Angiology最新文献_第10页

CircCDYL Contributes to Apoptosis, Ferroptosis, and Oxidative Stress of Ang II-Induced Vascular Smooth Muscle Cells in Thoracic Aortic Aneurysm. CircCDYL有助于胸主动脉瘤血管平滑肌细胞的凋亡、铁凋亡和氧化应激。

IF 2.2 3区医学

Angiology Pub Date : 2025-08-01 Epub Date: 2024-02-23 DOI: 10.1177/00033197241234075

Changjiang Fu, Xiangrong Zuo, Jinghui An, Yanlong Zhang, Lixin Guo, Huashun Li

{"title":"CircCDYL Contributes to Apoptosis, Ferroptosis, and Oxidative Stress of Ang II-Induced Vascular Smooth Muscle Cells in Thoracic Aortic Aneurysm.","authors":"Changjiang Fu, Xiangrong Zuo, Jinghui An, Yanlong Zhang, Lixin Guo, Huashun Li","doi":"10.1177/00033197241234075","DOIUrl":"10.1177/00033197241234075","url":null,"abstract":"Circular RNAs (circRNAs) have important regulation in thoracic aortic aneurysm (TAA). The function and mechanism of circCDYL (circ_0008285) was explored in TAA here. Angiotensin II (Ang II) was used to construct a TAA model. Real-time quantitative polymerase chain reaction (RT-qPCR) was performed for the detection of circCDYL, miR-1270, and a disintegrin and metalloproteinase 10 (ADAM10). Cell viability was examined via cell counting kit-8 (CCK-8) assay and proliferation was analyzed using Ethynyl-2'-deoxyuridine (EdU) assay. Apoptosis rate was assessed via flow cytometry. Western blot was used for protein detection. Oxidative stress was evaluated by commercial kits. CircCDYL was upregulated in TAA tissues and Ang II-induced circCDYL upregulation in vascular smooth muscle cells (VSMCs). Knockdown of circCDYL weakened Ang II-aroused inhibition of viability, proliferation, and promotion of apoptosis, ferroptosis, and oxidative stress in VSMCs. CircCDYL served as a miR-1270 sponge. The mitigated regulation of circCDYL knockdown for Ang II-induced injury was restored after miR-1270 downregulation. CircCDYL positively regulated ADAM10 through interacting with miR-1270. Overexpression of miR-1270 abated Ang II-induced injury by downregulating ADAM10. In conclusion, circCDYL was involved in the Ang II-induced VSMC injury in TAA via the miR-1270/ADAM10 axis.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"637-647"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139939406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Red Blood Cell Distribution Width and Coronary Calcification in Patients Referred for Invasive Coronary Angiography. 转诊接受侵入性冠状动脉造影术患者的红细胞分布宽度与冠状动脉钙化之间的关系

IF 2.2 3区医学

Angiology Pub Date : 2025-08-01 Epub Date: 2024-03-11 DOI: 10.1177/00033197241238509

Wen Jian, Xueqian Shen, Ze Zheng, Zheng Wu, Yuchen Shi, Jinghua Liu

{"title":"Association Between Red Blood Cell Distribution Width and Coronary Calcification in Patients Referred for Invasive Coronary Angiography.","authors":"Wen Jian, Xueqian Shen, Ze Zheng, Zheng Wu, Yuchen Shi, Jinghua Liu","doi":"10.1177/00033197241238509","DOIUrl":"10.1177/00033197241238509","url":null,"abstract":"This study aimed to determine whether red cell distribution width (RDW) is associated with coronary calcification. A total of 4796 patients who underwent coronary computed tomography angiography and subsequent invasive coronary angiography were consecutively enrolled. Coronary artery calcium score (CACS), demographic, clinical, and laboratory data were collected from electronic medical records. RDW were expressed in two forms, as a coefficient of variation (CV) or as a standard deviation (SD). Multivariable ordinal logistic regression was used to investigate the association of RDW with CACS grades (CACS 0-99, 100-399, 400-999, and >1000). A significant association was found between elevated RDW-SD and higher CACS grades after full adjustment (adjusted OR per 1-SD increase: 1.11, 95% CI: 1.05-1.18; P < .001), while no significant association was found between RDW-CV and CACS grades. When RDW-SD was analyzed as a categorical variable, it was primarily the 4th quartile of RDW-SD that was associated with elevated CACS grades compared with the 1st quartile (adjusted OR: 1.25, 95% CI: 1.07-1.46; P = .006), while the 2nd and 3rd quartiles showed no significantly higher risk. RDW-SD is a more robust biomarker for coronary calcification compared with RDW-CV.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"690-698"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Routine Blood Values as Diagnostic Parameters in Cardiovascular Diseases. 使用常规血液值作为心血管疾病的诊断参数。

