Applied Spectroscopy最新文献

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Absorption Coefficient Estimation of Pigmented Skin Phantoms Using Colorimetric Parameters. 利用比色参数估算色素皮肤模型的吸收系数
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-10-13 DOI: 10.1177/00037028241281388
Luismar Barbosa da Cruz Junior, Kaio Bernardo de Barros, Carlos Eduardo Girasol, Raissa Mendonça Quaranta Lobão, Luciano Bachmann
{"title":"Absorption Coefficient Estimation of Pigmented Skin Phantoms Using Colorimetric Parameters.","authors":"Luismar Barbosa da Cruz Junior, Kaio Bernardo de Barros, Carlos Eduardo Girasol, Raissa Mendonça Quaranta Lobão, Luciano Bachmann","doi":"10.1177/00037028241281388","DOIUrl":"10.1177/00037028241281388","url":null,"abstract":"<p><p>The increasing use of light-based treatments requires a better understanding of the light tissue interaction for pigmented skin. To enhance comprehension in this area, this study proposes the use of pigmented-mimicking skin phantoms to assess the optical properties based on their tone, represented by the individual typology angle (ITA) color scale. In this study, an epoxy resin matrix alongside compact facial powder and titanium dioxide was used to mimic the absorption, scattering, and shade properties of human skins. Eight phantoms covering the skin tones, light (ITA = 45.2°), tan (ITA = 23.3°), brown (ITA = 6.9°, -5.7°, and -16.9°), and dark (ITA = -34.6°, -41.6°, and -48.6°), were crafted. The absorption and reduced scattering coefficients were obtained using integrating spheres and calibrated spectrometers in the 500-900 nm range, and tones were measured using a commercial colorimeter. The experimental fitting proposed in this study could estimate the optical properties as a function of the skin tones through ITA values, by using an exponential function with a second-order polynomial exponent. This investigation aligns with prior studies involving human skin samples, and these findings hold promise for future clinical and diagnostic applications, particularly in the realm of light-based treatments to individual dermatological corrections in pigmented skin.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"376-384"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying Finite Mixture Models to Quantify Respirable Dust Mass in Coal and Metal-Nonmetal Mines Using Fourier Transform Infrared Spectroscopy. 傅里叶变换红外光谱技术在有限混合模型中量化煤矿和金属非金属矿山可吸入粉尘量的应用。
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-12-05 DOI: 10.1177/00037028241296158
Andrew T Weakley, David A Parks, Arthur L Miller
{"title":"Applying Finite Mixture Models to Quantify Respirable Dust Mass in Coal and Metal-Nonmetal Mines Using Fourier Transform Infrared Spectroscopy.","authors":"Andrew T Weakley, David A Parks, Arthur L Miller","doi":"10.1177/00037028241296158","DOIUrl":"10.1177/00037028241296158","url":null,"abstract":"<p><p>Respirable dust mass is a prevalent occupational health hazard to the mining workforce. Mineral matrices observed in the mine environment are complex, time varying, and heterogeneous. This poses a challenge to assessing dust exposure using Fourier transform infrared (FT-IR) spectrometry as calibrations for constituent dust species (e.g., crystalline silica) have historically been trained using homogeneous standards or simple mixtures therein. Investigations have considered direct-on-filter analysis, which collects FT-IR spectra directly from sampling filters for calibration, as an alternative. Direct-on-filter analysis using a partial least squares (PLS) method has gained particular interest recently due to the potential to rapidly quantify multiple species from a single filter at the mine site. By design, heterogeneity, and its presumed impact on method accuracy, cannot be addressed in the laboratory when using a direct-on-filter approach motivating the need for more advanced calibration approaches. When heterogeneity is present, mixture of experts (MoE) finite mixture models offer a promising and novel alternative to PLS direct-on-filter analysis as MoE incorporates cluster discovery, regression, and outlier identification into model fitting. Three MoE models of increasing complexity were tasked with determining respirable dust mass in 243 field samples from thirteen active coal, limestone, sandstone, and silver mines. All MoE models, including those using only \"expert\" spectroscopic predictors or a combination of expert and categorical \"gate\" variables (e.g., mine type), significantly outperform PLS in terms of accuracy (α = 0.05). Decomposing bias by mine type shows that accuracy generally improves across all types considered when MoE models are not overfitted. The MoE method's effectiveness was linked to its ability to endogenously classify outliers as well as possibly to the use of an additional cluster model for mass predictions. Overall, MoE methods appear as a capable and novel tool to addressing problems of heterogeneity for direct-on-filter quantitative analysis.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"364-375"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Breast Cancer Gene Type 1 (BRCA1) Protein Levels in Cancer Tissue Using Surface-Enhanced Raman Spectroscopy. 使用表面增强拉曼光谱评估乳腺癌基因1型(BRCA1)蛋白在癌组织中的水平。
