{"title":"Connexin 43 and Atypical Chemokine Receptor 3 in Peripheral Blood Mononuclear Cells of Patients With Aneurysmal Subarachnoid Hemorrhage.","authors":"Jian Yan, DianDa Chen, JinLin Xiao, XuYe Wu, ErMing Zeng, Tao Hong, Jian Duan","doi":"10.1177/00033197251350186","DOIUrl":"https://doi.org/10.1177/00033197251350186","url":null,"abstract":"<p><p>The expression levels of connexin 43 (Cx43) and atypical chemokine receptor 3 (ACKR3) in peripheral blood mononuclear cells (PBMCs) of patients with aneurysmal subarachnoid hemorrhage (aSAH) and their predictive value for cerebral vasospasm (CVS) were retrospectively analyzed. A total of 131 patients with aSAH were included in this study (49 males and 82 females) all of whom had headache as the first manifestation. The results showed that the mRNA expression of Cx43 and ACKR3 in PBMCs of patients with aSAH was significantly increased. The results of ROC curve showed that the combination of the two indicators was expected to assist clinical judgement in predicting the occurrence of CVS in patients with aSAH, which could be helpful for screening patients with high risk of CVS.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251350186"},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-06DOI: 10.1177/00033197251356582
Aykut Demirkıran, Cihan Aydın, Hüseyin Orta
{"title":"Letter: Comment on Cap et al., 2025: A Promising Coronary Flow Assessment Tool; However, Gaps Remain.","authors":"Aykut Demirkıran, Cihan Aydın, Hüseyin Orta","doi":"10.1177/00033197251356582","DOIUrl":"https://doi.org/10.1177/00033197251356582","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251356582"},"PeriodicalIF":2.6,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-05DOI: 10.1177/00033197251355348
Cihan Aydın, Aykut Demirkıran, Hüseyin Orta
{"title":"C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index and Length of Hospital Stay in Patients With Heart Failure.","authors":"Cihan Aydın, Aykut Demirkıran, Hüseyin Orta","doi":"10.1177/00033197251355348","DOIUrl":"https://doi.org/10.1177/00033197251355348","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251355348"},"PeriodicalIF":2.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Low Bone Mineral Content Index on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.","authors":"Tadashi Itagaki, Yasushi Ueki, Daisuke Sunohara, Moeko Aoki, Fumika Nomoto, Toshifumi Takamatsu, Tomoaki Mochidome, Takashi Miura, Toshio Kasai, Koichiro Kuwahara, Uichi Ikeda","doi":"10.1177/00033197231226348","DOIUrl":"10.1177/00033197231226348","url":null,"abstract":"<p><p>The prognostic value of bone mineral content (BMC) for the clinical outcomes of patients with coronary artery disease (CAD) remains unknown. The present study evaluated the association between BMC index (BMCI) and cardiovascular events between January 2020 to June 2021, in consecutive patients (n = 257) with CAD undergoing percutaneous coronary intervention (PCI) at the Nagano Municipal Hospital. BMCI was measured using bioelectrical impedance analysis and calculated as the BMC divided by height squared. Patients were classified as low (<0.918) or high BMCI (≥0.918) groups according to the receiver operating characteristics curve analysis for the primary endpoint, major adverse cardiovascular events (MACE), including cardiovascular death, spontaneous myocardial infarction, stroke, and any revascularization. During a median follow-up of 744 days, the low BMCI group (n = 152) had an increased risk of MACE compared with the high group (n = 105) (19.7 <i>vs</i> 6.7%, <i>P</i> = .004). A low BMCI was significantly associated with MACE in the multivariable Cox and the Inverse Probability of Treatment Weighting analyses (hazard ratio: 3.16, 95% confidence interval: 1.15-8.67, <i>P</i> = .025). In conclusion, among patients with CAD undergoing PCI, BMCI was a predictor for cardiovascular events. Further research is required to determine whether medical interventions for BMC can improve patient prognosis.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"580-588"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-01Epub Date: 2024-01-04DOI: 10.1177/00033197241226509
Sicheng Yao, Hongbo Ci
