Association of Endothelial Nitric Oxide Synthase and Angiotensin-Converting Enzyme Genes Polymorphism With In-Sent Restenosis of Bare Metal Stents vs Drug-Eluting Stents in Egyptians.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2025-05-01 Epub Date: 2023-12-01 DOI:10.1177/00033197231219837

Tarek A Abdelaziz, Randa H Mohamed, Sara F Saadawy

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引用次数: 0

Abstract

Despite its unequivocal superiority compared with balloon angioplasty, coronary stenting did not abolish restenosis. We aimed to evaluate the associations between a common single nucleotide polymorphism occurring in endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) genes and the risk of in-stent restenosis (ISR) of bare metal stents vs drug-eluting stents (BMS vs DES) implanted in Egyptian patients. Two hundred patients who had coronary stenting were divided into group I (n = 98) who received a BMS and group II (n = 102) who received a DES. eNOS and ACE genes polymorphism were analyzed by polymerase chain reaction (PCR). We found that the GA and AA genotypes of the eNOS gene were associated with the ISR with both BMS and DES. However, the ACE gene was not associated with ISR. We concluded that eNOS gene polymorphism is associated with ISR. Hypertension, stent length, and AA genotype of the eNOS gene were found to be independent predictors of the occurrence of ISR after both BMS and DES use.

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内皮型一氧化氮合酶和血管紧张素转换酶基因多态性与埃及裸金属支架与药物洗脱支架再狭窄的关系

尽管冠脉支架置入术与球囊血管成形术相比具有明显的优势，但它并不能消除再狭窄。我们的目的是评估内皮一氧化氮合酶(eNOS)和血管紧张素转换酶(ACE)基因中常见的单核苷酸多态性与在埃及患者中植入裸金属支架与药物洗脱支架(BMS vs DES)的支架内再狭窄(ISR)风险之间的关系。将200例冠状动脉支架植入术患者分为行BMS组(98例)和行des组(102例)，采用聚合酶链反应(PCR)分析eNOS和ACE基因多态性。我们发现eNOS基因的GA和AA基因型与BMS和DES的ISR相关，而ACE基因与ISR无关。我们认为eNOS基因多态性与ISR相关。高血压、支架长度和eNOS基因的AA型被发现是BMS和DES使用后发生ISR的独立预测因素。

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days