Annals of Nutrition and Metabolism最新文献

{"title":"Retracted Paper - Digitally Delivered Cognitive Behavioral Therapy (CBT) and Inflammation-Guided Nutrition to Enhance Recovery and Survival After Abdominoperineal Resection (APR): A Prospective Non-Randomized Controlled Cohort Study.","authors":"Shengjie Pan, Gang Wang","doi":"10.1159/000550675","DOIUrl":"10.1159/000550675","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding the Article by Ostojic (2025): Creatine Intake and Restrictive Diets.","authors":"Maximilian Andreas Storz","doi":"10.1159/000550318","DOIUrl":"10.1159/000550318","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"177-179"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Psychological Support and Prognostic Nutritional Index-Guided Early Enteral Nutrition Enhance Sleep, Nutritional Recovery, and Quality of Life after Curative Colorectal Cancer Surgery: A Randomized Controlled Trial.","authors":"Gang Wang, Shengjie Pan","doi":"10.1159/000549786","DOIUrl":"10.1159/000549786","url":null,"abstract":"<p><strong>Introduction: </strong>Despite advances in enhanced recovery after surgery (ERAS), many colorectal cancer (CRC) patients continue to experience sleep disturbance, nutritional decline, pain, and psychological distress. Evidence on integrated psychobehavioral and immunonutritional strategies remains limited.</p><p><strong>Methods: </strong>In this single-center randomized tcontrolled trial, 260 patients with stage I-III CRC undergoing elective curative resection were randomized (1:1) to receive standard ERAS care or an integrative program. The intervention comprised five structured sessions of resilience-oriented psychological support (two preoperatively, three postoperatively) and prognostic nutritional index (PNI)-guided early enteral nutrition (standard formula for PNI ≥45; ω-3-enriched immunonutrition with prebiotic and lactobacillus-derived postbiotic components for PNI <45, without the assumption of viable probiotic delivery). The primary endpoint was global Pittsburgh Sleep Quality Index (PSQI) score at postoperative day (POD) 15. Secondary endpoints included nutritional biomarkers, pain, anxiety and depression, and health-related quality of life (HRQoL). Exploratory endpoints were C-reactive protein (CRP) and interleukin-6 (IL-6).</p><p><strong>Results: </strong>Of 298 screened, 260 were randomized and 240 completed per protocol. Adherence exceeded 90% with no serious adverse events. At POD15, the intervention group had lower PSQI scores (adjusted mean difference -2.4; 95% confidence interval: -3.2 to -1.6; p < 0.001), with improvements in latency, disturbance, and daytime dysfunction. Nutritional recovery was enhanced (albumin +2.8 g/L, prealbumin +20.4 mg/L, transferrin +0.3 g/L, PⅢNP +15.2 ng/mL; all p < 0.05). Pain and opioid use were reduced (VAS POD3 -1.5; opioids -30 mg, both p < 0.001). Anxiety and depression scores improved (SAS -5.8, SDS -6.1; p < 0.001), alongside clinically meaningful HRQoL gains in global health (+8.7), physical (+7.2), and emotional functioning (+6.5). Subgroup analyses confirmed consistent benefits, while CRP (-4.8 mg/L) and IL-6 (-3.1 pg/mL) were lower in the intervention group.</p><p><strong>Conclusion: </strong>Integrative perioperative care combining psychological support with PNI-guided early enteral nutrition is safe, feasible, and effective in improving sleep, nutritional recovery, pain control, psychological well-being, and quality of life after CRC surgery.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"90-102"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Analysis of Diagnostic Markers for Malnutrition.","authors":"Nedim Ongun, Mustafa Çakır, Okan Oral, Mesut Yılmaz, Sinem Güzel","doi":"10.1159/000549549","DOIUrl":"10.1159/000549549","url":null,"abstract":"<p><strong>Introduction: </strong>Malnutrition leads to negative health outcomes such as delayed recovery, increased hospital stays, and higher costs. The study aimed to develop a predictive tool to diagnose malnutrition using patient data, including anthropometric, phenotypic, and laboratory information.</p><p><strong>Methods: </strong>A cohort of 252 adult patients was assessed at a tertiary hospital. Logistic regression and decision tree analysis were applied to evaluate the role of the data in predicting the risk of malnutrition. The performances of the models were tested with Akaike information criterion, null deviance, residual deviance, accuracy, and kappa metrics, and the statistical significance of the variables was evaluated with Wald-Z test. Attribute importance ranking was obtained by Bootstrap Optimized Random Univariate Tree Analysis algorithm.