{"title":"Nutrition for Preconception Health and Fertility.","authors":"Linden Stocker, Alexandra Kermack, Keith Godfrey","doi":"10.1159/000543616","DOIUrl":"https://doi.org/10.1159/000543616","url":null,"abstract":"<p><strong>Background: </strong>The importance of preconception care is now widely recognised. Optimisation of the lifestyle, nutrition, and the health of a couple not only affects the chances of conception and a successful pregnancy but also the health of the resulting offspring. Currently, limited data reinforce the importance of further research examining the role of individual nutrients. The complex interactions that these nutrients have with each other and the resultant effect on fertility should also be a focus for future investigation. Modifiable risk factors such as alcohol, caffeine, and body mass index should be optimised prior to attempting to conceive. New research is examining the role of personalised preconception advice.</p><p><strong>Summary: </strong>This review examines the roles of macronutrients, micronutrients, and lifestyle in fertility and reproductive health. Raising awareness of the importance of the effect of preconception nutrition and lifestyle on hormone balance, gamete development, implantation, and pregnancy should be paramount. This applies to all healthcare professionals who come into contact with people of child-bearing age, as well as the general public.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preface.","authors":"Flavia Indrio, Hania Szajewska","doi":"10.1159/000540495","DOIUrl":"https://doi.org/10.1159/000540495","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Calcium and Iron Nutrition through the Reproductive Life Course.","authors":"Kate A Ward, Ann Prentice","doi":"10.1159/000543618","DOIUrl":"https://doi.org/10.1159/000543618","url":null,"abstract":"<p><strong>Background: </strong>Two essential micronutrients over the life course are calcium and iron, and both are especially important during the reproductive cycle. The role of calcium in maternal and offspring bone health and in the prevention of pre-eclampsia in pregnancy are well described, although results from randomised controlled trials for both outcomes vary. Iron is essential for synthesis of red blood cells, being a core component of haemoglobin, which carries oxygen around the body, and hence is key in the prevention of anaemia and sequelae.</p><p><strong>Summary: </strong>This article reviews the evidence across the reproductive life course for dietary calcium and iron intakes and health outcomes. For calcium, focusing on bone health and prevention of pre-eclampsia, for iron considering its crucial role in foetal and neonatal development and how requirements may be impacted through inflammation and infection, particularly in environments where iron availability may be low.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maternal Nutrition and the Lifelong Health of Their Offspring.","authors":"Andrew Prentice","doi":"10.1159/000542383","DOIUrl":"https://doi.org/10.1159/000542383","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-4"},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Economic Burden of Obesity in Children and Adolescents in Austria.","authors":"Stephanie Reitzinger, Thomas Czypionka","doi":"10.1159/000545082","DOIUrl":"10.1159/000545082","url":null,"abstract":"<p><strong>Introduction: </strong>In Europe, one in three school-aged children live with overweight or obesity and are at high risk of continuing to be affected by it throughout their lives. The objective of our study was to quantify the economic burden of obesity among Austrian children and adolescents born between 2000 and 2019.</p><p><strong>Methods: </strong>We used obesity projections and the share of young adults assumed to have remained with obesity since childhood or adolescence to project the lifetime costs of birth cohorts from 2000 to 2019. We estimated lifetime costs per individual using population-attributable fractions, considering a discount rate of 3%, obesity-associated mortality, an obesity-associated \"income penalty,\" and future cost increases in the healthcare system.</p><p><strong>Results: </strong>For Austria, we estimated that around 95,000 of all children and adolescents in 2019 remain with obesity as adults, which leads to a present value of EUR 9.2 billion or an annuity of approximately EUR 285 million (0.07% of GDP in 2019). Approximately 15% of costs arise from direct costs and 85% from indirect costs.</p><p><strong>Conclusion: </strong>We highlighted the long-term economic burden of early-onset obesity in Austria and concluded that public health programs addressing children and adolescents with obesity could relieve high costs not only for individuals but also for society.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nutrition for Optimal Lactation.","authors":"Otilia Perichart-Perera","doi":"10.1159/000541757","DOIUrl":"https://doi.org/10.1159/000541757","url":null,"abstract":"<p><strong>Background: </strong>Breastfeeding is the ideal method of feeding for all newborns and is associated with multiple positive health outcomes. Human milk provides all essential nutrients and bioactive molecules needed for optimal infant health and development. Maternal nutrition during lactation plays an important role in supporting breastfeeding and in preventing nutrition and metabolic imbalances. The aim of this narrative review was to describe the most prevalent nutrition issues in lactating women and provide a summary of current diet recommendations as well as controversies on supplementation, in order to facilitate the information for clinicians and health professionals.</p><p><strong>Summary: </strong>Breastfeeding is a nutritionally demanding stage and adequate nutrition is key to avoid alterations in maternal nutritional status, to produce an adequate quantity of milk with good quality, and to avoid nutrition programming of diseases. Anemia and vitamin D, A, iodine, and iron deficiencies are common, while obesity and metabolic diseases keep rising. Inadequate maternal intake of many nutrients is also frequent in this stage.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nutrition during Pregnancy and Birth Outcomes.","authors":"Nandita Perumal, Alison D Gernand","doi":"10.1159/000541205","DOIUrl":"https://doi.org/10.1159/000541205","url":null,"abstract":"<p><strong>Background: </strong>The \"first 1,000 days\" - the duration of pregnancy and the first 2 years of life - is widely recognized as a sensitive period of early life, with implications for health and developmental outcomes throughout the life course. Optimal nutrition during pregnancy is therefore essential to reduce the risk of adverse pregnancy outcomes and support healthy life trajectories.