AngiologyPub Date : 2026-03-25DOI: 10.1177/00033197261427838
Cagatay Bolgen, Aziz Inan Celik
{"title":"Aortic Arch Calcification, Plaque Morphology, and the Modified Glasgow Prognostic Score as Predictors of Major Adverse Cardiovascular Events.","authors":"Cagatay Bolgen, Aziz Inan Celik","doi":"10.1177/00033197261427838","DOIUrl":"https://doi.org/10.1177/00033197261427838","url":null,"abstract":"<p><p>Aortic arch atherosclerosis is a marker of systemic vascular disease and may contribute to adverse cardiovascular outcomes. The modified Glasgow Prognostic Score (mGPS), reflecting systemic inflammation, may influence plaque vulnerability. The present study aimed to investigate the relationship between aortic arch calcification (AAC), aortic arch morphology (AAM), and mGPS, and to evaluate their prognostic significance for major adverse cardiovascular events (MACE). A total of 516 patients who underwent computed tomography angiography (CTA) were retrospectively analyzed. AAC was categorized as none, small, or considerable, and AAM as none, smooth, ulcerated, or protruding. MACE was defined as all-cause mortality, myocardial infarction, or stroke. Kaplan-Meier survival analysis and Cox proportional hazards regression were used to identify predictors of MACE. During a median follow-up 42 MACE occurred. Event-free survival progressively declined with increasing AAC and AAM severity (log-rank <i>P</i> < .001 for both). In multivariable Cox analysis, small and considerable AAC independently predicted MACE (<i>P</i> = .007 and <i>P</i> = .005). Similarly, smooth, ulcerated, and protruding plaques were associated with significantly higher risk (all <i>P</i> < .01). Although mGPS correlated with plaque complexity, it was not an independent predictor of MACE. CTA-based assessment of aortic arch features may enhance long-term cardiovascular risk stratification.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261427838"},"PeriodicalIF":2.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-12DOI: 10.1177/00033197261427837
Muhammed Erzurum, Mehmet Ali Felekoğlu, Nadire Isık Erol Algül, Alperen Taş, Nail Burak Özbeyaz, Engin Algül, Faruk Aydinyilmaz, Kamuran Kalkan, Tolga Han Efe
{"title":"Effect of SGLT2 Inhibitors on Atrial Electromechanical Delay in Patients with Type 2 Diabetes.","authors":"Muhammed Erzurum, Mehmet Ali Felekoğlu, Nadire Isık Erol Algül, Alperen Taş, Nail Burak Özbeyaz, Engin Algül, Faruk Aydinyilmaz, Kamuran Kalkan, Tolga Han Efe","doi":"10.1177/00033197261427837","DOIUrl":"https://doi.org/10.1177/00033197261427837","url":null,"abstract":"<p><p>Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been associated with lower atrial fibrillation (AF) incidence in diabetes mellitus (DM). Atrial electromechanical delay (AEMD) is an electrophysiological marker related to AF development. This study evaluated AEMD changes in type 2 DM patients treated with an SGLT2 inhibitor (dapagliflozin or empagliflozin). Baseline and 4-month follow-up data of 50 patients with type 2 diabetes who initiated SGLT2 inhibitor therapy were retrospectively obtained from medical records and analyzed. AEMD was measured using echocardiography and tissue Doppler. Inter-AEMD and intra-AEMD intervals were calculated. Left atrial volume (LAVOL) significantly decreased (45.23 ± 9.27 vs 42.21 ± 9.16; <i>P</i> < .001), while left intra-AEMD (19.58 ± 7.53 vs 16.76 ± 7.53; <i>P</i> <.001), right intra-AEMD (14.42 ± 5.81 vs 12.46 ± 8.05; <i>P</i> = .016), and inter-AEMD (34 ± 9.41 vs 29.22 ± 9.44; <i>P</i> < .001) were significantly reduced. Inter-AEMD change correlated with LAVOL, E/E' ratio, body mass index, and mean blood pressure changes (all <i>P</i> <.05). In diabetic patients treated with SGLT2 inhibitors, AEMD reduction was observed after 4 months, with favorable metabolic and hemodynamic effects. These findings suggest that SGLT2 inhibitors may protect against AF by improving atrial electromechanical function.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261427837"},"PeriodicalIF":2.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-12DOI: 10.1177/00033197261427829
Murat Küçükukur, Rıdvan Binici
