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Validation of the Prognostic Ability of Eight Risk Scores for Cardiovascular Events in NSTEMI Patients with Multi-Vessel Disease. 8项风险评分对NSTEMI合并多血管疾病患者心血管事件预后能力的验证
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-25 DOI: 10.1177/00033197251314638
Chen Wang, Jiachun Lang, He Jiao, Rongdi Xu, Yuecheng Hu, Jikun Wu, Tong Wang, Jingxia Zhang, Hongliang Cong, Le Wang
{"title":"Validation of the Prognostic Ability of Eight Risk Scores for Cardiovascular Events in NSTEMI Patients with Multi-Vessel Disease.","authors":"Chen Wang, Jiachun Lang, He Jiao, Rongdi Xu, Yuecheng Hu, Jikun Wu, Tong Wang, Jingxia Zhang, Hongliang Cong, Le Wang","doi":"10.1177/00033197251314638","DOIUrl":"https://doi.org/10.1177/00033197251314638","url":null,"abstract":"<p><p>This study compared eight risk scores regarding their predictive ability in non-ST-elevation myocardial infarction (NSTEMI) patients (<i>n</i> = 862) with multi-vessel disease (MVD) after percutaneous coronary intervention (PCI). The primary outcome was cardiac death. The secondary outcomes included major adverse cardiovascular event (MACE) [a composite of all-cause death, myocardial infarction (MI), and unplanned repeat revascularization], all-cause death, and MI. During a median follow-up of 4.8 years, 47 (5.5%) cardiac death, 218 (25.3%) MACE, 79 (9.2%) all-cause death, and 40 (4.6%) MI were recorded. The Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX) score II was the most accurate for cardiac death with the highest area under the receiver operating characteristic curve (AUC) (0.814, 95% CI: 0.758-0.869). The logistic SYNTAX score extended model (LSS<sub>extended</sub>) exhibited the most powerful ability in predicting MACE (AUC: 0.624, 95% CI: 0.580-0.667) and MI (AUC: 0.657, 95% CI: 0.567-0.747). The modified Age, Creatinine, and Ejection Fraction score (MAS) was the most accurate score in predicting all-cause death (AUC: 0.798, 95% CI: 0.752-0.844). The scores involving clinical variables showed better ability to predict adverse cardiovascular events among NSTEMI patients with MVD after PCI.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251314638"},"PeriodicalIF":2.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Prediction Models for Contrast-associated Acute Kidney Injury After Percutaneous Coronary Intervention: A Systematic Review. 经皮冠状动脉介入治疗后对比剂相关急性肾损伤的风险预测模型:一项系统综述。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-25 DOI: 10.1177/00033197251326394
Hui Zhang, Tongtong Chen, Ning Chen, Lixia Liu
{"title":"Risk Prediction Models for Contrast-associated Acute Kidney Injury After Percutaneous Coronary Intervention: A Systematic Review.","authors":"Hui Zhang, Tongtong Chen, Ning Chen, Lixia Liu","doi":"10.1177/00033197251326394","DOIUrl":"https://doi.org/10.1177/00033197251326394","url":null,"abstract":"<p><p>The aim of this review was to systematically review published studies on risk prediction models for contrast-associated acute kidney injury (CA-AKI) in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). We searched PubMed, Embase, Web of Science, Scopus, Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Chinese databases from inception to July 1, 2024. The Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies (CHARMS) was used to extract data and The Prediction Model Risk of Bias Assessment Tool (PROBAST) was used to assess the risk of bias and applicability. A total of 2784 publications were retrieved; 16 studies were included. The models' area under the curve (AUC) or C-index ranged from 0.719 to 0.877. Commonly used predictors included age, diabetes, Killip class, and use of intra-aortic balloon pump (IABP). Thirteen studies were determined to be at high risk of bias, while three were unclear, but their applicability was satisfactory. The models' clinical utility was still up for debate. Future development or validation of models should focus on methodology and combine machine learning and natural language processing to analyze data to improve the predictive ability and clinical applicability of models.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251326394"},"PeriodicalIF":2.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Metacognitive Strategy-guided Health Management Model in Patients with Hypertension and Hyperlipidemia. 元认知策略导向的健康管理模式在高血压高脂血症患者中的作用。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-21 DOI: 10.1177/00033197251333219
Yinghua Kuang, Ling Chen, LingLi Xie