IF 2.2 3区医学

Angiology Pub Date : 2025-08-01 Epub Date: 2024-04-01 DOI: 10.1177/00033197241244807

Mesut Engin, Kemal Parla, Orhan Guvenc, Ahmet Kagan As, Ahmet Fatih Ozyazicioglu

引用次数: 0

Focusing on Arterial and Cardiac Dysfunction in Systemic Sclerosis: Targeted Therapy is Still Pending. 关注系统性硬化症的动脉和心功能障碍：靶向治疗仍在等待中。

IF 2.2 3区医学

Angiology Pub Date : 2025-08-01 Epub Date: 2025-03-25 DOI: 10.1177/00033197251331652

Agata Buonacera, Benedetta Stancanelli, Michele Colaci, Lorenzo Malatino

{"title":"Focusing on Arterial and Cardiac Dysfunction in Systemic Sclerosis: Targeted Therapy is Still Pending.","authors":"Agata Buonacera, Benedetta Stancanelli, Michele Colaci, Lorenzo Malatino","doi":"10.1177/00033197251331652","DOIUrl":"10.1177/00033197251331652","url":null,"abstract":"Although the pathophysiology and therapy of microvascular damage was so far addressed by both rheumatologists and angiologists, cardiac disease related to Systemic sclerosis (SSc) remained obscure or misdiagnosed for long time. Although its pathogenetic chain is far to be completely understood, myocardial fibrosis and microvascular dysfunction play a prominent role in the clinical history of patients with SSc. Bearing in mind that it is one of the main causes of death and disabilities for SSc patients, an early screening has become mandatory at time of diagnosis, and then every year during the follow-up. Moreover, the prevalence of coronary heart disease in SSc resulted comparable, in older patients, to that of patients with type 2 diabetics. Global longitudinal strain (GLS), a well-known early echocardiographic marker of cardiac dysfunction, has been recently shown to be a useful tool predicting prognosis and effects of therapy in SSc. Target therapy for primary cardiac disease in SSc is so far not well established. Inhibitor of IL-1 and IL-6 are under investigation. The acute infusion of iloprost ameliorates the baseline depressed GLS of left ventricle in patients with SSc, but this beneficial effect remains to be confirmed during chronic treatment.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"613-614"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Possible Case of Hypertensive Crisis With Aortic Dissection After an Anti-COVID-19 Vaccine. 一例注射抗COVID-19疫苗后可能出现高血压危象并伴有主动脉夹层的病例

IF 2.2 3区医学

Angiology Pub Date : 2025-08-01 Epub Date: 2024-02-03 DOI: 10.1177/00033197241232619

Leila Mohsenian, Zahra Noroozi, Faramarz Farahmand

{"title":"A Possible Case of Hypertensive Crisis With Aortic Dissection After an Anti-COVID-19 Vaccine.","authors":"Leila Mohsenian, Zahra Noroozi, Faramarz Farahmand","doi":"10.1177/00033197241232619","DOIUrl":"10.1177/00033197241232619","url":null,"abstract":"Aortic dissection, a potentially fatal event, usually presents with acute intense chest or back pain. Painless aortic dissections constitute about 10% of all cases. High blood pressure is a common finding in both painless and painful aortic dissections. During the coronavirus disease (COVID-19) pandemic, various anti-COVID vaccines have been massively used. Although these vaccines are generally safe, there is a small risk of adverse effects which are mostly mild and transient, but sometimes they could be life-threatening. We report a case of painless aortic dissection that occurred within minutes of receiving the COVID-19 inactivated vaccine. A 65-year-old woman with chronic controlled systemic hypertension developed slurred speech, decreased level of consciousness, generalized weakness, and dyspnea without chest, back, or abdominal pain a few minutes after receiving the second dose of inactivated COVID-19 vaccine; she had a systolic blood pressure of 220 mmHg and left-sided pleural effusion. Drainage of the pleural effusion revealed gross blood and a spiral chest and mediastinum CT with intravenous contrast showed a penetrating atherosclerotic ulcer in the descending aorta. Therefore, thoracic endovascular aortic repair (TEVAR) was carried out, and the patient was discharged in satisfactory condition after 3 days.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"699-703"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated With Myocardial Infarction in a Rural Population With Peripheral Arterial Diseases. 患有外周动脉疾病的农村人口心肌梗死的相关因素