{"title":"Prognostic Value of FIB-4 Index and Non-Alcoholic Fatty Liver Disease in Myocardial Infarction With Non-Obstructive Coronary Arteries: A Prospective Cohort Study.","authors":"Murat Küçükukur, Rıdvan Binici","doi":"10.1177/00033197261427829","DOIUrl":"https://doi.org/10.1177/00033197261427829","url":null,"abstract":"<p><p>Myocardial infarction with non-obstructive coronary arteries (MINOCA) represents 5% to 10% of acute myocardial infarction cases. The Fibrosis-4 (FIB-4) index and non-alcoholic fatty liver disease (NAFLD) are emerging markers of systemic inflammation and metabolic dysfunction, yet their prognostic role in MINOCA remains unexplored. This prospective cohort study included 472 consecutive MINOCA patients from a tertiary cardiac center between September 2022 and October 2025. Patients were stratified by FIB-4 index (high ≥1.3, low <1.3). NAFLD was diagnosed using hepatic steatosis index. The primary endpoint was major adverse cardiovascular events (MACE): cardiovascular death, recurrent myocardial infarction, urgent revascularization, or hospitalization for heart failure or arrhythmia during 36-month follow-up. High FIB-4 index was independently associated with increased MACE risk (hazard ratio [HR]: 2.34, 95% confidence interval [CI]: 1.45-3.78, <i>P</i> < .001). NAFLD presence further augmented this risk (HR: 1.89, 95% CI: 1.23-2.91, <i>P</i> = .004). Patients with both high FIB-4 and NAFLD demonstrated worst outcomes (HR: 3.12, 95% CI: 1.87-5.21, <i>P</i> < .001). FIB-4 showed good discriminative ability for MACE prediction (AUC: 0.712, 95% CI: 0.665-0.759). FIB-4 index and NAFLD are independent predictors of adverse outcomes in MINOCA patients, offering simple, cost-effective tools for risk stratification.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261427829"},"PeriodicalIF":2.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-11DOI: 10.1177/00033197261428499
Sadeq Tabatabai, Nooshin Bazargani, Hesham Osman, Jasem Mohammed Alhashmi, Mosaad Abushabana, Kamaleldin Al-Tahmody, Praphul Misra, Eman Alhatou, Arif Al-Mulla
{"title":"Differences in Clinical Characteristics and In-Hospital Outcomes of Acute Myocardial Infarction Among Emiratis and Expatriates: Data from the Gulf Region.","authors":"Sadeq Tabatabai, Nooshin Bazargani, Hesham Osman, Jasem Mohammed Alhashmi, Mosaad Abushabana, Kamaleldin Al-Tahmody, Praphul Misra, Eman Alhatou, Arif Al-Mulla","doi":"10.1177/00033197261428499","DOIUrl":"https://doi.org/10.1177/00033197261428499","url":null,"abstract":"<p><p>This retrospective, single-center cohort study included all consecutive patients diagnosed with acute myocardial infarction between 2013 and 2018. A total of 2,975 patients were analyzed (mean age: 51.6 years; 92.3% were male). Emirati patients comprised 10.3% of the cohort and were significantly older than expatriates (62.4 vs 50.3 years; <i>P</i> < .001), with a higher proportion of females (28.0% vs 5.3%; <i>P</i> < .001). Emiratis had a greater prevalence of diabetes mellitus (55.4% vs 42.6%), hypertension (59.9% vs 36.2%), and prior myocardial infarction (all <i>P</i> < .001). Non-ST-elevation myocardial infarction was more common among Emiratis (<i>P</i> < .001), whereas smoking was more prevalent among expatriates (<i>P</i> < .001). In-hospital mortality was higher among Emiratis compared with expatriates (4.9% vs 2.3%; <i>P</i> = .006), as was the incidence of heart failure (12.7% vs 6.1%; <i>P</i> < .001). However, after multivariable adjustment, Emirati nationality was not independently associated with in-hospital adverse outcomes. Although trends indicated an increased risk for death (Adjusted odds ratio [aOR]: 1.39, 95% CI: 0.71-2.70; <i>P</i> = .335), cardiogenic shock (aOR: 1.85, 95% CI: 0.92-3.70; <i>P</i> = .082), cardiac arrest (aOR: 1.55, 95% CI: 0.80-3.00; <i>P</i> = .196), and heart failure (aOR: 1.50, 95% CI: 0.98-2.29; <i>P</i> = .063) among Emiratis, none of these associations achieved statistical significance.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261428499"},"PeriodicalIF":2.2,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-11DOI: 10.1177/00033197261422807
Jinyuan Yi, Fei Chai, Sheng Li, Zhongcheng Li
