AngiologyPub Date : 2025-02-17DOI: 10.1177/00033197251320141
Selim Aydemir, Sidar Şiyar Aydın, Onur Altınkaya, Emrah Aksakal, Murat Özmen
{"title":"Evaluation of Hematological and Biochemical Parameters that Predict the No-reflow Phenomenon in Patients Undergoing Primary Percutaneous Coronary Intervention.","authors":"Selim Aydemir, Sidar Şiyar Aydın, Onur Altınkaya, Emrah Aksakal, Murat Özmen","doi":"10.1177/00033197251320141","DOIUrl":"https://doi.org/10.1177/00033197251320141","url":null,"abstract":"<p><p>Acute coronary syndromes (ACS) are one of the most common causes of morbidity and mortality worldwide. Primary percutaneous coronary intervention (pPCI) is the main treatment strategy to restore myocardial perfusion. However, the no-reflow phenomenon (NRP) may block coronary flow. The present study focused on assessing and contrasting predictive parameters for NRP in ACS patients. Our research is a retrospective analysis. We assessed the parameters significantly associated with NRP using Cox regression and Receiver operating characteristic (ROC) Curve analysis. The study included 5122 patients who met the criteria. The average age of the patients was 63.9 + 13.2, and 74.4% were male. It was observed that NRP developed in 1.8% of all patients. Age, hemoglobin (Hb), white blood cell (WBC), glucose and low density lipoprotein cholesterol (LDL-C) were determined to be independent predictors of NRP. The power of these parameters to predict NRP was similar, and WBC was the most predictive (Area Under Curve (AUC): 0.605 95% CI: 0.539-0.671, <i>P</i> = .001). We believe that the use of these simple, practical, and routinely used hematological and biochemical parameters will help us predict the risk of developing NRP before pPCI. This information should improve management.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251320141"},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-14DOI: 10.1177/00033197251319600
Jonas Salm, Valeska Hofbauer-Milan, Elisabeth Wüstholz, Olaf Schneider, Dirk Westermann, Thomas Zeller
{"title":"Antibiotic Consumption and Bloodstream Infections in Patients With Chronic-limb Threatening Ischemia Following Endovascular Therapy in East-west Germany, 2019-2020.","authors":"Jonas Salm, Valeska Hofbauer-Milan, Elisabeth Wüstholz, Olaf Schneider, Dirk Westermann, Thomas Zeller","doi":"10.1177/00033197251319600","DOIUrl":"https://doi.org/10.1177/00033197251319600","url":null,"abstract":"<p><p>Patients with chronic-limb threatening ischemia (CLTI) and peripheral wounds might be predisposed for systemic infections. The study aimed to describe the rate of systemic infections in patients with CLTI compared with peripheral artery obstructive disease (PAOD) patients without CLTI, both independently of endovascular treatment (EVT) and after EVT. Administrative data of the AOK Baden-Wuerttemberg (AOK BW) from patients with PAOD were analyzed considering bloodstream infection (BSI), 30-day readmission and prescribed antibiotics for ischemic ulcers. The risk of BSI increased 3.9-fold (95% CI: 3.4-4.4) in patients with PAOD Rutherford-Becker category (RBC) 5 and 6 (<i>n</i> = 11,741) compared with PAOD RBC 1-4 (<i>n</i> = 23,482; 6.81% vs 1.67%, <i>P</i> < .01). The risk of <i>Staphylococcus aureus</i> BSI increased 5.6-fold (95% CI: 4.1-7.7) comparing RBC 5 and 6 (1.2%) with RBC 1-4 (0.22%, <i>P</i> < .01). Outpatient antibiotic prescriptions were dominated by aminopenicillins with β-lactamase inhibitors, accounting for 34.9%. Clindamycin, cefuroxime, and fluoroquinolones represented 14.9%, 13.5%, and 12.6% of prescriptions, respectively. Infections were responsible for 7.7% of 30-day readmissions following EVT. Patients with CLTI are at risk of developing BSI, and specifically <i>S. aureus</i> BSI. Infection-related causes in 30-day readmissions following EVT are common. The high use of clindamycin and cefuroxime in outpatients is concerning.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251319600"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-14DOI: 10.1177/00033197251319597
Fei Shao, Ruchang He, Yang Jin, Yunfeng Pang, Ziqiang Sun, Bin Zhang, Song Jin
