Predictive Value of Fat-Related Body Composition in Early Pregnancy for Macrosomia Using Propensity Score Matching.

IF 2.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Xiaoyue Zhu, Ran Tao, Zhouxing Liao
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引用次数: 0

Abstract

Introduction: This prospective cohort study aimed to assess the predictive capacity of fat-related body composition in early pregnancy for macrosomia and facilitate early screening.

Methods: We analyzed 949 women who delivered at Suzhou Hospital Affiliated to Nanjing Medical University (Suzhou Municipal Hospital) between March 2021 and March 2022, categorized into 54 macrosomia, 869 normal-weight, and 26 low-weight deliveries. At 13 weeks gestation, maternal adiposity indices, including fat mass index (FMI) and percent body fat, were measured. Propensity score matching (PSM) was performed at a 1:2 ratio to compare 53 macrosomic mothers with 106 normal mothers, controlling for maternal height, gestational age, and neonatal sex. Multivariate logistic regression identified independent risk factors for macrosomia.

Results: The macrosomia group exhibited significantly higher prepregnancy BMI (22.44 vs. 20.95 kg/m2), body fat percentage (32.41% vs. 29.58%), and FMI (7.16 vs. 6.09 kg/m2, all p < 0.001) than the control group. Notably, FMI (OR = 1.428, 95% CI: 1.017, 2.003, p = 0.039) and gestational age (OR = 1.619, 95% CI: 1.095, 2.395, p = 0.016) emerged as independent risk factors for macrosomia. The diagnostic accuracy of FMI for predicting macrosomia was moderate, with an area under the curve of 73.2%.

Conclusion: FMI during early pregnancy can serve as a predictive marker for macrosomia. Due to the objectivity and simplicity, FMI can be incorporated into prenatal care, which enables targeted lifestyle interventions, such as dietary counseling and exercise, reducing adverse pregnancy outcomes.

使用倾向评分匹配分析妊娠早期脂肪相关体成分对巨大儿的预测价值。
本回顾性研究的目的是评估妊娠早期脂肪相关体成分对巨大儿的预测能力,并促进早期筛查。我们分析了2021年3月至2022年3月期间在南京医科大学附属苏州医院(苏州市立医院)分娩的949名妇女,分为54名巨大儿、869名正常体重儿和26名低体重儿。在妊娠13周,测量肥胖指数,包括脂肪质量指数(FMI)和体脂百分比。在控制母亲身高、胎龄和新生儿性别的情况下,以1:2的比例对53名巨婴母亲与106名正常母亲进行倾向评分匹配(PSM)。多因素logistic回归确定了巨大儿的独立危险因素。结果显示,巨大儿组的孕前体重指数(BMI)、体脂率和FMI显著增高(P
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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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