{"title":"miR-1306-5p Alleviates Myocardial Cell Injury After Acute Myocardial Infarction Via Modulating TET3.","authors":"Jinyuan Yi, Fei Chai, Sheng Li, Zhongcheng Li","doi":"10.1177/00033197261422807","DOIUrl":"https://doi.org/10.1177/00033197261422807","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) has emerged as a key regulatory factor in cardiovascular diseases, including acute myocardial infarction (AMI). We aim to explore the effects of <i>miR-1306-5p</i> on AMI. We enrolled 130 AMI patients and 85 healthy individuals. The levels of genes were measured by real-time quantitative polymerase chain reaction (RT-qPCR). Cell proliferation, myocardial injury markers and inflammatory factor levels were assessed via cell counting kit-8 (CCK-8) and Enzyme-Linked Immunosorbent Assay (ELISA) assays. Target relationships were confirmed via dual-luciferase reporter assays and RNA immunoprecipitation (RIP) experiments. <i>miR-1306-5p</i> was remarkably diminished in AMI patients. It was an independent predictor of AMI, showing a positive correlation with the cardiac troponin I (cTnI) and a negative correlation with high-density lipoprotein cholesterol (HDL-C) and ejection fraction. Mechanistically, upregulated <i>miR-1306-5p</i> diminished the levels of cTnI, creatine kinase-MB (CK-MB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) while promoting proliferation in hypoxia-reoxygenation (H/R)-treated AC16 cells. These effects could be reversed by overexpressing <i>ten-eleven translocation 3 (TET3)</i>. Moreover, lncRNA <i>nuclear paraspeckle assembly transcript 1 (NEAT1)</i> was found to function as a microRNA sponge for <i>miR-1306-5p</i>. In conclusion, <i>miR-1306-5p</i> could bind to <i>NEAT1</i> and subsequently mitigate cardiomyocyte damage by negatively regulating <i>TET3</i>.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261422807"},"PeriodicalIF":2.2,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-11DOI: 10.1177/00033197261422789
Wael Al Mahmeed, Manal Al Kindi, Ahmed Al-Sarraf, Haitham Amin, Mahmoud Zirie, Fatheya Al Awadi, Hani Sabbour, Khalid Al-Waili, Nader Lessan, Alia Al Tikriti, Obada Salameh, Ibrahim Al-Zakwani, Khalid Al-Rasadi
{"title":"Residual Cardiovascular Risk Associated with Non-HDL-C in Statin-Treated Patients: Data from the Gulf Triglyceride and Residual Cardiovascular Risk (Gulf CALLS) Cohort.","authors":"Wael Al Mahmeed, Manal Al Kindi, Ahmed Al-Sarraf, Haitham Amin, Mahmoud Zirie, Fatheya Al Awadi, Hani Sabbour, Khalid Al-Waili, Nader Lessan, Alia Al Tikriti, Obada Salameh, Ibrahim Al-Zakwani, Khalid Al-Rasadi","doi":"10.1177/00033197261422789","DOIUrl":"https://doi.org/10.1177/00033197261422789","url":null,"abstract":"<p><p>Growing evidence suggests that lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels is associated with a reduced risk of cardiovascular diseases (CVD) events. However, data on this relationship remain scarce in the Arabian Gulf region. The Gulf TriglyCeride And ResiduaL CardiovascuLar RiSk (Gulf CALLS) study investigated the association between failure to achieve non-HDL-C targets (<2.6 mmol/L) and residual CVD risk in very high-risk patients from the region who were on statin therapy and had well-controlled low-density lipoprotein cholesterol (LDL-C) levels (<1.8 mmol/L [70 mg/dL]). This retrospective study evaluated patients across 5 Arabian Gulf countries, aged > 45 years with established CVD or diabetes, LDL-C levels <1.8 mmol/L (<70 mg/dL), and triglyceride levels <4.5 mmol/L (<400 mg/dL) on lipid-lowering therapy. A total of 22% (521/2344) of the patients did not achieve the non-HDL-C target. In the adjusted Cox regression model, patients who achieved the non-HDL-C goal at baseline had a 25% lower risk of subsequent CVD events than those who did not (hazard ratio, .75; 95% confidence interval: .58-.97; <i>P</i> = .028). In the present study involving very high-risk patients on statin therapy, failure to achieve non-HDL-C targets was associated with a significantly higher residual CVD risk, despite well-controlled LDL-C levels.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261422789"},"PeriodicalIF":2.2,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-10DOI: 10.1177/00033197261427826
Xiaoming Xie, Runze Jiao, Feng Chen, Wei Zhou
