Pathophysiology and Genetic Associations of Varicose Veins: A Narrative Review.

IF 2.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Angiology Pub Date : 2025-08-01 Epub Date: 2024-01-16 DOI:10.1177/00033197241227598
Tao Chen, Peng Liu, Chenguang Zhang, Song Jin, Yuhu Kong, Yanan Feng, Ziqiang Sun
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引用次数: 0

Abstract

Varicose veins (VVs) have a high prevalence worldwide and have become a major medical burden. Their pathophysiology involves a complex interplay of inflammation and tissue remodeling, and current treatment is limited by its impact on the pathophysiological mechanisms. In addition, despite clear environmental factors, family history is an important risk factor, suggesting a genetic component to the risk of developing VVs. Our understanding of the pathogenesis of these diseases has benefited greatly from the expansion of population genetic studies, from pioneering family studies to large genome-wide association studies; we now find multiple risk loci for each venous disease. This review considers the pathophysiology of VVs, highlighting the current state of genetic knowledge. We also propose future directions for research.

静脉曲张的病理生理学和遗传关联:叙述性综述。
静脉曲张(VVs)在全球发病率很高,已成为一种主要的医疗负担。静脉曲张的病理生理学涉及炎症和组织重塑的复杂相互作用,目前的治疗方法因其对病理生理学机制的影响而受到限制。此外,尽管有明确的环境因素,但家族史也是一个重要的风险因素,这表明罹患 VVs 的风险与遗传因素有关。从开创性的家族研究到大型的全基因组关联研究,人群遗传研究的扩展极大地促进了我们对这些疾病发病机制的了解;现在,我们发现每种静脉疾病都有多个风险基因位点。本综述探讨了静脉疾病的病理生理学,重点介绍了遗传学知识的现状。我们还提出了未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Angiology
Angiology 医学-外周血管病
CiteScore
5.50
自引率
14.30%
发文量
180
审稿时长
6-12 weeks
期刊介绍: A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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