{"title":"Effect of Metacognitive Strategy-guided Health Management Model in Patients with Hypertension and Hyperlipidemia.","authors":"Yinghua Kuang, Ling Chen, LingLi Xie","doi":"10.1177/00033197251333219","DOIUrl":"https://doi.org/10.1177/00033197251333219","url":null,"abstract":"<p><p>The present study assessed the effects of a metacognitive strategy-guided health management model on vascular endothelial function and quality of life in patients with hypertension and hyperlipidemia. Patient self-management ability, such as medication adherence, rational diet, and moderate exercise, before and after management was assessed by questionnaire (36-Item Short Form Health Survey, SF-36). Total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood pressure (BP) were compared. Vascular endothelial function was evaluated: Serum levels of endothelin-1 (ET-1) were measured by radioimmunoassay, and serum levels of nitric oxide (NO) were measured by a nitrate reduction method. Quality of life after management was assessed by the SF-36. The observation group (implementation of metacognitive strategy-guided health management) had higher self-management ability scores, lower lipid indicators, lower systolic and diastolic BP, decreased ET-1 and higher NO levels, and greater quality of life scores than the control group (no health management; all <i>P</i> < .05). Metacognitive strategy-guided health management model can improve vascular endothelial function and enhances quality of life in patients with hypertension and hyperlipidemia.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251333219"},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Anemia and Prognosis in Patients With Acute Coronary Syndrome and Atrial Fibrillation. 急性冠脉综合征和心房颤动患者贫血与预后的关系
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-12 DOI: 10.1177/00033197251333224
Yuyuan Shu, Lulu Wang, Yimeng Wang, Jiangshan Tan, Han Zhang, Yanmin Yang
{"title":"Association Between Anemia and Prognosis in Patients With Acute Coronary Syndrome and Atrial Fibrillation.","authors":"Yuyuan Shu, Lulu Wang, Yimeng Wang, Jiangshan Tan, Han Zhang, Yanmin Yang","doi":"10.1177/00033197251333224","DOIUrl":"https://doi.org/10.1177/00033197251333224","url":null,"abstract":"<p><p>Patients with acute coronary syndromes (ACS) and atrial fibrillation (AF) have more complex conditions, making risk stratification crucial. The added discriminatory power of including anemia in the CHA<sub>2</sub>DS<sub>2</sub>-VASc ([congestive heart failure, hypertension, age [>65 = 1 point, >75 = 2 points], diabetes, previous stroke/systemic embolism/transient ischemic attack [2 points], vascular disease, age 65-74 years, and sex category]) score for poor prognosis in this population remains unclear. This study investigates the impact of anemia on 1166 patients with ACS and AF from 2017 to 2019. Multivariate Cox regression analysis showed anemia significantly increased the risk of all-cause mortality (Hazard ratio [HR] = 1.935, 95% CI: 1.106-3.384, <i>P</i> = .021) and major adverse cardiovascular events (MACE; HR = 1.857, 95% CI: 1.171-2.945, <i>P</i> = .009), but not thromboembolic events (HR = 0.651, 95% CI: 0.210-2.022, <i>P</i> = .458). Receiver operating characteristic (ROC) curves showed that hemoglobin's area under the curve (AUC) for mortality and MACE was 0.722 and 0.710, respectively, improving to 0.770 and 0.772 when combined with the CHA<sub>2</sub>DS<sub>2</sub>-VASc score. Integrated discrimination improvement (IDI) and net reclassification improvement (NRI) metrics showed significant improvement in predicting mortality (NRI = 0.258, <i>P</i> = .004; IDI = 0.037, <i>P</i> < .001) and MACE (NRI = 0.232, <i>P</i> = .002; IDI = 0.026, <i>P</i> = .004). Adding hemoglobin to the CHA<sub>2</sub>DS<sub>2</sub>-VASc score enhances its predictive performance.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251333224"},"PeriodicalIF":2.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Carotid Plaque Characteristics and High-risk Coronary Plaque: A Virtual Histology Intravascular Ultrasound Study. 颈动脉斑块特征与高危冠状动脉斑块之间的关系:一项虚拟组织学血管内超声研究。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-12 DOI: 10.1177/00033197251333204
Peng Yan, Xinhao Yang, Zhengyu Yang, Hailing Wang, Jiehong Yuan, Maoyu Li, Xiaotong Ma, Xiang Wang, Qinjian Sun
