沙特成年人总能量和蛋白质摄入与MC4R rs17782313变异对脂质水平的相互作用:一项横断面研究

IF 2.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Israa M Shatwan, Maha S Al-Odinan, Najlaa M Aljefree, Noha M Almoraie, Basma Tariq Jamal, Marwan A Bakarman, Hani A Alhadrami
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引用次数: 0

摘要

遗传变异,包括MC4R基因中的rs17782313 (C/T),与血脂水平相关。基因-饮食相互作用有助于疾病的发展。本研究旨在探讨总能量摄入、蛋白质摄入和MC4R rs17782313之间的相互作用对沙特成年人脂质参数的影响。方法:在对268名沙特成年人(20-55岁)的横断面研究中,使用136项经验证的半定量食物频率问卷对饮食数据进行评估,并使用实时聚合酶链反应对MC4R (rs17782313)进行基因分型。结果:总能量和蛋白质热量摄入与MC4R rs17782313多态性相互作用,影响总胆固醇(TC) (P互作= 0.036,P互作=0.021)。总能量和蛋白质摄入量低与rs17782313所有基因型的TC水平降低有关。总能量摄入与MC4R rs17782313的交互作用影响甘油三酯水平(P交互作用=0.039)。蛋白质热量摄入与MC4R rs17782313在测定低密度脂蛋白方面存在显著交互作用(P交互作用= 0.042)。结论:在沙特成人rs17782313的所有基因型中,低总能量和蛋白质摄入与低脂水平相关。需要在更大的队列中进一步验证以证实这些发现并探索其临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interactions between total energy, and protein intake, and the MC4R rs17782313 variant on lipid levels in Saudi adults: A cross-sectional study.

Introduction: Genetic variations, including rs17782313 (C/T) in the MC4R gene, are associated with lipid levels. Gene-diet interactions contribute to disease development. This study aimed to investigate the effects of interactions between total energy intake, protein intake, and MC4R rs17782313 on lipid parameters in Saudi adults.

Methods: In a cross-sectional study of 268 Saudi adults (aged 20-55 years), dietary data were assessed using a 136-item validated semiquantitative food frequency questionnaire, and MC4R (rs17782313) was genotyped using real-time polymerase chain reaction.

Results: Total energy and protein calorie intake interacted with the MC4R rs17782313 polymorphism to influence total cholesterol (TC) (P interaction= 0.036 and P interaction=0.021, respectively). Low total energy and protein intake was associated with decreased TC levels in all genotypes at rs17782313. The interaction between total energy intake and MC4R rs17782313 affected triglyceride levels (P interaction=0.039). Protein calorie intake significantly interacted with MC4R rs17782313 in determining low-density lipoprotein (P interaction= 0.042).

Conclusion: Low total energy and protein intake is associated with low lipid levels among all genotypes at rs17782313 in Saudi adults. Further validation in larger cohorts is warranted to confirm these findings and explore their clinical implications.

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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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