</p><p><strong>Summary: </strong>This narrative review summarizes the physiological changes during pregnancy and how these changes affect the energy and nutrient requirements in pregnancy to support maternal, placental, and fetal development and tissue accretion. Recommendations for weight gain and macro- and micronutrient requirements during pregnancy are summarized along with the current evidence.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prehabilitation: Do We Need Metabolic Flexibility?","authors":"Nicholas Tetlow, John Whittle","doi":"10.1159/000545266","DOIUrl":"10.1159/000545266","url":null,"abstract":"<p><strong>Background: </strong>Metabolic flexibility, the capacity to switch between energy sources in response to changing physiological demands, emerges as a critical determinant of perioperative resilience. In the context of surgery, where metabolic demands are high and energy homeostasis is disrupted, patients with metabolic inflexibility may experience worse outcomes due to impaired immune responses and heightened insulin resistance, resulting in prolonged recovery times.</p><p><strong>Summary: </strong>This article explores the implications of metabolic flexibility in the perioperative period and examines the potential for prehabilitation strategies, such as targeted exercise and nutritional interventions, to improve patient readiness for surgery. Cardiopulmonary exercise testing is discussed as a valuable assessment tool for metabolic flexibility, capable of providing insights into a patient's fuel adaptability and overall metabolic health preoperatively. Evidence suggests that targeted exercise and nutritional strategies can enhance mitochondrial function, improve nutrient-sensing pathways, and increase substrate oxidation, which may reduce perioperative complications and support immune resilience.</p><p><strong>Key messages: </strong>Future research should prioritise refining methods to identify metabolically inflexible patients and tailoring prehabilitation interventions to optimise metabolic flexibility. Enhancing perioperative metabolic readiness is important for populations vulnerable to metabolic dysfunction, such as those with obesity, diabetes, and cancer. Aligning metabolic optimisation with surgical recovery demands may help establish new standards in perioperative care and improve patient outcomes.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"223-233"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do Global Infant Feeding Policies Respect the United Nations Principles on the Rights of Children and Families?","authors":"Stewart Forsyth","doi":"10.1159/000546054","DOIUrl":"10.1159/000546054","url":null,"abstract":"<p><strong>Background: </strong>Under the terms of the United Nations Convention on the Rights of the Child (UNCRC), governments are now required to enable all children to fulfil their full potential with the key principles being non-discrimination, the right to life and development, the best interests of the child, and the right to be heard. A recent statement by UNICEF indicated that implementation of the principles of the UNCRC provide a pathway for WHO, WHA, and UNICEF global infant feeding policy documents to be introduced into domestic law. But these documents are not recent and have not been updated, and they represent high levels of non-compliance. Moreover, do they actually comply with the principles set out in the UNCRC?</p><p><strong>Summary: </strong>Global decisions on infant feeding are being made by organisations who are distant from family circumstances and primarily reflect the views of WHO/UNICEF and activist groups. Evidence of dismissal of public consultation is discriminatory, and an unwillingness to manage differences of opinion is a denial of the right to be heard.</p><p><strong>Key message: </strong>National governments can serve the best interests of the child through sovereign rights, national responsibility and accountability, and development of national infant feeding policies that reflect UNCRC principles.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"245-249"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut Microbiota-Bone Axis.","authors":"Flavia Indrio, Alessia Salatto","doi":"10.1159/000541999","DOIUrl":"10.1159/000541999","url":null,"abstract":"<p><strong>Background: </strong>Knowledge of the complex interplay between gut microbiota and human health is gradually increasing as it has just recently been a field of such great interest.</p><p><strong>Summary: </strong>Recent studies have reported that communities of microorganisms inhabiting the gut influence the immune system through cellular responses and shape many physiological and pathophysiological aspects of the body, including muscle and bone metabolism (formation and resorption). Specifically, the gut microbiota affects skeletal homeostasis through changes in host metabolism, the immune system, hormone secretion, and the gut-brain axis. The major role on gut-bone axis is due to short-chain fatty acids (SCFAs). They have the ability to influence regulatory T-cell (Tregs) development and activate bone metabolism through the action of Wnt10. SCFA production may be a mechanism by which the microbial community, by increasing the serum level of insulin-like growth factor 1 (IGF-1), leads to the growth and regulation of bone homeostasis. A specific SCFA, butyrate, diffuses into the bone marrow where it expands Tregs. The Tregs induce production of the Wnt ligand Wnt10b by CD8+ T cells, leading to activation of Wnt signaling and stimulation of bone formation. At the hormonal level, the effect of the gut microbiota on bone homeostasis is expressed through the biphasic action of serotonin. Some microbiota, such as spore-forming microbes, regulate the level of serotonin in the gut, serum, and feces. Another group of bacterial species (Lactococcus, Mucispirillum, Lactobacillus, and Bifidobacterium) can increase the level of peripheral/vascular leptin, which in turn manages bone homeostasis through the action of brain serotonin.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"47-56"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}