AngiologyPub Date : 2025-03-24DOI: 10.1177/00033197251328773
Emine Altuntas, Abidin Emre Tırnaksız, Kadir Sadıkoğlu, Serkan Aslan, Gökhan Demirci, Ahmet Arif Yalcın, Ali Kemal Kalkan, Fatih Uzun, Ibrahim Faruk Aktürk, Omer Celik, Mehmet Ertürk
{"title":"Prognostic Value of the Triglycerides-glucose Index for Major Adverse Cardiac Events in Severe Aortic Stenosis Patients After TAVI.","authors":"Emine Altuntas, Abidin Emre Tırnaksız, Kadir Sadıkoğlu, Serkan Aslan, Gökhan Demirci, Ahmet Arif Yalcın, Ali Kemal Kalkan, Fatih Uzun, Ibrahim Faruk Aktürk, Omer Celik, Mehmet Ertürk","doi":"10.1177/00033197251328773","DOIUrl":"https://doi.org/10.1177/00033197251328773","url":null,"abstract":"<p><p>The present study aimed to evaluate whether the Triglycerides-Glucose (TyG) index has a prognostic value for major adverse cardiac events (MACEs), including stroke, necessity of pacemaker, acute kidney failure, and short-term all-cause mortality at 12 months, in aortic stenosis (AS) patients who underwent transcatheter aortic valve implantation (TAVI). A total of 380 patients who underwent TAVI due to severe AS were retrospectively included in the study. The main outcome of the study was MACEs at 12 months. The TyG index was found to be higher in TAVI patients who developed MACEs than in those who did not develop them. Multivariate Cox regression analysis revealed that TyG (<i>P</i> < .001) was an independent predictor of MACEs in AS patients after TAVI. A TyG index value of >4.77 following TAVI had 50% sensitivity and 50% specificity (AUC [area under the curve]: 0.694, <i>P</i> < .001) for MACEs. This is the first study to show that a high pre-procedural TyG index has a predictive value for MACEs in AS patients undergoing TAVI.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251328773"},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-03-21DOI: 10.1177/00033197251326354
Tala A Haddad, Ahmad A Toubasi, Abdallah Fahmawi, Ali Zaid
{"title":"Clinical Outcomes of PCI in Hospitals With or Without Surgical Backup: A Meta-analysis.","authors":"Tala A Haddad, Ahmad A Toubasi, Abdallah Fahmawi, Ali Zaid","doi":"10.1177/00033197251326354","DOIUrl":"https://doi.org/10.1177/00033197251326354","url":null,"abstract":"<p><p>Percutaneous coronary interventions (PCIs) have seen a steady rise. Recent guidelines have established that PCIs conducted at non-surgical on-site (NSOS) facilities have low complication rates and outcomes comparable to surgical on-site (SOS) centers. However, differing perspectives in the growing literature continue to sustain controversy. A thorough literature review was performed across four databases, including PubMed, Cochrane Library, Scopus, and Web of Science, to identify studies comparing outcomes between hospitals. The primary endpoints were: 30-day mortality, myocardial infarction (MI), cerebral vascular accident (CVA), emergency coronary artery bypass surgery (eCABG), rePCI, and target vessel revascularization (TVR). The final search yielded 22 studies, including a total of 2,181,897 patients. The majority of patients (71.9%) underwent PCI in SOS hospitals. There was a significant association of increased eCABG (OR = 1.99; 95% CI: 1.08-3.67) and rePCI (OR = 1.62; 95% CI: 1.37-1.91) rates in SOS hospitals. However, 30-day mortality (OR = 0.91; 95% CI: 0.53-1.54), MI (OR = 1.08; 95% CI: 0.91-1.28), CVA (OR = 1.13; 95% CI: 0.69-1.86), and TVR (OR = 1.06; 95% CI: 0.92-1.21) showed no significant difference between hospitals. Subgroup analyses among clinical trials and ST-segment elevation myocardial infarction (STEMI) patients found no significant associations. Conclusively, this meta-analysis provides updated insight into the impact of SOS on PCI outcomes, having no difference except for eCABG and rePCI rates.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251326354"},"PeriodicalIF":2.