Annals of Medical Research最新文献_第7页

Clinicopathological analysis of conjunctival lesions: An experience from the eastern part of Turkey 结膜病变的临床病理分析：土耳其东部地区的经验

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.01.09

A. Akatlı, S. Dikci

引用次数: 0

Retrospective analysis of the frequency and variety of skin lesions in patients diagnosed with sarcoidosis and examined by dermatology in a tertiary health care facility 对一家三级医疗机构皮肤科诊断出的肉样瘤病患者皮肤病变的频率和种类进行回顾性分析

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.12.397

D. Turkmen, Talat c, Hacer Karatoprak

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The Effect of Probiotic Therapy on Quality of Life and Depressive Symptoms in Patients with Diarrhea-Predominant Irritable Bowel Syndrome 益生菌治疗对腹泻型肠易激综合征患者生活质量和抑郁症状的影响

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.10.316

Ece Yiğit

{"title":"The Effect of Probiotic Therapy on Quality of Life and Depressive Symptoms in Patients with Diarrhea-Predominant Irritable Bowel Syndrome","authors":"Ece Yiğit","doi":"10.5455/annalsmedres.2022.10.316","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.316","url":null,"abstract":"Aim: The aim of the study was to analyze the effect of probiotics on quality of life and depressive symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS) and moderate or severe depressive mood. Materials and Methods: Patients diagnosed with diarrhea-predominant IBS using ROMA IV criteria and Bristol Stool Scale and moderate or severe depressive symptoms using the Beck Depression Inventory comprised the study participants. The patients were randomized and divided into two groups as the medication only group and the medication+probiotic group. IBS 36 questionnaire and Beck's Depression Inventory were administered to all patients in the first and second groups and the scores were recorded. Results: The change in IBS-36 scores from the beginning to the 10th week was significant in both groups (p<0.001). According to IBS-36 the median change from the beginning to the 10th week was 32 for the medication group, this difference was 48 for the medication+probiotic group. The difference was statistically significant (p<0.001). The change in Beck’s Depression Inventory scores from the beginning to the 10th week was significant in both the medication group and the medication+probiotic group (p<0.001). According to the Beck’s Depression Inventory the median change from the beginning to the 10th week was 7 for the medication group, this difference was 9.5 for the medication+probiotic group. The difference was statistically significant (p<0.001). Conclusion: In the treatment of diarrhea-predominant IBS patients, the use of probiotics together with classical drugs will improve quality of life by reducing both gastrointestinal symptoms and psychological symptoms.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89312956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Antitumor Effects of Anti-inflammatory Desloratadine and Trimebutine on Different Types of Human Cancer Cells: An In Vitro study 抗炎药地氯雷他定与曲美布汀对不同类型人癌细胞抗肿瘤作用的体外研究

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.05.122

Semiha Nur Ozkaya, Tuba Keskin, Ç. Tekin, S. Tekin, A. Beytur

{"title":"Investigation of the Antitumor Effects of Anti-inflammatory Desloratadine and Trimebutine on Different Types of Human Cancer Cells: An In Vitro study","authors":"Semiha Nur Ozkaya, Tuba Keskin, Ç. Tekin, S. Tekin, A. Beytur","doi":"10.5455/annalsmedres.2023.05.122","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.05.122","url":null,"abstract":"Objective: Inflammation is a process associated with the development and progression of cancer. Desloratadine (DES) and Trimebutin (TMB) are anti-inflammatory agents used in the treatment of various diseases. This study aimed to investigate the antitumor effects of DES and TMB, which exhibit anti-inflammatory effects, on different human cancer cell lines. Materials and Methods: In this study, human prostate (LNCaP), ovarian (A2780), breast (MCF-7) and colon cancer (Caco-2) cell lines were treated with DES and TMB at concentrations of 1, 5, 25, 50 and 100 µM. Cells were treated with the compounds for 6, 12, and 24 hours, and the change in cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The inhibitory concentration 50 (LogIC50) values of the compounds were calculated using GraphPad Prism 8 software based on cell viability results. The genotoxic effects of the compounds on cells were determined using the comet assay. Group comparisons were performed using the Kruskal-Wallis H test and p<0.05 was considered significant. Results: Exposure of LNCaP, A2780, MCF-7, and Caco-2 cells to DES and TMB agents for 6, 12 and 24 hours significantly reduced cell viability (p≤0.05). According to the comet assay results, DES and TMB caused significant DNA damage in the cell lines (p≤0.05). Conclusion: The study results demonstrate that DES and TMB, which have anti-inflammatory effects, exert cytotoxic effects by inducing DNA damage in cancer cells.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90918909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Delta Neutrophil Index (Immature Granulocyte) and Hematological Markers in the Diagnosis of Pediatric Acute Appendicitis 德尔塔中性粒细胞指数（未成熟粒细胞）和血液标记物在诊断小儿急性阑尾炎中的作用

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.01.028

M. K., Hakan Hakkoymaz

引用次数: 0

The Effect of Natural Antioxidant Levels in Pregnancy on Birth Weight 孕期天然抗氧化剂水平对出生体重的影响