{"title":"Regulation and Clinical Application of Exosomes in Venous Thrombosis.","authors":"Fei Shao, Ruchang He, Yang Jin, Yunfeng Pang, Ziqiang Sun, Bin Zhang, Song Jin","doi":"10.1177/00033197251319597","DOIUrl":"https://doi.org/10.1177/00033197251319597","url":null,"abstract":"<p><p>Exosomes refer to a group of extracellular vesicles naturally released from mammalian cells with a diameter of 30-150 nm. Exosomes contain a variety of biologically active molecules, such as cytoplasmic proteins, chemokines, cytokines, and microRNA (miRNA). They are widely involved in intercellular communication and regulate the behavior of recipient cells. Venous thrombosis is a pathological change caused by vascular endothelial cell damage, hemodynamic changes, and the hypercoagulable state of blood. Exosomes from different cell sources are involved in the process of venous thrombosis. Exosomes can also be used as therapeutic carriers for tissue regeneration and drug delivery. Therefore, the study of exosomes is crucial for the formation, diagnosis, and treatment of venous thrombosis. In this review, we summarize the biological characteristics of exosomes and their mechanism of action in venous thrombosis. In addition, we also focused on its potential clinical applications, including as a diagnostic marker and therapeutic carrier for venous thrombosis.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251319597"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-14DOI: 10.1177/00033197251321262
Jelena Petrovic, Yusuf Ziya Şener
{"title":"Letter: Confounding Factors in the Association Between Sarcopenia and Carotid Atherosclerosis Among Patients With Type 2 Diabetes Mellitus.","authors":"Jelena Petrovic, Yusuf Ziya Şener","doi":"10.1177/00033197251321262","DOIUrl":"https://doi.org/10.1177/00033197251321262","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251321262"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-14DOI: 10.1177/00033197251321263
Aykut Demirkıran, Cihan Aydın, Hüseyin Orta
{"title":"Letter: Relationships Between Inflammatory Parameters and Quantitative Flow Ratio May Be Misleading Because of Many Confounding Factors.","authors":"Aykut Demirkıran, Cihan Aydın, Hüseyin Orta","doi":"10.1177/00033197251321263","DOIUrl":"https://doi.org/10.1177/00033197251321263","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251321263"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-14DOI: 10.1177/00033197251316624
Ling-Ling Wang, Zi-Xiang Xu, Bo-Qian Sun, Jie Liu, Xue-Lian Liu, Dong Liu
{"title":"Sex Differences in the Relationship Between Lipid Ratios and the Risk of Carotid Plaque.","authors":"Ling-Ling Wang, Zi-Xiang Xu, Bo-Qian Sun, Jie Liu, Xue-Lian Liu, Dong Liu","doi":"10.1177/00033197251316624","DOIUrl":"https://doi.org/10.1177/00033197251316624","url":null,"abstract":"<p><p>Lipid ratio is a balance between atherogenesis and antiatherogenesis. it is an important predictive marker of carotid plaque. The lipid ratios, which include non-high-density lipoprotein cholesterol (non-HDL-C)/high-density lipoprotein cholesterol (HDL-C), remnant cholesterol (RC)/HDL-C, apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1), low-density lipoprotein cholesterol (LDL-C)/HDL-C, ApoB/HDL-C, total cholesterol (TC)/HDL-C, triglycerides (TG)/HDL-C, were included and analyzed. Sex differences in the relationship between lipid ratios and carotid plaque were discussed. The risk of carotid plaque was found to be significantly associated with the Non-HDL-C /HDL-C, RC/HDL-C, ApoB/ApoA1, LDL-C /HDL-C, ApoB/HDL-C, TC/HDL-C in females but not in males. The ApoB/HDL risk presented the highest relationship with carotid plaque in females only. The predictive value of the aforementioned lipid ratios for carotid plaque was observed in females only.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251316624"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-10DOI: 10.1177/00033197251318094
Nurbanu Sezak, Banu Karaca, Recep Balik, Murat Aksun
{"title":"Prognostic Value of Neutrophil/Lymphocyte, Lymphocyte/C-reactive protein, Platelet/ Lymphocyte Rates in Covid-19 Cases Monitored in the Intensive Care Unit.","authors":"Nurbanu Sezak, Banu Karaca, Recep Balik, Murat Aksun","doi":"10.1177/00033197251318094","DOIUrl":"https://doi.org/10.1177/00033197251318094","url":null,"abstract":"<p><p>Coronavirus 2019 (COVID-19) infection has a significant mortality rate. Despite the disease's extensive effects, little is known about the prognostic indicators that can be used. We aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-C-reactive protein ratio (LCR) and platelet-to- lymphocyte ratio (PLR) in predicting mortality of intensive care unit (ICU) patients. Demographic data, underlying diseases, laboratory parameters were evaluated. The study included 222 cases. The mortality rate was 57.65%. No significant differences in terms of sex, age, or underlying disease were observed between the two groups with and without mortality. Obesity, oxygen therapy, invasive mechanical ventilation (IMV) rates and high SOFA (Sequential Organ Failure Assessment) scores were found to be significantly higher in the group with a mortal course. The mortality rate was significantly higher in patients with lung involvement over 50%, with a low lymphocyte count at ICU admission. In this patient group, NLR was found to be higher, and LCR was found to be lower (<i>P</i> = .001). Although there was no significant difference in PLR between the two groups in univariate analysis, multivariate analysis revealed that PLR was independently associated with mortality. High NLR and low LCR values at ICU admission might serve as early warning signs for healthcare providers, allowing them to identify patients at higher risk of mortality.