Annals of Nutrition and Metabolism最新文献

{"title":"Impact of Nutritional Therapy during Intensive Care Unit Admission on Post-Intensive Care Syndrome in Patients with COVID-19.","authors":"Shinya Suganuma, Kensuke Nakamura, Hideaki Kato, Muneaki Hemmi, Keiichiro Kawabata, Mariko Hosozawa, Yoko Muto, Miyuki Hori, Arisa Iba, Tomohiro Asahi, Akira Kawauchi, Shigeki Fujitani, Junji Hatakeyama, Taku Oshima, Kohei Ota, Hiroshi Kamijo, Hiroyasu Iso","doi":"10.1159/000542298","DOIUrl":"10.1159/000542298","url":null,"abstract":"<p><strong>Introduction: </strong>Nutritional therapy is an important component of intensive care. We investigated the associations of nutritional therapy in the acute phase of severe COVID-19 with the long-term outcomes of post-intensive care syndrome (PICS) and post-COVID-19 conditions.</p><p><strong>Methods: </strong>A questionnaire on the health status after COVID-19 was sent to patients 1 year after infection and PICS was evaluated. Total energy and protein intakes during the first week after admission to the intensive care unit (ICU) were calculated. The primary endpoint was a decrease in quality of life (QOL) defined by EuroQol5-dimensions 5-level (EQ5D5L) <0.8. A multivariable regression analysis was used to examine.</p><p><strong>Results: </strong>A total of 220 ICU patients were included in this study. Median total energy and protein intakes were 65.1 kcal/kg/week and 3.3 g/kg/week, respectively. Total energy and protein intakes were associated with EQ5D5L scores (energy: unit odds ratio 0.98 [0.97-0.99], p value <0.01; protein: unit odds ratio 0.72 [0.59-0.87], p value <0.01). Insufficient total energy and protein intakes were associated with malaise, arthralgia, myalgia, palpitations, sleep disturbance, and muscle weakness.</p><p><strong>Conclusions: </strong>Poor nutrition during the first week after ICU admission was associated with a decreased QOL 1 year after. These nutrition shortages were also associated with an increased risk of developing PICS, post-COVID-19 conditions, which may contribute to decreased QOL.</p><p><strong>Introduction: </strong>Nutritional therapy is an important component of intensive care. We investigated the associations of nutritional therapy in the acute phase of severe COVID-19 with the long-term outcomes of post-intensive care syndrome (PICS) and post-COVID-19 conditions.</p><p><strong>Methods: </strong>A questionnaire on the health status after COVID-19 was sent to patients 1 year after infection and PICS was evaluated. Total energy and protein intakes during the first week after admission to the intensive care unit (ICU) were calculated. The primary endpoint was a decrease in quality of life (QOL) defined by EuroQol5-dimensions 5-level (EQ5D5L) <0.8. A multivariable regression analysis was used to examine.</p><p><strong>Results: </strong>A total of 220 ICU patients were included in this study. Median total energy and protein intakes were 65.1 kcal/kg/week and 3.3 g/kg/week, respectively. Total energy and protein intakes were associated with EQ5D5L scores (energy: unit odds ratio 0.98 [0.97-0.99], p value <0.01; protein: unit odds ratio 0.72 [0.59-0.87], p value <0.01). Insufficient total energy and protein intakes were associated with malaise, arthralgia, myalgia, palpitations, sleep disturbance, and muscle weakness.</p><p><strong>Conclusions: </strong>Poor nutrition during the first week after ICU admission was associated with a decreased QOL 1 year after. These nutrition shortages were also associat","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"41-50"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary Feeding and Future Health: The Importance of Tailored Evidence-Based Recommendations.","authors":"Raanan Shamir","doi":"10.1159/000542370","DOIUrl":"10.1159/000542370","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"5-7"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplements in Oncology: Uses, Hurdles, Guidance, and Future Perspectives.","authors":"Luca Scafuri, Carlo Buonerba, Anna Rita Amato, Antonio Verde, Vittorino Montanaro, Vincenzo Marotta, Vittorio Riccio, Federica Fortino, Giuseppe Di Lorenzo","doi":"10.1159/000543257","DOIUrl":"10.1159/000543257","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"119-122"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium and Iron Nutrition through the Reproductive Life Course.","authors":"Kate A Ward, Ann Prentice","doi":"10.1159/000543618","DOIUrl":"10.1159/000543618","url":null,"abstract":"<p><strong>Background: </strong>Two essential micronutrients over the life course are calcium and iron, and both are especially important during the reproductive cycle. The role of calcium in maternal and offspring bone health and in the prevention of pre-eclampsia in pregnancy are well described, although results from randomised controlled trials for both outcomes vary. Iron is essential for synthesis of red blood cells, being a core component of haemoglobin, which carries oxygen around the body, and hence is key in the prevention of anaemia and sequelae.