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.12.395

A. M. Res, Ahmet Ziya Şahi̇n, Ç. Demiroğlu

引用次数: 0

Evaluation of Blood and Biliary Drainage Cultures and Mortality after Percutaneous Transhepatic Biliary Drainage Procedure 经皮经肝胆道引流术后血液和胆道引流培养及死亡率的评估

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.02.054

Ayhan rk, A. Ayaz

{"title":"Evaluation of Blood and Biliary Drainage Cultures and Mortality after Percutaneous Transhepatic Biliary Drainage Procedure","authors":"Ayhan rk, A. Ayaz","doi":"10.5455/annalsmedres.2023.02.054","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.054","url":null,"abstract":"Introduction: Bacteremia and bile duct infection following percutaneous transhepatic biliary drainage (PTBD) are severe complications. Thus, the aim of this study was to investigate the risk factors of mortality and to evaluate the differences between blood and biliary drainage culture positive patients after PTBD. Materials and Methods: This is a retrospective study of 90 patients without any signs of infection prior to the PTBD procedures. Of these patients, we further divided them into three groups based on culture results: 1) first group was only bacteremic, 2) second group was only bile drainage culture-positive, and 3) third group was both bacteremic and bile drainage culture-positive. We compared clinical and laboratory parameters between these three groups and also evaluated the culture results in a high-resistance setting. Results: There were 90 patients who developed bacteremia, bile duct infections or both. In the laboratory findings, bacteremic patients showed significantly higher serum level of alanine aminotransferase (ALT) (p=0.001). Elevated neutrophil counts, lipase levels and carbapenem-resistant isolates were found to be the independent risk factors for 30-day mortality after PTBD. (p=0.01, p=0.01, and p=0.04, respectively). Gram-negative organisms were present in 71.2% of the cases; Escherichia coli was the most common species (28.1%) followed by Enterococcus faecium (18.1%), Klebsiella pneumoniae (15.8%) and Pseudomonas aeruginosa (9.9%). 51 (41.8%) of the cultured gram-negative bacteria were extended spectrum beta-lactamases positive and carbapenem resistance was found in 27 (15.8%) isolates. Conclusion: Elevated ALT level was only difference between three groups. Therefore, bacteremic and bile culture positive patients should be treated with the same care. Elevated neutrophil counts, lipase levels and carbapenem-resistant isolates were the independent risk factors for mortality. Finally, the choice of antibiotic prophylaxis should be reviewed according to the antimicrobial resistance profiles.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79064724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approach to the intracranial aneurysm in patients with autosomal dominant polycystic kidney; Are current radiological screening recommendations applied? 常染色体显性多囊肾患者颅内动脉瘤的治疗方法；目前的放射学筛查建议是否适用？

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.12.398

S. Ediz, U. Soylemez, Başak Atalay

引用次数: 0

Incidental cause of mild hyperglycemia in children: genetic, clinical, and follow-up features of Glucokinase-MODY diabetes 儿童轻度高血糖的偶然原因：葡萄糖激酶-MODY 型糖尿病的遗传、临床和随访特征

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.11.332

smail ndar

引用次数: 0

Enhanced anticancer potency of Aloe vera in combination with Royal jelly in non-small cell lung cancer and colorectal adenocarcinoma 芦荟与蜂王浆联合抗非小细胞肺癌和结直肠腺癌的研究

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.08.207

Tu l

{"title":"Enhanced anticancer potency of Aloe vera in combination with Royal jelly in non-small cell lung cancer and colorectal adenocarcinoma","authors":"Tu l","doi":"10.5455/annalsmedres.2023.08.207","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.207","url":null,"abstract":"Aim: The aim of this study was to determine the anticancer activity of royal jelly (RJ) and Aloe vera (AVE) separately and in combination on human non-small cell lung cancer (A549) and colorectal adenocarcinoma cells (HT29) and to investigate whether the side effects of AVE can be ameliorated by RJ. Materials and Methods: The antiproliferative activity of RJ, AVE, and the combination of AVE and RJ was performed in vitro on A549 and HT29 cells using a Real-Time Cell Analyzer (xCELLigence). To determine the mechanisms underlying the antiproliferative activity, cell apoptosis was performed by flow cytometry using the annexin V-FITC/PI apoptosis detection kit, while cell migration was determined by wound healing assay. Results: Treatment with varying concentrations of AVE, RJ, and the combination of AVE and RJ was concluded to have dose-dependent antiproliferative activity and that the AVE-RJ combination induced 41% of HT29 and 11.79% of A549 early apoptosis (p<0.05). However, the inhibition effect of the combination of AVE and RJ on cancer cell migration was not detected. Conclusion: Taken together, our results showed that the AVE-RJ combination could be a promising therapeutic combination in A549 and HT29 by inducing apoptosis. The obtained results revealed that the AVE (40 µg/mL) and RJ (300 mg/mL) combination in the A549 cell line exhibited earlier antiproliferative activity than the 40 µg/mL AVE. Also, it has been found that the antiproliferative activity of AVE is enhanced when used in combination with RJ. Keywords: Aloe vera; Royal jelly; Non-small cell lung cancer; Colorectal adenocarcinoma; Real-time cell analyzer/xCELLigence); Wound healing assay.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134979953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0