{"title":"Associations Between GGT/ALT Ratio and Carotid Plaque in Inpatients With Coronary Artery Disease: A RCSCD-TCM Study.","authors":"Ziqin Lai, Zhu Li, Mengnan Huang, Yang Wang, Lin Li, Fanfan Liu, Tong Yang, Yijia Liu, Qiang Xu, Shan Gao, Chunquan Yu","doi":"10.1177/00033197231197441","DOIUrl":"10.1177/00033197231197441","url":null,"abstract":"<p><p>This study investigated the relationship between gamma-glutamyltransferase/alanine aminotransferase (GGT/ALT) ratio and carotid plaques in patients with coronary artery disease (CAD). This multicenter retrospective study included 8,255 patients with CAD who were divided according to GGT/ALT quartiles: Q1 (GGT/ALT ≤ 1.00), Q2 (1.00 < GGT/ALT ≤ 1.41), Q3 (1.41 < GGT/ALT ≤ 2.05), and Q4 (GGT/ALT > 2.05). Logistic regression was used to analyze the relationship between GGT/ALT, carotid plaques, and carotid plaque echogenicity. GGT/ALT ratio (odds ratio [OR]: 1.16; 95% confidence interval [CI]: 1.11-1.21; <i>P</i> < .001) was significantly associated with carotid plaque risk. The degree of relevance was higher in men (OR: 1.71; 95% CI: 1.35-2.15; <i>P</i> < .001) than in women (OR: 1.56; 95% CI: 1.28-1.91; <i>P</i> < .001). The ORs value of carotid plaque risk was higher in middle-aged patients (OR: 2.23; 95% CI: 1.78-2.80; <i>P</i> < .001) than in older patients (OR: 1.77; 95% CI: 1.44-2.18; <i>P</i> < .001). The GGT/ALT ratio was significantly associated with different carotid plaque echogenicity, and the highest OR values were for isoechoic plaques (OR: 1.18; 95% CI: 1.12-1.24; <i>P</i> < .001). These findings suggest that the GGT/ALT ratio might be associated with a high risk of developing carotid plaques and different types of plaque echoes and was more significantly associated with isoechoic plaques.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"40-50"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10073322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-01-01Epub Date: 2023-08-23DOI: 10.1177/00033197231198253
Eman O Mahmoud, Yumn A Elsabagh, Nagwa Abd El Ghaffar, Mary Wadie Fawzy, Mohamed A Hussein
{"title":"Atherosclerosis Associated With COVID-19: Acute, Tends to Severely Involve Peripheral Arteries, and May be Reversible.","authors":"Eman O Mahmoud, Yumn A Elsabagh, Nagwa Abd El Ghaffar, Mary Wadie Fawzy, Mohamed A Hussein","doi":"10.1177/00033197231198253","DOIUrl":"10.1177/00033197231198253","url":null,"abstract":"<p><p>Arterial stiffness was reported with corona virus disease 2019 (COVID-19). We studied atherosclerosis in COVID-19 directly through duplex ultrasound measurements and their relation to co-morbidities, clinical and laboratory severity markers, and serum interleukin (IL) 6 and 17. Serum IL 6 and 17, average carotid intima-media thickness (cIMT), diameter and peak systolic velocities (PSV) of tibial, ulnar, radial arteries, and ankle brachial index (ABI) were measured in 44 COVID-19 patients and 44 healthy controls. Serum IL6, IL17, PSV, and cIMT were higher while diameter was lower (<i>P</i> ≤ .01) in cases. Clinical severity index correlated positively with age, co-morbidities, ferritin, IL6, IL17, cIMT, and PSV (<i>P</i> ≤ .04) and negatively with diameter and ABI (<i>P</i> = .04). Patients with severe lymphopenia had higher PSV, IL6, and IL17 and lower diameter (<i>P</i> < .00001). Ferritin positively correlated with PSV and negatively with diameter and ABI (<i>P</i> ≤ .01). Those who received an IL6 inhibitor (tocilizumab) showed lower PSV and higher diameter (<i>P</i> ≤ .01). In multiple regression analysis, IL17 and (age, co-morbidities) were related to (PSV, diameter) and cIMT (<i>P</i> ≤ .001, ≤0.02), respectively. COVID-19 may be associated with subclinical acute and may be reversible atherosclerosis severely involving peripheral arteries.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"77-84"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10414894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-01-01Epub Date: 2023-08-31DOI: 10.1177/00033197231199229
