Annals of Nutrition and Metabolism最新文献

{"title":"IUNS 22nd International Congress of Nutrition.","authors":"Hisanori Kato, Nobuko Murayama, Jaques Delarue, J Alfredo Martínez","doi":"10.1159/000530787","DOIUrl":"https://doi.org/10.1159/000530787","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 Suppl 1 ","pages":"9-11"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10386665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reduced Ability to Perform Activities of Daily Living Is Associated with Prolonged Duration before Rehabilitation Initiation and Lower Dietary Intake of Patients with Chronic Obstructive Pulmonary Disease Exacerbation.","authors":"Yohei Oyama, Hiroomi Tatsumi, Rie Tokunou, Natsuko Taniguchi, Yoshiki Masuda","doi":"10.1159/000534697","DOIUrl":"10.1159/000534697","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with exacerbated chronic obstructive pulmonary disease (COPD) have a reduced ability to perform activities of daily living (ADLs). Rehabilitation programs (RPs) and nutritional therapy may affect the ability to perform ADLs.</p><p><strong>Objective: </strong>The objective of the study was to clarify the factors associated with reduced ability to perform ADLs in patients with COPD exacerbation.</p><p><strong>Subjects/methods: </strong>A multivariate analysis of 75 patients (mean age, 77 years) with COPD exacerbation, divided into the Barthel index (BI) decline (△BI decreased ≥15) and without BI decline (△BI decreased ≤10) groups, was performed. Patient characteristics, duration before RP initiation, functional variables, and nutrition-related variables were compared between the groups.</p><p><strong>Results: </strong>The degree of dyspnea and serum albumin levels before and at RP initiation were significantly lower in the BI decline group. The Hoffer classification score and duration between hospital admission and RP initiation were significantly higher and longer, respectively, in the BI decline group. The duration between hospital admission and RP initiation and dietary intake at RP initiation were independent predictors of reduced ability to perform ADLs.</p><p><strong>Conclusions: </strong>Early RP initiation and aggressive nutritional therapy may mitigate the risk of reduced ability to perform ADLs, thus decreasing dependence and disability in patients with COPD exacerbation.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"485-492"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamate-Sensing Genes Are Conserved among Populations Compared to Glutamate Metabolism Genes.","authors":"Kosuke Goto, Yoko Masuzawa, Masanori Kohmura, Asuka Takumi, Haruko Takeyama, Satoru Miyazaki, Takashi Gojobori, Katsuhiko Mineta","doi":"10.1159/000535181","DOIUrl":"10.1159/000535181","url":null,"abstract":"<p><strong>Introduction: </strong>Glutamate is a representative taste molecule with an umami flavor and is a major nutrient found abundantly in nature. Furthermore, it plays a significant role in the human body as a key metabolic intermediate and neurotransmitter. Therefore, the divergence of glutamate functions among populations during their evolution is of particular interest with a hypothesis that the genetic variation can lead to understanding divergence in taste perception. To elucidate variation in glutamate applications and to deepen our understanding of taste perception, we examined the nucleotide diversity of genes associated with glutamate sensing and metabolism among human populations.</p><p><strong>Methods: </strong>We first established 67 genes related to glutamate sensing and metabolism based on the database and literature survey. Then, for those genes, we used a population genomics approach based on ten populations over 76,156 human genomes in the gnomAD database.</p><p><strong>Results: </strong>Statistical tests of means and medians of the minor allele frequencies did not show any significant difference among populations. However, we observed substantial differences between two functional groups, glutamate sensing and glutamate metabolism, in populations of Latino/admixed American, Ashkenazi Jewish, and Others. Interestingly, we could find significant differences between the African population and the East Asian population at the single nucleotide polymorphism level of glutamate metabolism genes, but no clear differences were noted in glutamate-sensing genes. These suggest that glutamate-sensing genes are under the functional constraint compared to glutamate metabolism genes.