利拉鲁肽3.0 mg对肥胖患者代谢功能障碍相关脂肪变性肝病的影响:一项现实世界研究

IF 2.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jungha Park, Jin-Wook Kim, Soo Lim
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引用次数: 0

摘要

摘要代谢功能障碍相关脂肪变性肝病(MASLD)是一种常见病,可发展为肝硬化和肝细胞癌。本研究评估了利拉鲁肽3.0 mg治疗肥胖患者MASLD的疗效。方法:从韩国10家三级医院招募年龄在18岁及以上、BMI≥27 kg/m²且患有肥胖相关疾病的成年人。最初包括503名参与者,分别在2个月、4个月和6个月随访了244名、190名和101名参与者。评估了人体测量和生化参数,特别是与masld相关的参数。结果:在该队列中,作为MASLD替代标志物的肝酶持续下降:天冬氨酸转肽酶从基线时的33.2±18.5 IU/L降至6个月时的27.4±12.8 IU/L(结论:利拉鲁肽3.0 mg改善肥胖个体MASLD替代标志物,表明它可能是同时解决这两种疾病的有希望的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Liraglutide 3.0 mg on Metabolic Dysfunction-Associated Steatotic Liver Disease in Individuals with Obesity: A Real-World Study.

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), a prevalent condition, can progress to liver cirrhosis and hepatocellular carcinoma. This study evaluated the efficacy of liraglutide 3.0 mg in treating MASLD in patients with obesity in real-world clinical settings.

Methods: Adults aged 18 years or older with BMI ≥27 kg/m2 and obesity-related diseases were enrolled from ten tertiary hospitals across South Korea. Initially, 503 participants were included, with follow-up at 2, 4, and 6 months involving 244, 190, and 101 participants, respectively. Anthropometric and biochemical parameters, particularly MASLD-related ones, were assessed.

Results: In this cohort, liver enzymes, which serve as surrogate markers for MASLD, decreased continuously: aspartate aminotransferase from 33.2 ± 18.5 IU/L at baseline to 27.4 ± 12.8 IU/L at 6 months (p < 0.001); alanine aminotransferase from 41.6 ± 29.9 IU/L to 30.6 ± 18.0 IU/L at 6 months (p < 0.001). Hepatic steatosis index (HSI) and nonalcoholic fatty liver disease (NAFLD) liver fat score also decreased significantly (HSI: 44.7 ± 6.2 to 42.2 ± 5.8, p < 0.001; NAFLD liver fat score: 2.12 ± 2.90 to 0.43 ± 1.91, p < 0.001). Single-point insulin sensitivity estimator, which indicates insulin sensitivity, steadily increased from 4.38 ± 0.93 to 4.72 ± 1.06 (p < 0.001). No serious adverse events were reported.

Conclusion: Liraglutide 3.0 mg improved surrogate markers of MASLD in individuals with obesity, suggesting it may be a promising approach to address both conditions concurrently.

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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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