{"title":"No Causal Association Between Inguinal Hernia and Aortic Aneurysm Using Mendelian Randomization Analysis.","authors":"Sicheng Yao, Hongbo Ci","doi":"10.1177/00033197241226509","DOIUrl":"10.1177/00033197241226509","url":null,"abstract":"<p><p>Aortic aneurysm (AA) is a serious disease that affects the aging population worldwide. Potential risk or associated factors, such as inguinal hernia, have been suggested by conventional studies. In the present study, summary statistics data for the associations of inguinal hernia were derived from a large genome-wide association study including 18,791 inguinal hernia cases and 93,955 controls in the UK Biobank. Corresponding data of AA were extracted from FinnGen, comprising 7603 cases and 317,899 controls in Finland. The causal association was assessed using Mendelian Randomization-Egger, weighted median, and inverse variance weighting methods, and compared with observational estimates previously published. Our analysis found no convincing causal effect between genetically predicted inguinal hernia and the risk of AA (odds ratio [OR] = 1.05, 95% confidence interval [CI] = 0.85-1.31, <i>P</i> = .65), abdominal aortic aneurysm (AAA, OR = 1.15, 95% CI = 0.92-1.46, <i>P</i> = .22), and thoracic aortic aneurysm (TAA, OR = 1.05, 95% CI = 0.85-1.30, <i>P</i> = .67). The results are in contrast to previous observational evidence suggesting a potentially common causal association between inguinal hernia and AA. Further research is needed to better understand the interplay between risk factors and their impact on aneurysm development.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"525-530"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-01Epub Date: 2024-02-05DOI: 10.1177/00033197241232165
Shuhong Dai, Bo Yin, Haiming Wang, Xiaowei Zhang
{"title":"Imbalance Between Angiotensin II and Kallikrein in Patients With ST-Segment Elevation Myocardial Infarction: A Case-Control Emergency Room Study.","authors":"Shuhong Dai, Bo Yin, Haiming Wang, Xiaowei Zhang","doi":"10.1177/00033197241232165","DOIUrl":"10.1177/00033197241232165","url":null,"abstract":"<p><p>The present study aimed to investigate the balance between angiotensin II (Ang-II) and kallikrein (KLK1) in the pathogenesis of ST-segment elevation acute myocardial infarction (STEMI). The study included a total of 261 participants: 151 STEMI patients and 110 individuals with normal coronary arteries. The plasma levels of Ang-II and KLK1 were measured using enzyme-linked immunosorbent assays (ELISA). Multivariate logistic regression analysis indicated that the plasma levels of Ang-II, KLK1 and the ratio of Ang-II and KLK1 (Ang-II/KLK1) independently correlated with the presence of STEMI. Furthermore, we found independent associations between STEMI and smoking, cholesterol (CHO), high-density lipoprotein cholesterol (HDL-c), as well as age. The ratio of Ang-II/KLK1 correlated with the plasma level of the inflammatory cytokine, interleukin-6 (IL-6). Both Ang-II and KLK1 levels are significantly elevated in patients with STEMI. An increased Ang-II/KLK1 ratio may result in the over-activation of Ang-II and exacerbate the progression of STEMI(<i>P</i> = .046). In conclusion, we have demonstrated, for the first time, an Ang-II and KLK1 imbalance in patients with STEMI.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"589-596"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-01Epub Date: 2024-01-07DOI: 10.1177/00033197241226863
Fatimah A Alhijab, Huda Ismail, Monirah Albabtain, Juan Alfonso, Khaled D Algarni, Claudio Pragliola, Adam I Adam, Amr A Arafat
{"title":"The Effect of Gender on Triple Heart Valve Surgery Outcomes; Reinforcing Women's Health.","authors":"Fatimah A Alhijab, Huda Ismail, Monirah Albabtain, Juan Alfonso, Khaled D Algarni, Claudio Pragliola, Adam I Adam, Amr A Arafat","doi":"10.1177/00033197241226863","DOIUrl":"10.1177/00033197241226863","url":null,"abstract":"<p><p>Female gender is a risk factor in several cardiac surgery risk stratification systems. This study explored the differences in the outcomes following triple heart valve surgery in men vs women. The study included 250 patients (males <i>n</i> = 101; females <i>n</i> = 149) who underwent triple valve surgery from 2009 to 2020. BMI (body mass index) was higher in females (29.6 vs 26.5 kg/m<sup>2</sup>, <i>P</i> < .001), and diabetes was more common in males (44 vs 42%, <i>P</i> = .012). The ejection fraction was higher in females (55 vs 50%, <i>P</i> < .001). The severity of mitral valve stenosis and tricuspid valve regurgitation was significantly greater in females (33.11 vs 27.72%, <i>P</i> = .003 and 44.30 vs 19.8%, <i>P</i> < .001, respectively). Mitral valve replacement was more common in females (<i>P</i> < .001), and they had lower concomitant coronary artery bypass grafting (<i>P</i> = .001). Bleeding and renal failure were lower in females (<i>P</i> = .021 and <0.001, respectively). Hospital mortality, readmission, and reintervention were not significantly different between genders. By multivariable analysis, male gender was a risk factor for lower survival [HR (hazard ratio): 2.18; <i>P</i> = .024]. Triple valve surgery can be performed safely in both genders, with better long-term survival in females. Female gender was not a risk factor in patients undergoing triple valve surgery.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"554-562"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-01Epub Date: 2024-01-18DOI: 10.1177/00033197241228043
