The children were also classified whether they had MetS (n =249) or were free of MetS (n = 421). We found highly significant difference between CRP groups in the occurrence of the MetS components (p < 0.001), hypertension (p < 0.001), hypertriglyceridemia (p < 0.001), and low high-density lipoprotein (HDL) cholesterol (p = 0.001), waist circumference (p < 0.001), body mass index(BMI) z-score (p < 0.001), fasting plasma glucose (p <0.001), homeostasis model assessment of insulin resistance (p <0.001) respectively. However, when BMI z-score was included in the model this relationship disappeared, suggesting that BMI has a more significant effect on the MetS components than CRP.Conclusion: Our results demonstrate that BMI z-score is the main determinant of the MetS and its components. However, CRP remains an important factor to be checked in overweight and obese children.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-17"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prehabilitation- Do we need metabolic flexibility.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-21 DOI: 10.1159/000545266

Nicholas Tetlow, John Whittle

{"title":"Prehabilitation- Do we need metabolic flexibility.","authors":"Nicholas Tetlow, John Whittle","doi":"10.1159/000545266","DOIUrl":"https://doi.org/10.1159/000545266","url":null,"abstract":"Metabolic flexibility, the capacity to switch between energy sources in response to changing physiological demands, emerges as a critical determinant of perioperative resilience. In the context of surgery, where metabolic demands are high and energy homeostasis is disrupted, patients with metabolic inflexibility may experience worse outcomes due to impaired immune responses and heightened insulin resistance, resulting in prolonged recovery times. This article explores the implications of metabolic flexibility in the perioperative period and examines the potential for prehabilitation strategies, such as targeted exercise and nutritional interventions, to improve patient readiness for surgery. Cardio-pulmonary exercise testing (CPET) is discussed as a valuable assessment tool for metabolic flexibility, capable of providing insights into a patient's fuel adaptability and overall metabolic health preoperatively. Evidence suggests that targeted exercise and nutritional strategies can enhance mitochondrial function, improve nutrient-sensing pathways, and increase substrate oxidation, which may reduce perioperative complications and support immune resilience. Future research should focus on refining methods to identify metabolically inflexible patients and tailoring prehabilitation interventions to optimise metabolic flexibility, particularly in populations vulnerable to metabolic dysfunction, such as those with obesity, diabetes, and cancer. This approach may establish new standards in perioperative care by aligning metabolic readiness with surgical recovery demands.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-22"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Economic Burden of Obesity in Children and Adolescents in Austria.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-21 DOI: 10.1159/000545082

Stephanie Reitzinger, Thomas Czypionka

{"title":"The Economic Burden of Obesity in Children and Adolescents in Austria.","authors":"Stephanie Reitzinger, Thomas Czypionka","doi":"10.1159/000545082","DOIUrl":"https://doi.org/10.1159/000545082","url":null,"abstract":"Introduction: In Europe, one in three school-aged children live with overweight or obesity and are at high risk of continuing to be affected by it throughout their lives.Methods: We used population projections and the share of young adults assumed to have remained obese since childhood or adolescence to project the lifetime costs of birth cohorts from 2000 to 2019. We estimated lifetime costs per individual using population-attributable fractions considering a discount rate of 3%, obesity-associated mortality, an obesity-associated \"income penalty\", and future cost increases in the health care system.Results: For Austria, we estimated that around 95,000 of all children and adolescents in 2019 will maintain obesity as adults, which leads to a present value of € 9.2 billion or an annuity of approximately €285 million (0.07% of GDP in 2019). Approximately 15% of costs arise from direct costs and 85% from indirect costs.Conclusion: We highlighted the long-term economic burden of early onset obesity in Austria and concluded that public health programs addressing children and adolescents with obesity could relieve high costs not only for individuals but also for society.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feeding Practices in the Introduction of Complementary Feeding and Implications for Future Healthy Eating.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-20 DOI: 10.1159/000543126

Elvira Verduci, Giulia Fiore, Marta Agostinelli, Gianvincenzo Zuccotti

{"title":"Feeding Practices in the Introduction of Complementary Feeding and Implications for Future Healthy Eating.","authors":"Elvira Verduci, Giulia Fiore, Marta Agostinelli, Gianvincenzo Zuccotti","doi":"10.1159/000543126","DOIUrl":"https://doi.org/10.1159/000543126","url":null,"abstract":"Background: Complementary feeding (CF) is the process of introducing foods that starts when breast milk or formula alone can no longer meet infant's nutritional requirements. Nevertheless, the goal of introducing solid foods is to supplement, not replace, human milk or infant formula. The timing of introduction of CF is a pivotal issue in paediatrics.Summary: According to the World Health organization (WHO), ideally CF begins at 6 months of age and continues until 23 months, although breastfeeding may extend beyond this period. In low-resource setting areas due to food and water hygiene issues and less availability of complementary foods (CFs) with good nutritional quality, early CF represents a harm. In the meantime, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and European Food Safety Authority (EFSA) recommend that CF should start between 17 and 26 weeks of age. This indication is provided because an early introduction of CFs before 4 months has harming results for both renal and gastrointestinal function and is inadequate with respect to neurodevelopmental skills. The concern about late introduction after 6 months mainly arises from inadequacy of breast milk in providing critical nutrients, particularly iron. Moreover, accumulating evidence suggests a potential higher risk of food allergies (i.e., peanut) when delaying exposure to allergens, rather than preventing their occurrence.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary Feeding and Future Health: The Importance of Tailored Evidence-Based Recommendations. 补充喂养与未来健康：有针对性的循证建议的重要性。

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-20 DOI: 10.1159/000542370

Raanan Shamir

引用次数: 0

Prehabilitation-Are There Sex and Gender-Specific Issues in Surgery Preparation?