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-12-05 DOI: 10.1177/00037028241297716
Ece Miser-Salihoğlu, Hasan İlhan, Uğur Tamer, Sevgi Akaydin
{"title":"Evaluation of Breast Cancer Gene Type 1 (BRCA1) Protein Levels in Cancer Tissue Using Surface-Enhanced Raman Spectroscopy.","authors":"Ece Miser-Salihoğlu, Hasan İlhan, Uğur Tamer, Sevgi Akaydin","doi":"10.1177/00037028241297716","DOIUrl":"10.1177/00037028241297716","url":null,"abstract":"<p><p>Raman spectroscopy is a chemical process that utilizes the interaction between light and matter to get significant insights into the structure or characteristics of matter. Raman spectroscopy techniques, such as quantitative evaluation, early diagnostic capabilities, and elucidation of the spectral properties of tissues, are excellent candidates for use in research. In cancer, changes in genes and proteins expressed by related genes are associated with a poor prognosis and aggressive tumor characteristics. Due to modifications and regulatory steps in protein translation, the results of the messenger RNA (mRNA) expression of genes may not correctly reflect the results of protein expression. For this reason, the mRNA and protein expressions of genes are studied in parallel in molecular studies on cancer. In our study, the breast cancer gene type 1 (BRCA1) gene, which is frequently studied in breast cancer and is relatively more difficult to measure by traditional methods due to its high molecular weight, was selected, and protein quantification was performed in tissue samples by Raman spectroscopy. With Raman spectroscopy, it is possible to obtain rapid and precise quantitative results even with a small amount of sample, so it is quite advantageous compared to traditional methods. In our study, we performed surface-enhanced Raman spectroscopy (SERS) to analyze the quantitative protein amount. SERS is a highly sensitive method for detecting compounds at low concentrations. For this purpose, magnetic nanoparticles modified with protein antibodies were used, and the target protein was withdrawn from the complex environment and transferred to an appropriate buffer environment. The calibration curve for BRCA1, which plots Raman intensity against concentration, was derived by calculating the average response reading from duplicate assays conducted under identical conditions. The BRCA1 protein levels of cells were determined from the regression curve of the BRCA1 protein. The relation between the concentration of BRCA1 protein and SERS spectrum intensity was determined to be logarithmic in the range of 300 µg·mL<sup>-1</sup> to 292 ng·mL<sup>-1</sup> (<i>R</i><sup>2</sup> = 0.9928, limit of detection = 10.41 µg·mL<sup>-1</sup>, and limit of quantitation = 31.24 µg·mL<sup>-1</sup>).</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"458-464"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quasi-Non-Destructive Estimation of Concrete Compression Strength Using Laser-Induced Breakdown Spectroscopy and Multivariate Analysis. EXPRESS:利用激光诱导击穿光谱和多元分析对混凝土压缩强度进行准无损估算。
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-07-21 DOI: 10.1177/00037028241262040
Shuzo Eto, Taku Otsuka
{"title":"Quasi-Non-Destructive Estimation of Concrete Compression Strength Using Laser-Induced Breakdown Spectroscopy and Multivariate Analysis.","authors":"Shuzo Eto, Taku Otsuka","doi":"10.1177/00037028241262040","DOIUrl":"10.1177/00037028241262040","url":null,"abstract":"<p><p>Micro- and non-destructive methods of estimating compressive strength are useful for diagnosing the degradation of reinforced structures. The velocity of waves propagating through concrete can be measured using conventional non-destructive methods; however, the propagation path of waves varies depending on the distribution of coarse aggregate, resulting in variations in velocity at different measurement points. To address this issue, a method based on laser-induced