{"title":"Genetic Evaluation in Symptomatic Spontaneous Isolated Superior Mesenteric Artery Dissection.","authors":"Xiaoming Xie, Runze Jiao, Feng Chen, Wei Zhou","doi":"10.1177/00033197261427826","DOIUrl":"https://doi.org/10.1177/00033197261427826","url":null,"abstract":"<p><p>To explore the contribution of genetic risk factors to isolated superior mesenteric artery dissection (ISMAD), this study detected variations in known arterial dissection-related genes in a cohort of patients with symptomatic ISMAD. Thirty-two patients were recruited. Whole-exome sequencing was conducted on blood samples from all participants and 83 controls. Prevalence, clinical characteristics, treatments, and causative gene carriers were also studied. Eleven (34.4%) patients with ISMAD had pathogenic variants in <i>COL3A1</i> (n = 3), <i>COL12A1</i> (n = 3), <i>TLN1</i> (n = 1), <i>FN1</i> (n = 2), and <i>TNXB</i> (n = 2). Pathogenic variants in the <i>COL3A1</i> and <i>COL12A1</i> genes are strongly correlated with ISMAD. In 9.4% (3/32) of the patients with ISMAD, conservative treatment failed and further endovascular treatment was required. Among them, 2 (66.7%) harbored pathogenic mutations in <i>COL3A1</i>. Pathogenic variants in the <i>COL3A1</i> gene are associated with a high predisposition to endovascular treatment (<i>P</i> = .02). <i>COL3A1</i>, <i>COL12A1</i>, and <i>TLN1</i> mutations may be risk factors for ISMAD. A small proportion of patients with ISMAD and carrying pathogenic mutations in <i>COL3A1</i> were more likely to experience more severe arterial tearing and require endovascular treatment.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261427826"},"PeriodicalIF":2.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-10DOI: 10.1177/00033197261425811
Song Peng Ang, Jia Ee Chia, Chayakrit Krittanawong, Bryan Gregory, Umabalan Thirupathy, Vikash Jaiswal, Muhammad Hanif, Mahboob Alam, Jose Iglesias, Debabrata Mukherjee
{"title":"Trends, Characteristics, and Outcomes of Percutaneous Coronary Intervention Among Kidney Transplant Recipients.","authors":"Song Peng Ang, Jia Ee Chia, Chayakrit Krittanawong, Bryan Gregory, Umabalan Thirupathy, Vikash Jaiswal, Muhammad Hanif, Mahboob Alam, Jose Iglesias, Debabrata Mukherjee","doi":"10.1177/00033197261425811","DOIUrl":"https://doi.org/10.1177/00033197261425811","url":null,"abstract":"<p><p>Kidney transplant recipients (KTRs) face high cardiovascular risk, yet outcomes after percutaneous coronary intervention (PCI) remain poorly characterized. We compared in-hospital outcomes, temporal trends, and predictors of mortality between KTRs and non-transplant patients undergoing PCI. Using the National Inpatient Sample (2016-2021), we identified adult PCI hospitalizations and classified them as KTRs or non-transplant patients. Outcomes included in-hospital mortality, acute kidney injury (AKI), bleeding, length of stay (LOS), and hospitalization costs. Propensity-score matching (PSM) reduced baseline differences, and multivariable logistic regression identified mortality predictors among KTRs. Of 2 677 410 PCI hospitalizations, 8300 involved KTRs. KTRs were younger but had higher comorbidity burden. Unadjusted mortality was higher in KTRs (3.55% vs 2.98%), but not after matching (PSM odds ratio [OR] 0.89; 95% CI, 0.67-1.20). KTRs had higher AKI risk (25.7% vs 16.1%; PSM OR 1.25; 95% CI, 1.10-1.42), whereas AKI requiring dialysis did not differ. Excess bleeding and transfusion in unadjusted analyses were attenuated after matching. KTRs had longer LOS and higher costs. Despite similar in-hospital mortality, KTRs undergoing PCI experience greater AKI risk and resource use, supporting tailored risk stratification and post-procedural monitoring in this population.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261425811"},"PeriodicalIF":2.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2026-03-06DOI: 10.1177/00033197261428830
Muhammed Bahadır
{"title":"Letter: Aortic Stiffness Can be Predicted From Different eGFR Formulas With Long Follow-Up in the Malmö Diet Cancer Study.","authors":"Muhammed Bahadır","doi":"10.1177/00033197261428830","DOIUrl":"https://doi.org/10.1177/00033197261428830","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197261428830"},"PeriodicalIF":2.2,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}