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-12 DOI: 10.1159/000545024

Adriana Angarita-Fonseca, Louise Pilote

{"title":"Prehabilitation-Are There Sex and Gender-Specific Issues in Surgery Preparation?","authors":"Adriana Angarita-Fonseca, Louise Pilote","doi":"10.1159/000545024","DOIUrl":"https://doi.org/10.1159/000545024","url":null,"abstract":"Background: Prehabilitation programs have advanced considerably; however, critical issues related to sex- and gender-specific factors remain largely unaddressed. Historically, research has been male-centered due to the underrepresentation of females in clinical trials, often attributed to concerns over hormonal variability. This focus has resulted in significant knowledge gaps and potential biases that impact effectiveness across sexes. We aim to highlight the need for integrating sex- and gender-specific considerations into prehabilitation to optimize surgical outcomes and promote equitable care for all patients.Summary: Both biological (sex-related) factors, such as differences in muscle mass, metabolism, and body composition, and social (gender-related) factors, such as caregiving roles and stress management, influence individuals' responses to pre-surgical preparation. A review of the existing literature reveals a scarcity of data on sex and gender differences in prehabilitation, highlighting a major barrier to designing equitable and effective programs. Evidence underscores that comprehensive prehabilitation approaches, integrating physical, nutritional, and psychological elements, must account for these differences to optimize recovery outcomes.Key messages: Sex- and gender-specific factors significantly shape patients' responses to prehabilitation and should be systematically incorporated into program design. The current lack of research on these differences limits the effectiveness of prehabilitation strategies, emphasizing the need for focused investigations. Addressing these gaps will facilitate the development of tailored, equitable prehabilitation programs that enhance pre-surgical care and improve recovery outcomes for all patients.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome and Brain Development: A Tale of Two Systems.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-10 DOI: 10.1159/000544950

John F Cryan

{"title":"Microbiome and Brain Development: A Tale of Two Systems.","authors":"John F Cryan","doi":"10.1159/000544950","DOIUrl":"https://doi.org/10.1159/000544950","url":null,"abstract":"Background: For the past two decades there has been a growing appreciation of the role that the microbiota (the trillions of microorganisms within and on our bodies) plays as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis across the lifespan but especially during neurodevelopment.Summary: The gut microbiota and its relevant metabolites interact with the immune and the central nervous systems during critical temporal windows of development. These critical developmental windows perinatally (during the first 1000 days) are susceptible timepoints for insults that can endure long-lasting effects on the microbiota-gut-brain axis. Accumulating evidence shows that a variety of factors can impact the microbiota in early life including mode of birth delivery, antibiotic exposure, mode of nutritional provision, infection, stress as well as host genetics. Additionally, sex differences occur in response to microbial manipulations in early life although the underlying mechanisms underpinning such effects remains elusive. Animal models have been essential in delineating a role of the microbiome in neurodevelopmental disorders ranging from autism spectrum disorder to attention deficit hyperactivity disorder. This mechanistic perspective should be supplemented with more translational studies to evaluate the applicability of findings from animal models to human subjects.Key messages: Studies examining the translation of these effects from animal models to humans are currently ongoing with evidence for microbial modulation of neurocognitive development and neurodevelopmental risk increasing.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-19"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-03-10 DOI: 10.1159/000545026

Paweł Kutnik, Bruna Da Silva, Marni E Shoemaker, Thiago G Barbosa-Silva, M Cristina Gonzalez, Dileep N Lobo, Carla M Prado

{"title":"Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation.","authors":"Paweł Kutnik, Bruna Da Silva, Marni E Shoemaker, Thiago G Barbosa-Silva, M Cristina Gonzalez, Dileep N Lobo, Carla M Prado","doi":"10.1159/000545026","DOIUrl":"https://doi.org/10.1159/000545026","url":null,"abstract":"Background Prehabilitation, the process of optimizing a patient's physical and nutritional status before surgery, has gained increasing attention for its potential to improve outcomes by enhancing physiological reserves and functional capacity. While body composition may play a role in these outcomes, its specific contribution remains underexplored. This narrative review summarizes current evidence on the effects of prehabilitation on body composition, focusing on exercise, nutritional interventions, and multimodal approaches. Summary Exercise, particularly a combination of aerobic and resistance training, has been shown to improve cardiorespiratory fitness, reduce fat mass, and enhance skeletal muscle and strength. Nutritional interventions, including increased protein intake, support skeletal muscle preservation and recovery. A multimodal approach, integrating both exercise and nutrition, yields the most significant improvements in body composition, showing enhanced skeletal muscle, reduced fat mass, and better functional outcomes. However, the limited duration of prehabilitation and the time required for detectable changes in body composition often prevent consistent observations. Furthermore, variations in assessment techniques and protocols across studies confound definitive conclusions. Key messages Despite some promising results, further research is needed to standardize protocols and explore the effects of prehabilitation on body composition across diverse patient populations. Finally, further research is needed to investigate the impact of prehabilitation on measurable changes in body composition, as this represents a critical gap in the field.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-17"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological and Experiential Factors That Impact the Acceptance of Complementary Foods.

IF 3.2 3区医学

Annals of Nutrition and Metabolism Pub Date : 2025-02-24 DOI: 10.1159/000542296

Julie A Mennella

引用次数: 0