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251318094"},"PeriodicalIF":2.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association Between Carotid Plaque Characteristics and Silent New Ipsilateral Ischemic Lesions After Carotid Artery Stenting.","authors":"Jiehong Yuan, Peng Yan, Zhengyu Yang, Yanan Song, Xinhao Yang, Xinyan Hu, Qiuting Wang, Maoyu Li, Xiaotong Ma, Xiang Wang, Qinjian Sun","doi":"10.1177/00033197251316629","DOIUrl":"https://doi.org/10.1177/00033197251316629","url":null,"abstract":"<p><p>Silent new ipsilateral ischemic lesions (sNIIL) detected by diffusion-weighted imaging (DWI) are commonly observed after carotid artery stenting (CAS). We aimed to analyze the association of carotid plaque characteristics on Virtual Histology Intravascular Ultrasound (VH-IVUS) with sNIIL, which is not well understood. Among 128 patients who underwent CAS and VH-IVUS, 112 patients who underwent DWI within 72 h after CAS were included for analysis. VH-IVUS detected cross-sectional composition of plaques including necrotic core (NC), dense calcium (DC), fibrous (FI), and fibrofatty (FF) in each frame. Plaques with ≥3 consecutive thin-cap fibroatheroma (TCFA) or calcified thin-cap fibroatheroma (CaTCFA) frames were defined as vulnerable. Logistic regression was applied to evaluate the association between plaque characteristics and sNIIL. A total of 56 patients (50%) had sNIIL. Larger NC in the maximum NC frame (odds ratio [OR] = 1.35; 95% confidence interval [CI]: 1.03-1.75; <i>P</i> = .029) and defined vulnerable plaques (OR = 3.89; 95% CI: 1.68-9.01; <i>P</i> = .001) were associated with sNIIL. Incidence of sNIIL showed an escalating trend with the increase of quartiles of NC (<i>P</i><sub>trend</sub> = .010). The findings of this study suggest that composition and distribution characteristics of carotid plaques on VH-IVUS during CAS have potential clinical significance.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251316629"},"PeriodicalIF":2.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-02DOI: 10.1177/00033197241308368
Piotr Kazmierski, Piotr Szpakowski, Andrzej Glabinski
{"title":"Letter: CXCL1 Index May Act as a Potential Biomarker of Plaque Instability in Patients with Carotid Stenosis. Authors' Reply.","authors":"Piotr Kazmierski, Piotr Szpakowski, Andrzej Glabinski","doi":"10.1177/00033197241308368","DOIUrl":"https://doi.org/10.1177/00033197241308368","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197241308368"},"PeriodicalIF":2.6,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-02-01Epub Date: 2023-12-21DOI: 10.1177/00033197231223616
Hao Wang, Ci Wang
{"title":"Prognostic Value of Endothelin-1 or Related Peptides in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis.","authors":"Hao Wang, Ci Wang","doi":"10.1177/00033197231223616","DOIUrl":"10.1177/00033197231223616","url":null,"abstract":"<p><p>There is increasing evidence that endothelin-1 (ET-1) or related peptides play a prognostic value in coronary artery disease (CAD). The objective of this systematic review and meta-analysis was to evaluate the predictive role of ET-1 or related peptides in CAD patients. We comprehensively searched PubMed and Embase databases until January 15, 2023. Studies examining the association of ET-1, big ET-1, or C-terminal proendothelin-1 (CT-proET-1) level with all-cause mortality or major adverse cardiovascular events (MACEs) in CAD patients were included. Fourteen studies with 30,181 patients were identified. Comparison of the top and the lowest ET-1 level, the pooled risk ratio (RR) of all-cause mortality was 3.77 (95% confidence interval [CI] 1.59-8.94) for ET-1 and 1.65 (95% CI 1.25-2.18) for big ET-1. The pooled RR of MACEs was 2.24 (95% CI 1.85-2.72) for ET-1, 1.49 (95% CI 1.10-2.03) for big ET-1, and 3.55 (95% CI 2.12-5.96) for CT-proET-1, respectively. Subgroup analysis indicated that elevated ET-1 level was associated with 2.66-fold and 2.09-fold higher risk of in-hospital/30-day and long-term MACEs. Elevated ET-1, big ET-1, or CT-proET-1 may be independently associated with higher risk of all-cause mortality and MACEs in patients with CAD.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"108-116"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138827943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}