</p><p><strong>Results: </strong>A total of 252 patients, 125 female (49.6%) and 127 male (50.4%), were included in the study. The mean age was 72.57 ± 13.6 years. Malnutrition was diagnosed in 174 patients (69%). According to the equations, the most important characteristics were determined as hand grip strength, weight loss, BMI, and gender. The model achieved high accuracy (89.8%) and a kappa value of 0.79, demonstrating its potential for clinical application.</p><p><strong>Conclusion: </strong>Machine learning model offers a faster, more efficient alternative to traditional diagnostic tools. The study concludes that machine learning-based models provide superior prediction performance and could significantly enhance the efficiency and accuracy of malnutrition diagnosis in healthcare.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"22-31"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145659925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the 34th Annual European Childhood Obesity Group Congress.","authors":"Leila Mathy","doi":"10.1159/000548970","DOIUrl":"10.1159/000548970","url":null,"abstract":"<p><p>The following document contains a total of 30 abstracts selected by the Board of Directors of the European Childhood Obesity Group (ECOG) for publication in the Annals of Nutrition and Metabolism in the context of the 34th ECOG annual congress.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"63-80"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145628095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant Feeding Policy: Can We Talk about Infant Formula?","authors":"Stewart Forsyth","doi":"10.1159/000551877","DOIUrl":"10.1159/000551877","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"232-236"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition from Breast Milk: When and How?","authors":"Makena Mwaniki, Helen M Nabwera","doi":"10.1159/000551169","DOIUrl":"10.1159/000551169","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Breastfeeding is the cornerstone of infant and young child nutrition with implications for long-term health and well-being. However, despite having World Health Organization guidance on the transition from exclusive breastfeeding to complementary feeding, in practice it is often fraught with challenges. This review examines the biological and clinical foundations of breastfeeding, addresses the critical questions of when and how to introduce complementary foods and discusses the gaps that hinder optimal infant feeding practices across different geographies. Finally, it highlights the pivotal role of healthcare professionals in guiding safe and responsive feeding transitions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary: &lt;/strong&gt;Human breast milk is an essential component of the factors that promote optimal child health, growth and neurodevelopment. Evidence supports exclusive breastfeeding for approximately 6 months. Readiness for complementary feeding should be judged by developmental cues rather than chronological age alone. Complementary feeding introduces new nutritional and immunological demands: texture progression supports oral-motor development, timely exposure to allergens may promote tolerance, and micronutrient status is critical. Global variation in infant feeding practices reflects socioeconomic, cultural, and structural barriers that often limit adherence to guidelines. When exclusive breastfeeding is not feasible despite an optimal healthcare provider and family, partial breastfeeding or formula feeding can support infant growth. However, such decisions ideally require guidance from healthcare providers, which may not be readily accessible to all mothers. Transitioning from exclusive breast milk should be viewed as a gradual layering of foods onto an existing nutritional foundation (often provided by breast milk) rather than abrupt weaning. For maternal and child health practitioners, the priority should be to provide person-centred care that is informed by the individual circumstances of the mother-infant dyad. This includes evidence-informed practical advice that is responsive to their needs, supporting exclusive breastfeeding whenever possible, while ensuring access to safe, nutritionally adequate and sustainable alternatives where needed. Aligning health systems, community support, and policy protections is essential to enable families globally to achieve optimal feeding practices.