{"title":"Association Between Carotid Plaque Characteristics and High-risk Coronary Plaque: A Virtual Histology Intravascular Ultrasound Study.","authors":"Peng Yan, Xinhao Yang, Zhengyu Yang, Hailing Wang, Jiehong Yuan, Maoyu Li, Xiaotong Ma, Xiang Wang, Qinjian Sun","doi":"10.1177/00033197251333204","DOIUrl":"https://doi.org/10.1177/00033197251333204","url":null,"abstract":"<p><p>This retrospective study aimed to investigate the association between carotid artery plaque characteristics evaluated by virtual histology intravascular ultrasound (VH-IVUS) and high-risk coronary plaques determined by coronary computed tomography angiography (CCTA) among patients (<i>n</i> = 72) who underwent carotid artery stenting (CAS). VH-IVUS examination was performed during CAS and CCTA examination before CAS. Logistic regression models were used to explore the association between carotid plaque characteristics and high-risk coronary plaque. Of 72 patients, 46 (63.9%) were diagnosed as having high-risk coronary plaques. The necrotic core (NC) area, NC percentage, dense calcium (DC) area, and symptomatic carotid artery stenosis were significantly associated with high-risk coronary plaques (all <i>P</i> <i><</i> .05). Isolated upper-NC area, and upper-NC area combined with upper-DC area were associated with high-risk coronary plaques. Compared with the lower-NC area and lower-DC area groups, participants with upper-NC area and upper-NC area had 12.53 times higher odds ratio of having high-risk coronary plaques. This study showed that the NC area, NC percentage, DC area and symptomatic carotid artery stenosis were associated with high-risk coronary plaques. Participants with both upper-NC area and upper-DC area might have a higher risk of high-risk coronary plaques.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251333204"},"PeriodicalIF":2.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Reply to "Cancer Paradox and Short-term STEMI-related Outcomes". 信件:回复“癌症悖论和短期stemi相关结果”。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-09 DOI: 10.1177/00033197251333870
Jia Ee Chia, Song Peng Ang, Muhammed Haris Usman, Chayakrit Krittanawong, Debabrata Mukherjee
{"title":"Letter: Reply to \"Cancer Paradox and Short-term STEMI-related Outcomes\".","authors":"Jia Ee Chia, Song Peng Ang, Muhammed Haris Usman, Chayakrit Krittanawong, Debabrata Mukherjee","doi":"10.1177/00033197251333870","DOIUrl":"https://doi.org/10.1177/00033197251333870","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251333870"},"PeriodicalIF":2.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: The Association Between Epicardial Adipose Tissue Thickness Clinical and Laboratory Characteristics in Prediabetic Obese Patients. 信:糖尿病前期肥胖患者心外膜脂肪组织厚度临床和实验室特征之间的关系。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-04 DOI: 10.1177/00033197251333868
Cihan Aydın, Aykut Demirkıran, Hüseyin Orta
{"title":"Letter: The Association Between Epicardial Adipose Tissue Thickness Clinical and Laboratory Characteristics in Prediabetic Obese Patients.","authors":"Cihan Aydın, Aykut Demirkıran, Hüseyin Orta","doi":"10.1177/00033197251333868","DOIUrl":"https://doi.org/10.1177/00033197251333868","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251333868"},"PeriodicalIF":2.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Value of GRACE Risk Score Combined With Systemic Immune-Inflammation Index in Patients With ST-Segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention. GRACE风险评分结合全身免疫炎症指数对经皮冠状动脉介入治疗后ST段抬高型心肌梗死患者的预后价值。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-01 Epub Date: 2023-11-07 DOI: 10.1177/00033197231213674
Jiaqi Wang, Feifei Zhang, Litian Liu, Man Gao, Xuelian Song, Yingxiao Li, Yi Dang, Xiaoyong Qi
{"title":"Prognostic Value of GRACE Risk Score Combined With Systemic Immune-Inflammation Index in Patients With ST-Segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention.","authors":"Jiaqi Wang, Feifei Zhang, Litian Liu, Man Gao, Xuelian Song, Yingxiao Li, Yi Dang, Xiaoyong Qi","doi":"10.1177/00033197231213674","DOIUrl":"10.1177/00033197231213674","url":null,"abstract":"<p><p>The Global Registry of Acute Coronary Events (GRACE) score and the systemic immune-inflammation index (SII) were used independently to predict adverse outcomes in patients with ST-elevation myocardial infarction (STEMI). In this study, 1041 patients with STEMI were divided into 4 groups based on GRACE scores and optimal cutoff values for SII. SII was positively correlated with GRACE score (r = 0.164; <i>P</i> < .001). SII (HR, hazard ratio: 2.051; 95%CI: 1.249-3.368; <i>P</i> = .005) and GRACE score (HR: 7.625; 95%CI: 3.692-15.746; <i>P</i> < .001) were independent risk predictors of short-term major adverse cardiovascular events (MACEs). Taking the low SII+low GRACE group as the reference group, the short-term MACE HR of the high SII+high GRACE group was 40.470 (95%CI: 5.547-295.253). Comparing the area under the curve, the combined use of SII and GRACE scores can significantly improve the prediction efficiency of short-term MACE compared with the single use of SII and GRACE scores. In conclusion, SII may be positively correlated with GRACE score, and the combination of the two accurately predicted the occurrence of short-term MACE in STEMI patients after percutaneous coronary intervention (PCI).</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"349-360"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptomatic Upper Extremity Peripheral Artery Disease is Associated With Poor Outcomes and a Broad Spectrum of Etiologies. 有症状的上肢外周动脉疾病与不良预后和广泛的病因有关。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-01 Epub Date: 2023-12-14 DOI: 10.1177/00033197231218332