</p><p><strong>Summary: </strong>This article reviews the evidence across the reproductive life course for dietary calcium and iron intakes and health outcomes. For calcium, focusing on bone health and prevention of pre-eclampsia, for iron considering its crucial role in foetal and neonatal development and how requirements may be impacted through inflammation and infection, particularly in environments where iron availability may be low.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"45-54"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Dietary Phosphate Load on Urinary Supersaturation and Phosphate Metabolism in Non-Stone-Forming Asian Individuals.","authors":"Xuezhu Li, Weichen Zhang, Tao Huang, Yingjie Chen, Jiaolun Li, Feng Ding, Wenji Wang","doi":"10.1159/000543068","DOIUrl":"10.1159/000543068","url":null,"abstract":"<p><strong>Introduction: </strong>Phosphate ion is common in the core of urinary stones and may initiate stone formation. However, the precise role of phosphate in the initiation of stone formation remains obscure. We assessed the effects of dietary phosphate load on urinary stone risk and phosphate metabolism.</p><p><strong>Methods: </strong>Ten non-stone-forming healthy volunteers completed this randomized, crossover study. Each subject was provided a high- or low-phosphate diet for 3 days. After a 2-day equilibration period with a moderate-phosphate diet, the participants received a low- or high-phosphate diet for another 3 days. Serum, fecal, and 24-h urine samples were collected at the end of each intervention.</p><p><strong>Results: </strong>High dietary phosphate load increased urinary phosphate excretion, and low dietary phosphate decreased urinary phosphate excretion. In addition, urine pH was lower and supersaturation (SS) index of uric acid (UA) was higher after a high-phosphate diet. There was no significant difference in the SS index for calcium oxalate, brushite and hydroxyapatite, or 24-h urinary citrate between the high and the low dietary phosphate. Also, no significant change was observed in fecal phosphate excretion after a high- or low-phosphate diet. The serum phosphate level increased after a high-phosphate diet, but there was no difference in serum phosphate between low-phosphate and moderate-phosphate diets.</p><p><strong>Conclusion: </strong>High dietary phosphate load led to higher urinary phosphate excretion, a higher SS index of UA, and lower urine pH. Stone formers should be advised to limit the intake of high-phosphate source diet, including high-protein diets and phosphate-based food additives.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"97-104"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-Reactive Protein and Metabolic Syndrome in Obese and Normal Weight Hungarian Children.","authors":"Dalma Béres, Regina Felső, Róbert Herczeg, Attila Gyenesei, Szilvia Bokor, Dénes Molnár","doi":"10.1159/000545201","DOIUrl":"10.1159/000545201","url":null,"abstract":"<p><strong>Introduction: </strong>It is well known that obese children frequently have high C-reactive protein (CRP) values. There are controversies about the association of the CRP and components of the metabolic syndrome (MetS). The aim of this study was to determine among children and adolescents the link between the most routinely used inflammation marker, CRP, and components of the MetS.</p><p><strong>Methods: </strong>The study recruited 506 obese/overweight and 249 normal weight participants (ages 4-18 years) with complete fasting laboratory and anthropometric data. Statistical analyses, including multinomial logistic regression, were conducted in R, with significance set at p < 0.05.