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key messages: &lt;/strong&gt;Exclusive breastfeeding for about 6 months provides significant nutritional, immunological, and developmental benefits, but readiness for complementary feeding should be guided by developmental cues, not chronological age alone. Complementary feeding should emphasise iron-rich, diverse foods introduced with appropriate texture progression, alongside continued breastfeeding for sustained child health and growth. Implementation gaps persist globally largely due to unaddressed maternal challenges of navigat","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"33-43"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FGF21 Promotes Thermogenesis by Browning Thermogenic Adipose Tissue during Cold Exposure.","authors":"Chen-Xi Li, Chuan-Fei Tan, Qi-Min Zhang, Liu-Guang Qin, Chun-Yu Cao, Xiao-Fei Huang","doi":"10.1159/000548868","DOIUrl":"10.1159/000548868","url":null,"abstract":"<p><strong>Background: </strong>The global obesity epidemic necessitates therapies that enhance energy expenditure. Non-shivering thermogenesis (NST) in brown/beige adipose tissue represents a promising target, with fibroblast growth factor 21 (FGF21) emerging as a critical regulator linking environmental stimuli to adipose plasticity and mitochondrial function. However, the precise mechanisms of FGF21 secretion and its specific role in adipose tissue browning and subsequent NST potentiation remain incompletely elucidated.</p><p><strong>Summary: </strong>FGF21 regulates NST via distinct spatiotemporal mechanisms. Acute cold exposure triggers hepatic FGF21 secretion through a β₃-adrenergic-lipolysis-PPARα axis to provide lipid substrates. In contrast, chronic cold adaptation involves adipose-derived FGF21 signaling via the FGFR1/β-Klotho complex, activating the PLCγ-Ca2+-cAMP response element-binding protein pathway to enhance UCP1 expression and mitochondrial biogenesis. Aging and statins impair NST via mitochondrial dysfunction and CoQ₁₀ depletion, inducing compensatory FGF21 upregulation. Clinically, the efficacy of FGF21-based therapies relies on full activation of adipose FGFR1/β-Klotho signaling, as demonstrated by the superiority of full agonists over partial agonists.</p><p><strong>Key messages: </strong>FGF21 exhibits dual regulation: hepatic (acute lipid mobilization) and adipose-based (chronic browning); adipose-targeted FGF21 delivery is essential for therapeutic efficacy, and future studies should integrate FGF21 with UCP1-independent pathways (e.g., creatine/succinate cycles) to advance obesity treatment.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"51-59"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145470593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationships between Sarcopenia, Bone Mass, and Metabolic Parameters in Pediatric Obesity.","authors":"Marcela Mikulska, Kamila Czepczor-Bernat, Katarzyna Sawielew, Patrycja Dolibog, Paweł T Dolibog, Paweł Matusik","doi":"10.1159/000549799","DOIUrl":"10.1159/000549799","url":null,"abstract":"<p><p><p>Introduction: Sarcopenic obesity (SO) is defined as co-existence of obesity and sarcopenia. The co-occurrence of sarcopenia and obesity might act synergistically and SO might have a greater effect on adverse health outcomes than sarcopenia or obesity alone. The term osteosarcopenic obesity was introduced recently to describe the impairment of bone, muscle, and fat tissues. This study aimed to evaluate cardiometabolic and bone parameters in relation with the presence of sarcopenia and their association with components of sarcopenia (muscle strength, muscle mass, and physical performance) in children and adolescents with obesity.</p><p><strong>Methods: </strong>A total of 95 children and adolescents with obesity (diagnosed with the use of International Obesity Task Force criteria) with a mean age of 12.7(±3) years participated in this study. Body composition was evaluated by bioelectrical impedance (BIA) and dual-energy X-ray absorptiometry (DXA). Grip strength and physical performance (six-minute walk test, timed up and go test) were evaluated. Blood pressure was measured and blood samples were taken. Sarcopenia was defined as co-occurrence of weak handgrip strength (≤10th centile) according to Dodds et al. [PLoS One. 2014;9(12):e113637] and low DXA-ASMM% (appendicular muscle mass/weight × 100%) (≤9nd centile) according to McCarthy et al. [Pediatr Obes. 2014;9(4):249-59].