Monica Verdoia, Orazio Viola, Biondino Marenna, Federica Marrara, Benedetta Bertola, Marta Francesca Brancati, Rocco Gioscia, Pier Luigi Soldà, Andrea Rognoni
{"title":"Managing Congenital Heart Defects in Elderly: The Platypnea-Orthodeoxia Syndrome in Underestimated Patent Foramen Ovale.","authors":"Monica Verdoia, Orazio Viola, Biondino Marenna, Federica Marrara, Benedetta Bertola, Marta Francesca Brancati, Rocco Gioscia, Pier Luigi Soldà, Andrea Rognoni","doi":"10.1177/00033197231199229","DOIUrl":"10.1177/00033197231199229","url":null,"abstract":"<p><p>The platypnea-orthodeoxia syndrome (POS) is a rare and often suboptimally managed condition with a complex diagnostic workup, conversely displaying an easy treatment and a good recovery of symptoms, especially if consequent to an intracardiac shunt. However, its identification is challenging, due to the several clinical manifestations, the multiple etiologies, representing often the delayed presentation of a congenital heart disease. We present a case report and review of available literature on patients with the POS secondary to a patent foramen ovale successfully treated with its closure.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"69-76"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10128866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-01-01Epub Date: 2023-10-11DOI: 10.1177/00033197231206430
Paolo Perini, Mauro Gargiulo, Roberto Silingardi, Stefano Bonardelli, Raffaello Bellosta, Gabriele Piffaretti, Stefano Michelagnoli, Mauro Ferrari, Giorgio Ubaldo Turicchia, Antonio Freyrie, Anna Fornasari, Erica Mariani, GianLuca Faggioli, Paolo Spath, Mattia Migliari, Stefano Gennai, Barbara Paro, Paolo Baggi, Luca Attisani, Matteo Pegorer, Marco Franchin, Francesca Mauri, Emiliano Chisci, Nicola Troisi, Elisa Paciaroni, Mara Fanelli
{"title":"Twenty-Five Year Multicentre Experience of Explantation of Infected Abdominal Aortic Endografts.","authors":"Paolo Perini, Mauro Gargiulo, Roberto Silingardi, Stefano Bonardelli, Raffaello Bellosta, Gabriele Piffaretti, Stefano Michelagnoli, Mauro Ferrari, Giorgio Ubaldo Turicchia, Antonio Freyrie, Anna Fornasari, Erica Mariani, GianLuca Faggioli, Paolo Spath, Mattia Migliari, Stefano Gennai, Barbara Paro, Paolo Baggi, Luca Attisani, Matteo Pegorer, Marco Franchin, Francesca Mauri, Emiliano Chisci, Nicola Troisi, Elisa Paciaroni, Mara Fanelli","doi":"10.1177/00033197231206430","DOIUrl":"10.1177/00033197231206430","url":null,"abstract":"<p><p>We report a multicenter experience of open conversions (OC) for aortic endograft infections (AEI). We retrospectively analyzed all patients who underwent OC for AEI after endovascular aneurysm repair (EVAR), from 1997 to 2021 in 12 Italian centers. The endpoints were as follows: mortality (30-days, in-hospital), major postoperative complications. Follow-up data included: survival, aortic-related complications, infection persistence or reoccurrence. Fifty-eight patients (mean age: 73.8 ± 6.6 years) were included. Median time from EVAR to OC was 14 months (interquartile range 7-45). Thirty-five patients (60.3%) were symptomatic at presentation. Aortic reconstruction was anatomic in 32 patients (55.2%), extra-anatomic in 26 (44.8%). Thirty-day mortality was 31% (18/58). Six additional patients died after 30 days during the same hospitalization (in-hospital mortality: 41.4%). Most common post-operative complications included respiratory failure (38.6%) and renal insufficiency (35.1%). During 28.1 ± 4 months follow-up, 4 aneurysm-related deaths were recorded. Infection re-occurred in 29.4% of the patients. Estimated survival was 50% at 1 year, and 30% at 5 years, and was significantly lower for patients who underwent extra-anatomic reconstructions (37 <i>vs</i> 61% at 1 year, 16 <i>vs</i> 45% at 5 years; log-rank <i>P</i> = .021). OC for AEI is associated with high early mortality. The poor mid-term survival is influenced by aortic complications and infection re-occurrence.