AngiologyPub Date : 2025-08-01Epub Date: 2024-01-16DOI: 10.1177/00033197241227598
Tao Chen, Peng Liu, Chenguang Zhang, Song Jin, Yuhu Kong, Yanan Feng, Ziqiang Sun
{"title":"Pathophysiology and Genetic Associations of Varicose Veins: A Narrative Review.","authors":"Tao Chen, Peng Liu, Chenguang Zhang, Song Jin, Yuhu Kong, Yanan Feng, Ziqiang Sun","doi":"10.1177/00033197241227598","DOIUrl":"10.1177/00033197241227598","url":null,"abstract":"<p><p>Varicose veins (VVs) have a high prevalence worldwide and have become a major medical burden. Their pathophysiology involves a complex interplay of inflammation and tissue remodeling, and current treatment is limited by its impact on the pathophysiological mechanisms. In addition, despite clear environmental factors, family history is an important risk factor, suggesting a genetic component to the risk of developing VVs. Our understanding of the pathogenesis of these diseases has benefited greatly from the expansion of population genetic studies, from pioneering family studies to large genome-wide association studies; we now find multiple risk loci for each venous disease. This review considers the pathophysiology of VVs, highlighting the current state of genetic knowledge. We also propose future directions for research.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"615-628"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-30DOI: 10.1177/00033197251355336
Mehmet Ali Cetiner, Marc Vorpahl, Melchior Seyfarth, Ulrich Wiederhold, Juliane Sophie Yu, Rojvan Bilgin, Ramazan Gökmen Turan
{"title":"A Comparison of Carotid Ultrasound and Coronary Optical Coherence Tomography in Assessing Plaque Morphology in Patients with Chronic Coronary Syndrome.","authors":"Mehmet Ali Cetiner, Marc Vorpahl, Melchior Seyfarth, Ulrich Wiederhold, Juliane Sophie Yu, Rojvan Bilgin, Ramazan Gökmen Turan","doi":"10.1177/00033197251355336","DOIUrl":"https://doi.org/10.1177/00033197251355336","url":null,"abstract":"<p><p>Atherosclerosis is a predominant cause of cardiovascular events and the accurate assessment of plaque morphology is crucial for risk stratification and treatment planning. Carotid ultrasound (CUS) and coronary artery optical coherence tomography (OCT) are valuable imaging modalities for evaluating atherosclerotic plaques. This study aimed to compare the reliability of CUS and OCT in assessing plaque morphology and atherosclerosis in patients with chronic coronary syndrome. Forty-six patients with chronic coronary syndrome underwent OCT to evaluate coronary plaques and CUS to assess carotid plaques. The findings showed that both imaging techniques detected the presence of plaques, with OCT providing more detailed information on coronary plaque morphology compared with CUS. OCT and CUS measurements demonstrated significant correlations in lumen stenosis, plaque sizes, and representations of calcified plaques. Furthermore, distinct differences were observed in plaque distribution and characteristics between the coronary and carotid arteries. Certain cardiovascular risk factors such as diabetes, arterial hypertension, and obesity were associated with specific plaque properties identified by OCT. This study underscores the complementary roles of OCT and CUS in assessing atherosclerosis and plaque vulnerability in patients with chronic coronary syndrome, providing valuable insights for clinical management and treatment strategies.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251355336"},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-29DOI: 10.1177/00033197251363663
Emine Altuntas, Abidin Emre Tırnaksız, Kadir Sadıkoğlu, Serkan Aslan, Gökhan Demirci, Ahmet Arif Yalcın, Ali Kemal Kalkan, Fatih Uzun, Ibrahim Faruk Akturk, Omer Celik, Mehmet Ertürk
{"title":"Response to the Letter Regarding: \"Prognostic Value of the Triglycerides-Glucose Index for Major-Adverse-Cardiac Events in Severe Aortic Stenosis Patients After TAVI\".","authors":"Emine Altuntas, Abidin Emre Tırnaksız, Kadir Sadıkoğlu, Serkan Aslan, Gökhan Demirci, Ahmet Arif Yalcın, Ali Kemal Kalkan, Fatih Uzun, Ibrahim Faruk Akturk, Omer Celik, Mehmet Ertürk","doi":"10.1177/00033197251363663","DOIUrl":"https://doi.org/10.1177/00033197251363663","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251363663"},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-29DOI: 10.1177/00033197251356583
Antonio V Sterpetti, Francesca Miceli, Alessia Di Girolamo, Immacolata Iannone, Paolo Sapienza, Luca Di Marzo