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural Abnormalities of the Achilles Tendon are Associated With Coronary Artery Disease Even Without Achilles Tendon Thickening.","authors":"Atsushi Tanita, Shinichiro Sunamura, Masahiro Suzuki, Tsuyoshi Ogata, Kazuki Noda, Toru Takii, Yoshio Nitta, Seijiro Yoshida, Shigeto Namiuchi","doi":"10.1177/00033197251326624","DOIUrl":"https://doi.org/10.1177/00033197251326624","url":null,"abstract":"<p><p>Achilles tendon ultrasonography is useful in diagnosing familial hypercholesterolemia, as it allows assessment of its thickening and structure. The association between structural abnormalities in the Achilles tendon and the severity of coronary artery disease (CAD) was investigated in a cross-sectional study. We conducted this study on 353 patients who underwent percutaneous coronary intervention (PCI). Ultrasound was used to examine the thickness and structural abnormalities of the Achilles tendon. Their CAD severity was assessed using the SYNTAX score before the first PCI. Abnormal findings on Achilles tendon ultrasonography were observed in 21 patients (5.9%). The SYNTAX score was compared between patients with and without abnormal Achilles tendon structure. The SYNTAX score was significantly higher in patients who had structural abnormalities but without thickening of the Achilles tendon (<i>P</i> = .002). Multivariate analysis revealed that abnormal Achilles tendon structure was one of the independent risk factors for an elevated SYNTAX score. In patients with CAD who underwent PCI, structural abnormalities in the Achilles tendon identified by ultrasonography were independently associated with an increase in the SYNTAX score.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251326624"},"PeriodicalIF":2.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-03-17DOI: 10.1177/00033197251329146
Jing-Xian Bai, De-Gang Mo
{"title":"Letter: Magnesium Levels Can Be Used as a Protective Factor Against Contrast-induced Nephropathy in Patients With STEMI Undergoing Primary PCI.","authors":"Jing-Xian Bai, De-Gang Mo","doi":"10.1177/00033197251329146","DOIUrl":"https://doi.org/10.1177/00033197251329146","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251329146"},"PeriodicalIF":2.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-03-14DOI: 10.1177/00033197251324630
Fabien Lareyre, Juliette Raffort
{"title":"Artificial Intelligence in Vascular Diseases: From Clinical Practice to Medical Research and Education.","authors":"Fabien Lareyre, Juliette Raffort","doi":"10.1177/00033197251324630","DOIUrl":"https://doi.org/10.1177/00033197251324630","url":null,"abstract":"<p><p>Artificial Intelligence (AI) has brought new opportunities in medicine, with a great potential to improve care provided to patients. Given the technical complexity and continuously evolving field, it can be challenging for vascular specialists to anticipate and foresee how AI will shape their practice. The aim of this review is to provide an overview of the current landscape of applications of AI in clinical practice for the management of non-cardiac vascular diseases including aortic aneurysm, peripheral artery disease, carotid stenosis, and venous diseases. The review describes and highlights how AI has the potential to shape the three pillars in the management of vascular diseases including clinical practice, medical research and education. In the limelight of these results, we show how AI should be considered and developed within a responsible ecosystem favoring transdisciplinary collaboration, where multiple stake holders can work together to face current challenges and move forward future directions.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251324630"},"PeriodicalIF":2.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-03-13DOI: 10.1177/00033197251326384
Ou Wu, Jin Gao, Xingyu Zhang, Wei Liu, Hu Zhang, Saber Khederzadeh, Xi Lu, Ya Wu