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"85-93"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41189501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-01-01Epub Date: 2023-09-11DOI: 10.1177/00033197231200029
Bekir S Yildiz, Ramazan Gunduz, Su Ozgur, Ahmet Y Cizgici, Ibrahim H Ozdemir
{"title":"Clinical Outcomes of Comparison Between Type III Coronary Artery Perforation (CAP) and non-CAP Acute Coronary Syndrome Patients During 3-Year Follow-up.","authors":"Bekir S Yildiz, Ramazan Gunduz, Su Ozgur, Ahmet Y Cizgici, Ibrahim H Ozdemir","doi":"10.1177/00033197231200029","DOIUrl":"10.1177/00033197231200029","url":null,"abstract":"<p><p>Coronary artery perforation (CAP) is a potentially fatal complication of percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS). This study aimed to investigate in-hospital, 1-year, and 3-year clinical outcomes of type III CAP during PCI in patients with ACS. The study retrospectively evaluated 118 patients with CAP and 43,226 case-control patients. Clinical, angiographic, and procedural characteristics, management, and outcomes were analyzed retrospectively at 1-year and 3-year follow-ups. The mean age of the patients was 66.5 ± 11.9 years (61.8% males). There was no significant difference in hospital mortality between the type III CAP and non-CAP groups. The all-cause mortality was 33.3% in the CAP group vs 1.8% in the non-CAP group at 1 year, and 28.3% in CAP group vs 6.9% in non-CAP group at 3 years (<i>p</i> = .001 for both comparisons). The procedural, clinical, and 1 and 3-year outcomes of type III CAP showed a relatively high risk of myocardial infarction, coronary artery bypass graft, cerebrovascular event, stent thrombosis, and major bleeding at the 1 and 3-year follow-ups. In addition, non-CAP ACS patients had better survival (log-rank: <i>p</i> < .001, 34.29 months 95% Confidence Interval [33.58-35.00]) than type III CAP ACS patients (29.53 months 95% Confidence Interval [27.28-31.78]) at the 3-year follow-up visit.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"58-68"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10570840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-01-01Epub Date: 2023-08-25DOI: 10.1177/00033197231197804
Yanqing Xie, Han Cen, Li Wang, Keai Cheng, Li Huang, Haoxuan Lu, Lili Ji, Yudan Chen, Zhong Zhou, Zhuo Yang, Sheng Jing, Haibo Zhu, Kan Chen, Si Chen, Wenming He
{"title":"Relationships Between Inflammatory Parameters Derived From Complete Blood Count and Quantitative Flow Ratio in Patients With Stable Coronary Artery Disease.","authors":"Yanqing Xie, Han Cen, Li Wang, Keai Cheng, Li Huang, Haoxuan Lu, Lili Ji, Yudan Chen, Zhong Zhou, Zhuo Yang, Sheng Jing, Haibo Zhu, Kan Chen, Si Chen, Wenming He","doi":"10.1177/00033197231197804","DOIUrl":"10.1177/00033197231197804","url":null,"abstract":"<p><p>To investigate the relationships between inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII), and quantitative flow ratio (QFR) in stable coronary artery disease (CAD) patients (<i>n</i> = 450) enrolled in this cross-sectional study. Logistic regression was performed to evaluate the associations of NLR, PLR, MLR, and SII evaluated as continuous and