</p><p><strong>Conclusion: </strong>Thus, glutamate-sensing genes and metabolism genes have a contrasting mode of the evolution, and glutamate-sensing genes are conservatively evolved, indicating its functional importance.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"502-510"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life in the Management of Home Parenteral Nutrition.","authors":"Katja A Schönenberger,&nbsp;Emilie Reber,&nbsp;Valentina V Huwiler,&nbsp;Christa Dürig,&nbsp;Raphaela Muri,&nbsp;Michèle Leuenberger,&nbsp;Stefan Mühlebach,&nbsp;Zeno Stanga","doi":"10.1159/000530082","DOIUrl":"10.1159/000530082","url":null,"abstract":"<p><strong>Introduction: </strong>Home parenteral nutrition (HPN) is a rare but challenging therapy for patients with mostly severe underlying diseases. We aimed to investigate patient-reported health-related quality of life (QOL) of patients receiving HPN and its development over time in particular.</p><p><strong>Methods: </strong>We assessed QOL of HPN patients in a prospective multicenter observational study (SWISSHPN II study). We designed a questionnaire to record symptoms and negative impacts of HPN and completed the validated Optum® SF-36v2® Health Survey with the patients.</p><p><strong>Results: </strong>Seventy patients (50% women) on HPN were included. HPN commonly affected feelings of dependency (n = 49, 70%), traveling/leaving home (n = 37, 53%), attending cultural and social events (n = 25, 36%), and sleep (n = 22, 31%). Most frequently reported symptoms were diarrhea (n = 30, 43%), polyuria (n = 28, 40%), nausea/emesis (n = 27, 39%), dysgeusia (n = 23, 33%), and cramps (n = 20, 29%). At baseline, mean (standard deviation) SF-36v2® physical and mental health component summary scores (PCS and MCS) were 45 (20) and 57 (19), respectively, and there was a trend toward improvement in PCS over the study period, while MCS remained stable. Satisfaction with health care professionals involved in HPN care was high.</p><p><strong>Conclusion: </strong>QOL is a crucial and decisive aspect of HPN patient care. Symptoms related to the underlying disease and PN are frequent. Impaired social life and an ambivalent attitude toward the life-saving therapy are major concerns for these patients and should be addressed in their care.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 3","pages":"326-333"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10566922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FINUT 2022 Conference Abstracts; October 9-11, 2022.","authors":"","doi":"10.1159/000526958","DOIUrl":"https://doi.org/10.1159/000526958","url":null,"abstract":"<p><p>The following document is dedicated to compiling the abstracts of the communications and lectures of the FINUT 2022 Conference. The document comprises 111 abstracts of the guest speakers participating in the scientific symposia and special lectures and more than 230 abstracts for oral and poster communications, representing more than 20 countries. FINUT Conferences seek to open a place for contrasted science shared by the Ibero-American region, a necessary space to open opportunities and to display the research work done in Food and Nutrition. The main objective of the FINUT 2022 Conference is to create a space for the exchange and discussion of ideas related to the main challenges of Food and Nutrition in Iberoamerica, in order to offer solutions aimed at improving the health status of populations, taking into account the impact of social inequalities in the region. The scientific program of the Conference includes 40 parallel symposia, 5 breakfasts with the experts, and 11 special lectures. In this second edition the Conference focused on 4 topics: • Healthy Nutrition in the Life Cycle and Clinical Nutrition • Nutritional Epidemiology and Public Health Challenges in Iberoamerica • Safe, Healthy, Sustainable, and Social Food • Methods and Tools in Nutrition The entity organizing the Conference is the Ibero-American Nutrition Foundation (FINUT) which was established in 2011. FINUT is a non-profit and financially self-supporting entity; our vision is to promote research and training, identify problems of public interest and provide scientific answers; and involve all stakeholders in our cause. We work throughout the year in many scientific virtual activities with a large number of beneficiaries and the FINUT Conferences give us the opportunity to meet them personally. We wish to thank the Organizing, Scientific, and Local Committees for the enthusiasm and commitment dedicated to this conference, our sponsors for trusting us again, and take the opportunity we offer them to contact the most valuable part of our event, the delegates; professionals, academics, clinicians, researchers, and students in the areas of Food, Nutrition, and Health, to whom we also extend our most sincere gratitude. ¡See you at FINUT 2024!