IF 2.2 3区医学

Angiology Pub Date : 2025-08-01 Epub Date: 2024-02-06 DOI: 10.1177/00033197241232608

Adeola O Awujoola, Moboni T Mokikan, Olufeyisayo O Odebunmi, Hadii M Mamudu, David W Stewart, Ghaith Husari, Krishna Singh, Cori Grant, Matthew Budoff, Timir K Paul

{"title":"Factors Associated With Myocardial Infarction in a Rural Population With Peripheral Arterial Diseases.","authors":"Adeola O Awujoola, Moboni T Mokikan, Olufeyisayo O Odebunmi, Hadii M Mamudu, David W Stewart, Ghaith Husari, Krishna Singh, Cori Grant, Matthew Budoff, Timir K Paul","doi":"10.1177/00033197241232608","DOIUrl":"10.1177/00033197241232608","url":null,"abstract":"Peripheral arterial disease (PAD) studies in rural populations are limited. The incidence of myocardial infarction (MI) is higher in patients with PAD. This study examined the association between sociodemographic and clinical risk factors and MI in patients with PAD in Central Appalachia, comprising of 230 counties across six states in the United States. Data from electronic medical records of 13,455 patients with PAD were extracted from a large health system in Central Appalachia. Bivariate and logistic regression analyses were conducted. The final sample consisted of 5574 patients with PAD, of whom 24.85% were also diagnosed with MI. The mean age was 71 ± 11.23 years, and the majority were male (56.40%). After adjusting for confounders, patients with hypertension had three times higher odds of MI (adjusted Odds Ratio [aOR] = 3.21; 95% CI: 2.50-4.14) compared with those without hypertension. The likelihood of MI increased by 51% among patients with diabetes (aOR = 1.51; 95% CI: 1.33-1.71), 34% among ever-smokers (aOR = 1.34; 95% CI: 1.18-1.52), and 45% in males (aOR = 1.45; 95% CI: 1.27-1.65). Hypertension, diabetes, smoking, and male sex were identified as significant risk factors for MI. Screening and effective management of these risk factors in rural areas could potentially prevent MI incidence among patients with PAD.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"674-680"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology and Genetic Associations of Varicose Veins: A Narrative Review. 静脉曲张的病理生理学和遗传关联：叙述性综述。

IF 2.2 3区医学

Angiology Pub Date : 2025-08-01 Epub Date: 2024-01-16 DOI: 10.1177/00033197241227598

Tao Chen, Peng Liu, Chenguang Zhang, Song Jin, Yuhu Kong, Yanan Feng, Ziqiang Sun

引用次数: 0

A Comparison of Carotid Ultrasound and Coronary Optical Coherence Tomography in Assessing Plaque Morphology in Patients with Chronic Coronary Syndrome. 颈动脉超声与冠状动脉光学相干断层扫描评估慢性冠脉综合征患者斑块形态的比较。

IF 2.2 3区医学

Angiology Pub Date : 2025-07-30 DOI: 10.1177/00033197251355336

Mehmet Ali Cetiner, Marc Vorpahl, Melchior Seyfarth, Ulrich Wiederhold, Juliane Sophie Yu, Rojvan Bilgin, Ramazan Gökmen Turan