binary variables with QFR ≤0.80. When treated as continuous variables, lnNLR was associated with QFR ≤0.80 with borderline significance in univariable (odds ratio (OR) = 1.60, <i>p</i> = .05) and multivariable analysis (OR = 1.72, <i>p</i> = .05), while lnMLR was associated with QFR ≤0.80 significantly in univariable analysis (OR = 1.87, <i>p</i> = .03) and with borderline significance in multivariable analysis (OR = 1.91, <i>p</i> = .05). When treated as binary variables, high levels of MLR and SII were significantly associated with QFR ≤0.80 in univariable (MLR: OR = 1.91, <i>p</i> = .02; SII: OR = 2.42, <i>p</i> = .006) and multivariable analysis (MLR: OR = 1.83, <i>p</i> = .04; SII: OR = 2.19, <i>p</i> = .02). NLR, MLR, and SII, but not PLR, were significantly associated with the severity of coronary physiology in stable CAD patients.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"51-57"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10076291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2024-11-09DOI: 10.1177/00033197241299129
Fareeha Imran, Menhas Ahmad, Muhammad H Sikandari
{"title":"Letter: Ethnic Disparities in ST-Segment Elevation Myocardial-Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors.","authors":"Fareeha Imran, Menhas Ahmad, Muhammad H Sikandari","doi":"10.1177/00033197241299129","DOIUrl":"https://doi.org/10.1177/00033197241299129","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197241299129"},"PeriodicalIF":2.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2024-11-01Epub Date: 2023-09-09DOI: 10.1177/00033197231193618
Lorenna F Cunha, Ronaldo B Santos, Soraya Giatti, Barbara K Parise, Aline N Aielo, Wagner A Silva, Silvana P Souza, Luiz A Bortolotto, Paulo A Lotufo, Isabela M Bensenor, Luciano F Drager
{"title":"Gender Modulated the Association of Sleep Apnea and Sleep Duration with Arterial Stiffness: The ELSA-Brasil Study.","authors":"Lorenna F Cunha, Ronaldo B Santos, Soraya Giatti, Barbara K Parise, Aline N Aielo, Wagner A Silva, Silvana P Souza, Luiz A Bortolotto, Paulo A Lotufo, Isabela M Bensenor, Luciano F Drager","doi":"10.1177/00033197231193618","DOIUrl":"10.1177/00033197231193618","url":null,"abstract":"<p><p>Increased arterial stiffness is independently associated with cardiovascular risk. Obstructive sleep apnea (OSA) and sleep duration (SDUR) may contribute to increased arterial stiffness, but it is unclear whether this association is modulated by gender. We aimed to evaluate the potential impact of gender in modulating the association of OSA and SDUR with arterial stiffness. Participants from the ELSA-Brasil study performed sleep assessments with portable polygraph to define OSA severity and SDUR by 1-week wrist actigraphy. Pulse wave velocity (PWV) was measured using a standard technique without access to the sleep data. We studied 1863 participants (42.2% male, age: 49±8 years, respiratory disturbance index (RDI): 9.9 (4.5-19.4) events/h, SDUR: 6.5 (5.9-7.1) hours, mean PWV: 7.3 ± 1.2 m/s). We found that men had higher PWV, higher frequency of diabetes, and higher blood pressure when compared to women. The regression analysis showed an independent association between increased RDI and PWV in men (ß: 0.007; 95% CI: 0.001-0.012), but not in women. In contrast, an independent association between SDUR and increased arterial stiffness was observed only in women (ß: 0.068; 95% CI: 0.002-0.134). In conclusion, the association of sleep disorders with arterial stiffness showed a distinct gender pattern depending on the sleep variable studied.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"976-984"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10188177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}