</p><p><strong>Results: </strong>The overall prevalence of sarcopenia was 17.89%. In comparison with patients without sarcopenia, those with sarcopenia had significantly higher high-density lipoprotein cholesterol (HDL-C) and significantly lower total body less head bone mineral content (BMC-TBLH) and total body less head bone mineral density (BMD-TBLH). Partial correlation analyses controlling for age and sex were performed. BIA-ASMM% and DXA-ASMM% were negatively correlated with insulin 0', homeostasis model assessment of insulin resistance (HOMA-IR) and diastolic blood pressure. DXA-ASMM% correlated negatively with total cholesterol. Handgrip strength was negatively correlated with total cholesterol, low-density lipoprotein (LDL), and HDL cholesterol. Maximal handgrip was positively correlated with bone parameters (BMC-TBLH, BMC-lumbar spine (LS), BMD-TBLH, and BMD-LS). The highest diagnostic value for detecting sarcopenia in children and adolescents with obesity was achieved by HDL-C (cut-off value >44.8 mg/dL), area under ROC curve (AUC) = 0.73).</p><p><strong>Conclusion: </strong>Muscle mass and muscle strength were significantly associated with cardiometabolic parameters in children and adolescents with obesity. The best independent predictive risk factor for diagnosing sarcopenia in obese children and adolescents is HDL-C (cut-off value >44.8 mg/dL). The results of our study regarding bone parameters suggest the presence of osteosarcopenic obesity. </p>.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"151-163"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Milk Oligosaccharides Support Coordinated Microbiome and Immune Development and Function in Infancy.","authors":"Sharon M Donovan","doi":"10.1159/000549867","DOIUrl":"10.1159/000549867","url":null,"abstract":"<p><strong>Background: </strong>Human milk contains functional ingredients that shape the microbiome and immune development of infants. Human milk oligosaccharides (HMOs) are among the largest and most diverse components of human milk. Their heterogeneity enables unique structure-function relationships that contribute to their physiological effects. This narrative review will focus on how HMOs directly and indirectly protect the infant from pathogens and educate the immune system.</p><p><strong>Summary: </strong>Preclinical research, observational studies, and intervention trials demonstrate that HMOs provide multilayer modulation of host defense and immune development. HMOs are soluble glycans that are acetylated, sialylated, or fucosylated, which mediate their interactions with viruses and bacteria to reduce infectivity. Additionally, HMOs enhance pathogen exclusion by promoting intestinal cell maturation, mucin production, and barrier function. Moreover, HMOs directly interact with immune cells through binding to carbohydrate recognition domains. HMOs promote the growth of beneficial bacteria, particularly Bifidobacterium longum subspecies infantis, which is also immunomodulatory. Lastly, HMOs are fermented to short-chain fatty acids, which lower the pH of the intestinal lumen, providing further antimicrobial defense.</p><p><strong>Key messages: </strong>Breastfed infants have a reduced risk of infectious disease compared to non-breastfed infants, attributable in part to the high concentration and structural diversity of HMOs. Clinical trials using formulas supplemented with synthetic human-identical milk oligosaccharides (HiMOs) have demonstrated benefits to adaptive and innate immunity, reduced infections, increased bifidobacteria, and reduced pathogenic bacteria. These benefits are amplified in formulas containing higher concentrations and greater varieties of HiMOs. However, the clinical benefit of routinely supplementing term infant formulae with HiMOs remains unsettled due to variability across existing clinical trials. Further research in healthy infants focused on short- and long-term immune outcomes is needed.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"8-22"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}