</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 1","pages":"49"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10700309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-Four Weeks of L-Carnitine Combined with Leucine Supplementation Does Not Increase the Muscle Carnitine Content in Healthy Active Subjects.","authors":"Emilia Samborowska, Robert A Olek","doi":"10.1159/000529333","DOIUrl":"10.1159/000529333","url":null,"abstract":"<p><strong>Introduction: </strong>To increase the total carnitine (TC) content in muscles, L-carnitine (LC) should be co-ingested with carbohydrates to induce an insulin response. Leucine has an insulin secretagogue effect. Therefore, the primary aim of this study was to examine the effects of 24 weeks of LC and leucine supplementation on the skeletal muscle TC content, muscle mass, and strength in active college-aged subjects. The secondary aim was to determine the activation of the Akt/mTOR signaling pathway in skeletal muscles after supplementation.</p><p><strong>Methods: </strong>Over the 24 weeks, the participants were supplemented with either 1 g of LC-L-tartrate and 3 g of leucine per day (LC + L group; n = 7) or 4 g of leucine per day (L group; n = 7) as a placebo. Before and 24 weeks after the initiation of the study protocol, the free carnitine (FC) and TC content in plasma and muscle samples, as well as body composition and muscle strength, were measured. In addition, the phosphorylation of the Akt/mTOR pathway proteins in muscles was evaluated.</p><p><strong>Results: </strong>Plasma FC and TC content increased in LC + L group after 24 weeks of supplementation (p = 0.003 and 0.010, respectively). However, the skeletal muscle FC and TC contents were not affected by the supplementation protocol. No changes were noted in the body mass and composition; serum insulin-like growth factor-1 concentration; and phosphorylation of the signaling pathway proteins Akt, mTOR, and p70S6K.</p><p><strong>Conclusion: </strong>LC supplementation may have the potential to exert beneficial effects in muscle atrophy. Therefore, additional research is necessary to investigate the effect of various LC supplementation protocols.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 2","pages":"219-227"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000533249","DOIUrl":"10.1159/000533249","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"408"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the Dietary Inflammatory Index and All-Cause Mortality in Adults with Obesity.","authors":"Xin Zheng, Yi-Zhong Ge, Guo-Tian Ruan, Shi-Qi Lin, Yue Chen, Chen-An Liu, Hai-Lun Xie, Meng-Meng Song, Tong Liu, Zi-Wen Wang, Jin-Yu Shi, He-Yang Zhang, Ming Yang, Xiao-Yue Liu, Li Deng, Han-Ping Shi","doi":"10.1159/000533380","DOIUrl":"10.1159/000533380","url":null,"abstract":"<p><strong>Introduction: </strong>The dietary inflammatory index (DII) is associated with numerous chronic noncommunicable diseases. Previous studies have shown that the pro-inflammatory DII categories are associated with abdominal and simple obesity. However, the association between DII and mortality in patients with abdominal obesity and simple overweight or obesity remains unclear.</p><p><strong>Methods: </strong>We used data from the US National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. A DII &gt;0 (positive DII) was defined as a pro-inflammatory diet. A restricted cubic spline curve was used to describe the trend between DII and all-cause mortality. We then examined the association between DII and all-cause mortality in different body types using a Cox regression analysis and investigated the differences between sexes. Finally, the mediating effects of systemic inflammation were explored.