breakdown spectroscopy and multivariate analysis was developed in this study for estimating the compressive strength of concrete non-destructively, ensuring the non-influence of the coarse aggregate spatial distribution. The method is based on the correlation between the emission intensity of the spectrum and the hardness of the object to be measured. Principal component analysis and partial least squares regression (PLSR) were used to extract the mortar spectrum, which determines the compressive strength of concrete, from a mixture of aggregate and mortar spectra. The compressive strength estimated based on the proposed method was consistent with the values obtained from the compressive strength test, which indicates the possibility of using multivariable analysis to estimate the compressive strength of concrete. Furthermore, the proposed method enabled on-site measurements through a simple experimental setup and insensitivity to spectral noise offered by PLSR.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"353-365"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing Correction Methods by Revisiting the Concept of Effective Thickness in Attenuated Total Reflection Spectroscopy. 通过重新审视衰减全反射光谱学中有效厚度的概念来开发校正方法。
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-10-29 DOI: 10.1177/00037028241290838
Thomas G Mayerhöfer, Jürgen Popp
{"title":"Developing Correction Methods by Revisiting the Concept of Effective Thickness in Attenuated Total Reflection Spectroscopy.","authors":"Thomas G Mayerhöfer, Jürgen Popp","doi":"10.1177/00037028241290838","DOIUrl":"10.1177/00037028241290838","url":null,"abstract":"<p><p>We propose a new way of deriving the effective thickness in attenuated total reflection (ATR) spectroscopy, initially introduced by Hansen and Harrick in 1965. While following Hansen's approach, our derivation is more straightforward and includes an intermediate approximation that more closely aligns with results derived from Fresnel's equations, particularly for organic and biological materials. Using this intermediate approximation, we present improved estimations for the effective thicknesses with <i>s</i>- and <i>p</i>-polarized light. These estimations enabled us to enhance a recently developed ATR correction scheme that relies on effective thickness. Additionally, we examined the wavelength dependence of the product of wavenumber and effective thickness, observing that it bears a resemblance to the refractive index function of the sample. This similarity increases with the angle of incidence and the refractive index of the ATR crystal. Based on this observation, we introduce a simple correction scheme using the Kramers-Kronig transformed absorbance. This correction has the potential to address spectral shifts, facilitating applications in pattern recognition and spectra identification.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"465-472"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning Approaches for the Fusion of Near-Infrared, Mid-Infrared, and Raman Data to Identify Cartilage Degradation in Human Osteochondral Plugs. 融合近红外、中红外和拉曼数据的机器学习方法,用于识别人体骨软骨塞中的软骨退化。
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1177/00037028241285583
Valeria Tafintseva, Ervin Nippolainen, Vesa Virtanen, Johanne Heitmann Solheim, Boris Zimmermann, Simo Saarakkala, Heikki Kröger, Achim Kohler, Juha Töyräs, Isaac O Afara, Rubina Shaikh
{"title":"Machine Learning Approaches for the Fusion of Near-Infrared, Mid-Infrared, and Raman Data to Identify Cartilage Degradation in Human Osteochondral Plugs.","authors":"Valeria Tafintseva, Ervin Nippolainen, Vesa Virtanen, Johanne Heitmann Solheim, Boris Zimmermann, Simo Saarakkala, Heikki Kröger, Achim Kohler, Juha Töyräs, Isaac O Afara, Rubina Shaikh","doi":"10.1177/00037028241285583","DOIUrl":"10.1177/00037028241285583","url":null,"abstract":"<p><p>Vibrational spectroscopy methods such as mid-infrared (MIR), near-infrared (NIR), and Raman spectroscopies have been shown to have great potential for in vivo biomedical applications, such as arthroscopic evaluation of joint injuries and degeneration. Considering that these techniques provide complementary chemical information, in this study, we hypothesized that combining the MIR, NIR, and Raman data from human osteochondral samples can improve the detection of cartilage degradation. This study evaluated 272 osteochondral samples from 18 human knee joins, comprising both healthy and damaged tissue according to the reference Osteoarthritis Research Society International grading system. We established the one-block