{"title":"Cardiovascular Oncology: Consensus Statements Are Still Lacking to Improve the Management of Side-Effects of Old and New Chemotherapeutic Agents.","authors":"Antonio V Sterpetti, Francesca Miceli, Alessia Di Girolamo, Immacolata Iannone, Paolo Sapienza, Luca Di Marzo","doi":"10.1177/00033197251356583","DOIUrl":"https://doi.org/10.1177/00033197251356583","url":null,"abstract":"<p><p>Significant advances in diagnostic methods and better life-expectancy have resulted in increased number of patients with cardiovascular diseases and cancer. Elderly patients are at risk for both diseases, and the treatment of patients with cardiovascular and oncologic problems represents a daily clinical challenge, considering the heterogeneity of clinical situations. The present review underlines the complexity of cardiovascular oncology. In the last 5 years >18 new drugs against cancer, with possible cardiovascular side-effects, were approved by the Food and Drug Administration. Several new drugs are under evaluation in multicenter prospective studies, and some of these agents have potential cardiovascular side-effects. This review analyzes the difficulties for cardiovascular specialists to keep updated regarding the possible side-effects of new chemotherapeutic agents. The analysis of the mechanisms involved in cancer occurrence and progression are a field of research in continuous development with new discoveries, and technologies applied at developing effective chemotherapeutic drugs. Several recommendations have been proposed by the American Heart Association and European Society of Cardiology, promoting the need for close collaboration between cardiologists, surgeons, and oncologists. It is important to develop strategies to support training in cardiovascular oncology.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251356583"},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Influence of Smoking and Systemic Inflammation on Carotid Artery Disease: A Cross-Sectional Analysis of Stenosis, Plaque Surface Characteristics.","authors":"Taylan Altiparmak, Hale Zeynep Batur Caglayan, Sevcihan Kesen Ozbek, Fatih Oncu, Atiye Cenay Karabork Kilic, Tugba Erdogan, Serife Yaymaci, Bijen Nazliel","doi":"10.1177/00033197251356577","DOIUrl":"https://doi.org/10.1177/00033197251356577","url":null,"abstract":"<p><p>The role of inflammation in carotid plaque formation and instability has been highlighted in recent studies. We assessed the significance of smoking status on systemic inflammation and their relationships with carotid stenosis and carotid plaque surface characteristics. A total of 822 patients diagnosed with carotid artery stenosis were recruited and evaluated with systemic inflammation indices according to smoking status. Subgroups were balanced in terms of gender, age, and additional diseases. Systemic inflammation indices were found to be substantially higher in smokers (<i>P</i> < .001) and in patients with irregular-ulcerated surface plaques (<i>P</i> < .001). Plaque surfaces were more irregular and ulcerated in smokers (<i>P</i> < .001). No difference was detected between stenosis degree and smoking status or with systemic inflammation (<i>P</i> > .05). Pan-immune-inflammatory value (PIV) had a strong correlation with both smoking and plaque instability (<i>P</i> < .001, <i>r</i> = .771). Additionally, high PIV levels displayed a significant risk augmentation for irregular/ulcerated surface plaques (<i>P</i> < .001, Odds Ratio (OR):13.796; 95%CI, 5.647-33.701). These findings suggest that in patients with carotid atherosclerotic stenosis, systemic inflammatory markers especially PIV, alongside with plaque surface characteristics, may serve as valuable tools for evaluating and monitoring plaque inflammation. This may lead to more personalized and effective treatment strategies, particularly in smokers.