</p><p><strong>Results: </strong>A pro-inflammatory diet increased all-cause mortality in adults with abdominal obesity (aHR: 1.31, 95% confidence interval [CI]: 1.11-1.54; p &lt; 0.001) and with simple overweight or obesity (aHR: 1.30, 95% CI: 1.11-1.53; p &lt; 0.001). In addition, the most pro-inflammatory DII increased the risk of mortality by 43% (hazard ratio [HR]: Q4 vs. Q1 = 1.43, 95% CI = 1.14-1.79; p = 0.002; p for trend = 0.003) and 39% (HR: Q4 vs. Q1 = 1.39, 95% CI = 1.13-1.74; p = 0.003; p for trend = 0.009) in participants with abdominal obesity and with simple overweight or obesity, respectively. However, this association was not present in normal-sized participants. Compared with men, women resisted the effects of a pro-inflammatory diet. Mediation analysis showed that white blood cell and neutrophil were mediators of the association between DII and all-cause mortality (p &lt; 0.001).</p><p><strong>Conclusion: </strong>A pro-inflammatory diet is associated with all-cause mortality in adults with abdominal obesity and simple overweight or obesity, and this effect differs between men and women. Systemic inflammation may mediate the association between DII and all-cause mortality.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"434-447"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10192913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Fatty Acid Biomarkers of Dairy Consumption Are Associated with Sex-Dependent Effects on Metabolic Syndrome Components in Mexican Adolescents.","authors":"Rebeca Trejo-Reyes, Alejandra Cantoral, Hector Lamadrid-Figueroa, Larissa Betanzos-Robledo, Martha María Téllez-Rojo, Karen E Peterson, Ana Baylin, Erica C Jansen","doi":"10.1159/000531972","DOIUrl":"10.1159/000531972","url":null,"abstract":"<p><strong>Introduction: </strong>During adolescence, dairy product intake has shown conflicting associations with metabolic syndrome (MetS) components, which are risk factors for cardiovascular disease (CVD). This study aims to investigate the association between plasma fatty acids (FAs) C15:0, C17:0, and t-C16:1n-7, as biomarkers of dairy intake, with MetS and its components in Mexican adolescents.</p><p><strong>Methods: </strong>A sample of 311 participants from the Early Life Exposure in Mexico City to Environmental Toxicants (ELEMENT) cohort was included in this cross-sectional analysis. FA concentrations were measured in plasma as a percentage of total FA. We used quantile regression models stratified by sex to evaluate the association between FA quantiles and MetS components, adjusting for age, socioeconomic status (SES), sedentary behavior, BMI z-score, pubertal status, and energy intake.</p><p><strong>Results: </strong>We found significant associations between dairy biomarkers and the median of MetS variables. In females, t-C16:1n-7 was associated with a decrease of 2.97 cm in WC (Q4 vs. Q1; 95% CI: -5.79, -0.16). In males, C15:0 was associated with an increase of 5.84 mm/Hg in SBP (Q4 vs. Q1; CI: 1.82, 9.85). For HDL-C, we observed opposite associations by sex. C15:0 in males was associated with decreased HDL-C (Q3 vs. Q1: β = -4.23; 95% CI: -7.98, -0.48), while in females, C15:0 and t-C16:1n-7 were associated with increased HDL-C (Q3 vs. Q1: β = 4.75; 95% CI: 0.68, 8.82 and Q4 vs. Q1: β = 6.54; 95% CI: 2.01, 11.07), respectively. Additionally, in both sexes, different levels of C15:0, C17:0, and t-C16:1n-7 were associated with increased triglycerides (TG).</p><p><strong>Conclusion: </strong>Our results suggest that adolescent dairy intake may be associated in different directions with MetS components and that associations are sex-dependent.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"343-354"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10262448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Childhood Obesity Group 2022 Congress.","authors":"","doi":"10.1159/000527413","DOIUrl":"https://doi.org/10.1159/000527413","url":null,"abstract":"<p><p>ECOG's congress aims to bring together childhood obesity experts and young scientists from across Europe. The scientific programme will approach the multidisciplinary nature of childhood obesity prevention and treatment, giving the floor to some of the finest experts in policies and management strategies, dietary interventions, appetite and eating behaviors, pharmacological strategies as well and family programs and general physiology and metabolism. In addition, international associations such as the World Health Organization and the European Association for the Study of Obesity will animate and lead specific sessions.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 1","pages":"29-48"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}