and multi-block classification models using partial least squares discriminant analysis (PLSDA), random forest, and support vector machine (SVM) algorithms. Feature modeling by principal component analysis was tested for the SVM (PCA-SVM) models. The best one-block models were built using MIR and Raman data, discriminating healthy cartilage from damaged with an accuracy of 77.5% for MIR and 77.8% for Raman using the PCA-SVM algorithm, whereas the NIR data did not perform as well achieving only 68.5% accuracy for the best model using PCA-SVM. The multi-block approach allowed an improvement with an accuracy of 81.4% for the best model by PCA-SVM. Fusing three blocks using MIR, NIR, and Raman by multi-block PLSDA significantly improved the performance of the single-block models to 79.1% correct classification. The significance was proven by statistical testing using analysis of variance. Thus, the study suggests the potential and the complementary value of the fusion of different spectroscopic techniques and provides valuable data analysis tools for the diagnostics of cartilage health.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"385-395"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platform for Aldehyde and Ketone Quantitation Using Surface-Enhanced Raman Spectroscopy. 利用表面增强拉曼光谱进行醛和酮定量的平台。
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1177/00037028241296845
Merwan Benhabib, Mark C Peterman
{"title":"Platform for Aldehyde and Ketone Quantitation Using Surface-Enhanced Raman Spectroscopy.","authors":"Merwan Benhabib, Mark C Peterman","doi":"10.1177/00037028241296845","DOIUrl":"10.1177/00037028241296845","url":null,"abstract":"<p><p>Colorimetric methods for aldehyde and ketone analyses are plagued by interferences. Each aldehyde or ketone generates a blue color, but with a different reaction coefficient. It is, therefore, not possible to differentiate these compounds from a single test. By using surface-enhanced Raman spectroscopy, we demonstrate unique fingerprints for each reaction product, enabling aldehyde and ketone speciation. With the further addition of an isotopologue internal standard, we demonstrate aldehyde and ketone quantification at levels lower than those possible with colorimetric techniques. This method paves the way for a powerful and practical tool for analyzing these crucial chemical building blocks.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"438-446"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodevelopmental Process Monitoring of Cytosine Arabinoside-Exposed Neurons Using Raman Spectroscopy. 利用拉曼光谱监测暴露于阿拉伯苷的胞嘧啶神经元的神经发育过程
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-03-01 Epub Date: 2024-11-04 DOI: 10.1177/00037028241289147
Kosuke Hashimoto, Hidetoshi Sato
{"title":"Neurodevelopmental Process Monitoring of Cytosine Arabinoside-Exposed Neurons Using Raman Spectroscopy.","authors":"Kosuke Hashimoto, Hidetoshi Sato","doi":"10.1177/00037028241289147","DOIUrl":"10.1177/00037028241289147","url":null,"abstract":"<p><p>Raman spectroscopy is used to monitor the development of live neurons exposed to cytosine arabinoside (ara-C). Ara-C is widely used to culture neurons and exclude non-neuronal cells. In this study, Raman spectra obtained from neurons exposed to ara-C were plotted using an analytical model of neuronal development to evaluate the impact of ara-C on neuronal development. After two days of culturing, neurons were exposed to ara-C for 24 h at final concentrations of 0 (control), 5, and 25 μM. Principal component analysis (PCA) was performed to build an analytical model for evaluating neurodevelopmental disorders caused by ara-C treatment. We projected the Raman spectra obtained from ara-C-treated cells onto the control group dataset. The distribution of PC1 scores for neurons exposed to ara-C at a final concentration of 5 μM was not significantly different from that of the control group. In contrast, under a final concentration of 25 μM, the data population at 10 and 15 days of culturing overlapped significantly with that of neurons at 4 days of normal culturing. These results suggest that Raman spectroscopy can detect very small physiological alterations in the neurons even after a short-term exposure (24 h) of ara-C. Our analytical method has high potential to evaluate the developmental stages for living neurons under exposure to chemicals.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"396-403"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of Spectral Overlap in Spectral Surface-Enhanced Raman Spectroscopy Imaging Using a Dove Prism.