</p><p><strong>Results: </strong>Children were divided into three groups according to CRP concentration (low <1 mg/L, medium: 1-3 mg/L, high >3 mg/L). The children were also classified whether they had MetS (n = 249) or were free of MetS (n = 421). We found highly significant difference between CRP groups in the occurrence of the MetS components (p < 0.001), hypertension (p < 0.001), hypertriglyceridemia (p < 0.001), and low high-density lipoprotein (HDL) cholesterol (p = 0.001), waist circumference (p < 0.001), body mass index (BMI) z-score (p < 0.001), fasting plasma glucose (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.001), respectively. However, when BMI z-score was included in the model this relationship disappeared, suggesting that BMI has a more significant effect on the MetS components than CRP.</p><p><strong>Conclusion: </strong>Our results demonstrate that BMI z-score is the main determinant of the MetS and its components. However, CRP remains an important factor to be checked in overweight and obese children.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"213-222"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stored Energy and Recovery: A Key Factor in Post-Stroke Sarcopenia Management.","authors":"Fumihiko Nagano, Yoshihiro Yoshimura, Ayaka Matsumoto, Yoichi Sato, Takafumi Abe, Sayuri Shimazu, Ai Shiraishi, Takahiro Bise, Yoshifumi Kido, Takenori Hamada, Kenichiro Maekawa, Kouki Yoneda, Kota Hori","doi":"10.1159/000541795","DOIUrl":"10.1159/000541795","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to determine the effects of Stored Energy on changes in body weight (BW) and skeletal muscle mass (SMM) in patients with post-acute stroke and sarcopenia.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with stroke and sarcopenia consecutively admitted to a Japanese rehabilitation hospital between 2015 and 2022. Sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia in 2019 criteria. Total Stored Energy (kcal) was defined as total energy intake minus total energy requirements during hospitalization, and energy requirements were estimated as actual BW (kg) × 30 (kcal/day). Multiple regression analysis was used to adjust for the effects of confounders and to analyze the association between Total Stored Energy divided by length of hospital stay (= Stored Energy) and changes in BW and SMM during hospitalization.</p><p><strong>Results: </strong>Of the total 556 patients, 193 patients (mean age, 80 years; 43% male) were analyzed. The median (IQR) Total Stored Energy was -1,544 (-18,524, 16,566) kcal and Stored Energy was -23 (-169, 165) kcal/day; 90 patients had Stored Energy >0. Multiple linear regression analysis showed that Stored Energy was independently and positively associated with BW gain (β = 0.412, p < 0.001) and SMM gain (β = 0.263, p < 0.001).</p><p><strong>Conclusion: </strong>Stored Energy has a positive impact on BW and SMM in patients with post-acute stroke and sarcopenia.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"88-96"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and Post-Operative Exercise and Nutrition Therapy in Patients with Esophageal Cancer Undergoing Esophagectomy: A Prospective Interventional Study.","authors":"Kohei Ueno, Tatsuto Nishigori, Shinya Yoshida, Koya Hida, Shigeru Tsunoda, Hisahiro Hosogi, Shigeo Hisamori, Ryosuke Okamura, Shintaro Okumura, Seiichiro Kanaya, Ami Kobayashi, Yukiko Nobori, Kenichiro Shide, Yuji Yoshioka, Yohei Oshima, Yoshihito Goto, Kentaro Goto, Nobuya Inagaki, Shuichi Matsuda, Kazutaka Obama","doi":"10.1159/000547965","DOIUrl":"10.1159/000547965","url":null,"abstract":"<p><p><p>Introduction: This study aimed to evaluate safety and feasibility of perioperative exercise and nutrition therapy and to explore perioperative changes in skeletal muscle mass (SMM) in patients with esophageal cancer.</p><p><strong>Methods: </strong>Patients scheduled for curative esophagectomy at two hospitals were enrolled. Exercise and nutrition therapy were performed for 3 weeks preoperatively and 4 weeks postoperatively. Outcomes included SMM, which was the sum of both mid-thigh cross-sectional area on computed tomography and physical function, assessed at T1 (intervention start), T2 (just before surgery), and T3 (1-month postoperatively). The SMM change rate between T1 and T3 was compared with the hypothesized value (-7.5%) from our previous study.</p><p><strong>Results: </strong>Thirty-six patients underwent intervention and esophagectomy (intervention completion rate: 94.4%, no serious adverse events). The SMM increased by 4.9% for T1-T2 (p < 0.001) but decreased by 10.1% for T1-T3 (p < 0.001), suggesting that the primary outcome was not achieved. Physical function results were significantly better at T3 than at T1. Postoperative SMM loss was lower in patients who maintained postoperative caloric intake and physical activity than in those who could not (-8.3% vs. -15.4%, p = 0.011).