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251356577"},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endocan, a Potential Biomarker of Endothelial Dysfunction: A Brief Overview.","authors":"Megha Bidlan, Mohit Kumar, Anurag Bhargava, Vrinda Goel, Vijay Kumar","doi":"10.1177/00033197251356576","DOIUrl":"https://doi.org/10.1177/00033197251356576","url":null,"abstract":"<p><p>Endocan (endothelial cell-specific molecule 1, ESM-1), is a proteoglycan produced by the vascular endothelium that modulates cellular functions such as adhesion, migration, and proliferation. Elevated serum endocan levels are associated with autoimmune and inflammatory disorders, acting as a marker of endothelial activation and dysfunction. This brief overview considers endocan's role in HTN, cirrhosis, diabetes, peripheral arterial disease (PAD), coronavirus Disease 2019 (COVID-19), erectile dysfunction (ED), and psoriasis vulgaris. Data were gathered from research reporting endocan levels, illness markers, and clinical outcomes. Elevated endocan levels are associated with endothelial dysfunction, which contributes to diabetes complications and associated with vascular endothelial growth factor A (VEGF-A) activation. In HTN, endocan promotes inflammatory signaling and lymphocyte infiltration. In liver disease, particularly cirrhosis, elevated levels correlate with hepatic fibrosis and poor prognosis. PAD patients show raised endocan correlating with disease severity. COVID-19 studies suggest coronavirus induces endotheliitis. In ED, higher endocan levels are linked with endothelial dysfunction and impaired vascular reactivity, serving as a potential biomarker for vascular-related ED. In psoriasis vulgaris, endocan levels correlate with disease severity and cardiovascular risk. The present brief overview supports that monitoring endocan levels may improve treatment and prognosis. Further research is required to define its clinical potential.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251356576"},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-22DOI: 10.1177/00033197251360684
Hilal Tunçer, Özden Seçkin, Serkan Ünlü
{"title":"Letter: Association Between Anemia and Prognosis in Patients With Acute Coronary Syndrome and Atrial Fibrillation.","authors":"Hilal Tunçer, Özden Seçkin, Serkan Ünlü","doi":"10.1177/00033197251360684","DOIUrl":"https://doi.org/10.1177/00033197251360684","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251360684"},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Latent Class Analysis Identifies Distinct Patient Phenotypes Associated With Mistaken Treatment Decisions and Adverse Outcomes in Coronary Artery Disease.","authors":"Jing Qi, Zhiqiang Wang, Xiaoteng Ma, Zhijian Wang, Yueping Li, Lixia Yang, Dongmei Shi, Yujie Zhou","doi":"10.1177/00033197251350182","DOIUrl":"https://doi.org/10.1177/00033197251350182","url":null,"abstract":"<p><p>This study aimed to identify patient characteristics linked to mistaken treatments and major adverse cardiovascular events (MACE) in percutaneous coronary intervention (PCI) for coronary artery disease (CAD) using deep learning-based fractional flow reserve (DEEPVESSEL-FFR, DVFFR). A retrospective cohort of 3,840 PCI patients was analyzed using latent class analysis (LCA) based on eight factors. Mistaken treatment was defined as negative DVFFR patients undergoing revascularization or positive DVFFR patients not receiving it. MACE included all-cause mortality, rehospitalization for unstable angina, and non-fatal myocardial infarction. Patients were classified into comorbidities (Class 1), smoking-drinking (Class 2), and relatively healthy (Class 3) groups. Mistaken treatment was highest in Class 2 (15.4% vs. 6.7%, <i>P</i> < .001), while MACE was highest in Class 1 (7.0% vs. 4.8%, <i>P</i> < .001). Adjusted analyses showed increased mistaken treatment risk in Class 1 (OR 1.96; 95% CI 1.49-2.57) and Class 2 (OR 1.69; 95% CI 1.28-2.25) compared with Class 3. Class 1 also had higher MACE risk (HR 1.53; 95% CI 1.10-2.12). In conclusion, comorbidities and smoking-drinking classes had higher mistaken treatment and MACE risks compared with the relatively healthy class.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251350182"},"PeriodicalIF":2.6,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-18DOI: 10.1177/00033197251359696
Jian-Yong Wang, Ai-Min Li, Na Gao
{"title":"Letter: Is AISI a Reliable Predictor of Prognosis in Patients With CAD and CKD?","authors":"Jian-Yong Wang, Ai-Min Li, Na Gao","doi":"10.1177/00033197251359696","DOIUrl":"https://doi.org/10.1177/00033197251359696","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251359696"},"PeriodicalIF":2.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-07-14DOI: 10.1177/00033197251359695
Nuo Li, De-Gang Mo
{"title":"Letter: Role of AISI in Prognosis of CAD With CKD: An Inflammatory Perspective.","authors":"Nuo Li, De-Gang Mo","doi":"10.1177/00033197251359695","DOIUrl":"https://doi.org/10.1177/00033197251359695","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251359695"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}