{"title":"A Comparison of Carotid Ultrasound and Coronary Optical Coherence Tomography in Assessing Plaque Morphology in Patients with Chronic Coronary Syndrome.","authors":"Mehmet Ali Cetiner, Marc Vorpahl, Melchior Seyfarth, Ulrich Wiederhold, Juliane Sophie Yu, Rojvan Bilgin, Ramazan Gökmen Turan","doi":"10.1177/00033197251355336","DOIUrl":"https://doi.org/10.1177/00033197251355336","url":null,"abstract":"Atherosclerosis is a predominant cause of cardiovascular events and the accurate assessment of plaque morphology is crucial for risk stratification and treatment planning. Carotid ultrasound (CUS) and coronary artery optical coherence tomography (OCT) are valuable imaging modalities for evaluating atherosclerotic plaques. This study aimed to compare the reliability of CUS and OCT in assessing plaque morphology and atherosclerosis in patients with chronic coronary syndrome. Forty-six patients with chronic coronary syndrome underwent OCT to evaluate coronary plaques and CUS to assess carotid plaques. The findings showed that both imaging techniques detected the presence of plaques, with OCT providing more detailed information on coronary plaque morphology compared with CUS. OCT and CUS measurements demonstrated significant correlations in lumen stenosis, plaque sizes, and representations of calcified plaques. Furthermore, distinct differences were observed in plaque distribution and characteristics between the coronary and carotid arteries. Certain cardiovascular risk factors such as diabetes, arterial hypertension, and obesity were associated with specific plaque properties identified by OCT. This study underscores the complementary roles of OCT and CUS in assessing atherosclerosis and plaque vulnerability in patients with chronic coronary syndrome, providing valuable insights for clinical management and treatment strategies.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251355336"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Letter Regarding: "Prognostic Value of the Triglycerides-Glucose Index for Major-Adverse-Cardiac Events in Severe Aortic Stenosis Patients After TAVI". 关于“甘油三酯-葡萄糖指数对TAVI后严重主动脉瓣狭窄患者主要心脏不良事件的预后价值”的回复。

IF 2.2 3区医学

Angiology Pub Date : 2025-07-29 DOI: 10.1177/00033197251363663

Emine Altuntas, Abidin Emre Tırnaksız, Kadir Sadıkoğlu, Serkan Aslan, Gökhan Demirci, Ahmet Arif Yalcın, Ali Kemal Kalkan, Fatih Uzun, Ibrahim Faruk Akturk, Omer Celik, Mehmet Ertürk

引用次数: 0

Cardiovascular Oncology: Consensus Statements Are Still Lacking to Improve the Management of Side-Effects of Old and New Chemotherapeutic Agents. 心血管肿瘤学：在改进新旧化疗药物副作用管理方面仍缺乏共识声明。

IF 2.2 3区医学

Angiology Pub Date : 2025-07-29 DOI: 10.1177/00033197251356583

Antonio V Sterpetti, Francesca Miceli, Alessia Di Girolamo, Immacolata Iannone, Paolo Sapienza, Luca Di Marzo

{"title":"Cardiovascular Oncology: Consensus Statements Are Still Lacking to Improve the Management of Side-Effects of Old and New Chemotherapeutic Agents.","authors":"Antonio V Sterpetti, Francesca Miceli, Alessia Di Girolamo, Immacolata Iannone, Paolo Sapienza, Luca Di Marzo","doi":"10.1177/00033197251356583","DOIUrl":"https://doi.org/10.1177/00033197251356583","url":null,"abstract":"Significant advances in diagnostic methods and better life-expectancy have resulted in increased number of patients with cardiovascular diseases and cancer. Elderly patients are at risk for both diseases, and the treatment of patients with cardiovascular and oncologic problems represents a daily clinical challenge, considering the heterogeneity of clinical situations. The present review underlines the complexity of cardiovascular oncology. In the last 5 years >18 new drugs against cancer, with possible cardiovascular side-effects, were approved by the Food and Drug Administration. Several new drugs are under evaluation in multicenter prospective studies, and some of these agents have potential cardiovascular side-effects. This review analyzes the difficulties for cardiovascular specialists to keep updated regarding the possible side-effects of new chemotherapeutic agents. The analysis of the mechanisms involved in cancer occurrence and progression are a field of research in continuous development with new discoveries, and technologies applied at developing effective chemotherapeutic drugs. Several recommendations have been proposed by the American Heart Association and European Society of Cardiology, promoting the need for close collaboration between cardiologists, surgeons, and oncologists. It is important to develop strategies to support training in cardiovascular oncology.","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251356583"},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0