Yusuf Can, Nimet Uçaroğlu Can, Çağla Akçay, Sena Boncuk Ulaş, Ibrahim Kocayiğit, Havva Kocayiğit, Mustafa Tarık Ağaç
{"title":"Increased Cardio-ankle Vascular Index Values in Migraine Patients With Aura.","authors":"Yusuf Can, Nimet Uçaroğlu Can, Çağla Akçay, Sena Boncuk Ulaş, Ibrahim Kocayiğit, Havva Kocayiğit, Mustafa Tarık Ağaç","doi":"10.1177/00033197241228043","DOIUrl":"10.1177/00033197241228043","url":null,"abstract":"<p><p>Patients with migraine with aura are at an increased risk of cardiovascular disease. There are limited data on arterial stiffness in migraine patients with aura. The present study evaluated arterial stiffness in these patients using the cardio-ankle vascular index (CAVI). This prospective study included 50 patients with migraine with aura (43 female, mean age 38.9 ± 9.9 years). The patient group was matched for age and gender with 50 healthy individuals with no history of migraine (43 female, mean age 39.3 ± 10.3 years). All patients and control subjects underwent a comprehensive clinical evaluation by an experienced neurologist and were interviewed about their headache histories. There was no significant difference in baseline demographic characteristics and echocardiographic parameters between migraine with aura patients and the control group. Both right and left CAVI values were significantly higher in the patients with migraine with aura (6.5 ± 1.2 vs 6.1 ± 0.7, <i>P</i> = .043 and 6.6 ± 1.2 <i>vs</i> 6.1 ± 0.7, <i>P</i> = .009, respectively). Arterial stiffness is an important mediator of cardiovascular diseases. We found that CAVI, a novel marker of the arterial stiffness, is increased in patients with migraine with aura.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"531-537"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-01Epub Date: 2024-02-09DOI: 10.1177/00033197241232719
Anders Christensson, Simon Lundgren, Madeleine Johansson, Peter M Nilsson, Gunnar Engström, Agne Laucyte-Cibulskiene
{"title":"Aortic Stiffness Can be Predicted From Different eGFR Formulas With Long Follow-Up in the Malmö Diet Cancer Study.","authors":"Anders Christensson, Simon Lundgren, Madeleine Johansson, Peter M Nilsson, Gunnar Engström, Agne Laucyte-Cibulskiene","doi":"10.1177/00033197241232719","DOIUrl":"10.1177/00033197241232719","url":null,"abstract":"<p><p>We studied the impact of estimated glomerular filtration rate (eGFR) based on either creatinine or cystatin C, or in combination, on vascular aging (aortic stiffness) and central hemodynamics (central systolic blood pressure) in a Swedish urban population with median 17 years of follow-up. Participants (<i>n</i> = 5049) from the population-based Malmö Diet and Cancer Study that underwent baseline examination and later participated in the prospective cardiovascular arm were selected. Of these, 2064 with measured carotid-femoral pulse wave velocity (cfPWV) and central blood pressure at follow-up were enrolled. eGFR was calculated using cystatin C (eGFR<sub>CYS</sub>) and creatinine (eGFR<sub>CR</sub>) equations: Caucasian, Asian, pediatric, and adult cohorts (CAPA), the Lund-Malmö revised (LMrev), and the European Kidney Function Consortium (EKFC) equations. Lower adjusted eGFR<sub>CR</sub>, but not eGFR<sub>CYS</sub>, were independently associated with higher cfPWV (<i>P</i> < .001, respectively). eGFR <60 mL/min/1.73 m<sup>2</sup> determined higher cfPWV except when using the EKFC equation. Conversely, CAPA/LMrev and CAPA/EKFC ratios were not associated with aortic stiffness. Lower eGFR<sub>CR</sub> is associated with higher future aortic stiffness independently of age, sex, heart rate, mean blood pressure, body mass index, and antihypertensive treatment. The ratio of eGFR<sub>CYS</sub> and eGFR<sub>CR</sub> equations could not predict aortic stiffness at all.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"563-571"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139705940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-01Epub Date: 2024-01-31DOI: 10.1177/00033197241231150
Xin Zhang, Yong Yang, Yun-Shan Jiang
{"title":"Triglyceride-Glucose Index as a Novel Biomarker for Major Adverse Cardiovascular Events.","authors":"Xin Zhang, Yong Yang, Yun-Shan Jiang","doi":"10.1177/00033197241231150","DOIUrl":"10.1177/00033197241231150","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"602-603"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}