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-02-26 DOI: 10.1177/00037028251322540
Deben N Shoup, Abigail E Smith, Zachary D Schultz
{"title":"Reduction of Spectral Overlap in Spectral Surface-Enhanced Raman Spectroscopy Imaging Using a Dove Prism.","authors":"Deben N Shoup, Abigail E Smith, Zachary D Schultz","doi":"10.1177/00037028251322540","DOIUrl":"https://doi.org/10.1177/00037028251322540","url":null,"abstract":"<p><p>The ability to combine microscopy and spectroscopy is beneficial for directly monitoring physical and biological processes. Spectral imaging approaches, where a transmission diffraction grating is placed near an imaging sensor to collect both the spatial image and spectrum for each object in the field of view, provide a relatively simple method to simultaneously collect images and spectroscopic responses on the same sensor. Initially demonstrated with fluorescence spectroscopy, the use of spectral imaging in Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS) can provide a vibrational spectrum containing molecularly specific information that can inform on chemical changes. However, a major complication to this approach is the spectral overlap that occurs when objects are spaced closely together horizontally. In this work, we add a dove prism to a spectral imaging instrument developed for SERS imaging, enabling rotation of the collected SERS image and dispersed spectrum onto the imaging complementary metal-oxide semiconductor (CMOS) sensor. We demonstrate that this effectively reduces spectral overlap for emitters with clear separation between them and emitters with slightly overlapping point spread functions thereby facilitating collection of unambiguous spectra from each emitter.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"37028251322540"},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectroscopic Study of Micro-/Nano-Hydroxyapatite Polymer Composites Modified with Carbon Nanofibers.
IF 2.2 3区 化学
Applied Spectroscopy Pub Date : 2025-02-16 DOI: 10.1177/00037028251316290
Anna Kołodziej, Małgorzata Rachwał, Elżbieta Długoń, Magdalena Ziąbka, Aleksandra Wesełucha-Birczyńska
{"title":"Spectroscopic Study of Micro-/Nano-Hydroxyapatite Polymer Composites Modified with Carbon Nanofibers.","authors":"Anna Kołodziej, Małgorzata Rachwał, Elżbieta Długoń, Magdalena Ziąbka, Aleksandra Wesełucha-Birczyńska","doi":"10.1177/00037028251316290","DOIUrl":"https://doi.org/10.1177/00037028251316290","url":null,"abstract":"<p><p>Nowadays, novel biomaterials are under intense research because they are part of promising therapies for the treatment of age-related diseases such as osteoporosis and bone defects. In the presented study, composites of poly(ε-caprolactone) (PCL), micro and nano hydroxyapatite (µ-HAp and n-HAp) and carbon nanofibers (CNFs) were prepared. The influence of additives on polymeric matrix was analyzed using scanning electron microscopy (SEM), Raman micro-spectroscopy, Raman mapping, and two-dimensional correlation spectroscopy (2D-COS). The bioactivity in vitro was evaluated by a 21-day incubation of prepared membranes in simulated body fluid (SBF). It was concluded that additives can behave as crystallization nuclei of PCL, but they are also located across the entire surface of PCL spherulites, not only in the center. With an increasing content of HAp additives, polymeric spherulites become smaller. The type of HAp (µ-HAp or n-HAp) influences the PCL matrix differently, as confirmed by 2D-COS. The component whose addition leads to most significant changes in the polymer is CNFs; polymeric spherulites are small to the extent that they are not distinguishable, and the overall amorphousness of the polymer is the highest among all tested materials, as is its hydrophobicity. The bioactivity test indicated that the membrane with the greatest potential for use as a biomaterial in bone tissue engineering is one consisting of n-HAp (15 wt%) and CNFs, as very uniform coverage of the produced apatite was observed on the surface of this membrane after incubation in SBF.</p>","PeriodicalId":8253,"journal":{"name":"Applied Spectroscopy","volume":" ","pages":"37028251316290"},"PeriodicalIF":2.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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