</p><p><strong>Conclusions: </strong>Perioperative exercise and nutrition therapy were safe and feasible. An increase in preoperative SMM and postoperative physical function were observed, although SMM decreased after surgery. Further investigation is warranted to evaluate the efficacy of this intervention. </p>.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"347-356"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation.","authors":"Paweł Kutnik, Bruna Ramos Da Silva, Marni E Shoemaker, Thiago G Barbosa-Silva, M Cristina Gonzalez, Dileep N Lobo, Carla M Prado","doi":"10.1159/000545026","DOIUrl":"10.1159/000545026","url":null,"abstract":"<p><strong>Background: </strong>Prehabilitation, the process of optimizing a patient's physical and nutritional status before surgery, has gained increasing attention for its potential to improve outcomes by enhancing physiological reserves and functional capacity. While body composition may play a role in these outcomes, its specific contribution remains underexplored. This narrative review summarizes current evidence on the effects of prehabilitation on body composition, focusing on exercise, nutritional interventions, and multimodal approaches.</p><p><strong>Summary: </strong>Exercise, particularly a combination of aerobic and resistance training, has been shown to improve cardiorespiratory fitness, reduce fat mass, and enhance skeletal muscle and strength. Nutritional interventions, including increased protein intake, support skeletal muscle preservation, and recovery. A multimodal approach, integrating both exercise and nutrition, yields the most significant improvements in body composition, showing enhanced skeletal muscle, reduced fat mass, and better functional outcomes. However, the limited duration of prehabilitation and the time required for detectable changes in body composition often prevent consistent observations. Furthermore, variations in assessment techniques and protocols across studies confound definitive conclusions.</p><p><strong>Key messages: </strong>Despite some promising results, further research is needed to standardize protocols and explore the effects of prehabilitation on body composition across diverse patient populations. Finally, further research is needed to investigate the impact of prehabilitation on measurable changes in body composition as this represents a critical gap in the field.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"180-190"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Growth in Early Childhood a Window of Opportunity for Programming Long-Term Health?","authors":"Berthold V Koletzko, Veronica Luque, Veit Grote, Martina Totzauer","doi":"10.1159/000545315","DOIUrl":"10.1159/000545315","url":null,"abstract":"<p><strong>Background: </strong>Rapid growth characterizes early childhood, with the highest weight gain in early infancy and continued relatively high gains during preschool years.</p><p><strong>Summary: </strong>Subnormal weight and length gain from birth to about 2 years of age predict increased childhood wasting and stunting, whereas excessive weight gain in infancy and early childhood is associated with increased later obesity. Breastfeeding attenuates the risk of high early weight gain and later obesity, adding another reason for promoting, protecting and supporting breastfeeding. Avoiding high infant protein intakes from infant formula and complementary foods is strongly recommended since it markedly reduces later obesity and adiposity. This can be achieved by avoiding cows' and other animal milks as a drink in infancy and choosing infant formula with a low protein content, more similar to breastmilk, for infants not (fully) breastfed. High weight gain in toddlers is also associated with increased later obesity, predicted by overfeeding, high intakes of sugary foods and beverages, and high intakes of protein, particularly animal protein. In an ongoing controlled trial in Germany and Spain, we randomized 1,618 toddlers to milk drinks in the second year of life, providing protein contents either similar to cows' milk or more similar to human milk. First results show high protein milk inducing high weight and length gains, deviating from normal growth trajectories, whereas reduced protein intakes support weight and length growth matching WHO growth standards. Follow-up until early school age is ongoing to explore a potential impact on later growth and overweight risk.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"80 Suppl 1","pages":"29-38"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}