Guillaume Armengol, Guillaume Goudot, Sébastien Miranda, Ygal Benhamou, Muriel Tafflet, Henri Guillet, Hélène Mortelette, Hervé Levesque, Emmanuel Messas, Tristan Mirault
{"title":"Symptomatic Upper Extremity Peripheral Artery Disease is Associated With Poor Outcomes and a Broad Spectrum of Etiologies.","authors":"Guillaume Armengol, Guillaume Goudot, Sébastien Miranda, Ygal Benhamou, Muriel Tafflet, Henri Guillet, Hélène Mortelette, Hervé Levesque, Emmanuel Messas, Tristan Mirault","doi":"10.1177/00033197231218332","DOIUrl":"10.1177/00033197231218332","url":null,"abstract":"<p><p>The symptomatic upper extremity peripheral artery disease (sUE-PAD) is poorly studied compared with the lower extremity peripheral artery disease (LE-PAD). We aimed to describe sUE-PAD etiologies and outcomes at 2 years. From an observational survey conducted in two French tertiary hospitals, demographic characteristics, etiology, treatment, and outcomes during follow-up were collected on patients with ICD-10 I74.2 code (arterial thrombosis of the upper limbs). We identified 181 patients (53% male, 55 ± 17 years) with hypothenar hammer syndrome (13.8%), cardioembolism (13.3%), atheroma (12.7%), or connective tissue disease (10.5%). No etiology could be found for 16.0% of them. The amputation rate was 13.3%, and lasting symptoms remained at 21.3%. During follow-up, atrial fibrillation occurred in 1 patient and cancer in 4. At 2 years, 59 patients were lost to follow-up, 110 patients were alive, and 12 patients had died. Age and cancer were associated with death. sUE-PAD is not benign, with 20% impaired upper extremity outcome and 10% overall mortality at 2 years. Less frequent than LE-PAD, sUE-PAD presents different characteristics: more women, younger age, and a broad spectrum of etiologies. sUE-PAD requires thorough etiological assessment and is considered to be associated with a severe overall prognosis.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"382-390"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous Iron for Heart Failure: Updated Systematic Review and Meta-Analysis. 静脉注射铁治疗心力衰竭:最新系统综述和荟萃分析。
IF 2.6 3区 医学
Angiology Pub Date : 2025-04-01 Epub Date: 2023-11-02 DOI: 10.1177/00033197231213181
Witina Techasatian, Yoshito Nishimura, Manasawee Tanariyakul, Clarke Morihara, Chinnawat Arayangkool, Alexander Settle, Noppawit Aiumtrakul, Jakrin Kewcharoen
{"title":"Intravenous Iron for Heart Failure: Updated Systematic Review and Meta-Analysis.","authors":"Witina Techasatian, Yoshito Nishimura, Manasawee Tanariyakul, Clarke Morihara, Chinnawat Arayangkool, Alexander Settle, Noppawit Aiumtrakul, Jakrin Kewcharoen","doi":"10.1177/00033197231213181","DOIUrl":"10.1177/00033197231213181","url":null,"abstract":"<p><p>While the administration of intravenous (IV) iron to those with heart failure has been implicated to be associated with a possible reduction in hospitalizations and improvement in symptoms, a recent large multicenter trial only showed modest benefits in reducing hospitalization, necessitating the updated systematic review. We conducted a systematic review and meta-analysis, searching the MEDLINE and EMBASE database until January 9, 2023. Outcomes included total heart failure hospitalizations, first heart failure hospitalization, six-minute walk test (6MWT) distance, and incidence of infection. There were 13 studies with 3410 participants (1,790 with IV iron). Pooled analysis that reported the incidence of cardiovascular death showed that patients with IV iron did not have significantly lower odds of cardiovascular death or first heart failure hospitalization. In contrast, those who received IV iron had significantly lower total heart failure hospitalization (pooled odds ratio (OR) 0.63, 95% confidence interval (CI) 0.44-0.90, <i>I</i> <sup>2</sup> 59.0%, <i>P</i> = .017) and a composite of cardiovascular death and first heart failure hospitalization (pooled OR 0.55, 95% CI 0.47-0.64, <i>I</i> <sup>2</sup> 0%, <i>P</i> = .656). While the efficacy is modest, IV iron therapy could be associated with reduced hospitalization for heart failure without significant adverse events.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"370-381"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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