{"title":"TLR5's Role in Obesity-related Hypertension: Updated Evidence and Prospects.","authors":"Ou Wu, Jin Gao, Xingyu Zhang, Wei Liu, Hu Zhang, Saber Khederzadeh, Xi Lu, Ya Wu","doi":"10.1177/00033197251326384","DOIUrl":"https://doi.org/10.1177/00033197251326384","url":null,"abstract":"<p><p>Toll-like receptor 5 (TLR5), integral to the immune system as a primary sensor for flagellin, is central to the link between innate and adaptive immunity, modulating immune responses and cytokine production essential for defense against flagellated pathogens and immune tolerance. This review consolidates the understanding of TLR5's structural and signaling mechanisms and its interactions with flagellin, shedding light on its dual role in immune responses and its promise as a therapeutic target. It highlights TLR5's intricate role in the pathogenesis of obesity-related hypertension, a growing global health concern that correlates with rising obesity rates and is characterized by a complex interplay of immune responses and metabolic dysregulation. Despite the current understanding, the impact of TLR5 on obesity-related hypertension is marked by conflicting findings, indicating a need for further exploration. The review critically analyzes the existing literature, providing novel insights from rodent models and human studies that underscore TLR5's therapeutic potential, setting the stage for transformative research in managing obesity-related hypertension. It calls for deeper investigation into TLR5's multifaceted role, emphasizing its promise as a target for managing obesity-related hypertension and the necessity for future research to clarify its complexities and to innovate treatment strategies.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251326384"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-03-12DOI: 10.1177/00033197251326400
Ömer Faruk Yılmaz, Yusuf Ziya Şener
{"title":"Letter: Cancer Paradox and Short-term STEMI-related Outcomes.","authors":"Ömer Faruk Yılmaz, Yusuf Ziya Şener","doi":"10.1177/00033197251326400","DOIUrl":"https://doi.org/10.1177/00033197251326400","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251326400"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differential Impact of Chronic Kidney Disease Stages on the Survival Benefit of Percutaneous Coronary Intervention: A Large Real-world Cohort Study.","authors":"Xiaozhao Lu, Jin Liu, Jingru Deng, Chenyang Wang, Yuqi Li, Jielan Wu, Ying Shi, Shiqun Chen, Ziyao Yuan, Ning Tan, Jiyan Chen, Yong Liu, Fei Gao","doi":"10.1177/00033197251324629","DOIUrl":"https://doi.org/10.1177/00033197251324629","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is prevalent among patients with coronary artery disease (CAD) and exacerbates myocardial ischemia. However, the survival benefit of percutaneous coronary intervention (PCI) across different stages of CKD remains controversial. CAD patients (<i>n</i> = 17,418) with CKD (mean age, 69.5 ± 9.9 years; 70.9% male) were included in the Cardiorenal Improvement II cohort from 2007 to 2020. Patients were grouped by PCI or medical treatment and further categorized by stages 3a-5 CKD. Multivariable Cox regression was performed to investigate the associations of cardiovascular- and all-cause mortality with PCI and CKD stage, and to compare predictors of outcomes in patients stratified by advanced CKD. During a median follow-up of 4.2 years, 4605 (26.4%) participants died. Compared with medical treatment, PCI was not associated with improved survival benefit among patients with stage 3b-5 CKD (all <i>P</i> > .05). Among patients with advanced CKD, hypertension, hyperfibrinogenemia and moderate-severe malnutrition were more significantly associated with increased cardiovascular mortality with relatively high attributable risk. PCI was not associated with a survival advantage among patients with advanced CKD. Hypertension, hyperfibrinogenemia and malnutrition may contribute to poor prognosis in patients with advanced kidney disease.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251324629"},"PeriodicalIF":2.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-03-04DOI: 10.1177/00033197251324625
Agnieszka Sawicka
{"title":"Letter: C-reactive protein: An Important Inflammatory Marker of Coronary Atherosclerotic Disease or an Innocent Bystander?","authors":"Agnieszka Sawicka","doi":"10.1177/00033197251324625","DOIUrl":"https://doi.org/10.1177/00033197251324625","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251324625"},"PeriodicalIF":2.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}